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14-September-2008 18:02:43 - receptor 2 The correct title of this article is Leukotriene B4 receptor 2. It appears incorrectly here because of technical restrictions. Leukotriene B4 receptor 2 Identifiers Symbols LTB4R2; BLT2; BLTR2; JULF2; KPG_004; NOP9 External IDs OMIM: 605773 MGI: 1888501 HomoloGene: 10519 Gene ontology Molecular function: receptor activity leukotriene receptor activity Cellular component: integral to plasma membrane membrane Biological process: chemotaxis signal transduction G-protein coupled receptor protein signaling pathway negative regulation of adenylate cyclase activity antimicrobial humoral response Orthologs Human Mouse Entrez 56413 57260 Ensembl n/a ENSMUSG00000040432 Uniprot Q9NPC1 Q3KP98 Refseq NM_019839 mRNA NP_062813 protein NM_020490 mRNA NP_065236 protein Location n/a Chr 14: 54.72 - 54.72 Mb Pubmed search 1 2 Leukotriene B4 receptor 2, also known as LTB4R2, is a human gene.1 This is a low-affinity receptor for leukotrienes, especially leukotriene B4. It mediates chemotaxis of granulocytes and macrophages. Contents 1 See also 2 References 3 Further reading 4 External links See also Eicosanoid receptor References ^ Entrez Gene: LTB4R2 leukotriene B4 receptor 2. Further reading Tager AM, Luster AD 2004. BLT1 and BLT2: the leukotriene B4 receptors.. Prostaglandins Leukot. Essent. Fatty Acids 69 2-3: 123-34. PMID 12895595. Kamohara M, Takasaki J, Matsumoto M, et al. 2000. Molecular cloning and characterization of another leukotriene B4 receptor.. J. Biol. Chem. 275 35: 27000-4. doi:10.1074/jbc.C000382200. PMID 10889186. Tryselius Y, Nilsson NE, Kotarsky K, et al. 2000. Cloning and characterization of cDNA encoding a novel human leukotriene B4 receptor.. Biochem. Biophys. Res. Commun. 274 2: 377-82. doi:10.1006/bbrc.2000.3152. PMID 10913346. Nilsson NE, Tryselius Y, Owman C 2000. Genomic organization of the leukotriene B4 receptor locus of human chromosome 14.. Biochem. Biophys. Res. Commun. 274 2: 383-8. doi:10.1006/bbrc.2000.3153. PMID 10913347. Kato K, Yokomizo T, Izumi T, Shimizu T 2000. Cell-specific transcriptional regulation of human leukotriene B4 receptor gene.. J. Exp. Med. 192 3: 413-20. PMID 10934229. Yokomizo T, Kato K, Terawaki K, et al. 2000. A second leukotriene B4 receptor, BLT2. A new therapeutic target in inflammation and immunological disorders.. J. Exp. Med. 192 3: 421-32. PMID 10934230. Wang S, Gustafson E, Pang L, et al. 2001. A novel hepatointestinal leukotriene B4 receptor. Cloning and functional characterization.. J. Biol. Chem. 275 52: 40686-94. doi:10.1074/jbc.M004512200. PMID 11006272. Takeda S, Kadowaki S, Haga T, et al. 2002. Identification of G protein-coupled receptor genes from the human genome sequence.. FEBS Lett. 520 1-3: 97-101. PMID 12044878. Strausberg RL, Feingold EA, Grouse LH, et al. 2003. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 99 26: 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. Hashimoto A, Endo H, Hayashi I, et al. 2003. Differential expression of leukotriene B4 receptor subtypes BLT1 and BLT2 in human synovial tissues and synovial fluid leukocytes of patients with rheumatoid arthritis.. J. Rheumatol. 