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14-September-2008 18:02:43 - receptor The correct title of this article is Leukotriene B4 receptor. It appears incorrectly here because of technical restrictions. Leukotriene B4 receptor Identifiers Symbols LTB4R; BLT1; BLTR; CMKRL1; GPR16; LTB4R1; LTBR1; P2RY7; P2Y7 External IDs OMIM: 601531 MGI: 1309472 HomoloGene: 22477 Gene ontology Molecular function: nucleotide binding receptor activity leukotriene receptor activity Cellular component: integral to plasma membrane membrane Biological process: cell motility muscle contraction inflammatory response immune response signal transduction G-protein signaling, coupled to IP3 second messenger phospholipase C activating Orthologs Human Mouse Entrez 1241 16995 Ensembl n/a ENSMUSG00000046908 Uniprot n/a Q3U2P2 Refseq NM_181657 mRNA NP_858043 protein NM_008519 mRNA NP_032545 protein Location n/a Chr 14: 54.72 - 54.72 Mb Pubmed search 1 2 Leukotriene B4 receptor, also known as LTB4R, is a human gene.1 Contents 1 See also 2 References 3 Further reading 4 External links See also Eicosanoid receptor References ^ Entrez Gene: LTB4R leukotriene B4 receptor. Further reading Raport CJ, Schweickart VL, Chantry D, et al. 1996. New members of the chemokine receptor gene family.. J. Leukoc. Biol. 59 1: 18-23. PMID 8558062. Tager AM, Luster AD 2004. BLT1 and BLT2: the leukotriene B4 receptors.. Prostaglandins Leukot. Essent. Fatty Acids 69 2-3: 123-34. PMID 12895595. Miyahara N, Miyahara S, Takeda K, Gelfand EW 2006. Role of the LTB4/BLT1 pathway in allergen-induced airway hyperresponsiveness and inflammation.. Allergology international : official journal of the Japanese Society of Allergology 55 2: 91-7. doi:10.2332/allergolint.55.91. PMID 17075244. Akbar GK, Dasari VR, Webb TE, et al. 1996. Molecular cloning of a novel P2 purinoceptor from human erythroleukemia cells.. J. Biol. Chem. 271 31: 18363-7. PMID 8702478. Hillier LD, Lennon G, Becker M, et al. 1997. Generation and analysis of 280,000 human expressed sequence tags.. Genome Res. 6 9: 807-28. PMID 8889549. Owman C, Nilsson C, Lolait SJ 1997. Cloning of cDNA encoding a putative chemoattractant receptor.. Genomics 37 2: 187-94. doi:10.1006/geno.1996.0541. PMID 8921391. Yokomizo T, Izumi T, Chang K, et al. 1997. A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis.. Nature 387 6633: 620-4. doi:10.1038/42506. PMID 9177352. Maier R, Glatz A, Mosbacher J, Bilbe G 1997. Cloning of P2Y6 cDNAs and identification of a pseudogene: comparison of P2Y receptor subtype expression in bone and brain tissues.. Biochem. Biophys. Res. Commun. 237 2: 297-302. doi:10.1006/bbrc.1997.7135. PMID 9268704. Gaudreau R, Le Gouill C, Métaoui S, et al. 1998. Signalling through the leukotriene B4 receptor involves both alphai and alpha16, but not alphaq or alpha11 G-protein subunits.. Biochem. J. 335 Pt 1: 15-8. PMID 9742207. Kato K, Yokomizo T, Izumi T, Shimizu T 2000. Cell-specific transcriptional regulation of human leukotriene B4 receptor gene.. J. Exp. Med. 192 3: 413-20. PMID 10934229. Yokomizo T, Kato K, Terawaki K, et al. 2000. A second leukotriene B4 receptor, BLT2. A new therapeutic target in inflammation and immunological disorders.. J. Exp. Med. 192 3: 421-32. PMID 10934230. Stankova J, Turcotte S, Harris J, Rola-Pleszczynski M 2002. Modulation of leukotriene B4 receptor-1 expression by dexamethasone: potential mechanism for enhanced neutrophil survival.. J. Immunol. 168 7: 3570-6. PMID 11907121. Gaudreau R, Le Gouill C, Venne MH, et al. 2002. Threonine 308 within a putative casein kinase 2 site of the cytoplasmic tail of leukotriene B4 receptor BLT1 is crucial for ligand-induced, G-protein-coupled receptor-specific kinase 6-mediated desensitization.. J. Biol. Chem. 277 35: 31567-76. doi:10.1074/jbc.M202723200. PMID 12077128. Hennig R, Ding XZ, Tong WG, et al. 2002. 