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14-September-2008 18:02:44 - 5 receptor Melanocortin 5 receptor Identifiers Symbols MC5R; External IDs OMIM: 600042 MGI: 99420 HomoloGene: 4321 Gene ontology Molecular function: rhodopsin-like receptor activity receptor activity melanocortin receptor activity Cellular component: integral to plasma membrane membrane Biological process: signal transduction G-protein signaling, coupled to cyclic nucleotide second messenger RNA expression pattern More reference expression data Orthologs Human Mouse Entrez 4161 17203 Ensembl ENSG00000176136 ENSMUSG00000007480 Uniprot P33032 Q496T0 Refseq NM_005913 mRNA NP_005904 protein NM_013596 mRNA NP_038624 protein Location Chr 18: 13.82 - 13.82 Mb Chr 18: 68.46 - 68.47 Mb Pubmed search 1 2 Melanocortin 5 receptor, also known as MC5R, is a human gene.1 It is located on the chromosome 18 in the human genome.1 When the melanocortin 5 receptor was disrupted in transgenic mice, it induced disruption of their exocrine glands and resulted in decreased production of sebum.2 See also Melanocortin receptor References ^ a b Entrez Gene: MC5R melanocortin 5 receptor. ^ Thiboutot, Diane; Sivarajah, Aruntha; Gilliland, Kathryn ; Cong, Zhaoyuan; Clawson, Gary 2000. The Melanocortin 5 Receptor is Expressed in Human Sebaceous Glands and Rat Preputial Cells. Journal of Investigative Dermatology 115: 614-619. doi:10.1046/j.1523-1747.2000.00094.x. Retrieved on 2008-01-04. Further reading Fathi Z, Iben LG, Parker EM 1995. Cloning, expression, and tissue distribution of a fifth melanocortin receptor subtype.. Neurochem. Res. 20 1: 107-13. PMID 7739752. Chowdhary BP, Gustavsson I, Wikberg JE, Chhajlani V 1994. Localization of the human melanocortin-5 receptor gene MC5R to chromosome band 18p11.2 by fluorescence in situ hybridization.. Cytogenet. Cell Genet. 68 1-2: 79-81. PMID 7956366. Griffon N, Mignon V, Facchinetti P, et al. 1994. Molecular cloning and characterization of the rat fifth melanocortin receptor.. Biochem. Biophys. Res. Commun. 200 2: 1007-14. PMID 8179577. Gantz I, Shimoto Y, Konda Y, et al. 1994. Molecular cloning, expression, and characterization of a fifth melanocortin receptor.. Biochem. Biophys. Res. Commun. 200 3: 1214-20. doi:10.1006/bbrc.1994.1580. PMID 8185570. Chhajlani V, Muceniece R, Wikberg JE 1993. Molecular cloning of a novel human melanocortin receptor.. Biochem. Biophys. Res. Commun. 195 2: 866-73. doi:10.1006/bbrc.1993.2125. PMID 8396929. Chhajlani V 1997. Distribution of cDNA for melanocortin receptor subtypes in human tissues.. Biochem. Mol. Biol. Int. 38 1: 73-80. PMID 8932521. Yang YK, Ollmann MM, Wilson BD, et al. 1997. Effects of recombinant agouti-signaling protein on melanocortin action.. Mol. Endocrinol. 11 3: 274-80. PMID 9058374. Frändberg PA, Xu X, Chhajlani V 1997. Glutamine235 and arginine272 in human melanocortin 5 receptor determines its low affinity to MSH.. Biochem. Biophys. Res. Commun. 236 2: 489-92. doi:10.1006/bbrc.1997.6994. PMID 9240466. Yang YK, Thompson DA, Dickinson CJ, et al. 1999. Characterization of Agouti-related protein binding to melanocortin receptors.. Mol. Endocrinol. 13 1: 148-55. PMID 9892020. Hatta N, Dixon C, Ray AJ, et al. 2001. Expression, candidate gene, and population studies of the melanocortin 5 receptor.. J. Invest. Dermatol. 116 4: 564-70. doi:10.1046/j.0022-202x.2001.01286.x. PMID 11286624. Bednarek MA, MacNeil T, Kalyani RN, et al. 2001. Selective, high affinity peptide antagonists of alpha-melanotropin action at human melanocortin receptor 4: their synthesis and biological evaluation in vitro.. J. Med. Chem. 44 22: 3665-72. PMID 11606131. Strausberg RL, Feingold EA, Grouse LH, et al. 2003. