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14-September-2008 18:02:44 - Purinergic receptor P2Y, G-protein coupled, 1 Identifiers Symbols P2RY1; P2Y1 External IDs OMIM: 601167 MGI: 105049 HomoloGene: 1926 Gene ontology Molecular function: rhodopsin-like receptor activity receptor activity purinergic nucleotide receptor activity, G-protein coupled Cellular component: integral to plasma membrane membrane Biological process: G-protein signaling, coupled to IP3 second messenger phospholipase C activating blood coagulation RNA expression pattern More reference expression data Orthologs Human Mouse Entrez 5028 18441 Ensembl ENSG00000169860 ENSMUSG00000027765 Uniprot P47900 Q544J5 Refseq NM_002563 mRNA NP_002554 protein NM_008772 mRNA NP_032798 protein Location Chr 3: 154.04 - 154.04 Mb Chr 3: 61.09 - 61.1 Mb Pubmed search 1 2 Purinergic receptor P2Y, G-protein coupled, 1, also known as P2RY1, is a human gene. The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor functions as a receptor for extracellular ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation.1 See also P2Y receptor References ^ Entrez Gene: P2RY1 purinergic receptor P2Y, G-protein coupled, 1. Further reading Ayyanathan K, Webbs TE, Sandhu AK, et al. 1996. Cloning and chromosomal localization of the human P2Y1 purinoceptor.. Biochem. Biophys. Res. Commun. 218 3: 783-8. doi:10.1006/bbrc.1996.0139. PMID 8579591. Janssens R, Communi D, Pirotton S, et al. 1996. Cloning and tissue distribution of the human P2Y1 receptor.. Biochem. Biophys. Res. Commun. 221 3: 588-93. doi:10.1006/bbrc.1996.0640. PMID 8630005. Léon C, Vial C, Cazenave JP, Gachet C 1996. Cloning and sequencing of a human cDNA encoding endothelial P2Y1 purinoceptor.. Gene 171 2: 295-7. PMID 8666290. Léon C, Hechler B, Vial C, et al. 1997. The P2Y1 receptor is an ADP receptor antagonized by ATP and expressed in platelets and megakaryoblastic cells.. FEBS Lett. 403 1: 26-30. PMID 9038354. Ayyanathan K, Naylor SL, Kunapuli SP 1997. Structural characterization and fine chromosomal mapping of the human P2Y1 purinergic receptor gene P2RY1.. Somat. Cell Mol. Genet. 22 5: 419-24. PMID 9039850. Maier R, Glatz A, Mosbacher J, Bilbe G 1997. Cloning of P2Y6 cDNAs and identification of a pseudogene: comparison of P2Y receptor subtype expression in bone and brain tissues.. Biochem. Biophys. Res. Commun. 237 2: 297-302. doi:10.1006/bbrc.1997.7135. PMID 9268704. Jin J, Daniel JL, Kunapuli SP 1998. Molecular basis for ADP-induced platelet activation. II. The P2Y1 receptor mediates ADP-induced intracellular calcium mobilization and shape change in platelets.. J. Biol. Chem. 273 4: 2030-4. PMID 9442040. Hall RA, Ostedgaard LS, Premont RT, et al. 1998. A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of PDZ proteins.. Proc. Natl. Acad. Sci. U.S.A. 95 15: 8496-501. PMID 9671706. Sabala P, Czajkowski R, Przybyłek K, et al. 2001. Two subtypes of G protein-coupled nucleotide receptors, P2Y1 and P2Y2 are involved in calcium signalling in glioma C6 cells.. Br. J. Pharmacol. 132 2: 393-402. doi:10.1038/sj.bjp.0703843. PMID 11159687. Yoshioka K, Saitoh O, Nakata H 2001. Heteromeric association creates a P2Y-like adenosine receptor.. Proc. Natl. Acad. Sci. U.S.A. 98 13: 7617-22. doi:10.1073/pnas.121587098. PMID 11390975. James G, Butt AM 2001. Changes in P2Y and P2X purinoceptors in reactive glia following axonal degeneration in the rat optic nerve.. Neurosci. Lett. 312 1: 33-6. PMID 11578839. Moore DJ, Chambers JK, Wahlin JP, et al. 2001. Expression pattern of human P2Y receptor subtypes: a quantitative reverse transcription-polymerase chain reaction study.. Biochim. Biophys. Acta 1521 1-3: 107-19. PMID 11690642. Czajkowski R, Lei L, Sabała P, Barańska J 2002. ADP-evoked phospholipase C stimulation and adenylyl cyclase inhibition in glioma C6 cells occur through two distinct nucleotide receptors, P2Y1 and P2Y12.. FEBS Lett. 513 2-3: 179-83. PMID 11904146. Aktas B, Hönig-Liedl P, Walter U, Geiger J 2002. Inhibition of platelet P2Y12 and alpha2A receptor signaling by cGMP-dependent protein kinase.. Biochem. Pharmacol. 