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14-September-2008 18:02:43 - KiSS1-derived peptide receptor KISS1 receptor Identifiers Symbols KISS1R; AXOR12; GPR54; HOT7T175 External IDs OMIM: 604161 MGI: 2148793 HomoloGene: 11411 Gene ontology Molecular function: receptor activity protein binding neuropeptide receptor activity Cellular component: cell surface membrane integral to membrane Biological process: signal transduction G-protein coupled receptor protein signaling pathway behavior negative regulation of cell proliferation negative regulation of cell migration Orthologs Human Mouse Entrez 84634 114229 Ensembl ENSG00000116014 ENSMUSG00000035773 Uniprot Q969F8 Q91V45 Refseq NM_032551 mRNA NP_115940 protein NM_053244 mRNA NP_444474 protein Location Chr 19: 0.87 - 0.87 Mb Chr 10: 79.32 - 79.33 Mb Pubmed search 1 2 The KiSS1-derived peptide receptor also known as GPR54 is a G protein-coupled receptor1 which binds the peptide hormone kisspeptin.234 The protein encoded by this gene is a galanin-like G protein-coupled receptor that binds metastin, a peptide encoded by the metastasis suppressor gene KISS1. The tissue distribution of the expressed gene suggests that it is involved in the regulation of endocrine function, and this is supported by the finding that this gene appears to play a role in the onset of puberty.5 References ^ Lee DK, Nguyen T, O'Neill GP, Cheng R, Liu Y, Howard AD, Coulombe N, Tan CP, Tang-Nguyen AT, George SR, O'Dowd BF 1999. Discovery of a receptor related to the galanin receptors. FEBS Lett. 446 1: 103-7. PMID 10100623. ^ Ohtaki T, Shintani Y, Honda S, Matsumoto H, Hori A, Kanehashi K, Terao Y, Kumano S, Takatsu Y, Masuda Y, Ishibashi Y, Watanabe T, Asada M, Yamada T, Suenaga M, Kitada C, Usuki S, Kurokawa T, Onda H, Nishimura O, Fujino M 2001. Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor. Nature 411 6837: 613-7. doi:10.1038/35079135. PMID 11385580. ^ Muir AI, Chamberlain L, Elshourbagy NA, Michalovich D, Moore DJ, Calamari A, Szekeres PG, Sarau HM, Chambers JK, Murdock P, Steplewski K, Shabon U, Miller JE, Middleton SE, Darker JG, Larminie CG, Wilson S, Bergsma DJ, Emson P, Faull R, Philpott KL, Harrison DC 2001. AXOR12, a novel human G protein-coupled receptor, activated by the peptide KiSS-1. J. Biol. Chem. 276 31: 28969-75. doi:10.1074/jbc.M102743200. PMID 11387329. ^ Kotani M, Detheux M, Vandenbogaerde A, Communi D, Vanderwinden JM, Le Poul E, Brézillon S, Tyldesley R, Suarez-Huerta N, Vandeput F, Blanpain C, Schiffmann SN, Vassart G, Parmentier M 2001. The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54. J. Biol. Chem. 276 37: 34631-6. doi:10.1074/jbc.M104847200. PMID 11457843. ^ Entrez Gene: KISS1R KISS1 receptor. Further reading Colledge WH 2005. GPR54 and puberty.. Trends Endocrinol. Metab. 15 9: 448-53. doi:10.1016/j.tem.2004.09.008. PMID 15519892. Kaiser UB, Kuohung W 2006. KiSS-1 and GPR54 as new players in gonadotropin regulation and puberty.. Endocrine 26 3: 277-84. PMID 16034182. Seminara SB 2006. Metastin and its G protein-coupled receptor, GPR54: critical pathway modulating GnRH secretion.. Frontiers in neuroendocrinology 26 3-4: 131-8. doi:10.1016/j.yfrne.2005.10.001. PMID 16309735. Tena-Sempere M 2006. GPR54 and kisspeptin in reproduction.. Hum. Reprod. Update 12 5: 631-9. doi:10.1093/humupd/dml023. PMID 16731583. Cerrato F, Seminara SB 2007. Human genetics of GPR54.. Reviews in endocrine metabolic disorders 8 1: 47-55. doi:10.1007/s11154-007-9027-3. PMID 17334928. Lee DK, Nguyen T, O'Neill GP, et al. 1999. Discovery of a receptor related to the galanin receptors.. FEBS Lett. 446 1: 103-7. PMID 10100623. Ohtaki T, Shintani Y, Honda S, et al. 2001. Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor.. Nature 411 6837: 613-7. doi:10.1038/35079135. PMID 11385580. Muir AI, Chamberlain L, Elshourbagy NA, et al. 2001. AXOR12, a novel human G protein-coupled receptor, activated by the peptide KiSS-1.. J. Biol. Chem. 276 31: 28969-75. doi:10.1074/jbc.M102743200. PMID 11387329. Clements MK, McDonald TP, Wang R, et al. 2001. FMRFamide-related neuropeptides are agonists of the orphan G-protein-coupled receptor GPR54.. Biochem. Biophys. Res. Commun. 284 5: 1189-93. doi:10.1006/bbrc.2001.5098. PMID 11414709. Kotani M, Detheux M, Vandenbogaerde A, et al. 2001. The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54.. J. Biol. Chem. 276 37: 34631-6. doi:10.1074/jbc.M104847200. PMID 11457843. Hori A, Honda S, Asada M, et al. 2001. Metastin suppresses the motility and growth of CHO cells transfected with its receptor.. Biochem. Biophys. Res. Commun. 286 5: 958-63. doi:10.1006/bbrc.2001.5470. PMID 11527393. Ringel MD, Hardy E, Bernet VJ, et al. 2002. Metastin receptor is overexpressed in papillary thyroid cancer and activates MAP kinase in thyroid cancer cells.. J. Clin. Endocrinol. Metab. 87 5: 2399. PMID 11994395. Janneau JL, Maldonado-Estrada J, Tachdjian G, et al. 2002. Transcriptional expression of genes involved in cell invasion and migration by normal and tumoral trophoblast cells.. J. Clin. Endocrinol. Metab. 87 11: 5336-9. PMID 12414911. Bo-Abbas Y, Acierno JS, Shagoury JK, et al. 2003. Autosomal recessive idiopathic hypogonadotropic hypogonadism: genetic analysis excludes mutations in the gonadotropin-releasing hormone GnRH and GnRH receptor genes.. J. Clin. Endocrinol. Metab. 88 6: 2730-7. PMID 12788881. Ikeguchi M, Hirooka Y, Kaibara N 2003. Quantitative reverse transcriptase polymerase chain reaction analysis for KiSS-1 and orphan G-protein-coupled receptor hOT7T175 gene expression in hepatocellular carcinoma.. J. Cancer Res. Clin. Oncol. 129 9: 531-5. doi:10.1007/s00432-003-0469-z. PMID 12898236. de Roux N, Genin E, Carel JC, et al. 2003. Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54.. Proc. Natl. Acad. Sci. U.S.A. 100 19: 10972-6. doi:10.1073/pnas.1834399100. PMID 12944565. Seminara SB, Messager S, Chatzidaki EE, et al. 2003. The GPR54 gene as a regulator of puberty.. N. Engl. J. Med. 349 17: 1614-27. doi:10.1056/NEJMoa035322. PMID 14573733. Ikeguchi M, Yamaguchi K, Kaibara N 2004. Clinical significance of the loss of KiSS-1 and orphan G-protein-coupled receptor hOT7T175 gene expression in esophageal squamous cell carcinoma.. Clin. Cancer Res. 10 4: 1379-83. PMID 14977840. Bilban M, Ghaffari-Tabrizi N, Hintermann E, et al. 2004. Kisspeptin-10, a KiSS-1/metastin-derived decapeptide, is a physiological invasion inhibitor of primary human trophoblasts.. J. Cell. Sci. 117 Pt 8: 1319-28. doi:10.1242/jcs.00971. PMID 