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 99 26: 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. Lapinsh M, Veiksina S, Uhlén S, et al. 2005. Proteochemometric mapping of the interaction of organic compounds with melanocortin receptor subtypes.. Mol. Pharmacol. 67 1: 50-9. doi:10.1124/mol.104.002857. PMID 15470082. Gerhard DS, Wagner L, Feingold EA, et al. 2004. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection MGC.. Genome Res. 14 10B: 2121-7. doi:10.1101/gr.2596504. PMID 15489334. Lohoff FW, Berrettini WH 2006. Lack of association between variations in the melanocortin 5 receptor gene and bipolar disorder.. Psychiatr. Genet. 15 4: 255-8. PMID 16314755. Grieco P, Cai M, Han G, et al. 2007. Further structure-activity studies of lactam derivatives of MT-II and SHU-9119: their activity and selectivity at human melanocortin receptors 3, 4, and 5.. Peptides 28 6: 1191-6. doi:10.1016/j.peptides.2007.02.012. PMID 17482720. This article incorporates text from the United States National Library of Medicine, which is in the public domain. This transmembrane receptor-related article is a stub. v d e Transmembrane receptor: G protein-coupled receptors Class A: Rhodopsin like Adrenergic α1 A, B, D, α2 A, B, C, β1, β2, β3 Eicosanoid CysLT 1, 2, LTB4 1, 2, FPRL1, OXE, Prostaglandin DP, EP 1, 2, 3, 4, PGF, Prostacyclin, Thromboxane Neuropeptide B/W 1, 2, FF 1, 2, S, Y 1, 2, 4, 5 Orphan GPR 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182 Purinergics Adenosine A1, A2a, A2b, A3, P2Y, 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14 Serotonin all but 5-HT3 5-HT1 A, B, D, E, F, 5-HT2 A, B, C, 5-HT 4, 5A, 6, 7 Other Acetylcholine M1, M2, M3, M4, M5 - Adrenomedullin - Anaphylatoxin C3a, C5a - Angiotensin 1, 2 - Apelin - Bile acid - Bombesin BRS3, GRPR, NMBR - Bradykinin B1, B2 - Cannabinoid CB1, CB2 - Chemokine - Cholecystokinin A, B - Dopamine D1, D2, D3, D4, D5 - EBI2 - Endothelin A, B - Estrogen - Formyl peptide 1, L1, L2 - Free fatty acid 1, 2, 3, 4 - FSH - Galanin 1, 2, 3 - Gonadotropin-releasing hormone 1, 2 - Ghrelin - Histamine H1, H2, H3, H4 - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid 1, 2, 3, 4, 5, 6, 7, 8 - MAS 1, 1L, D, E, F, G, X1, X2, X3, X4 - Melanocortin 1, 2, 3, 4, 5 - MCHR 1, 2 - Melatonin 1A, 1B- Motilin - neuromedin B, U 1, 2 - Neurotensin 1, 2 - Opioid Delta, Kappa, Mu, Nociceptin, but not Sigma - Olfactory - Opsin 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH - Orexin 1, 2 - Oxytocin - Oxoglutarate - PAF - Prokineticin 1, 2 - Prolactin-releasing peptide - Protease-activated 1, 2, 3, 4 - Relaxin 1, 2, 3, 4 - Somatostatin 1, 2, 3, 4, 5 - SREB - Succinate - TAAR 1, 2, 3, 5, 6, 8, 9 - Tachykinin 1, 2, 3 - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin 1A, 1B, 2 Class B: Secretin like Brain-specific angiogenesis inhibitor 1, 2, 3 - Cadherin 1, 2, 3 - Calcitonin - CD97 - Corticotropin-releasing hormone 1, 2 - EMR 1, 2, 3 - Glucagon GR, GIPR, GLP1R, GLP2R - Growth hormone releasing hormone - PACAPR1- GPR 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157 - Latrophilin 1, 2, 3, ELTD1 - Parathyroid hormone 1, 2 - Secretin - Vasoactive intestinal peptide 1, 2 Class C: Metabotropic glutamate / pheromone Calcium-sensing receptor - GABA B 1, 2 - Glutamate receptor Metabotropic glutamate 1, 2, 3, 4, 5, 6, 7, 8 - GPRC6A - GPR 156, 158, 179 - RAIG 1, 2, 3, 4 - Taste receptors TAS1R 1, 2, 3 TAS2R 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50 Frizzled / Smoothened Frizzled 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 - Smoothened Retrieved from http://en..org/wiki/Melanocortin_5_receptor Categories: Genes on chromosome 18 | Human proteins | Transmembrane receptor stubs | G protein coupled receptorsHidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 8 July 2008, at 12:00
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