Sierra Acai Company
Sierra Acai Company
Open 7 Days a Week
MonaVie Independent Distributor
Distributor Training
Shop Online
Enroll Now
Buy Wholesale and maintain an Active status for 2 months and we will refund your $39 Distributor Fee
Friends
Buy Wholesale and maintain an Active status for 2 months and we will refund your $39 Distributor Fee
14-September-2008 18:02:44 - Platelet-activating factor receptor Platelet-activating factor receptor Identifiers Symbols PTAFR; PAFR External IDs OMIM: 173393 MGI: 106066 HomoloGene: 20260 Gene ontology Molecular function: receptor activity platelet activating factor receptor activity phospholipid binding Cellular component: integral to plasma membrane membrane Biological process: cytokine production chemotaxis inflammatory response immune response signal transduction G-protein coupled receptor protein signaling pathway antimicrobial humoral response phosphoinositide-mediated signaling RNA expression pattern More reference expression data Orthologs Human Mouse Entrez 5724 19204 Ensembl ENSG00000169403 ENSMUSG00000056529 Uniprot P25105 Q62035 Refseq NM_000952 mRNA NP_000943 protein XM_357441 mRNA XP_357441 protein Location Chr 1: 28.35 - 28.39 Mb Chr 4: 131.84 - 131.85 Mb Pubmed search 1 2 The platelet-activating factor receptor is a G-protein coupled receptor which binds platelet-activating factor.12 PTAFR shows structural characteristics of the rhodopsin MIM 180380 gene family and binds platelet-activating factor PAF. PAF is a phospholipid 1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine that has been implicated as a mediator in diverse pathologic processes, such as allergy, asthma, septic shock, arterial thrombosis, and inflammatory processes.supplied by OMIM3 References ^ Seyfried CE, Schweickart VL, Godiska R, Gray PW 1992. The human platelet-activating factor receptor gene PTAFR contains no introns and maps to chromosome 1. Genomics 13 3: 832-4. doi:10.1016/0888-75439290162-L. PMID 1322356. ^ Ishii S, Nagase T, Shimizu T 2002. Platelet-activating factor receptor. Prostaglandins Other Lipid Mediat. 68-69: 599-609. doi:10.1016/S0090-69800200058-8. PMID 12432946. ^ Entrez Gene: PTAFR platelet-activating factor receptor. Further reading Shukla SD 1992. Platelet-activating factor receptor and signal transduction mechanisms.. FASEB J. 6 6: 2296-301. PMID 1312046. Sugimoto T, Tsuchimochi H, McGregor CG, et al. 1993. Molecular cloning and characterization of the platelet-activating factor receptor gene expressed in the human heart.. Biochem. Biophys. Res. Commun. 189 2: 617-24. PMID 1281995. Seyfried CE, Schweickart VL, Godiska R, Gray PW 1992. The human platelet-activating factor receptor gene PTAFR contains no introns and maps to chromosome 1.. Genomics 13 3: 832-4. PMID 1322356. Kunz D, Gerard NP, Gerard C 1992. The human leukocyte platelet-activating factor receptor. cDNA cloning, cell surface expression, and construction of a novel epitope-bearing analog.. J. Biol. Chem. 267 13: 9101-6. PMID 1374385. Ye RD, Prossnitz ER, Zou AH, Cochrane CG 1991. Characterization of a human cDNA that encodes a functional receptor for platelet activating factor.. Biochem. Biophys. Res. Commun. 180 1: 105-11. PMID 1656963. Nakamura M, Honda Z, Izumi T, et al. 1991. Molecular cloning and expression of platelet-activating factor receptor from human leukocytes.. J. Biol. Chem. 266 30: 20400-5. PMID 1657923. Haslam RJ, Williams KA, Davidson MM 1986. Receptor-effector coupling in platelets: roles of guanine nucleotides.. Adv. Exp. Med. Biol. 192: 265-80. PMID 3010668. Valone FH 1984. Isolation of a platelet membrane protein which binds the platelet-activating factor 1-0-hexadecyl-2-acetyl-SN-glycero-3-phosphorylcholine.. Immunology 52 1: 169-74. PMID 6325330. Cundell DR, Gerard NP, Gerard C, et al. 1995. Streptococcus pneumoniae anchor to activated human cells by the receptor for platelet-activating factor.. Nature 377 6548: 435-8. doi:10.1038/377435a0. PMID 7566121. Izumi T, Kishimoto S, Takano T, et al. 1995. Expression of human platelet-activating factor receptor gene in EoL-1 cells following butyrate-induced differentiation.. Biochem. J. 305 Pt 3: 829-35. PMID 7848283. Bito H, Honda Z, Nakamura M, Shimizu T 1994. Cloning, expression and tissue distribution of rat platelet-activating-factor-receptor cDNA.. Eur. J. Biochem. 