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14-September-2008 18:02:44 - Motilin receptor Motilin receptor Identifiers Symbols MLNR; GPR38; MTLR1 External IDs OMIM: 602885 HomoloGene: 74398 Gene ontology Molecular function: rhodopsin-like receptor activity receptor activity growth hormone-releasing hormone receptor activity Cellular component: integral to plasma membrane membrane Biological process: smooth muscle contraction signal transduction G-protein coupled receptor protein signaling pathway digestion RNA expression pattern More reference expression data Orthologs Human Mouse Entrez 2862 n/a Ensembl ENSG00000102539 n/a Uniprot O43193 n/a Refseq NM_001507 mRNA NP_001498 protein n/a mRNA n/a protein Location Chr 13: 48.69 - 48.69 Mb n/a Pubmed search 1 n/a Motilin receptor is a G protein-coupled receptor which binds motilin.12 Motilin in turn is an intestinal peptide that stimulates contraction of gut smooth muscle. References ^ Depoortere I 2001. Motilin and motilin receptors: characterization and functional significance. Verh. K. Acad. Geneeskd. Belg. 63 6: 511-29. PMID 11813507. ^ Yang X, Dong L, Yang H 2006. Evidence for the presence of motilin receptor and a study on the mechanism of motilin induced Ca2+ signaling in rat myenteric neurons in Chinese. Sichuan Da Xue Xue Bao Yi Xue Ban 37 5: 683-6. PMID 17037727. Further reading Smith RG, Leonard R, Bailey AR, et al. 2001. Growth hormone secretagogue receptor family members and ligands.. Endocrine 14 1: 9-14. PMID 11322507. McKee KK, Tan CP, Palyha OC, et al. 1998. Cloning and characterization of two human G protein-coupled receptor genes GPR38 and GPR39 related to the growth hormone secretagogue and neurotensin receptors.. Genomics 46 3: 426-34. doi:10.1006/geno.1997.5069. PMID 9441746. Feighner SD, Tan CP, McKee KK, et al. 1999. Receptor for motilin identified in the human gastrointestinal system.. Science 284 5423: 2184-8. PMID 10381885. Miller P, Roy A, St-Pierre S, et al. 2000. Motilin receptors in the human antrum.. Am. J. Physiol. Gastrointest. Liver Physiol. 278 1: G18-23. PMID 10644557. Thielemans L, Depoortere I, Van Assche G, et al. 2001. Demonstration of a functional motilin receptor in TE671 cells from human cerebellum.. Brain Res. 895 1-2: 119-28. PMID 11259768. Coulie B, Matsuura B, Dong M, et al. 2001. Identification of peptide ligand-binding domains within the human motilin receptor using photoaffinity labeling.. J. Biol. Chem. 276 38: 35518-22. doi:10.1074/jbc.M104489200. PMID 11461914. Thielemans L, Depoortere I, Vanden Broeck J, Peeters TL 2002. The motilin pharmacophore in CHO cells expressing the human motilin receptor.. Biochem. Biophys. Res. Commun. 293 4: 1223-7. doi:10.1016/S0006-291X0200356-X. PMID 12054506. Depoortere I, Thijs T, Thielemans L, et al. 2003. Interaction of the growth hormone-releasing peptides ghrelin and growth hormone-releasing peptide-6 with the motilin receptor in the rabbit gastric antrum.. J. Pharmacol. Exp. Ther. 305 2: 660-7. doi:10.1124/jpet.102.047563. PMID 12606621. Dunham A, Matthews LH, Burton J, et al. 2004. The DNA sequence and analysis of human chromosome 13.. Nature 428 6982: 522-8. doi:10.1038/nature02379. PMID 15057823. Matsuura B, Dong M, Naik S, et al. 2006. Differential contributions of motilin receptor extracellular domains for peptide and non-peptidyl agonist binding and activity.. J. Biol. Chem. 281 18: 12390-6. doi:10.1074/jbc.M511921200. PMID 16531413. External links IUPHAR GPCR Database - Motilin receptor MeSH Motilin+receptor This transmembrane receptor-related article is a stub. v d e Transmembrane receptor: G protein-coupled receptors Class A: Rhodopsin like Adrenergic α1 A, B, D, α2 A, B, C, β1, β2, β3 Eicosanoid CysLT 1, 2, LTB4 1, 2, FPRL1, OXE, Prostaglandin DP, EP 1, 2, 3, 4, PGF, Prostacyclin, Thromboxane Neuropeptide B/W 1, 2, FF 1, 2, S, Y 1, 2, 4, 5 Orphan GPR 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182 Purinergics Adenosine A1, A2a, A2b, A3, P2Y, 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14 Serotonin all but 5-HT3 5-HT1 A, B, D, E, F, 5-HT2 A, B, C, 5-HT 4, 5A, 6, 7 Other Acetylcholine M1, M2, M3, M4, M5 - Adrenomedullin - Anaphylatoxin C3a, C5a - Angiotensin 1, 2 - Apelin - Bile acid - Bombesin BRS3, GRPR, NMBR - Bradykinin B1, B2 - Cannabinoid CB1, CB2 - Chemokine - Cholecystokinin A, B - Dopamine D1, D2, D3, D4, D5 - EBI2 - Endothelin A, B - Estrogen - Formyl peptide 1, L1, L2 - Free fatty acid 1, 2, 3, 4 - FSH - Galanin 1, 2, 3 - Gonadotropin-releasing hormone 1, 2 - Ghrelin - Histamine H1, H2, H3, H4 - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid 1, 2, 3, 4, 5, 6, 7, 8 - MAS 1, 1L, D, E, F, G, X1, X2, X3, X4 - Melanocortin 1, 2, 3, 4, 5 - MCHR 1, 2 - Melatonin 1A, 1B- Motilin - neuromedin B, U 1, 2 - Neurotensin 1, 2 - Opioid Delta, Kappa, Mu, Nociceptin, but not Sigma - Olfactory - Opsin 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH - Orexin 1, 2 - Oxytocin - Oxoglutarate - PAF - Prokineticin 1, 2 - Prolactin-releasing peptide - Protease-activated 1, 2, 3, 4 - Relaxin 1, 2, 3, 4 - Somatostatin 1, 2, 3, 4, 5 - SREB - Succinate - TAAR 1, 2, 3, 5, 6, 8, 9 - Tachykinin 1, 2, 3 - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin 1A, 1B, 2 Class B: Secretin like Brain-specific angiogenesis inhibitor 1, 2, 3 - Cadherin 1, 2, 3 - Calcitonin - CD97 - Corticotropin-releasing hormone 1, 2 - EMR 1, 2, 3 - Glucagon GR, GIPR, GLP1R, GLP2R - Growth hormone releasing hormone - PACAPR1- GPR 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157 - Latrophilin 1, 2, 3, ELTD1 - Parathyroid hormone 1, 2 - Secretin - Vasoactive intestinal peptide 1, 2 Class C: Metabotropic glutamate / pheromone Calcium-sensing receptor - GABA B 1, 2 - Glutamate receptor Metabotropic glutamate 1, 2, 3, 4, 5, 6, 7, 8 - GPRC6A - GPR 156, 158, 179 - RAIG 1, 2, 3, 4 - Taste receptors TAS1R 1, 2, 3 TAS2R 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50 Frizzled / Smoothened Frizzled 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 - Smoothened Retrieved from http://en..org/wiki/Motilin_receptor Categories: Genes on chromosome 13 | Human proteins | Transmembrane receptor stubs | G protein coupled receptorsHidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 8 July 2008, at 03:5
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