15020672. Grimwood J, Gordon LA, Olsen A, et al. 2004. The DNA sequence and biology of human chromosome 19.. Nature 428 6982: 529-35. doi:10.1038/nature02399. PMID 15057824. External links IUPHAR GPCR Database - KiSS1-derived peptide receptor MeSH KISS1R+protein,+human This transmembrane receptor-related article is a stub. This article incorporates text from the United States National Library of Medicine, which is in the public domain. v d e Transmembrane receptor: G protein-coupled receptors Class A: Rhodopsin like Adrenergic α1 A, B, D, α2 A, B, C, β1, β2, β3 Eicosanoid CysLT 1, 2, LTB4 1, 2, FPRL1, OXE, Prostaglandin DP, EP 1, 2, 3, 4, PGF, Prostacyclin, Thromboxane Neuropeptide B/W 1, 2, FF 1, 2, S, Y 1, 2, 4, 5 Orphan GPR 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182 Purinergics Adenosine A1, A2a, A2b, A3, P2Y, 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14 Serotonin all but 5-HT3 5-HT1 A, B, D, E, F, 5-HT2 A, B, C, 5-HT 4, 5A, 6, 7 Other Acetylcholine M1, M2, M3, M4, M5 - Adrenomedullin - Anaphylatoxin C3a, C5a - Angiotensin 1, 2 - Apelin - Bile acid - Bombesin BRS3, GRPR, NMBR - Bradykinin B1, B2 - Cannabinoid CB1, CB2 - Chemokine - Cholecystokinin A, B - Dopamine D1, D2, D3, D4, D5 - EBI2 - Endothelin A, B - Estrogen - Formyl peptide 1, L1, L2 - Free fatty acid 1, 2, 3, 4 - FSH - Galanin 1, 2, 3 - Gonadotropin-releasing hormone 1, 2 - Ghrelin - Histamine H1, H2, H3, H4 - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid 1, 2, 3, 4, 5, 6, 7, 8 - MAS 1, 1L, D, E, F, G, X1, X2, X3, X4 - Melanocortin 1, 2, 3, 4, 5 - MCHR 1, 2 - Melatonin 1A, 1B- Motilin - neuromedin B, U 1, 2 - Neurotensin 1, 2 - Opioid Delta, Kappa, Mu, Nociceptin, but not Sigma - Olfactory - Opsin 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH - Orexin 1, 2 - Oxytocin - Oxoglutarate - PAF - Prokineticin 1, 2 - Prolactin-releasing peptide - Protease-activated 1, 2, 3, 4 - Relaxin 1, 2, 3, 4 - Somatostatin 1, 2, 3, 4, 5 - SREB - Succinate - TAAR 1, 2, 3, 5, 6, 8, 9 - Tachykinin 1, 2, 3 - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin 1A, 1B, 2 Class B: Secretin like Brain-specific angiogenesis inhibitor 1, 2, 3 - Cadherin 1, 2, 3 - Calcitonin - CD97 - Corticotropin-releasing hormone 1, 2 - EMR 1, 2, 3 - Glucagon GR, GIPR, GLP1R, GLP2R - Growth hormone releasing hormone - PACAPR1- GPR 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157 - Latrophilin 1, 2, 3, ELTD1 - Parathyroid hormone 1, 2 - Secretin - Vasoactive intestinal peptide 1, 2 Class C: Metabotropic glutamate / pheromone Calcium-sensing receptor - GABA B 1, 2 - Glutamate receptor Metabotropic glutamate 1, 2, 3, 4, 5, 6, 7, 8 - GPRC6A - GPR 156, 158, 179 - RAIG 1, 2, 3, 4 - Taste receptors TAS1R 1, 2, 3 TAS2R 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50 Frizzled / Smoothened Frizzled 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 - Smoothened Retrieved from http://en..org/wiki/KiSS1-derived_peptide_receptor Categories: Genes on chromosome 19 | Human proteins | Transmembrane receptor stubs | G protein coupled receptorsHidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages Deutsch This page was last modified on 8 July 2008, at 06:29
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