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14-September-2008 18:02:44 - SW Opsin 1 cone pigments, short-wave-sensitive color blindness, tritan Identifiers Symbols OPN1SW; BCP; BOP; CBT External IDs OMIM: 190900 MGI: 99438 HomoloGene: 1291 Gene ontology Molecular function: rhodopsin-like receptor activity receptor activity blue light photoreceptor activity Cellular component: photoreceptor outer segment integral to plasma membrane membrane Biological process: signal transduction G-protein coupled receptor protein signaling pathway visual perception phototransduction protein-chromophore linkage response to stimulus RNA expression pattern More reference expression data Orthologs Human Mouse Entrez 611 12057 Ensembl ENSG00000128617 ENSMUSG00000058831 Uniprot P03999 P51491 Refseq NM_001708 mRNA NP_001699 protein NM_007538 mRNA NP_031564 protein Location Chr 7: 128.2 - 128.2 Mb Chr 6: 29.33 - 29.33 Mb Pubmed search 1 2 Opsin 1 cone pigments, short-wave-sensitive color blindness, tritan, also known as OPN1SW, is a human gene.1 See also Opsin References ^ Entrez Gene: OPN1SW opsin 1 cone pigments, short-wave-sensitive color blindness, tritan. Further reading Applebury ML, Hargrave PA 1987. Molecular biology of the visual pigments.. Vision Res. 26 12: 1881-95. PMID 3303660. Swanson WH, Cohen JM 2003. Color vision.. Ophthalmology clinics of North America 16 2: 179-203. PMID 12809157. Weitz CJ, Went LN, Nathans J 1992. Human tritanopia associated with a third amino acid substitution in the blue-sensitive visual pigment.. Am. J. Hum. Genet. 51 2: 444-6. PMID 1386496. Weitz CJ, Miyake Y, Shinzato K, et al. 1992. Human tritanopia associated with two amino acid substitutions in the blue-sensitive opsin.. Am. J. Hum. Genet. 50 3: 498-507. PMID 1531728. Oprian DD, Asenjo AB, Lee N, Pelletier SL 1992. Design, chemical synthesis, and expression of genes for the three human color vision pigments.. Biochemistry 30 48: 11367-72. PMID 1742276. Sarkar G, Sommer SS 1989. Access to a messenger RNA sequence or its protein product is not limited by tissue or species specificity.. Science 244 4902: 331-4. PMID 2565599. Nathans J, Thomas D, Hogness DS 1986. Molecular genetics of human color vision: the genes encoding blue, green, and red pigments.. Science 232 4747: 193-202. PMID 2937147. Nathans J, Piantanida TP, Eddy RL, et al. 1986. Molecular genetics of inherited variation in human color vision.. Science 232 4747: 203-10. PMID 3485310. Fitzgibbon J, Appukuttan B, Gayther S, et al. 1994. Localisation of the human blue cone pigment gene to chromosome band 7q31.3-32.. Hum. Genet. 93 1: 79-80. PMID 8270261. Shimmin LC, Mai P, Li WH 1997. Sequences and evolution of human and squirrel monkey blue opsin genes.. J. Mol. Evol. 44 4: 378-82. PMID 9089077. Scherer SW, Cheung J, MacDonald JR, et al. 2003. Human chromosome 7: DNA sequence and biology.. Science 300 5620: 767-72. doi:10.1126/science.1083423. PMID 12690205. Gunther KL, Neitz J, Neitz M 2006. A novel mutation in the short-wavelength-sensitive cone pigment gene associated with a tritan color vision defect.. Vis. Neurosci. 23 3-4: 403-9. doi:10.1017/S0952523806233169. PMID 16961973. This transmembrane receptor-related article is a stub. v d e Transmembrane receptor: G protein-coupled receptors Class A: Rhodopsin like Adrenergic α1 A, B, D, α2 A, B, C, β1, β2, β3 Eicosanoid CysLT 1, 2, LTB4 1, 2, FPRL1, OXE, Prostaglandin DP, EP 1, 2, 3, 4, PGF, Prostacyclin, Thromboxane Neuropeptide B/W 1, 2, FF 1, 2, S, Y 1, 2, 4, 5 Orphan GPR 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182 Purinergics Adenosine A1, A2a, A2b, A3, P2Y, 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14 Serotonin all but 5-HT3 5-HT1 A, B, D, E, F, 5-HT2 A, B, C, 5-HT 4, 5A, 6, 7 Other Acetylcholine M1, M2, M3, M4, M5 - Adrenomedullin - Anaphylatoxin C3a, C5a - Angiotensin 1, 2 - Apelin - Bile acid - Bombesin BRS3, GRPR, NMBR - Bradykinin B1, B2 - Cannabinoid CB1, CB2 - Chemokine - Cholecystokinin A, B - Dopamine D1, D2, D3, D4, D5 - EBI2 - Endothelin A, B - Estrogen - Formyl peptide 1, L1, L2 - Free fatty acid 1, 2, 3, 4 - FSH - Galanin 1, 2, 3 - Gonadotropin-releasing hormone 1, 2 - Ghrelin - Histamine H1, H2, H3, H4 - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid 1, 2, 3, 4, 5, 6, 7, 8 - MAS 1, 1L, D, E, F, G, X1, X2, X3, X4 - Melanocortin 1, 2, 3, 4, 5 - MCHR 1, 2 - Melatonin 1A, 1B- Motilin - neuromedin B, U 1, 2 - Neurotensin 1, 2 - Opioid Delta, Kappa, Mu, Nociceptin, but not Sigma - Olfactory - Opsin 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH - Orexin 1, 2 - Oxytocin - Oxoglutarate - PAF - Prokineticin 1, 2 - Prolactin-releasing peptide - Protease-activated 1, 2, 3, 4 - Relaxin 1, 2, 3, 4 - Somatostatin 1, 2, 3, 4, 5 - SREB - Succinate - TAAR 1, 2, 3, 5, 6, 8, 9 - Tachykinin 1, 2, 3 - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin 1A, 1B, 2 Class B: Secretin like Brain-specific angiogenesis inhibitor 1, 2, 3 - Cadherin 1, 2, 3 - Calcitonin - CD97 - Corticotropin-releasing hormone 1, 2 - EMR 1, 2, 3 - Glucagon GR, GIPR, GLP1R, GLP2R - Growth hormone releasing hormone - PACAPR1- GPR 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157 - Latrophilin 1, 2, 3, ELTD1 - Parathyroid hormone 1, 2 - Secretin - Vasoactive intestinal peptide 1, 2 Class C: Metabotropic glutamate / pheromone Calcium-sensing receptor - GABA B 1, 2 - Glutamate receptor Metabotropic glutamate 1, 2, 3, 4, 5, 6, 7, 8 - GPRC6A - GPR 156, 158, 179 - RAIG 1, 2, 3, 4 - Taste receptors TAS1R 1, 2, 3 TAS2R 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50 Frizzled / Smoothened Frizzled 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 - Smoothened Retrieved from http://en..org/wiki/OPN1SW Categories: Genes on chromosome 7 | Human proteins | Transmembrane receptor stubs | G protein coupled receptorsHidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 8 July 2008, at 11:47
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