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14-September-2008 18:02:44 - 2 Parathyroid hormone receptor 2 Identifiers Symbols PTHR2; External IDs OMIM: 601469 MGI: 2180917 HomoloGene: 3701 Gene ontology Molecular function: receptor activity G-protein coupled receptor activity parathyroid hormone receptor activity Cellular component: integral to plasma membrane membrane Biological process: chondrocyte differentiation osteoblast development cellular calcium ion homeostasis signal transduction G-protein signaling, adenylate cyclase activating pathway G-protein signaling, coupled to IP3 second messenger phospholipase C activating positive regulation of cell proliferation negative regulation of cell proliferation bone mineralization bone resorption cell maturation RNA expression pattern More reference expression data Orthologs Human Mouse Entrez 5746 213527 Ensembl ENSG00000144407 ENSMUSG00000025946 Uniprot P49190 Q8BUM8 Refseq NM_005048 mRNA NP_005039 protein NM_139270 mRNA NP_644676 protein Location Chr 2: 208.98 - 209.07 Mb Chr 1: 65.25 - 65.32 Mb Pubmed search 1 2 Parathyroid hormone receptor 2, also known as PTHR2, is a human gene.1 The protein encoded by this gene is a member of the G-protein coupled receptor family 2. This protein is a receptor for parathyroid hormone PTH. This receptor is more selective in ligand recognition and has a more specific tissue distribution compared to parathyroid hormone receptor 1 PTHR1. It is activated only by PTH and not by parathyroid hormone-like hormone PTHLH and is particularly abundant in brain and pancreas.1 Contents 1 See also 2 References 3 Further reading 4 External links See also Parathyroid hormone receptor References ^ a b Entrez Gene: PTHR2 parathyroid hormone receptor 2. Further reading Usdin TB, Gruber C, Bonner TI 1995. Identification and functional expression of a receptor selectively recognizing parathyroid hormone, the PTH2 receptor.. J. Biol. Chem. 270 26: 15455-8. PMID 7797535. Usdin TB, Modi W, Bonner TI 1997. Assignment of the human PTH2 receptor gene PTHR2 to chromosome 2q33 by fluorescence in situ hybridization.. Genomics 37 1: 140-1. doi:10.1006/geno.1996.0532. PMID 8921382. Clark JA, Bonner TI, Kim AS, Usdin TB 1998. Multiple regions of ligand discrimination revealed by analysis of chimeric parathyroid hormone 2 PTH2 and PTH/PTH-related peptide PTHrP receptors.. Mol. Endocrinol. 12 2: 193-206. PMID 9482662. Hoare SR, Clark JA, Usdin TB 2000. Molecular determinants of tuberoinfundibular peptide of 39 residues TIP39 selectivity for the parathyroid hormone-2 PTH2 receptor. N-terminal truncation of TIP39 reverses PTH2 receptor/PTH1 receptor binding selectivity.. J. Biol. Chem. 275 35: 27274-83. doi:10.1074/jbc.M003910200. PMID 10854439. John MR, Arai M, Rubin DA, et al. 2002. Identification and characterization of the murine and human gene encoding the tuberoinfundibular peptide of 39 residues.. Endocrinology 143 3: 1047-57. PMID 11861531. Strausberg RL, Feingold EA, Grouse LH, et al. 2003. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 99 26: 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. Seeliger S, Hausberg M, Eue I, et al. 2003. The parathyroid hormone-2 receptor is expressed on human leukocytes and down-regulated in hyperparathyroidism.. Clin. Nephrol. 59 6: 429-35. PMID 12834174. Bisello A, Manen D, Pierroz DD, et al. 2004. Agonist-specific regulation of parathyroid hormone PTH receptor type 2 activity: structural and functional analysis of PTH- and tuberoinfundibular peptide TIP 39-stimulated desensitization and internalization.. Mol. Endocrinol. 