Sierra Acai Company
Sierra Acai Company
Open 7 Days a Week
MonaVie Independent Distributor
Distributor Training
Shop Online
Enroll Now
Buy Wholesale and maintain an Active status for 2 months and we will refund your $39 Distributor Fee
Friends
Buy Wholesale and maintain an Active status for 2 months and we will refund your $39 Distributor Fee
14-September-2008 18:02:43 - hormone receptor Growth hormone releasing hormone receptor Identifiers Symbols GHRHR; GHRFR; GHRHRpsv; GRFR External IDs OMIM: 139191 MGI: 95710 HomoloGene: 640 Gene ontology Molecular function: receptor activity G-protein coupled receptor activity vasoactive intestinal polypeptide receptor activity growth hormone-releasing hormone receptor activity Cellular component: plasma membrane membrane integral to membrane Biological process: skeletal development signal transduction G-protein coupled receptor protein signaling pathway adenylate cyclase activation biological_process RNA expression pattern More reference expression data Orthologs Human Mouse Entrez 2692 14602 Ensembl ENSG00000106128 ENSMUSG00000004654 Uniprot Q02643 Q0VB62 Refseq NM_000823 mRNA NP_000814 protein NM_001003685 mRNA NP_001003685 protein Location Chr 7: 30.97 - 30.99 Mb Chr 6: 55.31 - 55.32 Mb Pubmed search 1 2 The growth hormone releasing hormone receptor GHRHR is a G-protein coupled receptor which binds growth hormone releasing hormone.1 This gene, expressed in the pituitary, encodes a receptor for growth hormone-releasing hormone. Binding of this hormone to the receptor leads to synthesis and release of growth hormone. Mutations in this gene have been associated with isolated growth hormone deficiency IGHD, also known as Dwarfism of Sindh, a disorder characterized by short stature. Many alternate transcriptional splice variants encoding different isoforms have been described, but only two have been characterized to date.2 References ^ Gaylinn BD 2002. Growth hormone releasing hormone receptor. Recept. Channels 8 3-4: 155-62. doi:10.1080/10606820213679. PMID 12529933. ^ Entrez Gene: GHRHR growth hormone releasing hormone receptor. Further reading Gaylinn BD 1999. Molecular and cell biology of the growth hormone-releasing hormone receptor.. Growth Horm. IGF Res. 9 Suppl A: 37-44. PMID 10429879. Lin-Su K, Wajnrajch MP 2003. Growth Hormone Releasing Hormone GHRH and the GHRH Receptor.. Reviews in endocrine metabolic disorders 3 4: 313-23. PMID 12424433. Mayo KE 1992. Molecular cloning and expression of a pituitary-specific receptor for growth hormone-releasing hormone.. Mol. Endocrinol. 6 10: 1734-44. PMID 1333056. Squire J, Zhou A, Hassel BA, et al. 1994. Localization of the interferon-induced, 2-5A-dependent RNase gene RNS4 to human chromosome 1q25.. Genomics 19 1: 174-5. doi:10.1006/geno.1994.1033. PMID 7514564. Hashimoto K, Koga M, Motomura T, et al. 1995. Identification of alternatively spliced messenger ribonucleic acid encoding truncated growth hormone-releasing hormone receptor in human pituitary adenomas.. J. Clin. Endocrinol. Metab. 80 10: 2933-9. PMID 7559877. Tang J, Lagacé G, Castagné J, Collu R 1995. Identification of human growth hormone-releasing hormone receptor splicing variants.. J. Clin. Endocrinol. Metab. 80 8: 2381-7. PMID 7629234. Gaylinn BD, Harrison JK, Zysk JR, et al. 1993. Molecular cloning and expression of a human anterior pituitary receptor for growth hormone-releasing hormone.. Mol. Endocrinol. 