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14-September-2008 18:02:46 - Goitre Goitre Classification and external resources A woman with a goiter. ICD-10 E01.0-E01.2 ICD-9 240.9 DiseasesDB 5332 MedlinePlus 001178 MeSH Goiter A goitre BrE, or goiter AmE Latin struma, also called a bronchocele, is a swelling in the neck just below the Adam's apple or larynx due to an enlarged thyroid gland. Contents 1 Classification 2 Causes 3 Occurence 4 Treatment 5 Symptoms 6 History and future 7 Famous goitre sufferers 8 See also 9 References 10 External links Classification They are classified in different ways: A diffuse goiter is a goiter that has spread through all of the thyroid and can be a simple goitre, or a multinodular goitre. Toxic goitre refers to goitre with hyperthyroidism. These most commonly due to Graves' disease, but can be caused by inflammation or a multinodular goitre. Nontoxic goitre associated with normal or low thyroid levels refers to all other types such as that caused by lithium or certain other autoimmune diseases. Other type of classification: I - palpation struma - in normal posture of head it cannot be seen. Only found when palpating. II - struma is palpative and can be easily seen. III - struma is very big and is retrosternal. Pressure and compression marks. Causes The most common cause for goitre is iodine deficiency. Other causes are: Hashimoto's thyroiditis E06.3 Graves-Basedow disease E05.0 Inborn errors of thyroid hormone synthesis, causing congenital hypothyroidism E03.0 Thyroiditis acute, chronic E06 Side-effects of pharmacological therapy E03.2 Thyroid cancer Occurence Iodine is necessary for the synthesis of the thyroid hormones thyroxine T4 and triiodothyronine T3. In endemic goitre, iodine deficiency leaves the thyroid gland unable to produce its hormones because the hormones are made out of iodine. When levels of thyroid hormones fall, thyrotropin-releasing hormone TRH is produced by the hypothalamus. TRH then prompts the pituitary gland to make thyrotropin or thyroid stimulating hormone TSH, which stimulates the thyroid gland's production of T4 and T3. It also causes the thyroid gland to grow in size by increasing cell division. Nodular goitre of a young south asian woman. Nodular goitre of a young south asian woman. Goitre is more common among women, but this includes the many types of goitre caused by autoimmune problems, and not only those caused by simple lack of iodine. Treatment Treatment may not be necessary if the goitre is small. Goitre may be related to hyper- and hypothyroidism especially Graves' disease and may be reversed by treatment of hyper- and hypothyroidism. Grave's disease can be corrected with antithyroid drugs such as propylthiouracil and methimazole, thyroidectomy surgical removal of the thyroid gland, and iodine-131 131I - a radioactive isotope of iodine that is absorbed by the thyroid gland and destroys it. Hypothyroidism may raise the risk of goitre because it usually increases the production of TRH and TSH. Levothyroxine, used to treat hypothyroidism, can also be used in euthyroid patients for the treatment of goitre. Levothyroxine suppressive therapy decreases the production of TRH and TSH and may reduce goitre, thyroid nodules, and thyroid cancer. Blood tests are needed to ensure that TSH is still in range and the patient has not become subclinically hyperthyroid. If TSH levels are not carefully monitored, levothyroxine may increase the risk of osteoporosis. Thyroidectomy with 131I may be necessary in euthyroid goitrous patients who do not respond to levothyroxine treatment, especially if the patients have difficulty breathing or swallowing. 