18 6: 1486-98. doi:10.1210/me.2003-0487. PMID 14988434. Gerhard DS, Wagner L, Feingold EA, et al. 2004. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection MGC.. Genome Res. 14 10B: 2121-7. doi:10.1101/gr.2596504. PMID 15489334. Mahon MJ, Shimada M 2005. Calmodulin interacts with the cytoplasmic tails of the parathyroid hormone 1 receptor and a sub-set of class b G-protein coupled receptors.. FEBS Lett. 579 3: 803-7. doi:10.1016/j.febslet.2004.12.056. PMID 15670850. External links IUPHAR GPCR Database - Parathyroid Hormone Receptors MeSH Receptor,+Parathyroid+Hormone,+Type+2 v d e Transmembrane receptor: G protein-coupled receptors Class A: Rhodopsin like Adrenergic α1 A, B, D, α2 A, B, C, β1, β2, β3 Eicosanoid CysLT 1, 2, LTB4 1, 2, FPRL1, OXE, Prostaglandin DP, EP 1, 2, 3, 4, PGF, Prostacyclin, Thromboxane Neuropeptide B/W 1, 2, FF 1, 2, S, Y 1, 2, 4, 5 Orphan GPR 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182 Purinergics Adenosine A1, A2a, A2b, A3, P2Y, 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14 Serotonin all but 5-HT3 5-HT1 A, B, D, E, F, 5-HT2 A, B, C, 5-HT 4, 5A, 6, 7 Other Acetylcholine M1, M2, M3, M4, M5 - Adrenomedullin - Anaphylatoxin C3a, C5a - Angiotensin 1, 2 - Apelin - Bile acid - Bombesin BRS3, GRPR, NMBR - Bradykinin B1, B2 - Cannabinoid CB1, CB2 - Chemokine - Cholecystokinin A, B - Dopamine D1, D2, D3, D4, D5 - EBI2 - Endothelin A, B - Estrogen - Formyl peptide 1, L1, L2 - Free fatty acid 1, 2, 3, 4 - FSH - Galanin 1, 2, 3 - Gonadotropin-releasing hormone 1, 2 - Ghrelin - Histamine H1, H2, H3, H4 - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid 1, 2, 3, 4, 5, 6, 7, 8 - MAS 1, 1L, D, E, F, G, X1, X2, X3, X4 - Melanocortin 1, 2, 3, 4, 5 - MCHR 1, 2 - Melatonin 1A, 1B- Motilin - neuromedin B, U 1, 2 - Neurotensin 1, 2 - Opioid Delta, Kappa, Mu, Nociceptin, but not Sigma - Olfactory - Opsin 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH - Orexin 1, 2 - Oxytocin - Oxoglutarate - PAF - Prokineticin 1, 2 - Prolactin-releasing peptide - Protease-activated 1, 2, 3, 4 - Relaxin 1, 2, 3, 4 - Somatostatin 1, 2, 3, 4, 5 - SREB - Succinate - TAAR 1, 2, 3, 5, 6, 8, 9 - Tachykinin 1, 2, 3 - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin 1A, 1B, 2 Class B: Secretin like Brain-specific angiogenesis inhibitor 1, 2, 3 - Cadherin 1, 2, 3 - Calcitonin - CD97 - Corticotropin-releasing hormone 1, 2 - EMR 1, 2, 3 - Glucagon GR, GIPR, GLP1R, GLP2R - Growth hormone releasing hormone - PACAPR1- GPR 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157 - Latrophilin 1, 2, 3, ELTD1 - Parathyroid hormone 1, 2 - Secretin - Vasoactive intestinal peptide 1, 2 Class C: Metabotropic glutamate / pheromone Calcium-sensing receptor - GABA B 1, 2 - Glutamate receptor Metabotropic glutamate 1, 2, 3, 4, 5, 6, 7, 8 - GPRC6A - GPR 156, 158, 179 - RAIG 1, 2, 3, 4 - Taste receptors TAS1R 1, 2, 3 TAS2R 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50 Frizzled / Smoothened Frizzled 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 - Smoothened This transmembrane receptor-related article is a stub. This article incorporates text from the United States National Library of Medicine, which is in the public domain. Retrieved from http://en..org/wiki/Parathyroid_hormone_receptor_2 Categories: Genes on chromosome 2 | Human proteins | Transmembrane receptor stubs | G protein coupled receptorsHidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 8 July 2008, at 12:05
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