30 8: 1712-8. PMID 12913925. Yoo MH, Song H, Woo CH, et al. 2005. Role of the BLT2, a leukotriene B4 receptor, in Ras transformation.. Oncogene 23 57: 9259-68. doi:10.1038/sj.onc.1208151. PMID 15489890. Qiu H, Johansson AS, Sjöström M, et al. 2006. Differential induction of BLT receptor expression on human endothelial cells by lipopolysaccharide, cytokines, and leukotriene B4.. Proc. Natl. Acad. Sci. U.S.A. 103 18: 6913-8. doi:10.1073/pnas.0602208103. PMID 16624877. Lundeen KA, Sun B, Karlsson L, Fourie AM 2006. Leukotriene B4 receptors BLT1 and BLT2: expression and function in human and murine mast cells.. J. Immunol. 177 5: 3439-47. PMID 16920986. External links IUPHAR GPCR Database - Leukotriene receptors MeSH LTB4R2+protein,+human MeSH Receptors,+Leukotriene+B4 This article incorporates text from the United States National Library of Medicine, which is in the public domain. This transmembrane receptor-related article is a stub. v d e Transmembrane receptor: G protein-coupled receptors Class A: Rhodopsin like Adrenergic α1 A, B, D, α2 A, B, C, β1, β2, β3 Eicosanoid CysLT 1, 2, LTB4 1, 2, FPRL1, OXE, Prostaglandin DP, EP 1, 2, 3, 4, PGF, Prostacyclin, Thromboxane Neuropeptide B/W 1, 2, FF 1, 2, S, Y 1, 2, 4, 5 Orphan GPR 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182 Purinergics Adenosine A1, A2a, A2b, A3, P2Y, 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14 Serotonin all but 5-HT3 5-HT1 A, B, D, E, F, 5-HT2 A, B, C, 5-HT 4, 5A, 6, 7 Other Acetylcholine M1, M2, M3, M4, M5 - Adrenomedullin - Anaphylatoxin C3a, C5a - Angiotensin 1, 2 - Apelin - Bile acid - Bombesin BRS3, GRPR, NMBR - Bradykinin B1, B2 - Cannabinoid CB1, CB2 - Chemokine - Cholecystokinin A, B - Dopamine D1, D2, D3, D4, D5 - EBI2 - Endothelin A, B - Estrogen - Formyl peptide 1, L1, L2 - Free fatty acid 1, 2, 3, 4 - FSH - Galanin 1, 2, 3 - Gonadotropin-releasing hormone 1, 2 - Ghrelin - Histamine H1, H2, H3, H4 - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid 1, 2, 3, 4, 5, 6, 7, 8 - MAS 1, 1L, D, E, F, G, X1, X2, X3, X4 - Melanocortin 1, 2, 3, 4, 5 - MCHR 1, 2 - Melatonin 1A, 1B- Motilin - neuromedin B, U 1, 2 - Neurotensin 1, 2 - Opioid Delta, Kappa, Mu, Nociceptin, but not Sigma - Olfactory - Opsin 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH - Orexin 1, 2 - Oxytocin - Oxoglutarate - PAF - Prokineticin 1, 2 - Prolactin-releasing peptide - Protease-activated 1, 2, 3, 4 - Relaxin 1, 2, 3, 4 - Somatostatin 1, 2, 3, 4, 5 - SREB - Succinate - TAAR 1, 2, 3, 5, 6, 8, 9 - Tachykinin 1, 2, 3 - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin 1A, 1B, 2 Class B: Secretin like Brain-specific angiogenesis inhibitor 1, 2, 3 - Cadherin 1, 2, 3 - Calcitonin - CD97 - Corticotropin-releasing hormone 1, 2 - EMR 1, 2, 3 - Glucagon GR, GIPR, GLP1R, GLP2R - Growth hormone releasing hormone - PACAPR1- GPR 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157 - Latrophilin 1, 2, 3, ELTD1 - Parathyroid hormone 1, 2 - Secretin - Vasoactive intestinal peptide 1, 2 Class C: Metabotropic glutamate / pheromone Calcium-sensing receptor - GABA B 1, 2 - Glutamate receptor Metabotropic glutamate 1, 2, 3, 4, 5, 6, 7, 8 - GPRC6A - GPR 156, 158, 179 - RAIG 1, 2, 3, 4 - Taste receptors TAS1R 1, 2, 3 TAS2R 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50 Frizzled / Smoothened Frizzled 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 - Smoothened Retrieved from http://en..org/wiki/Leukotriene_B4_receptor_2 Categories: Human proteins | Transmembrane receptor stubs | G protein coupled receptorsHidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 8 July 2008, at 12:45
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