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14-September-2008 18:02:44 - Pancreatic polypeptide receptor 1 Pancreatic polypeptide receptor 1 Identifiers Symbols PPYR1; PP1; MGC116897; NPY4-R; NPY4R; Y4 External IDs OMIM: 601790 MGI: 105374 HomoloGene: 38119 Gene ontology Molecular function: rhodopsin-like receptor activity peptide YY receptor activity pancreatic polypeptide receptor activity receptor activity Cellular component: integral to plasma membrane membrane Biological process: signal transduction G-protein coupled receptor protein signaling pathway digestion feeding behavior circulation RNA expression pattern More reference expression data Orthologs Human Mouse Entrez 5540 19065 Ensembl ENSG00000204174 ENSMUSG00000048337 Uniprot P50391 Q3UN46 Refseq XM_001129329 mRNA XP_001129329 protein NM_008919 mRNA NP_032945 protein Location Chr 10: 46.5 - 46.51 Mb Chr 14: 32.97 - 32.98 Mb Pubmed search 1 2 Pancreatic polypeptide receptor 1, also known as PPYR1, is a human gene.1 See also Neuropeptide Y receptor References ^ Entrez Gene: PPYR1 pancreatic polypeptide receptor 1. Further reading Keire DA, Bowers CW, Solomon TE, Reeve JR 2002. Structure and receptor binding of PYY analogs.. Peptides 23 2: 305-21. PMID 11825645. Balasubramaniam A 2002. Clinical potentials of neuropeptide Y family of hormones.. Am. J. Surg. 183 4: 430-4. PMID 11975932. Parker E, Van Heek M, Stamford A 2002. Neuropeptide Y receptors as targets for anti-obesity drug development: perspective and current status.. Eur. J. Pharmacol. 440 2-3: 173-87. PMID 12007534. Benaim G, Villalobo A 2002. Phosphorylation of calmodulin. Functional implications.. Eur. J. Biochem. 269 15: 3619-31. PMID 12153558. Lundell I, Blomqvist AG, Berglund MM, et al. 1996. Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY.. J. Biol. Chem. 270 49: 29123-8. PMID 7493937. Bard JA, Walker MW, Branchek TA, Weinshank RL 1995. Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY.. J. Biol. Chem. 270 45: 26762-5. PMID 7592911. Yan H, Yang J, Marasco J, et al. 1996. Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors.. Proc. Natl. Acad. Sci. U.S.A. 93 10: 4661-5. PMID 8643460. Kawabe T, Muslin AJ, Korsmeyer SJ 1997. HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint.. Nature 385 6615: 454-8. doi:10.1038/385454a0. PMID 9009195. Lutz CM, Richards JE, Scott KL, et al. 1998. Neuropeptide Y receptor genes mapped in human and mouse: receptors with high affinity for pancreatic polypeptide are not clustered with receptors specific for neuropeptide Y and peptide YY.. Genomics 46 2: 287-90. doi:10.1006/geno.1997.5024. PMID 9417917. Darby K, Eyre HJ, Lapsys N, et al. 1998. Assignment of the Y4 receptor gene PPYR1 to human chromosome 10q11.2 and mouse chromosome 14.. Genomics 46 3: 513-5. doi:10.1006/geno.1997.5071. PMID 9441761. Hsieh-Wilson LC, Allen PB, Watanabe T, et al. 1999. Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase-1.. Biochemistry 38 14: 4365-73. doi:10.1021/bi982900m. PMID 10194355. Smith FD, Oxford GS, Milgram SL 1999. Association of the D2 dopamine receptor third cytoplasmic loop with spinophilin, a protein phosphatase-1-interacting protein.. J. Biol. Chem. 274 28: 19894-900. PMID 10391935. Marx SO, Reiken S, Hisamatsu Y, et al. 2000. PKA phosphorylation dissociates FKBP12.6 from the calcium release channel ryanodine receptor: defective regulation in failing hearts.. Cell 101 4: 365-76. PMID 10830164. Connor JH, Weiser DC, Li S, et al. 2001. Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1.. Mol. Cell. Biol. 21 20: 6841-50. doi:10.1128/MCB.21.20.6841-6850.2001. PMID 11564868. Cavadas C, Silva AP, Mosimann F, et al. 2001. NPY regulates catecholamine secretion from human adrenal chromaffin cells.. J. Clin. Endocrinol. Metab. 86 12: 5956-63. PMID 11739470. Cox HM, Tough IR 2002. Neuropeptide Y, Y1, Y2 and Y4 receptors mediate Y agonist responses in isolated human colon mucosa.. Br. J. Pharmacol. 135 6: 1505-12. doi:10.1038/sj.bjp.0704604. PMID 11906964. Wu DY, Tkachuck DC, Roberson RS, Schubach WH 2002. The human SNF5/INI1 protein facilitates the function of the growth arrest and DNA damage-inducible protein GADD34 and modulates GADD34-bound protein phosphatase-1 activity.. J. Biol. Chem. 277 31: 27706-15. doi:10.1074/jbc.M200955200. PMID 12016208. This transmembrane receptor-related article is a stub. This article incorporates text from the United States National Library of Medicine, which is in the public domain. v d e Transmembrane receptor: G protein-coupled receptors Class A: Rhodopsin like Adrenergic α1 A, B, D, α2 A, B, C, β1, β2, β3 Eicosanoid CysLT 1, 2, LTB4 1, 2, FPRL1, OXE, Prostaglandin DP, EP 1, 2, 3, 4, PGF, Prostacyclin, Thromboxane Neuropeptide B/W 1, 2, FF 1, 2, S, Y 1, 2, 4, 5 Orphan GPR 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182 Purinergics Adenosine A1, A2a, A2b, A3, P2Y, 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14 Serotonin all but 5-HT3 5-HT1 A, B, D, E, F, 5-HT2 A, B, C, 5-HT 4, 5A, 6, 7 Other Acetylcholine M1, M2, M3, M4, M5 - Adrenomedullin - Anaphylatoxin C3a, C5a - Angiotensin 1, 2 - Apelin - Bile acid - Bombesin BRS3, GRPR, NMBR - Bradykinin B1, B2 - Cannabinoid CB1, CB2 - Chemokine - Cholecystokinin A, B - Dopamine D1, D2, D3, D4, D5 - EBI2 - Endothelin A, B - Estrogen - Formyl peptide 1, L1, L2 - Free fatty acid 1, 2, 3, 4 - FSH - Galanin 1, 2, 3 - Gonadotropin-releasing hormone 1, 2 - Ghrelin - Histamine H1, H2, H3, H4 - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid 1, 2, 3, 4, 5, 6, 7, 8 - MAS 1, 1L, D, E, F, G, X1, X2, X3, X4 - Melanocortin 1, 2, 3, 4, 5 - MCHR 1, 2 - Melatonin 1A, 1B- Motilin - neuromedin B, U 1, 2 - Neurotensin 1, 2 - Opioid Delta, Kappa, Mu, Nociceptin, but not Sigma - Olfactory - Opsin 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH - Orexin 1, 2 - Oxytocin - Oxoglutarate - PAF - Prokineticin 1, 2 - Prolactin-releasing peptide - Protease-activated 1, 2, 3, 4 - Relaxin 1, 2, 3, 4 - Somatostatin 1, 2, 3, 4, 5 - SREB - Succinate - TAAR 1, 2, 3, 5, 6, 8, 9 - Tachykinin 1, 2, 3 - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin 1A, 1B, 2 Class B: Secretin like Brain-specific angiogenesis inhibitor 1, 2, 3 - Cadherin 1, 2, 3 - Calcitonin - CD97 - Corticotropin-releasing hormone 1, 2 - EMR 1, 2, 3 - Glucagon GR, GIPR, GLP1R, GLP2R - Growth hormone releasing hormone - PACAPR1- GPR 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157 - Latrophilin 1, 2, 3, ELTD1 - Parathyroid hormone 1, 2 - Secretin - Vasoactive intestinal peptide 1, 2 Class C: Metabotropic glutamate / pheromone Calcium-sensing receptor - GABA B 1, 2 - Glutamate receptor Metabotropic glutamate 1, 2, 3, 4, 5, 6, 7, 8 - GPRC6A - GPR 156, 158, 179 - RAIG 1, 2, 3, 4 - Taste receptors TAS1R 1, 2, 3 TAS2R 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50 Frizzled / Smoothened Frizzled 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 - Smoothened Retrieved from http://en..org/wiki/Pancreatic_polypeptide_receptor_1 Categories: Genes on chromosome 10 | Human proteins | Transmembrane receptor stubs | G protein coupled receptorsHidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 8 July 2008, at 13:21
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