131I, with or without the pre-injection of synthetic TSH, can relieve obstruction and reduce the size of the goitre by thirty to sixty-five percent. Depending on how large the goitre is and how much of the thyroid gland must be removed or destroyed, thyroidectomy or 131 may produce hypothyroidism requiring life-long treatment. Symptoms The symptoms of goiter/goitre are mainly the swelling of the front part of the neck and protruding eyes. History and future Further information: List of Chinese inventions Chinese physicians of the Tang Dynasty 618-907 were the first to successfully treat patients with goiter by using the iodine-rich thyroid gland of animals such as sheep and pigs-in raw, pill, or powdered-mixture-in-wine form.1 This was outlined in Zhen Quan's died 643 AD book, as well as several others.2 One Chinese book i.e. The Pharmacopoeia of the Heavenly Husbandman asserted that iodine-rich sargassum was used to treat goiter patients by the 1st century BC, but this book was written much later.3 In the 12th century, al-Jurjani, a Persian physician, provided the first description of Graves' disease after noting the association of goitre and exophthalmos in his Thesaurus of the Shah of Khwarazm, the major medical dictionary of its time.45 Al-Jurjani also established an association between goitre and palpitation.6 The disease was later named after Irish doctor Robert James Graves,7 who described a case of goiter with exophthalmos in 1835. The German Karl Adolph von Basedow also independently reported the same constellation of symptoms in 1840, while earlier reports of the disease were also published by the Italians Giuseppe Flajani and Antonio Giuseppe Testa, in 1802 and 1810 respectively,8 and by the English physician Caleb Hillier Parry a friend of Edward Jenner in the late 18th century.9 Paracelsus 1493-1541 was the first person to propose a relationship between goitre and minerals particularly lead in drinking water.10 Iodine was later discovered by Bernard Courtois in 1811 from seaweed ash. Goitre was previously common in many areas that were deficient in iodine in the soil. For example, in the English Midlands, the condition was known as Derbyshire Neck. In the United States, goitre was found in the Great Lakes, Midwest, and Intermountain regions. The condition now is practically absent in affluent nations, where table salt is supplemented with iodine. However, it is still prevalent in India,11 Central Asia and Central Africa. Some health workers fear that a resurgence of goitre might occur because of the trend to use rock salt and/or sea salt, which has not been fortified with iodine. New research indicates that there may in fact be a tendency to inherit an increased vulnerability to goitre. Famous goitre sufferers Former President George H. W. Bush and his wife Barbara Bush both were diagnosed with Graves' disease and goitres, within two years of each other. In the president's case, the disease caused hyperthyroidism and cardiac dysrhythmia.12131415 Scientists said that the odds of both George and Barbara Bush having Graves' disease might be 1 in 100,000 or as low as 1 in 3,000,00016 Andrea True according to an interview on VH-1 17 Jose Fadul Kim Il-sung George Lucas See also Wikimedia Commons has media related to: Goiters Struma ovarii a kind of teratoma David Marine conducted substantial research on the treatment of goiter with iodine. References ^ Temple, Robert. 1986. The Genius of China: 3,000 Years of Science, Discovery, and Invention. With a forward by Joseph Needham. New York: Simon and Schuster, Inc. ISBN 0671620282. Pages 133-134. ^ Temple, Robert. 1986. The Genius of China: 3,000 Years of Science, Discovery, and Invention. With a forward by Joseph Needham. New York: Simon and Schuster, Inc. ISBN 0671620282. Page 134. ^ Temple, Robert. 