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14-September-2008 18:02:44 - 4 Purinergic receptor P2Y, G-protein coupled, 14 Identifiers Symbols P2RY14; GPR105; KIAA0001; P2Y14 External IDs OMIM: 610116 MGI: 2155705 HomoloGene: 15769 Gene ontology Molecular function: rhodopsin-like receptor activity receptor activity purinergic nucleotide receptor activity, G-protein coupled UDP-activated nucleotide receptor activity Cellular component: membrane integral to membrane Biological process: signal transduction G-protein coupled receptor protein signaling pathway RNA expression pattern More reference expression data Orthologs Human Mouse Entrez 9934 140795 Ensembl ENSG00000174944 ENSMUSG00000036381 Uniprot Q15391 Q544F4 Refseq NM_001081455 mRNA NP_001074924 protein NM_001008497 mRNA NP_001008497 protein Location Chr 3: 152.41 - 152.48 Mb Chr 3: 59.2 - 59.22 Mb Pubmed search 1 2 Purinergic receptor P2Y, G-protein coupled, 14, also known as P2RY14, is a human gene.1 The product of this gene belongs to the family of G-protein coupled receptors, which contains several receptor subtypes with different pharmacological selectivity for various adenosine and uridine nucleotides. This receptor is a P2Y purinergic receptor for UDP-glucose and other UDP-sugars coupled to G-proteins. It has been implicated in extending the known immune system functions of P2Y receptors by participating in the regulation of the stem cell compartment, and it may also play a role in neuroimmune function. Two transcript variants encoding the same protein have been identified for this gene.1 See also P2Y receptor References ^ a b Entrez Gene: P2RY14 purinergic receptor P2Y, G-protein coupled, 14. Further reading Gerard C, Gerard NP 1994. C5A anaphylatoxin and its seven transmembrane-segment receptor.. Annu. Rev. Immunol. 12: 775-808. doi:10.1146/annurev.iy.12.040194.004015. PMID 8011297. Müller CE 2003. P2-pyrimidinergic receptors and their ligands.. Curr. Pharm. Des. 8 26: 2353-69. PMID 12369950. Abbracchio MP, Boeynaems JM, Barnard EA, et al. 2003. Characterization of the UDP-glucose receptor re-named here the P2Y14 receptor adds diversity to the P2Y receptor family.. Trends Pharmacol. Sci. 24 2: 52-5. PMID 12559763. von Kügelgen I 2006. Pharmacological profiles of cloned mammalian P2Y-receptor subtypes.. Pharmacol. Ther. 110 3: 415-32. doi:10.1016/j.pharmthera.2005.08.014. PMID 16257449. Brunschweiger A, Müller CE 2006. P2 receptors activated by uracil nucleotides--an update.. Curr. Med. Chem. 13 3: 289-312. PMID 16475938. Nomura N, Miyajima N, Sazuka T, et al. 1995. Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes KIAA0001-KIAA0040 deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1.. DNA Res. 1 1: 27-35. PMID 7584026. Nomura N, Miyajima N, Sazuka T, et al. 1995. Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes KIAA0001-KIAA0040 deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 supplement.. DNA Res. 1 1: 47-56. PMID 7584028. Charlton ME, Williams AS, Fogliano M, et al. 1997. The isolation and characterization of a novel G protein-coupled receptor regulated by immunologic challenge.. Brain Res. 764 1-2: 141-8. PMID 9295203. Joensuu T, Hämäläinen R, Lehesjoki AE, et al. 2000. A sequence-ready map of the Usher syndrome type III critical region on chromosome 3q.. Genomics 63 3: 409-16. doi:10.1006/geno.1999.6096. PMID 10704288. Chambers JK, Macdonald LE, Sarau HM, et al. 2000. A G protein-coupled receptor for UDP-glucose.. J. Biol. Chem. 275 15: 10767-71. PMID 10753868. Wittenberger T, Schaller HC, Hellebrand S 2001. An expressed sequence tag EST data mining strategy succeeding in the discovery of new G-protein coupled receptors.. J. Mol. Biol. 307 3: 799-813. doi:10.1006/jmbi.2001.4520. PMID 11273702. Joensuu T, Hämäläinen R, Yuan B, et al. 2001. Mutations in a novel gene with transmembrane domains underlie Usher syndrome type 3.. Am. J. Hum. Genet. 69 4: 673-84. PMID 11524702. Strausberg RL, Feingold EA, Grouse LH, et al. 2003. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 99 26: 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. Lazarowski ER, Shea DA, Boucher RC, Harden TK 2003. Release of cellular UDP-glucose as a potential extracellular signaling molecule.. Mol. Pharmacol. 63 5: 1190-7. PMID 12695547. Lee BC, Cheng T, Adams GB, et al. 2003. P2Y-like receptor, GPR105 P2Y14, identifies and mediates chemotaxis of bone-marrow hematopoietic stem cells.. Genes Dev. 17 13: 1592-604. doi:10.1101/gad.1071503. PMID 12842911. Skelton L, Cooper M, Murphy M, Platt A 2003. Human immature monocyte-derived dendritic cells express the G protein-coupled receptor GPR105 KIAA0001, P2Y14 and increase intracellular calcium in response to its agonist, uridine diphosphoglucose.. J. Immunol. 171 4: 1941-9. PMID 12902497. Moore DJ, Murdock PR, Watson JM, et al. 2004. GPR105, a novel Gi/o-coupled UDP-glucose receptor expressed on brain glia and peripheral immune cells, is regulated by immunologic challenge: possible role in neuroimmune function.. Brain Res. Mol. Brain Res. 118 1-2: 10-23. PMID 14559350. This transmembrane receptor-related article is a stub. This article incorporates text from the United States National Library of Medicine, which is in the public domain. v d e Transmembrane receptor: G protein-coupled receptors Class A: Rhodopsin like Adrenergic α1 A, B, D, α2 A, B, C, β1, β2, β3 Eicosanoid CysLT 1, 2, LTB4 1, 2, FPRL1, OXE, Prostaglandin DP, EP 1, 2, 3, 4, PGF, Prostacyclin, Thromboxane Neuropeptide B/W 1, 2, FF 1, 2, S, Y 1, 2, 4, 5 Orphan GPR 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182 Purinergics Adenosine A1, A2a, A2b, A3, P2Y, 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14 Serotonin all but 5-HT3 5-HT1 A, B, D, E, F, 5-HT2 A, B, C, 5-HT 4, 5A, 6, 7 Other Acetylcholine M1, M2, M3, M4, M5 - Adrenomedullin - Anaphylatoxin C3a, C5a - Angiotensin 1, 2 - Apelin - Bile acid - Bombesin BRS3, GRPR, NMBR - Bradykinin B1, B2 - Cannabinoid CB1, CB2 - Chemokine - Cholecystokinin A, B - Dopamine D1, D2, D3, D4, D5 - EBI2 - Endothelin A, B - Estrogen - Formyl peptide 1, L1, L2 - Free fatty acid 1, 2, 3, 4 - FSH - Galanin 1, 2, 3 - Gonadotropin-releasing hormone 1, 2 - Ghrelin - Histamine H1, H2, H3, H4 - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid 1, 2, 3, 4, 5, 6, 7, 8 - MAS 1, 1L, D, E, F, G, X1, X2, X3, X4 - Melanocortin 1, 2, 3, 4, 5 - MCHR 1, 2 - Melatonin 1A, 1B- Motilin - neuromedin B, U 1, 2 - Neurotensin 1, 2 - Opioid Delta, Kappa, Mu, Nociceptin, but not Sigma - Olfactory - Opsin 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH - Orexin 1, 2 - Oxytocin - Oxoglutarate - PAF - Prokineticin 1, 2 - Prolactin-releasing peptide - Protease-activated 1, 2, 3, 4 - Relaxin 1, 2, 3, 4 - Somatostatin 1, 2, 3, 4, 5 - SREB - Succinate - TAAR 1, 2, 3, 5, 6, 8, 9 - Tachykinin 1, 2, 3 - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin 1A, 1B, 2 Class B: Secretin like Brain-specific angiogenesis inhibitor 1, 2, 3 - Cadherin 1, 2, 3 - Calcitonin - CD97 - Corticotropin-releasing hormone 1, 2 - EMR 1, 2, 3 - Glucagon GR, GIPR, GLP1R, GLP2R - Growth hormone releasing hormone - PACAPR1- GPR 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157 - Latrophilin 1, 2, 3, ELTD1 - Parathyroid hormone 1, 2 - Secretin - Vasoactive intestinal peptide 1, 2 Class C: Metabotropic glutamate / pheromone Calcium-sensing receptor - GABA B 1, 2 - Glutamate receptor Metabotropic glutamate 1, 2, 3, 4, 5, 6, 7, 8 - GPRC6A - GPR 156, 158, 179 - RAIG 1, 2, 3, 4 - Taste receptors TAS1R 1, 2, 3 TAS2R 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50 Frizzled / Smoothened Frizzled 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 - Smoothened Retrieved from http://en..org/wiki/P2RY14 Categories: Genes on chromosome 3 | Human proteins | Transmembrane receptor stubs | G protein coupled receptorsHidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 8 July 2008, at 12:18
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