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14-September-2008 18:02:43 - LPHN3 Latrophilin 3 Identifiers Symbols LPHN3; CIRL3; LEC3 External IDs MGI: 2441950 HomoloGene: 22878 Gene ontology Molecular function: receptor activity G-protein coupled receptor activity sugar binding latrotoxin receptor activity Cellular component: membrane integral to membrane Biological process: signal transduction neuropeptide signaling pathway Orthologs Human Mouse Entrez 23284 319387 Ensembl ENSG00000150471 ENSMUSG00000037605 Uniprot Q9HAR2 Q80TS3 Refseq NM_015236 mRNA NP_056051 protein NM_198702 mRNA NP_941991 protein Location Chr 4: 62.05 - 62.62 Mb Chr 5: 82.1 - 82.87 Mb Pubmed search 1 2 Latrophilin 3, also known as LPHN3, is a human gene.1 This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors GPCR. Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS G-protein-coupled-receptor proteolysis site domain resulted in two subunits a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs being non-covalently bound at the cell membrane.1 See also Latrophilin receptor References ^ a b Entrez Gene: LPHN3 latrophilin 3. Further reading Hayflick JS 2001. A family of heptahelical receptors with adhesion-like domains: a marriage between two super families.. J. Recept. Signal Transduct. Res. 20 2-3: 119-31. PMID 10994649. Südhof TC 2001. alpha-Latrotoxin and its receptors: neurexins and CIRL/latrophilins.. Annu. Rev. Neurosci. 24: 933-62. doi:10.1146/annurev.neuro.24.1.933. PMID 11520923. Ushkaryov YA, Volynski KE, Ashton AC 2004. The multiple actions of black widow spider toxins and their selective use in neurosecretion studies.. Toxicon 43 5: 527-42. doi:10.1016/j.toxicon.2004.02.008. PMID 15066411. Soares MB, Bonaldo MF, Jelene P, et al. 1994. Construction and characterization of a normalized cDNA library.. Proc. Natl. Acad. Sci. U.S.A. 91 20: 9228-32. PMID 7937745. Toward a complete human genome sequence. 1999. Genome Res. 8 11: 1097-108. PMID 9847074. Nagase T, Ishikawa K, Suyama M, et al. 1999. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.. DNA Res. 5 5: 277-86. PMID 9872452. Kreienkamp HJ, Zitzer H, Gundelfinger ED, et al. 2000. The calcium-independent receptor for alpha-latrotoxin from human and rodent brains interacts with members of the ProSAP/SSTRIP/Shank family of multidomain proteins.. J. Biol. Chem. 275 42: 32387-90. doi:10.1074/jbc.C000490200. PMID 10964907. Strausberg RL, Feingold EA, Grouse LH, et al. 2003. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 99 26: 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. Ota T, Suzuki Y, Nishikawa T, et al. 2004. Complete sequencing and characterization of 21,243 full-length human cDNAs.. Nat. Genet. 36 1: 40-5. doi:10.1038/ng1285. PMID 14702039. Bjarnadóttir TK, Fredriksson R, Höglund PJ, et al. 2005. The human and mouse repertoire of the adhesion family of G-protein-coupled receptors.. Genomics 84 1: 23-33. doi:10.1016/j.ygeno.2003.12.004. PMID 15203201. This transmembrane receptor-related article is a stub. This article incorporates text from the United States National Library of Medicine, which is in the public domain. v d e Transmembrane receptor: G protein-coupled receptors Class A: Rhodopsin like Adrenergic α1 A, B, D, α2 A, B, C, β1, β2, β3 Eicosanoid CysLT 1, 2, LTB4 1, 2, FPRL1, OXE, Prostaglandin DP, EP 1, 2, 3, 4, PGF, Prostacyclin, Thromboxane Neuropeptide B/W 1, 2, FF 1, 2, S, Y 1, 2, 4, 5 Orphan GPR 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182 Purinergics Adenosine A1, A2a, A2b, A3, P2Y, 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14 Serotonin all but 5-HT3 5-HT1 A, B, D, E, F, 5-HT2 A, B, C, 5-HT 4, 5A, 6, 7 Other Acetylcholine M1, M2, M3, M4, M5 - Adrenomedullin - Anaphylatoxin C3a, C5a - Angiotensin 1, 2 - Apelin - Bile acid - Bombesin BRS3, GRPR, NMBR - Bradykinin B1, B2 - Cannabinoid CB1, CB2 - Chemokine - Cholecystokinin A, B - Dopamine D1, D2, D3, D4, D5 - EBI2 - Endothelin A, B - Estrogen - Formyl peptide 1, L1, L2 - Free fatty acid 1, 2, 3, 4 - FSH - Galanin 1, 2, 3 - Gonadotropin-releasing hormone 1, 2 - Ghrelin - Histamine H1, H2, H3, H4 - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid 1, 2, 3, 4, 5, 6, 7, 8 - MAS 1, 1L, D, E, F, G, X1, X2, X3, X4 - Melanocortin 1, 2, 3, 4, 5 - MCHR 1, 2 - Melatonin 1A, 1B- Motilin - neuromedin B, U 1, 2 - Neurotensin 1, 2 - Opioid Delta, Kappa, Mu, Nociceptin, but not Sigma - Olfactory - Opsin 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH - Orexin 1, 2 - Oxytocin - Oxoglutarate - PAF - Prokineticin 1, 2 - Prolactin-releasing peptide - Protease-activated 1, 2, 3, 4 - Relaxin 1, 2, 3, 4 - Somatostatin 1, 2, 3, 4, 5 - SREB - Succinate - TAAR 1, 2, 3, 5, 6, 8, 9 - Tachykinin 1, 2, 3 - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin 1A, 1B, 2 Class B: Secretin like Brain-specific angiogenesis inhibitor 1, 2, 3 - Cadherin 1, 2, 3 - Calcitonin - CD97 - Corticotropin-releasing hormone 1, 2 - EMR 1, 2, 3 - Glucagon GR, GIPR, GLP1R, GLP2R - Growth hormone releasing hormone - PACAPR1- GPR 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157 - Latrophilin 1, 2, 3, ELTD1 - Parathyroid hormone 1, 2 - Secretin - Vasoactive intestinal peptide 1, 2 Class C: Metabotropic glutamate / pheromone Calcium-sensing receptor - GABA B 1, 2 - Glutamate receptor Metabotropic glutamate 1, 2, 3, 4, 5, 6, 7, 8 - GPRC6A - GPR 156, 158, 179 - RAIG 1, 2, 3, 4 - Taste receptors TAS1R 1, 2, 3 TAS2R 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50 Frizzled / Smoothened Frizzled 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 - Smoothened Retrieved from http://en..org/wiki/LPHN3 Categories: Genes on chromosome 4 | Human proteins | Transmembrane receptor stubs | G protein coupled receptorsHidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 8 July 2008, at 12:23
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