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14-September-2008 18:02:43 - 2 Hypocretin orexin receptor 2 Identifiers Symbols HCRTR2; OX2R External IDs OMIM: 602393 MGI: 2680765 HomoloGene: 1168 Gene ontology Molecular function: rhodopsin-like receptor activity receptor activity neuropeptide receptor activity orexin receptor activity Cellular component: integral to plasma membrane membrane Biological process: signal transduction G-protein signaling, coupled to IP3 second messenger phospholipase C activating neuropeptide signaling pathway synaptic transmission feeding behavior RNA expression pattern More reference expression data Orthologs Human Mouse Entrez 3062 387285 Ensembl ENSG00000137252 ENSMUSG00000032360 Uniprot O43614 Q8BV78 Refseq NM_001526 mRNA NP_001517 protein NM_198962 mRNA NP_945200 protein Location Chr 6: 55.15 - 55.26 Mb Chr 9: 76.01 - 76.11 Mb Pubmed search 1 2 Hypocretin orexin receptor 2, also known as HCRTR2, is a human gene.1 HCRTR2 is a G-protein coupled receptor expressed exclusively in the brain. It has 64% identity with HCRTR1. HCRTR2 binds both orexin A and orexin B neuropeptides. HCRTR2 is involved in the central feedback mechanism that regulates feeding behaviour.1 See also Orexin receptor References ^ a b Entrez Gene: HCRTR2 hypocretin orexin receptor 2. Further reading Flier JS, Maratos-Flier E 1998. Obesity and the hypothalamus: novel peptides for new pathways.. Cell 92 4: 437-40. PMID 9491885. Willie JT, Chemelli RM, Sinton CM, Yanagisawa M 2001. To eat or to sleep? Orexin in the regulation of feeding and wakefulness.. Annu. Rev. Neurosci. 24: 429-58. doi:10.1146/annurev.neuro.24.1.429. PMID 11283317. Hungs M, Mignot E 2001. Hypocretin/orexin, sleep and narcolepsy.. Bioessays 23 5: 397-408. doi:10.1002/bies.1058. PMID 11340621. de Lecea L, Kilduff TS, Peyron C, et al. 1998. The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity.. Proc. Natl. Acad. Sci. U.S.A. 95 1: 322-7. PMID 9419374. Sakurai T, Amemiya A, Ishii M, et al. 1998. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior.. Cell 92 4: 573-85. PMID 9491897. Sakurai T, Amemiya A, Ishii M, et al. 1998. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior.. Cell 92 5: 1 page following 696. PMID 9527442. Peyron C, Faraco J, Rogers W, et al. 2000. A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains.. Nat. Med. 6 9: 991-7. doi:10.1038/79690. PMID 10973318. Wright GJ, Puklavec MJ, Willis AC, et al. 2000. Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function.. Immunity 13 2: 233-42. PMID 10981966. Hartley JL, Temple GF, Brasch MA 2001. DNA cloning using in vitro site-specific recombination.. Genome Res. 10 11: 1788-95. PMID 11076863. Mazzocchi G, Malendowicz LK, Gottardo L, et al. 2001. Orexin A stimulates cortisol secretion from human adrenocortical cells through activation of the adenylate cyclase-dependent signaling cascade.. J. Clin. Endocrinol. Metab. 86 2: 778-82. PMID 11158046. Blanco M, López M, García-Caballero T, et al. 2001. Cellular localization of orexin receptors in human pituitary.. J. Clin. Endocrinol. Metab. 86 4: 1616-9. PMID 11297593. Blanco M, López M, GarcIa-Caballero T, et al. 2001. Cellular localization of orexin receptors in human pituitary.. J. Clin. Endocrinol. Metab. 86 7: 1616-9. PMID 11443222. Karteris E, Randeva HS, Grammatopoulos DK, et al. 2001. Expression and coupling characteristics of the CRH and orexin type 2 receptors in human fetal adrenals.. J. Clin. Endocrinol. Metab. 86 9: 4512-9. PMID 11549701. Randeva HS, Karteris E, Grammatopoulos D, Hillhouse EW 2001. Expression of orexin-A and functional orexin type 2 receptors in the human adult adrenals: implications for adrenal function and energy homeostasis.. J. Clin. Endocrinol. Metab. 