7 1: 77-84. PMID 7680413. Gaylinn BD, von Kap-Herr C, Golden WL, Thorner MO 1994. Assignment of the human growth hormone-releasing hormone receptor gene GHRHR to 7p14 by in situ hybridization.. Genomics 19 1: 193-5. doi:10.1006/geno.1994.1045. PMID 8188233. Wajnrajch MP, Gertner JM, Harbison MD, et al. 1996. Nonsense mutation in the human growth hormone-releasing hormone receptor causes growth failure analogous to the little lit mouse.. Nat. Genet. 12 1: 88-90. doi:10.1038/ng0196-88. PMID 8528260. Netchine I, Talon P, Dastot F, et al. 1998. Extensive phenotypic analysis of a family with growth hormone GH deficiency caused by a mutation in the GH-releasing hormone receptor gene.. J. Clin. Endocrinol. Metab. 83 2: 432-6. PMID 9467553. Petersenn S, Rasch AC, Heyens M, Schulte HM 1998. Structure and regulation of the human growth hormone-releasing hormone receptor gene.. Mol. Endocrinol. 12 2: 233-47. PMID 9482665. Maheshwari HG, Silverman BL, Dupuis J, Baumann G 1998. Phenotype and genetic analysis of a syndrome caused by an inactivating mutation in the growth hormone-releasing hormone receptor: Dwarfism of Sindh.. J. Clin. Endocrinol. Metab. 83 11: 4065-74. PMID 9814493. Salvatori R, Hayashida CY, Aguiar-Oliveira MH, et al. 1999. Familial dwarfism due to a novel mutation of the growth hormone-releasing hormone receptor gene.. J. Clin. Endocrinol. Metab. 84 3: 917-23. PMID 10084571. Morel G, Gallego R, Boulanger L, et al. 2000. Restricted presence of the growth hormone-releasing hormone receptor to somatotropes in rat and human pituitaries.. Neuroendocrinology 70 2: 128-36. PMID 10461027. Rekasi Z, Czompoly T, Schally AV, Halmos G 2000. Isolation and sequencing of cDNAs for splice variants of growth hormone-releasing hormone receptors from human cancers.. Proc. Natl. Acad. Sci. U.S.A. 97 19: 10561-6. doi:10.1073/pnas.180313297. PMID 10962031. Salvatori R, Fan X, Phillips JA, et al. 2001. Three new mutations in the gene for the growth hormone gh-releasing hormone receptor in familial isolated gh deficiency type ib.. J. Clin. Endocrinol. Metab. 86 1: 273-9. PMID 11232012. Kiaris H, Schally AV, Busto R, et al. 2002. Expression of a splice variant of the receptor for GHRH in 3T3 fibroblasts activates cell proliferation responses to GHRH analogs.. Proc. Natl. Acad. Sci. U.S.A. 99 1: 196-200. doi:10.1073/pnas.012590999. PMID 11773624. Salvatori R, Fan X, Mullis PE, et al. 2002. Decreased expression of the GHRH receptor gene due to a mutation in a Pit-1 binding site.. Mol. Endocrinol. 16 3: 450-8. PMID 11875102. Plonowski A, Schally AV, Busto R, et al. 2003. Expression of growth hormone-releasing hormone GHRH and splice variants of GHRH receptors in human experimental prostate cancers.. Peptides 23 6: 1127-33. PMID 12126741. External links IUPHAR GPCR Database - GHRH receptor MeSH somatotropin+releasing+hormone+receptor This transmembrane receptor-related article is a stub. This article incorporates text from the United States National Library of Medicine, which is in the public domain. v d e Transmembrane receptor: G protein-coupled receptors Class A: Rhodopsin like Adrenergic α1 A, B, D, α2 A, B, C, β1, β2, β3 Eicosanoid CysLT 1, 2, LTB4 1, 2, FPRL1, OXE, Prostaglandin DP, EP 1, 2, 3, 4, PGF, Prostacyclin, Thromboxane Neuropeptide