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14-September-2008 18:02:40 - Mixed inhibition Mixed inhibition refers to a combination of two different types of reversible enzyme inhibition - competitive inhibition and uncompetitive inhibition. The term 'mixed' is used when the inhibitor can bind to either the free enzyme or the enzyme-substrate complex. In mixed inhibition, the inhibitor binds to a site different from the active site where the substrate binds. Mixed inhibition results in a decrease in the apparent affinity of the enzyme for the substrate K_m^app K_m and a decrease in the apparent maximum enzyme reaction rate V_max^app V_max .1 Mathematically, mixed inhibition occurs when the factors α and α' introduced into the Michaelis-Menten equation to account for competitive and uncompetitive inhibition, respectively are both greater than 1. In the special case where α = α', noncompetitive inhibition occurs, in which case V_max^app is reduced but Km is unaffected. This is very unusual in practice1 References ^ a b 2004 Functional Metabolism: Regulation and Adaptation. Wiley-IEEE, 12. ISBN 047141090X. v d e Pharmacology: enzyme inhibition Class Competitive inhibition - Uncompetitive inhibition - Non-competitive inhibition - Suicide inhibition - Mixed inhibition Substrate Oxidoreductase EC 1: Aromatase inhibitors - Lipoxygenase inhibitor - Monoamine oxidase inhibitors - COX-2 inhibitor Transferase EC 2: Integrase inhibitor - Protein kinase inhibitors - Reverse transcriptase inhibitors - COMT inhibitors Hydrolase EC 3: Acetylcholinesterase inhibitors - Phosphodiesterase inhibitors - Protease inhibitors ACE inhibitor, Trypsin inhibitor - Histone deacetylase inhibitor Lyase EC 4: Carbonic anhydrase inhibitors This biochemistry article is a stub. Retrieved from http://en..org/wiki/Mixed_inhibition Categories: Biochemistry stubs Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages Español This page was last modified on 13 January 2008, at 22:3
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