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News About HomoloGene

14-September-2008 18:02:43 - HomoloGene HomoloGene, a tool of the National Center for Biotechnology Information NCBI, is a system for automated detection of homologs similarity attributable to descent from a common ancestor among the annotated genes of several completely sequenced eukaryotic genomes. The HomoloGene processing consists of the protein analysis from the input organisms. Sequences are compared using blastp1, then matched up and put into groups, using a taxonomic tree built from sequence similarity, where closer related organisms are matched up first, and then further organisms are added to the tree. The protein alignments are mapped back to their corresponding DNA sequences, and then distance metrics as molecular distances Jukes and Cantor 1969, Ka/Ks ratio can be calculated. The sequences are matched up by using a heuristic algorithm for maximizing the score globally, rather than locally, in a bipartite matching see complete bipartite graph. And then it calculates the statistical significance of each match. Cutoffs are made per position and Ks values are set to prevent false orthologs from being grouped together. Paralogs are identified by finding sequences that are closer within species than other species. Input organisms Homo sapiens, Pan troglodytes, Canis lupus familiaris, Bos taurus, Mus musculus, Danio rerio, Rattus norvegicus, Arabidopsis thaliana, Gallus gallus, Oryza sativa, Anopheles gambiae, Drosophila melanogaster, Magnaporthe grisea, Neurospora crassa, Caenorhabditis elegans, Saccharomyces cerevisiae, Kluyveromyces lactis, Eremothecium gossypii, Schizosaccharomyces pombe and Plasmodium falciparum. Interface The HomoloGene is linked to all Entrez databases and based on homology and phenotype information of these links: Mouse Genome Informatics MGI, Zebrafish Information Network ZFIN, Saccharomyces Genome Database SGD, Clusters of Orthologous Groups COG, FlyBase, Online Mendelian Inheritance in Man OMIM As a result HomoloGene displays information about Genes, Proteins, Phenotypes, and Conserved Domains. External links HomoloGene at the National Center for Biotechnology Information Bioinformatic Harvester - Bioinformatic Harvester, a meta search engine that uses Homologene OMIM ZFIN SGD COG FlyBase MGI Rat Genome Database v d e Databases supported by Bioinformatic Harvester NCBI-BLAST · CDD · Ensembl · Entrez · Flybase · Flymine · GFP-cDNA · Genome browser · GeneCard · Google Scholar · GoPubMed · HomoloGene · iHOP · IPI · OMIM · MGI · Mitocheck · PSORT · PolyMeta · RGD · UniProt · SOURCE · SOSUI · RZPD · Sciencenet · STRING · SMART · TAIR · WikiProfessional · ZFIN Retrieved from http://en..org/wiki/HomoloGene Categories: Genetics | Bioinformatics Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages Deutsch This page was last modified on 27 June 2008, at 20:10

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39 Reasons to Drink Acai Juice Every Day
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Why Drink MonaVie?

So many of us do not eat a balanced diet, get enough sleep, have too much stress, or are impacted with toxins and pollutants. Drinking 2 ounces of MonaVie twice a day will help your body detoxify as well as build your immune system. Its the smartest thing you can do for yourself, so start today. Buying MonaVie through our company guarantees you support 7 days a week and, if you would like to share MonaVie with your family and friends we will guide you from start to finish.

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