1986. The Genius of China: 3,000 Years of Science, Discovery, and Invention. With a forward by Joseph Needham. New York: Simon and Schuster, Inc. ISBN 0671620282. Pages 134-135 ^ Basedow's syndrome or disease at Who Named It - the history and naming of the disease ^ Ljunggren JG August 1983. Who was the man behind the syndrome: Ismail al-Jurjani, Testa, Flagani, Parry, Graves or Basedow? Use the term hyperthyreosis instead. Lakartidningen 80 32-33: 2902. PMID 6355710. ^ Nabipour, I. 2003, Clinical Endocrinology in the Islamic Civilization in Iran, International Journal of Endocrinology and Metabolism 1: 43-45 45 ^ Robert James Graves at Who Named It ^ Giuseppe Flajani at Who Named It ^ Hull G 1998. Caleb Hillier Parry 1755-1822: a notable provincial physician. Journal of the Royal Society of Medicine 91 6: 335-8. PMID 9771526. ^ Paracelsus Britannica ^ In Raising the World's I.Q., the Secret's in the Salt, article by Donald G. McNeil, Jr., December 16, 2006, New York Times ^ The Health and Medical History of President George Bush DoctorZebra.com. 8 August 2004. Retrieved 8 October 2006. ^ George H.W. Bush. NNDB. ^ Robert G. Lahita and Ina Yalof. Women and Autoimmune Disease: The Mysterious Ways Your Body Betrays Itself. Page 158. ^ Lawrence K. Altman, M.D. Doctors Say Bush Is in Good Health. The New York Times. September 14, 1991. ^ http://query.nytimes.com/gst/fullpage.html?res=9D0CE7DD1039F93BA15756C0A967958260sec=spon=pagewanted=1 Lawrence K. Altman, M.D. The Doctor's World; A White House Puzzle: Immunity Ailments. The New York Times. May 28, 1991 ^ http://celebrity.elle.com/celebrity-Andrea+True Andrea True. Elle. October 2006 External links Goiter National Health Services, UK Network for Sustained Elimination of Iodine Deficiency Network for Sustained Elimination of Iodine Deficiency - alternate site at Emory University's School of Public Health v d e Endocrine pathology: endocrine diseases E00-35, 240-259 Pancreas/ glucose metabolism Diabetes mellitus types: type 1, type 2, MODY, complications: coma, angiopathy, ketoacidosis, nephropathy, neuropathy, retinopathy Hypoglycemia - Hyperinsulinism - Zollinger-Ellison syndrome - insulin receptor Rabson-Mendenhall syndrome - Insulin resistance Hypothalamic/ pituitary axes Pituitary Hyperpituitarism Acromegaly, Hyperprolactinaemia, SIADH Hypopituitarism Sheehan's syndrome, Kallmann syndrome, Growth hormone deficiency, Diabetes insipidus Adiposogenital dystrophy - Empty sella syndrome - Pituitary apoplexy - ACTH deficiency Thyroid Hypothyroidism Iodine deficiency, Cretinism, Congenital hypothyroidism, Goitre, Myxedema Hyperthyroidism Graves disease, Toxic multinodular goitre, Teratoma with thyroid tissue or Struma ovarii Thyroiditis De Quervain's thyroiditis, Hashimoto's thyroiditis, Riedel's thyroiditis Euthyroid sick syndrome - Thyroid hormone resistance - Thyroid nodule Parathyroid Hypoparathyroidism Pseudohypoparathyroidism - Hyperparathyroidism Primary, Secondary, Tertiary Adrenal Adrenocortical hyperfunction: Cushing's syndrome Nelson's syndrome, Pseudo-Cushing's syndrome - Hyperaldosteronism Conn syndrome, Bartter syndrome CAH Lipoid, 3β, 11β, 17α, 21α Adrenal insufficiency Addison's disease, Waterhouse-Friderichsen syndrome - Hypoaldosteronism Gonads ovarian Polycystic ovary syndrome, Premature ovarian failure testicular 5-alpha-reductase deficiency, 17-beta-hydroxysteroid dehydrogenase deficiency general Hypogonadism, Delayed puberty, Precocious puberty Other Androgen insensitivity syndrome - Autoimmune polyendocrine syndrome - Carcinoid syndrome - Gigantism - Short stature Laron syndrome, Psychogenic dwarfism - Multiple endocrine neoplasia 1, 2 - Progeria - Woodhouse-Sakati syndrome - thymus Abscess of thymus, Thymus hyperplasia see also congenital, neoplasia Retrieved from http://en..org/wiki/Goitre Categories: Thyroid disease | MalnutritionHidden category: Articles needing additional references from October 2006 Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages العربية Bosanski Dansk Deutsch Español Euskara Français Bahasa Indonesia Italiano עברית Nederlands 日本語 Kurdî / كوردی ‪Norsk bokmÃ¥l‬ Polski Português Suomi Svenska தமிழà¯? ä¸æ–‡ This page was last modified on 13 September 2008, at 16:59
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