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14-September-2008 18:02:44 - 2 Neurotensin receptor 2 Identifiers Symbols NTSR2; NTR2 External IDs OMIM: 605538 MGI: 108018 HomoloGene: 7452 Gene ontology Molecular function: rhodopsin-like receptor activity receptor activity neurotensin receptor activity, G-protein coupled Cellular component: integral to plasma membrane membrane Biological process: G-protein coupled receptor protein signaling pathway sensory perception RNA expression pattern More reference expression data Orthologs Human Mouse Entrez 23620 18217 Ensembl ENSG00000169006 ENSMUSG00000020591 Uniprot O95665 Q8VIF4 Refseq XM_001129997 mRNA XP_001129997 protein NM_008747 mRNA NP_032773 protein Location Chr 2: 11.72 - 11.73 Mb Chr 12: 16.68 - 16.69 Mb Pubmed search 1 2 Neurotensin receptor 2, also known as NTSR2, is a human gene.1 The protein encoded by this gene belongs to the G protein-coupled receptor family that activate a phosphatidylinositol-calcium second messenger system. Binding and pharmacological studies demonstrate that this receptor binds neurotensin as well as several other ligands already described for neurotensin NT1 receptor. However, unlike NT1 receptor, this gene recognizes, with high affinity, levocabastine, a histamine H1 receptor antagonist previously shown to compete with neurotensin for low-affinity binding sites in brain. These activities suggest that this receptor may be of physiological importance and that a natural agonist for the receptor may exist.1 See also Neurotensin receptor References ^ a b Entrez Gene: NTSR2 neurotensin receptor 2. Further reading Vincent JP, Mazella J, Kitabgi P 1999. Neurotensin and neurotensin receptors.. Trends Pharmacol. Sci. 20 7: 302-9. PMID 10390649. Chalon P, Vita N, Kaghad M, et al. 1996. Molecular cloning of a levocabastine-sensitive neurotensin binding site.. FEBS Lett. 386 2-3: 91-4. PMID 8647296. Mazella J, Botto JM, Guillemare E, et al. 1996. Structure, functional expression, and cerebral localization of the levocabastine-sensitive neurotensin/neuromedin N receptor from mouse brain.. J. Neurosci. 16 18: 5613-20. PMID 8795617. Vita N, Oury-Donat F, Chalon P, et al. 1999. Neurotensin is an antagonist of the human neurotensin NT2 receptor expressed in Chinese hamster ovary cells.. Eur. J. Pharmacol. 360 2-3: 265-72. PMID 9851594. Ramez M, Bagot M, Nikolova M, et al. 2001. Functional characterization of neurotensin receptors in human cutaneous T cell lymphoma malignant lymphocytes.. J. Invest. Dermatol. 117 3: 687-93. doi:10.1046/j.0022-202x.2001.01439.x. PMID 11564178. Martin S, Vincent JP, Mazella J 2002. Recycling ability of the mouse and the human neurotensin type 2 receptors depends on a single tyrosine residue.. J. Cell. Sci. 115 Pt 1: 165-73. PMID 11801734. Bourcier T, Rondeau N, Paquet S, et al. 2002. Expression of neurotensin receptors in human corneal keratocytes.. Invest. Ophthalmol. Vis. Sci. 43 6: 1765-71. PMID 12036977. Leyton J, Garcia-Marin L, Jensen RT, Moody TW 2002. Neurotensin causes tyrosine phosphorylation of focal adhesion kinase in lung cancer cells.. Eur. J. Pharmacol. 442 3: 179-86. PMID 12065070. Somaï S, Gompel A, Rostène W, Forgez P 2002. Neurotensin counteracts apoptosis in breast cancer cells.. Biochem. Biophys. Res. Commun. 295 2: 482-8. PMID 12150975. Strausberg RL, Feingold EA, Grouse LH, et al. 2003. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 99 26: 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. Holst B, Holliday ND, Bach A, et al. 2005. Common structural basis for constitutive activity of the ghrelin receptor family.. J. Biol. Chem. 279 51: 53806-17. doi:10.1074/jbc.M407676200. PMID 15383539. Gerhard DS, Wagner L, Feingold EA, et al. 2004. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection MGC.. Genome Res. 14 10B: 2121-7. doi:10.1101/gr.2596504. PMID 15489334. This transmembrane receptor-related article is a stub. This article incorporates text from the United States National Library of Medicine, which is in the public domain. v d e Transmembrane receptor: G protein-coupled receptors Class A: Rhodopsin like Adrenergic α1 A, B, D, α2 A, B, C, β1, β2, β3 Eicosanoid CysLT 1, 2, LTB4 1, 2, FPRL1, OXE, Prostaglandin DP, EP 1, 2, 3, 4, PGF, Prostacyclin, Thromboxane Neuropeptide B/W 1, 2, FF 1, 2, S, Y 1, 2, 4, 5 Orphan GPR 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182 Purinergics Adenosine A1, A2a, A2b, A3, P2Y, 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14 Serotonin all but 5-HT3 5-HT1 A, B, D, E, F, 5-HT2 A, B, C, 5-HT 4, 5A, 6, 7 Other Acetylcholine M1, M2, M3, M4, M5 - Adrenomedullin - Anaphylatoxin C3a, C5a - Angiotensin 1, 2 - Apelin - Bile acid - Bombesin BRS3, GRPR, NMBR - Bradykinin B1, B2 - Cannabinoid CB1, CB2 - Chemokine - Cholecystokinin A, B - Dopamine D1, D2, D3, D4, D5 - EBI2 - Endothelin A, B - Estrogen - Formyl peptide 1, L1, L2 - Free fatty acid 1, 2, 3, 4 - FSH - Galanin 1, 2, 3 - Gonadotropin-releasing hormone 1, 2 - Ghrelin - Histamine H1, H2, H3, H4 - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid 1, 2, 3, 4, 5, 6, 7, 8 - MAS 1, 1L, D, E, F, G, X1, X2, X3, X4 - Melanocortin 1, 2, 3, 4, 5 - MCHR 1, 2 - Melatonin 1A, 1B- Motilin - neuromedin B, U 1, 2 - Neurotensin 1, 2 - Opioid Delta, Kappa, Mu, Nociceptin, but not Sigma - Olfactory - Opsin 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH - Orexin 1, 2 - Oxytocin - Oxoglutarate - PAF - Prokineticin 1, 2 - Prolactin-releasing peptide - Protease-activated 1, 2, 3, 4 - Relaxin 1, 2, 3, 4 - Somatostatin 1, 2, 3, 4, 5 - SREB - Succinate - TAAR 1, 2, 3, 5, 6, 8, 9 - Tachykinin 1, 2, 3 - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin 1A, 1B, 2 Class B: Secretin like Brain-specific angiogenesis inhibitor 1, 2, 3 - Cadherin 1, 2, 3 - Calcitonin - CD97 - Corticotropin-releasing hormone 1, 2 - EMR 1, 2, 3 - Glucagon GR, GIPR, GLP1R, GLP2R - Growth hormone releasing hormone - PACAPR1- GPR 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157 - Latrophilin 1, 2, 3, ELTD1 - Parathyroid hormone 1, 2 - Secretin - Vasoactive intestinal peptide 1, 2 Class C: Metabotropic glutamate / pheromone Calcium-sensing receptor - GABA B 1, 2 - Glutamate receptor Metabotropic glutamate 1, 2, 3, 4, 5, 6, 7, 8 - GPRC6A - GPR 156, 158, 179 - RAIG 1, 2, 3, 4 - Taste receptors TAS1R 1, 2, 3 TAS2R 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50 Frizzled / Smoothened Frizzled 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 - Smoothened Retrieved from http://en..org/wiki/Neurotensin_receptor_2 Categories: Genes on chromosome 2 | Human proteins | Transmembrane receptor stubs | G protein coupled receptorsHidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 8 July 2008, at 12:24
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