5-Lipoxygenase and leukotriene B4 receptor are expressed in human pancreatic cancers but not in pancreatic ducts in normal tissue.. Am. J. Pathol. 161 2: 421-8. PMID 12163367. Ito N, Yokomizo T, Sasaki T, et al. 2003. Requirement of phosphatidylinositol 3-kinase activation and calcium influx for leukotriene B4-induced enzyme release.. J. Biol. Chem. 277 47: 44898-904. doi:10.1074/jbc.M208051200. PMID 12244116. Tong WG, Ding XZ, Hennig R, et al. 2003. Leukotriene B4 receptor antagonist LY293111 inhibits proliferation and induces apoptosis in human pancreatic cancer cells.. Clin. Cancer Res. 8 10: 3232-42. PMID 12374694. Strausberg RL, Feingold EA, Grouse LH, et al. 2003. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 99 26: 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. Yokomizo T, Noiri E, Izumi T, Shimizu T 2003. In vivo chemotaxis using CHO cells expressing human leukotriene B4 receptor.. Adv. Exp. Med. Biol. 507: 357-61. PMID 12664610. External links IUPHAR GPCR Database - Leukotriene receptors MeSH LTB4R+protein,+human MeSH Receptors,+Leukotriene+B4 This article incorporates text from the United States National Library of Medicine, which is in the public domain. This transmembrane receptor-related article is a stub. v d e Transmembrane receptor: G protein-coupled receptors Class A: Rhodopsin like Adrenergic α1 A, B, D, α2 A, B, C, β1, β2, β3 Eicosanoid CysLT 1, 2, LTB4 1, 2, FPRL1, OXE, Prostaglandin DP, EP 1, 2, 3, 4, PGF, Prostacyclin, Thromboxane Neuropeptide B/W 1, 2, FF 1, 2, S, Y 1, 2, 4, 5 Orphan GPR 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182 Purinergics Adenosine A1, A2a, A2b, A3, P2Y, 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14 Serotonin all but 5-HT3 5-HT1 A, B, D, E, F, 5-HT2 A, B, C, 5-HT 4, 5A, 6, 7 Other Acetylcholine M1, M2, M3, M4, M5 - Adrenomedullin - Anaphylatoxin C3a, C5a - Angiotensin 1, 2 - Apelin - Bile acid - Bombesin BRS3, GRPR, NMBR - Bradykinin B1, B2 - Cannabinoid CB1, CB2 - Chemokine - Cholecystokinin A, B - Dopamine D1, D2, D3, D4, D5 - EBI2 - Endothelin A, B - Estrogen - Formyl peptide 1, L1, L2 - Free fatty acid 1, 2, 3, 4 - FSH - Galanin 1, 2, 3 - Gonadotropin-releasing hormone 1, 2 - Ghrelin - Histamine H1, H2, H3, H4 - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid 1, 2, 3, 4, 5, 6, 7, 8 - MAS 1, 1L, D, E, F, G, X1, X2, X3, X4 - Melanocortin 1, 2, 3, 4, 5 - MCHR 1, 2 - Melatonin 1A, 1B- Motilin - neuromedin B, U 1, 2 - Neurotensin 1, 2 - Opioid Delta, Kappa, Mu, Nociceptin, but not Sigma - Olfactory - Opsin 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH - Orexin 1, 2 - Oxytocin - Oxoglutarate - PAF - Prokineticin 1, 2 - Prolactin-releasing peptide - Protease-activated 1, 2, 3, 4 - Relaxin 1, 2, 3, 4 - Somatostatin 1, 2, 3, 4, 5 - SREB - Succinate - TAAR 1, 2, 3, 5, 6, 8, 9 - Tachykinin 1, 2, 3 - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin 1A, 1B, 2 Class B: Secretin like Brain-specific angiogenesis inhibitor 1, 2, 3 - Cadherin 1, 2, 3 - Calcitonin - CD97 - Corticotropin-releasing hormone 1, 2 - EMR 1, 2, 3 - Glucagon GR, GIPR, GLP1R, GLP2R - Growth hormone releasing hormone - PACAPR1- GPR 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157 - Latrophilin 1, 2, 3, ELTD1 - Parathyroid hormone 1, 2 - Secretin - Vasoactive intestinal peptide 1, 2 Class C: Metabotropic glutamate / pheromone Calcium-sensing receptor - GABA B 1, 2 - Glutamate receptor Metabotropic glutamate 1, 2, 3, 4, 5, 6, 7, 8 - GPRC6A - GPR 156, 158, 179 - RAIG 1, 2, 3, 4 - Taste receptors TAS1R 1, 2, 3 TAS2R 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50 Frizzled / Smoothened Frizzled 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 - Smoothened Retrieved from http://en..org/wiki/Leukotriene_B4_receptor Categories: Human proteins | Transmembrane receptor stubs | G protein coupled receptorsHidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 8 July 2008, at 05:44
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