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14-September-2008 18:02:44 - 2 Neuromedin U receptor 2 Identifiers Symbols NMUR2; FM4; NMU2R External IDs OMIM: 605108 MGI: 2441765 HomoloGene: 49618 Gene ontology Molecular function: rhodopsin-like receptor activity neuromedin U receptor activity receptor activity intracellular calcium activated chloride channel activity GTP binding Cellular component: integral to plasma membrane membrane Biological process: calcium ion transport regulation of smooth muscle contraction signal transduction G-protein signaling, coupled to IP3 second messenger phospholipase C activating elevation of cytosolic calcium ion concentration neuropeptide signaling pathway central nervous system development feeding behavior transmission of nerve impulse calcium-dependent phospholipase A2 activation secretory pathway inositol phosphate-mediated signaling arachidonic acid secretion Orthologs Human Mouse Entrez 56923 216749 Ensembl ENSG00000132911 ENSMUSG00000037393 Uniprot Q9GZQ4 Q8BZ39 Refseq NM_020167 mRNA NP_064552 protein NM_153079 mRNA NP_694719 protein Location Chr 5: 151.75 - 151.77 Mb Chr 11: 55.87 - 55.88 Mb Pubmed search 1 2 Neuromedin U receptor 2, also known as NMUR2, is a human gene.1 See also Neuromedin U receptor References ^ Entrez Gene: NMUR2 neuromedin U receptor 2. Further reading Tate CG, Grisshammer R 1997. Heterologous expression of G-protein-coupled receptors.. Trends Biotechnol. 14 11: 426-30. doi:10.1016/0167-77999610059-7. PMID 8940772. Hosoya M, Moriya T, Kawamata Y, et al. 2000. Identification and functional characterization of a novel subtype of neuromedin U receptor.. J. Biol. Chem. 275 38: 29528-32. doi:10.1074/jbc.M004261200. PMID 10887190. Howard AD, Wang R, Pong SS, et al. 2000. Identification of receptors for neuromedin U and its role in feeding.. Nature 406 6791: 70-4. doi:10.1038/35017610. PMID 10894543. Raddatz R, Wilson AE, Artymyshyn R, et al. 2000. Identification and characterization of two neuromedin U receptors differentially expressed in peripheral tissues and the central nervous system.. J. Biol. Chem. 275 42: 32452-9. doi:10.1074/jbc.M004613200. PMID 10899166. Shan L, Qiao X, Crona JH, et al. 2001. Identification of a novel neuromedin U receptor subtype expressed in the central nervous system.. J. Biol. Chem. 275 50: 39482-6. doi:10.1074/jbc.C000522200. PMID 11010960. Fernández Alvarez C, Debeljuk L, Díaz Rodríguez E, Díaz López B 2003. Developmental pattern of tachykinins during aging in several organs: effect of exogenous melatonin.. Peptides 23 9: 1617-23. PMID 12217422. Strausberg RL, Feingold EA, Grouse LH, et al. 2003. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 99 26: 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. Gerhard DS, Wagner L, Feingold EA, et al. 2004. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection MGC.. Genome Res. 14 10B: 2121-7. doi:10.1101/gr.2596504. PMID 15489334. Bhattacharyya S, Luan J, Farooqi IS, et al. 2004. Studies of the neuromedin U-2 receptor gene in human obesity: evidence for the existence of two ancestral forms of the receptor.. J. Endocrinol. 183 1: 115-20. doi:10.1677/joe.1.05830. PMID 15525579. Mori K, Miyazato M, Ida T, et al. 2005. Identification of neuromedin S and its possible role in the mammalian circadian oscillator system.. EMBO J. 24 2: 325-35. doi:10.1038/sj.emboj.7600526. PMID 15635449. Fang L, Zhang M, Li C, et al. 2006. Chemical genetic analysis reveals the effects of NMU2R on the expression of peptide hormones.. Neurosci. Lett. 404 1-2: 148-53. doi:10.1016/j.neulet.2006.05.034. PMID 16781063. This transmembrane receptor-related article is a stub. v d e Transmembrane receptor: G protein-coupled receptors Class A: Rhodopsin like Adrenergic α1 A, B, D, α2 A, B, C, β1, β2, β3 Eicosanoid CysLT 1, 2, LTB4 1, 2, FPRL1, OXE, Prostaglandin DP, EP 1, 2, 3, 4, PGF, Prostacyclin, Thromboxane Neuropeptide B/W 1, 2, FF 1, 2, S, Y 1, 2, 4, 5 Orphan GPR 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182 Purinergics Adenosine A1, A2a, A2b, A3, P2Y, 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14 Serotonin all but 5-HT3 5-HT1 A, B, D, E, F, 5-HT2 A, B, C, 5-HT 4, 5A, 6, 7 Other Acetylcholine M1, M2, M3, M4, M5 - Adrenomedullin - Anaphylatoxin C3a, C5a - Angiotensin 1, 2 - Apelin - Bile acid - Bombesin BRS3, GRPR, NMBR - Bradykinin B1, B2 - Cannabinoid CB1, CB2 - Chemokine - Cholecystokinin A, B - Dopamine D1, D2, D3, D4, D5 - EBI2 - Endothelin A, B - Estrogen - Formyl peptide 1, L1, L2 - Free fatty acid 1, 2, 3, 4 - FSH - Galanin 1, 2, 3 - Gonadotropin-releasing hormone 1, 2 - Ghrelin - Histamine H1, H2, H3, H4 - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid 1, 2, 3, 4, 5, 6, 7, 8 - MAS 1, 1L, D, E, F, G, X1, X2, X3, X4 - Melanocortin 1, 2, 3, 4, 5 - MCHR 1, 2 - Melatonin 1A, 1B- Motilin - neuromedin B, U 1, 2 - Neurotensin 1, 2 - Opioid Delta, Kappa, Mu, Nociceptin, but not Sigma - Olfactory - Opsin 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH - Orexin 1, 2 - Oxytocin - Oxoglutarate - PAF - Prokineticin 1, 2 - Prolactin-releasing peptide - Protease-activated 1, 2, 3, 4 - Relaxin 1, 2, 3, 4 - Somatostatin 1, 2, 3, 4, 5 - SREB - Succinate - TAAR 1, 2, 3, 5, 6, 8, 9 - Tachykinin 1, 2, 3 - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin 1A, 1B, 2 Class B: Secretin like Brain-specific angiogenesis inhibitor 1, 2, 3 - Cadherin 1, 2, 3 - Calcitonin - CD97 - Corticotropin-releasing hormone 1, 2 - EMR 1, 2, 3 - Glucagon GR, GIPR, GLP1R, GLP2R - Growth hormone releasing hormone - PACAPR1- GPR 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157 - Latrophilin 1, 2, 3, ELTD1 - Parathyroid hormone 1, 2 - Secretin - Vasoactive intestinal peptide 1, 2 Class C: Metabotropic glutamate / pheromone Calcium-sensing receptor - GABA B 1, 2 - Glutamate receptor Metabotropic glutamate 1, 2, 3, 4, 5, 6, 7, 8 - GPRC6A - GPR 156, 158, 179 - RAIG 1, 2, 3, 4 - Taste receptors TAS1R 1, 2, 3 TAS2R 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50 Frizzled / Smoothened Frizzled 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 - Smoothened Retrieved from http://en..org/wiki/Neuromedin_U_receptor_2 Categories: Genes on chromosome 5
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