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14-September-2008 18:02:44 - 8 Glutamate receptor, metabotropic 8 Identifiers Symbols GRM8; FLJ41058; GLUR8; GPRC1H; MGC126724; MGLUR8; mGlu8 External IDs OMIM: 601116 MGI: 1351345 HomoloGene: 654 Gene ontology Molecular function: receptor activity metabotropic glutamate, GABA-B-like receptor activity Cellular component: integral to plasma membrane membrane Biological process: signal transduction G-protein coupled receptor protein signaling pathway negative regulation of adenylate cyclase activity synaptic transmission visual perception sensory perception of smell negative regulation of cAMP biosynthetic process response to stimulus Orthologs Human Mouse Entrez 2918 14823 Ensembl n/a ENSMUSG00000024211 Uniprot n/a Q05BD6 Refseq NM_000845 mRNA NP_000836 protein NM_008174 mRNA NP_032200 protein Location n/a Chr 6: 27.23 - 28.08 Mb Pubmed search 1 2 Glutamate receptor, metabotropic 8, also known as GRM8, is a human gene.1 L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternative splice variants of GRM8 have been described but their full-length nature has not been determined.1 Contents 1 Ligands 2 See also 3 References 4 Further reading Ligands S-3,4-DCPG: agonist2 See also Metabotropic glutamate receptor References ^ a b Entrez Gene: GRM8 glutamate receptor, metabotropic 8. ^ Thomas NK, Wright RA, Howson PA, Kingston AE, Schoepp DD, Jane DE 2001. S-3,4-DCPG, a potent and selective mGlu8a receptor agonist, activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord. Neuropharmacology 40 3: 311-8. PMID 11166323. Further reading Scherer SW, Duvoisin RM, Kuhn R, et al. 1997. Localization of two metabotropic glutamate receptor genes, GRM3 and GRM8, to human chromosome 7q.. Genomics 31 2: 230-3. doi:10.1006/geno.1996.0036. PMID 8824806. Scherer SW, Soder S, Duvoisin RM, et al. 1997. The human metabotropic glutamate receptor 8 GRM8 gene: a disproportionately large gene located at 7q31.3-q32.1.. Genomics 44 2: 232-6. doi:10.1006/geno.1997.4842. PMID 9299241. Wu S, Wright RA, Rockey PK, et al. 1998. Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells.. Brain Res. Mol. Brain Res. 53 1-2: 88-97. PMID 9473604. Malherbe P, Kratzeisen C, Lundstrom K, et al. 1999. Cloning and functional expression of alternative spliced variants of the human metabotropic glutamate receptor 8.. Brain Res. Mol. Brain Res. 67 2: 201-10. PMID 10216218. Thomas NK, Wright RA, Howson PA, et al. 2001. S-3,4-DCPG, a potent and selective mGlu8a receptor agonist, activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord.. Neuropharmacology 40 3: 311-8. PMID 11166323. Enz R 2002. The actin-binding protein Filamin-A interacts with the metabotropic glutamate receptor type 7.. FEBS Lett. 514 2-3: 184-8. PMID 11943148. Strausberg RL, Feingold EA, Grouse LH, et al. 2003. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 99 26: 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. Gerhard DS, Wagner L, Feingold EA, et al. 2004. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection MGC.. Genome Res. 14 10B: 2121-7. doi:10.1101/gr.2596504. PMID 15489334. Tang Z, El Far O, Betz H, Scheschonka A 2006. Pias1 interaction and sumoylation of metabotropic glutamate receptor 8.. J. Biol. Chem. 280 46: 38153-9. doi:10.1074/jbc.M508168200. PMID 16144832. Kobayashi Y, Akiyoshi J, Kanehisa M, et al. 2007. Lack of polymorphism in genes encoding mGluR 7, mGluR 8, GABAA receptor alfa-6 subunit and nociceptin/orphanin FQ receptor and panic disorder.. Psychiatr. Genet. 17 1: 9. doi:10.1097/YPG.0b013e32801118bc. PMID 17167337. This transmembrane receptor-related article is a stub. This article incorporates text from the United States National Library of Medicine, which is in the public domain. v d e Transmembrane receptor: G protein-coupled receptors Class A: Rhodopsin like Adrenergic α1 A, B, D, α2 A, B, C, β1, β2, β3 Eicosanoid CysLT 1, 2, LTB4 1, 2, FPRL1, OXE, Prostaglandin DP, EP 1, 2, 3, 4, PGF, Prostacyclin, Thromboxane Neuropeptide B/W 1, 2, FF 1, 2, S, Y 1, 2, 4, 5 Orphan GPR 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182 Purinergics Adenosine A1, A2a, A2b, A3, P2Y, 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14 Serotonin all but 5-HT3 5-HT1 A, B, D, E, F, 5-HT2 A, B, C, 5-HT 4, 5A, 6, 7 Other Acetylcholine M1, M2, M3, M4, M5 - Adrenomedullin - Anaphylatoxin C3a, C5a - Angiotensin 1, 2 - Apelin - Bile acid - Bombesin BRS3, GRPR, NMBR - Bradykinin B1, B2 - Cannabinoid CB1, CB2 - Chemokine - Cholecystokinin A, B - Dopamine D1, D2, D3, D4, D5 - EBI2 - Endothelin A, B - Estrogen - Formyl peptide 1, L1, L2 - Free fatty acid 1, 2, 3, 4 - FSH - Galanin 1, 2, 3 - Gonadotropin-releasing hormone 1, 2 - Ghrelin - Histamine H1, H2, H3, H4 - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid 1, 2, 3, 4, 5, 6, 7, 8 - MAS 1, 1L, D, E, F, G, X1, X2, X3, X4 - Melanocortin 1, 2, 3, 4, 5 - MCHR 1, 2 - Melatonin 1A, 1B- Motilin - neuromedin B, U 1, 2 - Neurotensin 1, 2 - Opioid Delta, Kappa, Mu, Nociceptin, but not Sigma - Olfactory - Opsin 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH - Orexin 1, 2 - Oxytocin - Oxoglutarate - PAF - Prokineticin 1, 2 - Prolactin-releasing peptide - Protease-activated 1, 2, 3, 4 - Relaxin 1, 2, 3, 4 - Somatostatin 1, 2, 3, 4, 5 - SREB - Succinate - TAAR 1, 2, 3, 5, 6, 8, 9 - Tachykinin 1, 2, 3 - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin 1A, 1B, 2 Class B: Secretin like Brain-specific angiogenesis inhibitor 1, 2, 3 - Cadherin 1, 2, 3 - Calcitonin - CD97 - Corticotropin-releasing hormone 1, 2 - EMR 1, 2, 3 - Glucagon GR, GIPR, GLP1R, GLP2R - Growth hormone releasing hormone - PACAPR1- GPR 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157 - Latrophilin 1, 2, 3, ELTD1 - Parathyroid hormone 1, 2 - Secretin - Vasoactive intestinal peptide 1, 2 Class C: Metabotropic glutamate / pheromone Calcium-sensing receptor - GABA B 1, 2 - Glutamate receptor Metabotropic glutamate 1, 2, 3, 4, 5, 6, 7, 8 - GPRC6A - GPR 156, 158, 179 - RAIG 1, 2, 3, 4 - Taste receptors TAS1R 1, 2, 3 TAS2R 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50 Frizzled / Smoothened Frizzled 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 - Smoothened Retrieved from http://en..org/wiki/Metabotropic_glutamate_receptor_8 Categories: Human proteins | Transmembrane receptor stubs | G protein coupled receptorsHidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 10 August 2008, at 15:2
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