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14-September-2008 18:02:44 - 2 Melanin-concentrating hormone receptor 2 Identifiers Symbols MCHR2; MCH2; GPR145; MCH2R; SLT External IDs OMIM: 606111 HomoloGene: 50004 Gene ontology Molecular function: rhodopsin-like receptor activity receptor activity Cellular component: membrane integral to membrane Biological process: signal transduction G-protein coupled receptor protein signaling pathway Orthologs Human Mouse Entrez 84539 n/a Ensembl ENSG00000152034 n/a Uniprot Q969V1 n/a Refseq NM_001040179 mRNA NP_001035269 protein n/a mRNA n/a protein Location Chr 6: 100.47 - 100.55 Mb n/a Pubmed search 1 n/a Melanin-concentrating hormone receptor 2, also known as MCHR2, is a human gene.1 See also Melanin-concentrating hormone receptor References ^ Entrez Gene: MCHR2 melanin-concentrating hormone receptor 2. Further reading Hill J, Duckworth M, Murdock P, et al. 2001. Molecular cloning and functional characterization of MCH2, a novel human MCH receptor.. J. Biol. Chem. 276 23: 20125-9. doi:10.1074/jbc.M102068200. PMID 11274220. Mori M, Harada M, Terao Y, et al. 2001. Cloning of a novel G protein-coupled receptor, SLT, a subtype of the melanin-concentrating hormone receptor.. Biochem. Biophys. Res. Commun. 283 5: 1013-8. doi:10.1006/bbrc.2001.4893. PMID 11355873. Sailer AW, Sano H, Zeng Z, et al. 2001. Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R.. Proc. Natl. Acad. Sci. U.S.A. 98 13: 7564-9. doi:10.1073/pnas.121170598. PMID 11404457. An S, Cutler G, Zhao JJ, et al. 2001. Identification and characterization of a melanin-concentrating hormone receptor.. Proc. Natl. Acad. Sci. U.S.A. 98 13: 7576-81. doi:10.1073/pnas.131200698. PMID 11416225. Wang S, Behan J, O'Neill K, et al. 2001. Identification and pharmacological characterization of a novel human melanin-concentrating hormone receptor, mch-r2.. J. Biol. Chem. 276 37: 34664-70. doi:10.1074/jbc.M102601200. PMID 11459838. Bednarek MA, Feighner SD, Hreniuk DL, et al. 2001. Short segment of human melanin-concentrating hormone that is sufficient for full activation of human melanin-concentrating hormone receptors 1 and 2.. Biochemistry 40 31: 9379-86. PMID 11478907. Bednarek MA, Tan C, Hreniuk DL, et al. 2002. Synthesis and biological evaluation in vitro of a selective, high potency peptide agonist of human melanin-concentrating hormone action at human melanin-concentrating hormone receptor 1.. J. Biol. Chem. 277 16: 13821-6. doi:10.1074/jbc.M200563200. PMID 11839762. Audinot V, Lahaye C, Suply T, et al. 2002. SVK14 cells express an MCH binding site different from the MCH1 or MCH2 receptor.. Biochem. Biophys. Res. Commun. 295 4: 841-8. PMID 12127971. Strausberg RL, Feingold EA, Grouse LH, et al. 2003. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 99 26: 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. Logan DW, Bryson-Richardson RJ, Pagán KE, et al. 2003. The structure and evolution of the melanocortin and MCH receptors in fish and mammals.. Genomics 81 2: 184-91. PMID 12620396. Mungall AJ, Palmer SA, Sims SK, et al. 2003. The DNA sequence and analysis of human chromosome 6.. Nature 425 6960: 805-11. doi:10.1038/nature02055. PMID 14574404. Ota T, Suzuki Y, Nishikawa T, et al. 2004. Complete sequencing and characterization of 21,243 full-length human cDNAs.. Nat. Genet. 