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14-September-2008 18:02:44 - Prostacyclin receptor Redirected from PTGIR Prostaglandin I2 prostacyclin receptor IP Identifiers Symbols PTGIR; IP; MGC102830; PRIPR External IDs OMIM: 600022 MGI: 99535 HomoloGene: 7496 Gene ontology Molecular function: rhodopsin-like receptor activity receptor activity thromboxane receptor activity Cellular component: integral to plasma membrane membrane integral to membrane Biological process: signal transduction G-protein coupled receptor protein signaling pathway G-protein signaling, coupled to cyclic nucleotide second messenger cell-cell signaling RNA expression pattern More reference expression data Orthologs Human Mouse Entrez 5739 19222 Ensembl ENSG00000160013 ENSMUSG00000043017 Uniprot P43119 Q3U4F1 Refseq NM_000960 mRNA NP_000951 protein NM_008967 mRNA NP_032993 protein Location Chr 19: 51.82 - 51.82 Mb Chr 7: 16.07 - 16.07 Mb Pubmed search 1 2 Prostacyclin receptor or prostaglandin I2 receptor is a receptor for prostacyclin. It is a member of the G-protein coupled receptor family. Prostacyclin, the major product of cyclooxygenase in macrovascular endothelium, elicits a potent vasodilation and inhibition of platelet aggregation through binding to this receptor.1 Contents 1 Transduction 1.1 In vasodilation 2 Gene 3 See also 4 References 5 Further reading Transduction When binding a prostacyclin-molecule, the receptor changes conformation and activates Gs, with its activation of cAMP and increase in protein kinase A PKA activity. In vasodilation In vasodilation, the PKA activity causes phosphorylation of MLCK, decreasing its activity, resulting in dephosphorylation of MLC of myosin. The smooth muscle relaxation leads to vasodilation.2 Gene The receptor is encoded by the human gene PTGIR.1 See also Eicosanoid receptor References ^ a b Entrez Gene: PTGIR prostaglandin I2 prostacyclin receptor IP. ^ Walter F., PhD. Boron. Medical Physiology: A Cellular And Molecular Approaoch. Elsevier/Saunders. ISBN 1-4160-2328-3. Page 479 Further reading Coleman RA, Smith WL, Narumiya S 1994. International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes.. Pharmacol. Rev. 46 2: 205-29. PMID 7938166. Rauvala H, Peng HB 1997. HB-GAM heparin-binding growth-associated molecule and heparin-type glycans in the development and plasticity of neuron-target contacts.. Prog. Neurobiol. 52 2: 127-44. PMID 9185236. Smyth EM, FitzGerald GA 2003. Human prostacyclin receptor.. Vitam. Horm. 65: 149-65. PMID 12481546. Boie Y, Rushmore TH, Darmon-Goodwin A, et al. 1994. Cloning and expression of a cDNA for the human prostanoid IP receptor.. J. Biol. Chem. 269 16: 12173-8. PMID 7512962. Katsuyama M, Sugimoto Y, Namba T, et al. 1994. Cloning and expression of a cDNA for the human prostacyclin receptor.. FEBS Lett. 344 1: 74-8. PMID 7514139. Ogawa Y, Tanaka I, Inoue M, et al. 1995. Structural organization and chromosomal assignment of the human prostacyclin receptor gene.. Genomics 27 1: 142-8. PMID 7665161. Duncan AM, Anderson LL, Funk CD, et al. 1995. Chromosomal localization of the human prostanoid receptor gene family.. Genomics 25 3: 740-2. PMID 7759114. Nakagawa O, Tanaka I, Usui T, et al. 1994. Molecular cloning of human prostacyclin receptor cDNA and its gene expression in the cardiovascular system.. Circulation 90 4: 1643-7. PMID 7923647. Bonaldo MF, Lennon G, Soares MB 1997. Normalization and subtraction: two approaches to facilitate gene discovery.. Genome Res. 6 9: 791-806. PMID 8889548. Sasaki Y, Takahashi T, Tanaka I, et al. 1997. Expression of prostacyclin receptor in human megakaryocytes.. Blood 90 3: 1039-46. PMID 9242534. Fisch A, Tobusch K, Veit K, et al. 1997. Prostacyclin receptor desensitization is a reversible phenomenon in human platelets.. Circulation 96 3: 756-60. PMID 9264479. Smyth EM, Li WH, FitzGerald GA 1998. Phosphorylation of the prostacyclin receptor during homologous desensitization. A critical role for protein kinase c.. J. Biol. Chem. 273 36: 23258-66. PMID 9722557. Kömhoff M, Lesener B, Nakao K, et al. 1999. Localization of the prostacyclin