64 3: 433-9. PMID 12147294. Nurden P, Poujol C, Winckler J, et al. 2003. Immunolocalization of P2Y1 and TPalpha receptors in platelets showed a major pool associated with the membranes of alpha -granules and the open canalicular system.. Blood 101 4: 1400-8. doi:10.1182/blood-2002-02-0642. PMID 12393588. Strausberg RL, Feingold EA, Grouse LH, et al. 2003. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 99 26: 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. Burrell HE, Bowler WB, Gallagher JA, Sharpe GR 2003. Human keratinocytes express multiple P2Y-receptors: evidence for functional P2Y1, P2Y2, and P2Y4 receptors.. J. Invest. Dermatol. 120 3: 440-7. doi:10.1046/j.1523-1747.2003.12050.x. PMID 12603858. Jagroop IA, Burnstock G, Mikhailidis DP 2003. Both the ADP receptors P2Y1 and P2Y12, play a role in controlling shape change in human platelets.. Platelets 14 1: 15-20. PMID 12623443. Greig AV, Linge C, Terenghi G, et al. 2003. Purinergic receptors are part of a functional signaling system for proliferation and differentiation of human epidermal keratinocytes.. J. Invest. Dermatol. 120 6: 1007-15. PMID 12787128. Wang L, Ostberg O, Wihlborg AK, et al. 2003. Quantification of ADP and ATP receptor expression in human platelets.. J. Thromb. Haemost. 1 2: 330-6. PMID 12871508. This transmembrane receptor-related article is a stub. This article incorporates text from the United States National Library of Medicine, which is in the public domain. v d e Transmembrane receptor: G protein-coupled receptors Class A: Rhodopsin like Adrenergic α1 A, B, D, α2 A, B, C, β1, β2, β3 Eicosanoid CysLT 1, 2, LTB4 1, 2, FPRL1, OXE, Prostaglandin DP, EP 1, 2, 3, 4, PGF, Prostacyclin, Thromboxane Neuropeptide B/W 1, 2, FF 1, 2, S, Y 1, 2, 4, 5 Orphan GPR 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182 Purinergics Adenosine A1, A2a, A2b, A3, P2Y, 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14 Serotonin all but 5-HT3 5-HT1 A, B, D, E, F, 5-HT2 A, B, C, 5-HT 4, 5A, 6, 7 Other Acetylcholine M1, M2, M3, M4, M5 - Adrenomedullin - Anaphylatoxin C3a, C5a - Angiotensin 1, 2 - Apelin - Bile acid - Bombesin BRS3, GRPR, NMBR - Bradykinin B1, B2 - Cannabinoid CB1, CB2 - Chemokine - Cholecystokinin A, B - Dopamine D1, D2, D3, D4, D5 - EBI2 - Endothelin A, B - Estrogen - Formyl peptide 1, L1, L2 - Free fatty acid 1, 2, 3, 4 - FSH - Galanin 1, 2, 3 - Gonadotropin-releasing hormone 1, 2 - Ghrelin - Histamine H1, H2, H3, H4 - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid 1, 2, 3, 4, 5, 6, 7, 8 - MAS 1, 1L, D, E, F, G, X1, X2, X3, X4 - Melanocortin 1, 2, 3, 4, 5 - MCHR 1, 2 - Melatonin 1A, 1B- Motilin - neuromedin B, U 1, 2 - Neurotensin 1, 2 - Opioid Delta, Kappa, Mu, Nociceptin, but not Sigma - Olfactory - Opsin 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH - Orexin 1, 2 - Oxytocin - Oxoglutarate - PAF - Prokineticin 1, 2 - Prolactin-releasing peptide - Protease-activated 1, 2, 3, 4 - Relaxin 1, 2, 3, 4 - Somatostatin 1, 2, 3, 4, 5 - SREB - Succinate - TAAR 1, 2, 3, 5, 6, 8, 9 - Tachykinin 1, 2, 3 - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin 1A, 1B, 2 Class B: Secretin like Brain-specific angiogenesis inhibitor 1, 2, 3 - Cadherin 1, 2, 3 - Calcitonin - CD97 - Corticotropin-releasing hormone 1, 2 - EMR 1, 2, 3 - Glucagon GR, GIPR, GLP1R, GLP2R - Growth hormone releasing hormone - PACAPR1- GPR 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157 - Latrophilin 1, 2, 3, ELTD1 - Parathyroid hormone 1, 2 - Secretin - Vasoactive intestinal peptide 1, 2 Class C: Metabotropic glutamate / pheromone Calcium-sensing receptor - GABA B 1, 2 - Glutamate receptor Metabotropic glutamate 1, 2, 3, 4, 5, 6, 7, 8 - GPRC6A - GPR 156, 158, 179 - RAIG 1, 2, 3, 4 - Taste receptors TAS1R 1, 2, 3 TAS2R 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50 Frizzled / Smoothened Frizzled 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 - Smoothened Retrieved from http://en..org/wiki/P2RY1 Categories: Genes on chromosome 3 | Human proteins | Transmembrane receptor stubs | G protein coupled receptorsHidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 8 July 2008, at 09:24
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