B/W 1, 2, FF 1, 2, S, Y 1, 2, 4, 5 Orphan GPR 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182 Purinergics Adenosine A1, A2a, A2b, A3, P2Y, 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14 Serotonin all but 5-HT3 5-HT1 A, B, D, E, F, 5-HT2 A, B, C, 5-HT 4, 5A, 6, 7 Other Acetylcholine M1, M2, M3, M4, M5 - Adrenomedullin - Anaphylatoxin C3a, C5a - Angiotensin 1, 2 - Apelin - Bile acid - Bombesin BRS3, GRPR, NMBR - Bradykinin B1, B2 - Cannabinoid CB1, CB2 - Chemokine - Cholecystokinin A, B - Dopamine D1, D2, D3, D4, D5 - EBI2 - Endothelin A, B - Estrogen - Formyl peptide 1, L1, L2 - Free fatty acid 1, 2, 3, 4 - FSH - Galanin 1, 2, 3 - Gonadotropin-releasing hormone 1, 2 - Ghrelin - Histamine H1, H2, H3, H4 - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid 1, 2, 3, 4, 5, 6, 7, 8 - MAS 1, 1L, D, E, F, G, X1, X2, X3, X4 - Melanocortin 1, 2, 3, 4, 5 - MCHR 1, 2 - Melatonin 1A, 1B- Motilin - neuromedin B, U 1, 2 - Neurotensin 1, 2 - Opioid Delta, Kappa, Mu, Nociceptin, but not Sigma - Olfactory - Opsin 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH - Orexin 1, 2 - Oxytocin - Oxoglutarate - PAF - Prokineticin 1, 2 - Prolactin-releasing peptide - Protease-activated 1, 2, 3, 4 - Relaxin 1, 2, 3, 4 - Somatostatin 1, 2, 3, 4, 5 - SREB - Succinate - TAAR 1, 2, 3, 5, 6, 8, 9 - Tachykinin 1, 2, 3 - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin 1A, 1B, 2 Class B: Secretin like Brain-specific angiogenesis inhibitor 1, 2, 3 - Cadherin 1, 2, 3 - Calcitonin - CD97 - Corticotropin-releasing hormone 1, 2 - EMR 1, 2, 3 - Glucagon GR, GIPR, GLP1R, GLP2R - Growth hormone releasing hormone - PACAPR1- GPR 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157 - Latrophilin 1, 2, 3, ELTD1 - Parathyroid hormone 1, 2 - Secretin - Vasoactive intestinal peptide 1, 2 Class C: Metabotropic glutamate / pheromone Calcium-sensing receptor - GABA B 1, 2 - Glutamate receptor Metabotropic glutamate 1, 2, 3, 4, 5, 6, 7, 8 - GPRC6A - GPR 156, 158, 179 - RAIG 1, 2, 3, 4 - Taste receptors TAS1R 1, 2, 3 TAS2R 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50 Frizzled / Smoothened Frizzled 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 - Smoothened Retrieved from http://en..org/wiki/Growth_hormone_releasing_hormone_receptor Categories: Genes on chromosome 7 | Human proteins | Transmembrane receptor stubs | G protein coupled receptorsHidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 8 July 2008, at 05:35
39 Reasons to Drink Acai Juice Every Day
What is MonaVie - Watch the 8-minute video
Discovering MonaVie Video
The Power of You Video
Effects of MonaVie Active on Antioxidant Capacity in Humans
Log into your Wholesale MonaVie Account
So many of us do not eat a balanced diet, get enough sleep, have too much stress, or are impacted with toxins and pollutants. Drinking 2 ounces of MonaVie twice a day will help your body detoxify as well as build your immune system. Its the smartest thing you can do for yourself, so start today. Buying MonaVie through our company guarantees you support 7 days a week and, if you would like to share MonaVie with your family and friends we will guide you from start to finish.
1. Click on Enroll Now (30 - 55% off retail price)
2. Pay $39 for your Wholesale ID number.
3. NO minimum order required.
4. MonaVie is delivered to your door in 3 to 5 days.