receptor in human kidney.. Kidney Int. 54 6: 1899-908. doi:10.1046/j.1523-1755.1998.00213.x. PMID 9853255. Hayes JS, Lawler OA, Walsh MT, Kinsella BT 1999. The prostacyclin receptor is isoprenylated. Isoprenylation is required for efficient receptor-effector coupling.. J. Biol. Chem. 274 34: 23707-18. PMID 10446129. Smyth EM, Austin SC, Reilly MP, FitzGerald GA 2000. Internalization and sequestration of the human prostacyclin receptor.. J. Biol. Chem. 275 41: 32037-45. doi:10.1074/jbc.M003873200. PMID 10889200. Lawler OA, Miggin SM, Kinsella BT 2001. Protein kinase A-mediated phosphorylation of serine 357 of the mouse prostacyclin receptor regulates its coupling to Gs-, to Gi-, and to Gq-coupled effector signaling.. J. Biol. Chem. 276 36: 33596-607. doi:10.1074/jbc.M104434200. PMID 11443126. Zhang Z, Austin SC, Smyth EM 2001. Glycosylation of the human prostacyclin receptor: role in ligand binding and signal transduction.. Mol. Pharmacol. 60 3: 480-7. PMID 11502878. Fortier I, Patry C, Lora M, et al. 2001. Immunohistochemical localization of the prostacyclin receptor IP human bone.. Prostaglandins Leukot. Essent. Fatty Acids 65 2: 79-83. doi:10.1054/plef.2001.0292. PMID 11545623. This transmembrane receptor-related article is a stub. This article incorporates text from the United States National Library of Medicine, which is in the public domain. v d e Transmembrane receptor: G protein-coupled receptors Class A: Rhodopsin like Adrenergic α1 A, B, D, α2 A, B, C, β1, β2, β3 Eicosanoid CysLT 1, 2, LTB4 1, 2, FPRL1, OXE, Prostaglandin DP, EP 1, 2, 3, 4, PGF, Prostacyclin, Thromboxane Neuropeptide B/W 1, 2, FF 1, 2, S, Y 1, 2, 4, 5 Orphan GPR 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182 Purinergics Adenosine A1, A2a, A2b, A3, P2Y, 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14 Serotonin all but 5-HT3 5-HT1 A, B, D, E, F, 5-HT2 A, B, C, 5-HT 4, 5A, 6, 7 Other Acetylcholine M1, M2, M3, M4, M5 - Adrenomedullin - Anaphylatoxin C3a, C5a - Angiotensin 1, 2 - Apelin - Bile acid - Bombesin BRS3, GRPR, NMBR - Bradykinin B1, B2 - Cannabinoid CB1, CB2 - Chemokine - Cholecystokinin A, B - Dopamine D1, D2, D3, D4, D5 - EBI2 - Endothelin A, B - Estrogen - Formyl peptide 1, L1, L2 - Free fatty acid 1, 2, 3, 4 - FSH - Galanin 1, 2, 3 - Gonadotropin-releasing hormone 1, 2 - Ghrelin - Histamine H1, H2, H3, H4 - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid 1, 2, 3, 4, 5, 6, 7, 8 - MAS 1, 1L, D, E, F, G, X1, X2, X3, X4 - Melanocortin 1, 2, 3, 4, 5 - MCHR 1, 2 - Melatonin 1A, 1B- Motilin - neuromedin B, U 1, 2 - Neurotensin 1, 2 - Opioid Delta, Kappa, Mu, Nociceptin, but not Sigma - Olfactory - Opsin 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH - Orexin 1, 2 - Oxytocin - Oxoglutarate - PAF - Prokineticin 1, 2 - Prolactin-releasing peptide - Protease-activated 1, 2, 3, 4 - Relaxin 1, 2, 3, 4 - Somatostatin 1, 2, 3, 4, 5 - SREB - Succinate - TAAR 1, 2, 3, 5, 6, 8, 9 - Tachykinin 1, 2, 3 - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin 1A, 1B, 2 Class B: Secretin like Brain-specific angiogenesis inhibitor 1, 2, 3 - Cadherin 1, 2, 3 - Calcitonin - CD97 - Corticotropin-releasing hormone 1, 2 - EMR 1, 2, 3 - Glucagon GR, GIPR, GLP1R, GLP2R - Growth hormone releasing hormone - PACAPR1- GPR 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157 - Latrophilin 1, 2, 3, ELTD1 - Parathyroid hormone 1, 2 - Secretin - Vasoactive intestinal peptide 1, 2 Class C: Metabotropic glutamate / pheromone Calcium-sensing receptor - GABA B 1, 2 - Glutamate receptor Metabotropic glutamate 1, 2, 3, 4, 5, 6, 7, 8 - GPRC6A - GPR 156, 158, 179 - RAIG 1, 2, 3, 4 - Taste receptors TAS1R 1, 2, 3 TAS2R 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50 Frizzled / Smoothened Frizzled 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 - Smoothened Retrieved from http://en..org/wiki/Prostacyclin_receptor Categories: Genes on chromosome 19 | Human proteins | Transmembrane receptor stubs | G protein coupled receptorsHidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 8 July 2008, at 13:1
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