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14-September-2008 18:02:44 - receptor melanin-concentrating hormone receptor 1 Identifiers Symbol MCHR1 Alt. Symbols GPR24 Entrez 2847 HUGO 4479 OMIM 601751 RefSeq NM_005297 UniProt Q99705 Other data Locus Chr. 22 q13.3 melanin-concentrating hormone receptor 2 Identifiers Symbol MCHR2 Alt. Symbols GPR145 Entrez 84539 HUGO 20867 OMIM 606111 RefSeq NM_032503 UniProt Q969V1 Other data Locus Chr. 6 q16 Two Melanin-concentrating hormone receptors MCHR have recently been characterized: MCH-R1 and MCH-R2. These two receptors share approximately 38% homology. MCH-R1 is expressed in all mammals. MCH-R2 is only found in some primates and carnivores including dogs, ferrets and man. Contents 1 Clinical significance 2 References 3 See also 4 External links Clinical significance Antagonists might be useful in the treatment of obesity12 and anxiety and depression.3 An agonist might have possible utility as a treatment for osteoporosis.4 Research is ongoing for antagonists affecting MCH receptors R1 and R2.56 References ^ Handlon AL, Zhou H 2006. Melanin-concentrating hormone-1 receptor antagonists for the treatment of obesity. J. Med. Chem. 49 14: 4017-22. doi:10.1021/jm058239j. PMID 16821761. ^ Luthin DR 2007. Anti-obesity effects of small molecule melanin-concentrating hormone receptor 1 MCHR1 antagonists. Life Sci. 81 6: 423-40. doi:10.1016/j.lfs.2007.05.029. PMID 17655875. ^ Shimazaki T, Yoshimizu T, Chaki S 2006. Melanin-concentrating hormone MCH1 receptor antagonists: a potential new approach to the treatment of depression and anxiety disorders. CNS drugs 20 10: 801-11. PMID 16999451. ^ Bohlooly-Y M, Mahlapuu M, Andersén H, Astrand A, Hjorth S, Svensson L, Törnell J, Snaith MR, Morgan DG, Ohlsson C 2004. Osteoporosis in MCHR1-deficient mice. Biochem. Biophys. Res. Commun. 318 4: 964-9. doi:10.1016/j.bbrc.2004.04.122. PMID 15147966. ^ Saito Y, Maruyama K 2006. Identification of melanin-concentrating hormone receptor and its impact on drug discovery. J. Exp. Zoolog. Part A Comp. Exp. Biol. 305 9: 761-8. doi:10.1002/jez.a.311. PMID 16902961. ^ McBriar MD 2006. Recent advances in the discovery of melanin-concentrating hormone receptor antagonists. Current opinion in drug discovery development 9 4: 496-508. PMID 16889232. See also Melanin concentrating hormone Melanin External links IUPHAR GPCR Database - Melanin-concentrating hormone receptors MeSH melanin-concentrating+hormone+receptor MeSH MCHR1+protein,+human MeSH MCHR2+protein,+human v d e Transmembrane receptor: G protein-coupled receptors Class A: Rhodopsin like Adrenergic α1 A, B, D, α2 A, B, C, β1, β2, β3 Eicosanoid CysLT 1, 2, LTB4 1, 2, FPRL1, OXE, Prostaglandin DP, EP 1, 2, 3, 4, PGF, Prostacyclin, Thromboxane Neuropeptide B/W 1, 2, FF 1, 2, S, Y 1, 2, 4, 5 Orphan GPR 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182 Purinergics Adenosine A1, A2a, A2b, A3, P2Y, 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14 Serotonin all but 5-HT3 5-HT1 A, B, D, E, F, 5-HT2 A, B, C, 5-HT 4, 5A, 6, 7 Other Acetylcholine M1, M2, M3, M4, M5 - Adrenomedullin - Anaphylatoxin C3a, C5a - Angiotensin 1, 2 - Apelin - Bile acid - Bombesin BRS3, GRPR, NMBR - Bradykinin B1, B2 - Cannabinoid CB1, CB2 - Chemokine - Cholecystokinin A, B - Dopamine D1, D2, D3, D4, D5 - EBI2 - Endothelin A, B - Estrogen - Formyl peptide 1, L1, L2 - Free fatty acid 1, 2, 3, 4 - FSH - Galanin 1, 2, 3 - Gonadotropin-releasing hormone 1, 2 - Ghrelin - Histamine H1, H2, H3, H4 - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid 1, 2, 3, 4, 5, 6, 7, 8 - MAS 1, 1L, D, E, F, G, X1, X2, X3, X4 - Melanocortin 1, 2, 3, 4, 5 - MCHR 1, 2 - Melatonin 1A, 1B- Motilin - neuromedin B, U 1, 2 - Neurotensin 1, 2 - Opioid Delta, Kappa, Mu, Nociceptin, but not Sigma - Olfactory - Opsin 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH - Orexin 1, 2 - Oxytocin - Oxoglutarate - PAF - Prokineticin 1, 2 - Prolactin-releasing peptide - Protease-activated 1, 2, 3, 4 - Relaxin 1, 2, 3, 4 - Somatostatin 1, 2, 3, 4, 5 - SREB - Succinate - TAAR 1, 2, 3, 5, 6, 8, 9 - Tachykinin 1, 2, 3 - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin 1A, 1B, 2 Class B: Secretin like Brain-specific angiogenesis inhibitor 1, 2, 3 - Cadherin 1, 2, 3 - Calcitonin - CD97 - Corticotropin-releasing hormone 1, 2 - EMR 1, 2, 3 - Glucagon GR, GIPR, GLP1R, GLP2R - Growth hormone releasing hormone - PACAPR1- GPR 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157 - Latrophilin 1, 2, 3, ELTD1 - Parathyroid hormone 1, 2 - Secretin - Vasoactive intestinal peptide 1, 2 Class C: Metabotropic glutamate / pheromone Calcium-sensing receptor - GABA B 1, 2 - Glutamate receptor Metabotropic glutamate 1, 2, 3, 4, 5, 6, 7, 8 - GPRC6A - GPR 156, 158, 179 - RAIG 1, 2, 3, 4 - Taste receptors TAS1R 1, 2, 3 TAS2R 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50 Frizzled / Smoothened Frizzled 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 - Smoothened This transmembrane receptor-related article is a stub. Retrieved from http://en..org/wiki/Melanin-concentrating_hormone_receptor Categories: Genes on chromosome 22 | Genes on chromosome 6 | Transmembrane receptor stubs | G protein coupled receptorsHidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 15 June 2008, at 13:54
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