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14-September-2008 18:02:44 - E receptor 3 Redirected from PTGER3 Prostaglandin E receptor 3 subtype EP3 Identifiers Symbols PTGER3; EP3; EP3-I; EP3-II; EP3-III; EP3-IV; EP3e; MGC141828; MGC141829; MGC27302 External IDs OMIM: 176806 MGI: 97795 HomoloGene: 22622 Gene ontology Molecular function: rhodopsin-like receptor activity receptor activity ligand-dependent nuclear receptor activity prostaglandin E receptor activity Cellular component: nuclear envelope plasma membrane integral to plasma membrane membrane integral to membrane Biological process: transcription, DNA-dependent signal transduction G-protein coupled receptor protein signaling pathway biological_process cell death RNA expression pattern More reference expression data Orthologs Human Mouse Entrez 5733 19218 Ensembl ENSG00000050628 ENSMUSG00000040016 Uniprot P43115 P30557 Refseq NM_000957 mRNA NP_000948 protein NM_011196 mRNA NP_035326 protein Location Chr 1: 71.09 - 71.29 Mb Chr 3: 157.5 - 157.58 Mb Pubmed search 1 2 Prostaglandin E receptor 3 subtype EP3, also known as PTGER3, is a prostaglandin receptor, but also denotes the human gene encoding it.1 Contents 1 Receptor 2 Variations 3 See also 4 References 5 Further reading Receptor The receptor is a member of the G-protein coupled receptor family. It is one of four receptors identified for prostaglandin E2 PGE2. This receptor may have many biological functions, which involve digestion, nervous system, kidney reabsorption, and uterine contraction activities. In the stomach, it inhibits gastric acid secretions. Studies of the mouse counterpart suggest that this receptor may also mediate adrenocorticotropic hormone response as well as fever generation in response to exogenous and endogenous stimuli. Variations Multiple alternatively spliced transcript variants encoding eight distinct isoforms have been reported.1 See also Eicosanoid receptor References ^ a b Entrez Gene: PTGER3 prostaglandin E receptor 3 subtype EP3. Further reading Kotani M, Tanaka I, Ogawa Y, et al. 1995. Molecular cloning and expression of multiple isoforms of human prostaglandin E receptor EP3 subtype generated by alternative messenger RNA splicing: multiple second messenger systems and tissue-specific distributions.. Mol. Pharmacol. 48 5: 869-79. PMID 7476918. Duncan AM, Anderson LL, Funk CD, et al. 1995. Chromosomal localization of the human prostanoid receptor gene family.. Genomics 25 3: 740-2. PMID 7759114. Schmid A, Thierauch KH, Schleuning WD, Dinter H 1995. Splice variants of the human EP3 receptor for prostaglandin E2.. Eur. J. Biochem. 228 1: 23-30. PMID 7883006. An S, Yang J, So SW, et al. 1995. Isoforms of the EP3 subtype of human prostaglandin E2 receptor transduce both intracellular calcium and cAMP signals.. Biochemistry 33 48: 14496-502. PMID 7981210. Regan JW, Bailey TJ, Donello JE, et al. 1994. Molecular cloning and expression of human EP3 receptors: evidence of three variants with differing carboxyl termini.. Br. J. Pharmacol. 112 2: 377-85. PMID 8075855. Yang J, Xia M, Goetzl EJ, An S 1994. Cloning and expression of the EP3-subtype of human receptors for prostaglandin E2.. Biochem. Biophys. Res. Commun. 198 3: 999-1006. PMID 8117308. Kunapuli SP, Fen Mao G, Bastepe M, et al. 1994. Cloning and expression of a prostaglandin E receptor EP3 subtype from human erythroleukaemia cells.. Biochem. J. 298 Pt 2: 263-7. PMID 8135729. Adam M, Boie Y, Rushmore TH, et al. 1994. Cloning and expression of three isoforms of the human EP3 prostanoid receptor.. FEBS Lett. 338 2: 170-4. PMID 8307176. Chang C, Negishi M, Nishigaki N, Ichikawa A 1997. Functional interaction of the carboxylic acid group of agonists and the arginine residue of the seventh transmembrane domain of prostaglandin E receptor EP3 subtype.. Biochem. J. 322 Pt 2: 597-601. PMID 9065782. Kotani M, Tanaka I, Ogawa Y, et al. 1997. Structural organization of the human prostaglandin EP3 receptor subtype gene PTGER3.. Genomics 40 3: 425-34. doi:10.1006/geno.1996.4585. PMID 9073510. Ushikubi F, Segi E, Sugimoto Y, et al. 1998. Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3.. Nature 395 6699: 281-4. doi:10.1038/26233. PMID 9751056. Bhattacharya M, Peri K, Ribeiro-da-Silva A, et al. 1999. Localization of functional prostaglandin E2 receptors EP3 and EP4 in the nuclear envelope.. J. Biol. Chem. 274 22: 15719-24. PMID 10336471. Liu J, Akahoshi T, Jiang S, et al. 2000. Induction of neutrophil death resembling neither apoptosis nor necrosis by ONO-AE-248, a selective agonist for PGE2 receptor subtype 3.. J. Leukoc. Biol. 68 2: 187-93. PMID 10947062. Kurihara Y, Endo H, Kondo H 2001. Induction of IL-6 via the EP3 subtype of prostaglandin E receptor in rat adjuvant-arthritic synovial cells.. Inflamm. Res. 50 1: 1-5. PMID 11235015. Strausberg RL, Feingold EA, Grouse LH, et al. 2003. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 99 26: 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. Matsuoka Y, Furuyashiki T, Bito H, et al. 2003. Impaired adrenocorticotropic hormone response to bacterial endotoxin in mice deficient in prostaglandin E receptor EP1 and EP3 subtypes.. Proc. Natl. Acad. Sci. U.S.A. 100 7: 4132-7. doi:10.1073/pnas.0633341100. PMID 12642666. Wing DA, Goharkhay N, Hanna M, et al. 2003. EP3-2 receptor mRNA expression is reduced and EP3-6 receptor mRNA expression is increased in gravid human myometrium.. J. Soc. Gynecol. Investig. 10 3: 124-9. PMID 12699873. Abulencia JP, Gaspard R, Healy ZR, et al. 2003. Shear-induced cyclooxygenase-2 via a JNK2/c-Jun-dependent pathway regulates prostaglandin receptor expression in chondrocytic cells.. J. Biol. Chem. 278 31: 28388-94. doi:10.1074/jbc.M301378200. PMID 12743126. Richards JA, Brueggemeier RW 2003. Prostaglandin E2 regulates aromatase activity and expression in human adipose stromal cells via two distinct receptor subtypes.. J. Clin. Endocrinol. Metab. 88 6: 2810-6. PMID 12788892. Moreland RB, Kim N, Nehra A, et al. 2004. Functional prostaglandin E EP receptors in human penile corpus cavernosum.. Int. J. Impot. Res. 15 5: 362-8. doi:10.1038/sj.ijir.3901042. PMID 14562138. This transmembrane receptor-related article is a stub. This article incorporates text from the United States National Library of Medicine, which is in the public domain. v d e Transmembrane receptor: G protein-coupled receptors Class A: Rhodopsin like Adrenergic α1 A, B, D, α2 A, B, C, β1, β2, β3 Eicosanoid CysLT 1, 2, LTB4 1, 2, FPRL1, OXE, Prostaglandin DP, EP 1, 2, 3, 4, PGF, Prostacyclin, Thromboxane Neuropeptide B/W 1, 2, FF 1, 2, S, Y 1, 2, 4, 5 Orphan GPR 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182 Purinergics Adenosine A1, A2a, A2b, A3, P2Y, 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14 Serotonin all but 5-HT3 5-HT1 A, B, D, E, F, 5-HT2 A, B, C, 5-HT 4, 5A, 6, 7 Other Acetylcholine M1, M2, M3, M4, M5 - Adrenomedullin - Anaphylatoxin C3a, C5a - Angiotensin 1, 2 - Apelin - Bile acid - Bombesin BRS3, GRPR, NMBR - Bradykinin B1, B2 - Cannabinoid CB1, CB2 - Chemokine - Cholecystokinin A, B - Dopamine D1, D2, D3, D4, D5 - EBI2 - Endothelin A, B - Estrogen - Formyl peptide 1, L1, L2 - Free fatty acid 1, 2, 3, 4 - FSH - Galanin 1, 2, 3 - Gonadotropin-releasing hormone 1, 2 - Ghrelin - Histamine H1, H2, H3, H4 - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid 1, 2, 3, 4, 5, 6, 7, 8 - MAS 1, 1L, D, E, F, G, X1, X2, X3, X4 - Melanocortin 1, 2, 3, 4, 5 - MCHR 1, 2 - Melatonin 1A, 1B- Motilin - neuromedin B, U 1, 2 - Neurotensin 1, 2 - Opioid Delta, Kappa, Mu, Nociceptin, but not Sigma - Olfactory - Opsin 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH - Orexin 1, 2 - Oxytocin - Oxoglutarate - PAF - Prokineticin 1, 2 - Prolactin-releasing peptide - Protease-activated 1, 2, 3, 4 - Relaxin 1, 2, 3, 4 - Somatostatin 1, 2, 3, 4, 5 - SREB - Succinate - TAAR 1, 2, 3, 5, 6, 8, 9 - Tachykinin 1, 2, 3 - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin 1A, 1B, 2 Class B: Secretin like Brain-specific angiogenesis inhibitor 1, 2, 3 - Cadherin 1, 2, 3 - Calcitonin - CD97 - Corticotropin-releasing hormone 1, 2 - EMR 1, 2, 3 - Glucagon GR, GIPR, GLP1R, GLP2R - Growth hormone releasing hormone - PACAPR1- GPR 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157 - Latrophilin 1, 2, 3, ELTD1 - Parathyroid hormone 1, 2 - Secretin - Vasoactive intestinal peptide 1, 2 Class C: Metabotropic glutamate / pheromone Calcium-sensing receptor - GABA B 1, 2 - Glutamate receptor Metabotropic glutamate 1, 2, 3, 4, 5, 6, 7, 8 - GPRC6A - GPR 156, 158, 179 - RAIG 1, 2, 3, 4 - Taste receptors TAS1R 1, 2, 3 TAS2R 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50 Frizzled / Smoothened Frizzled 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 - Smoothened Retrieved from http://en..org/wiki/Prostaglandin_E_receptor_3 Categories: Genes on chromosome 1 | Human proteins | Transmembrane receptor stubs | G protein coupled receptorsHidden category: Protein pages needing a picture
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