36 1: 40-5. doi:10.1038/ng1285. PMID 14702039. Vitale RM, Pedone C, De Benedetti PG, Fanelli F 2004. Structural features of the inactive and active states of the melanin-concentrating hormone receptors: insights from molecular simulations.. Proteins 56 3: 430-48. doi:10.1002/prot.20125. PMID 15229878. Hawes BE, Green B, O'Neill K, et al. 2004. Identification and characterization of single-nucleotide polymorphisms in MCH-R1 and MCH-R2.. Obes. Res. 12 8: 1327-34. PMID 15340116. Gerhard DS, Wagner L, Feingold EA, et al. 2004. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection MGC.. Genome Res. 14 10B: 2121-7. doi:10.1101/gr.2596504. PMID 15489334. This transmembrane receptor-related article is a stub. v d e Transmembrane receptor: G protein-coupled receptors Class A: Rhodopsin like Adrenergic α1 A, B, D, α2 A, B, C, β1, β2, β3 Eicosanoid CysLT 1, 2, LTB4 1, 2, FPRL1, OXE, Prostaglandin DP, EP 1, 2, 3, 4, PGF, Prostacyclin, Thromboxane Neuropeptide B/W 1, 2, FF 1, 2, S, Y 1, 2, 4, 5 Orphan GPR 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182 Purinergics Adenosine A1, A2a, A2b, A3, P2Y, 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14 Serotonin all but 5-HT3 5-HT1 A, B, D, E, F, 5-HT2 A, B, C, 5-HT 4, 5A, 6, 7 Other Acetylcholine M1, M2, M3, M4, M5 - Adrenomedullin - Anaphylatoxin C3a, C5a - Angiotensin 1, 2 - Apelin - Bile acid - Bombesin BRS3, GRPR, NMBR - Bradykinin B1, B2 - Cannabinoid CB1, CB2 - Chemokine - Cholecystokinin A, B - Dopamine D1, D2, D3, D4, D5 - EBI2 - Endothelin A, B - Estrogen - Formyl peptide 1, L1, L2 - Free fatty acid 1, 2, 3, 4 - FSH - Galanin 1, 2, 3 - Gonadotropin-releasing hormone 1, 2 - Ghrelin - Histamine H1, H2, H3, H4 - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid 1, 2, 3, 4, 5, 6, 7, 8 - MAS 1, 1L, D, E, F, G, X1, X2, X3, X4 - Melanocortin 1, 2, 3, 4, 5 - MCHR 1, 2 - Melatonin 1A, 1B- Motilin - neuromedin B, U 1, 2 - Neurotensin 1, 2 - Opioid Delta, Kappa, Mu, Nociceptin, but not Sigma - Olfactory - Opsin 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH - Orexin 1, 2 - Oxytocin - Oxoglutarate - PAF - Prokineticin 1, 2 - Prolactin-releasing peptide - Protease-activated 1, 2, 3, 4 - Relaxin 1, 2, 3, 4 - Somatostatin 1, 2, 3, 4, 5 - SREB - Succinate - TAAR 1, 2, 3, 5, 6, 8, 9 - Tachykinin 1, 2, 3 - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin 1A, 1B, 2 Class B: Secretin like Brain-specific angiogenesis inhibitor 1, 2, 3 - Cadherin 1, 2, 3 - Calcitonin - CD97 - Corticotropin-releasing hormone 1, 2 - EMR 1, 2, 3 - Glucagon GR, GIPR, GLP1R, GLP2R - Growth hormone releasing hormone - PACAPR1- GPR 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157 - Latrophilin 1, 2, 3, ELTD1 - Parathyroid hormone 1, 2 - Secretin - Vasoactive intestinal peptide 1, 2 Class C: Metabotropic glutamate / pheromone Calcium-sensing receptor - GABA B 1, 2 - Glutamate receptor Metabotropic glutamate 1, 2, 3, 4, 5, 6, 7, 8 - GPRC6A - GPR 156, 158, 179 - RAIG 1, 2, 3, 4 - Taste receptors TAS1R 1, 2, 3 TAS2R 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50 Frizzled / Smoothened Frizzled 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 - Smoothened Retrieved from http://en..org/wiki/Melanin-concentrating_hormone_receptor_2 Categories: Genes on chromosome 6 | Human proteins | Transmembrane receptor stubs | G protein coupled receptorsHidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 8 July 2008, at 13:17
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