86 10: 4808-13. PMID 11600545. Olafsdóttir BR, Rye DB, Scammell TE, et al. 2002. Polymorphisms in hypocretin/orexin pathway genes and narcolepsy.. Neurology 57 10: 1896-9. PMID 11723285. Blanco M, García-Caballero T, Fraga M, et al. 2002. Cellular localization of orexin receptors in human adrenal gland, adrenocortical adenomas and pheochromocytomas.. Regul. Pept. 104 1-3: 161-5. PMID 11830291. Strausberg RL, Feingold EA, Grouse LH, et al. 2003. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 99 26: 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. This transmembrane receptor-related article is a stub. This article incorporates text from the United States National Library of Medicine, which is in the public domain. v d e Transmembrane receptor: G protein-coupled receptors Class A: Rhodopsin like Adrenergic α1 A, B, D, α2 A, B, C, β1, β2, β3 Eicosanoid CysLT 1, 2, LTB4 1, 2, FPRL1, OXE, Prostaglandin DP, EP 1, 2, 3, 4, PGF, Prostacyclin, Thromboxane Neuropeptide B/W 1, 2, FF 1, 2, S, Y 1, 2, 4, 5 Orphan GPR 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182 Purinergics Adenosine A1, A2a, A2b, A3, P2Y, 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14 Serotonin all but 5-HT3 5-HT1 A, B, D, E, F, 5-HT2 A, B, C, 5-HT 4, 5A, 6, 7 Other Acetylcholine M1, M2, M3, M4, M5 - Adrenomedullin - Anaphylatoxin C3a, C5a - Angiotensin 1, 2 - Apelin - Bile acid - Bombesin BRS3, GRPR, NMBR - Bradykinin B1, B2 - Cannabinoid CB1, CB2 - Chemokine - Cholecystokinin A, B - Dopamine D1, D2, D3, D4, D5 - EBI2 - Endothelin A, B - Estrogen - Formyl peptide 1, L1, L2 - Free fatty acid 1, 2, 3, 4 - FSH - Galanin 1, 2, 3 - Gonadotropin-releasing hormone 1, 2 - Ghrelin - Histamine H1, H2, H3, H4 - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid 1, 2, 3, 4, 5, 6, 7, 8 - MAS 1, 1L, D, E, F, G, X1, X2, X3, X4 - Melanocortin 1, 2, 3, 4, 5 - MCHR 1, 2 - Melatonin 1A, 1B- Motilin - neuromedin B, U 1, 2 - Neurotensin 1, 2 - Opioid Delta, Kappa, Mu, Nociceptin, but not Sigma - Olfactory - Opsin 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH - Orexin 1, 2 - Oxytocin - Oxoglutarate - PAF - Prokineticin 1, 2 - Prolactin-releasing peptide - Protease-activated 1, 2, 3, 4 - Relaxin 1, 2, 3, 4 - Somatostatin 1, 2, 3, 4, 5 - SREB - Succinate - TAAR 1, 2, 3, 5, 6, 8, 9 - Tachykinin 1, 2, 3 - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin 1A, 1B, 2 Class B: Secretin like Brain-specific angiogenesis inhibitor 1, 2, 3 - Cadherin 1, 2, 3 - Calcitonin - CD97 - Corticotropin-releasing hormone 1, 2 - EMR 1, 2, 3 - Glucagon GR, GIPR, GLP1R, GLP2R - Growth hormone releasing hormone - PACAPR1- GPR 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157 - Latrophilin 1, 2, 3, ELTD1 - Parathyroid hormone 1, 2 - Secretin - Vasoactive intestinal peptide 1, 2 Class C: Metabotropic glutamate / pheromone Calcium-sensing receptor - GABA B 1, 2 - Glutamate receptor Metabotropic glutamate 1, 2, 3, 4, 5, 6, 7, 8 - GPRC6A - GPR 156, 158, 179 - RAIG 1, 2, 3, 4 - Taste receptors TAS1R 1, 2, 3 TAS2R 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50 Frizzled / Smoothened Frizzled 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 - Smoothened Retrieved from http://en..org/wiki/Hypocretin_orexin_receptor_2 Categories: Genes on chromosome 6 | Human proteins | Transmembrane receptor stubs | G protein coupled receptorsHidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 8 July 2008, at 11:58
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