221 1: 211-8. PMID 8168510. Chase PB, Halonen M, Regan JW 1993. Cloning of a human platelet-activating factor receptor gene: evidence for an intron in the 5'-untranslated region.. Am. J. Respir. Cell Mol. Biol. 8 3: 240-4. PMID 8383507. Mutoh H, Bito H, Minami M, et al. 1993. Two different promoters direct expression of two distinct forms of mRNAs of human platelet-activating factor receptor.. FEBS Lett. 322 2: 129-34. PMID 8387031. Nakamura M, Honda Z, Matsumoto T, et al. 1993. Isolation and properties of platelet-activating factor receptor cDNAs.. Journal of lipid mediators 6 1-3: 163-8. PMID 8395240. Kishimoto S, Shimadzu W, Izumi T, et al. 1996. Regulation by IL-5 of expression of functional platelet-activating factor receptors on human eosinophils.. J. Immunol. 157 9: 4126-32. PMID 8892648. Chase PB, Yang JM, Thompson FH, et al. 1997. Regional mapping of the human platelet-activating factor receptor gene PTAFR to 1p35--p34.3 by fluorescence in situ hybridization.. Cytogenet. Cell Genet. 72 2-3: 205-7. PMID 8978777. Le Gouill C, Parent JL, Rola-Pleszczynski M, Stanková J 1997. Role of the Cys90, Cys95 and Cys173 residues in the structure and function of the human platelet-activating factor receptor.. FEBS Lett. 402 2-3: 203-8. PMID 9037196. Ahmed A, Dearn S, Shams M, et al. 1998. Localization, quantification, and activation of platelet-activating factor receptor in human endometrium during the menstrual cycle: PAF stimulates NO, VEGF, and FAKpp125.. FASEB J. 12 10: 831-43. PMID 9657523. Cargill M, Altshuler D, Ireland J, et al. 1999. Characterization of single-nucleotide polymorphisms in coding regions of human genes.. Nat. Genet. 22 3: 231-8. doi:10.1038/10290. PMID 10391209. External links IUPHAR GPCR Database - Platelet-activating factor receptor MeSH platelet+activating+factor+receptor This transmembrane receptor-related article is a stub. This article incorporates text from the United States National Library of Medicine, which is in the public domain. v d e Transmembrane receptor: G protein-coupled receptors Class A: Rhodopsin like Adrenergic α1 A, B, D, α2 A, B, C, β1, β2, β3 Eicosanoid CysLT 1, 2, LTB4 1, 2, FPRL1, OXE, Prostaglandin DP, EP 1, 2, 3, 4, PGF, Prostacyclin, Thromboxane Neuropeptide B/W 1, 2, FF 1, 2, S, Y 1, 2, 4, 5 Orphan GPR 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182 Purinergics Adenosine A1, A2a, A2b, A3, P2Y, 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14 Serotonin all but 5-HT3 5-HT1 A, B, D, E, F, 5-HT2 A, B, C, 5-HT 4, 5A, 6, 7 Other Acetylcholine M1, M2, M3, M4, M5 - Adrenomedullin - Anaphylatoxin C3a, C5a - Angiotensin 1, 2 - Apelin - Bile acid - Bombesin BRS3, GRPR, NMBR - Bradykinin B1, B2 - Cannabinoid CB1, CB2 - Chemokine - Cholecystokinin A, B - Dopamine D1, D2, D3, D4, D5 - EBI2 - Endothelin A, B - Estrogen - Formyl peptide 1, L1, L2 - Free fatty acid 1, 2, 3, 4 - FSH - Galanin 1, 2, 3 - Gonadotropin-releasing hormone 1, 2 - Ghrelin - Histamine H1, H2, H3, H4 - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid 1, 2, 3, 4, 5, 6, 7, 8 - MAS 1, 1L, D, E, F, G, X1, X2, X3, X4 - Melanocortin 1, 2, 3, 4, 5 - MCHR 1, 2 - Melatonin 1A, 1B- Motilin - neuromedin B, U 1, 2 - Neurotensin 1, 2 - Opioid Delta, Kappa, Mu, Nociceptin, but not Sigma - Olfactory - Opsin 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH - Orexin 1, 2 - Oxytocin - Oxoglutarate - PAF - Prokineticin 1, 2 - Prolactin-releasing peptide - Protease-activated 1, 2, 3, 4 - Relaxin 1, 2, 3, 4 - Somatostatin 1, 2, 3, 4, 5 - SREB - Succinate - TAAR 1, 2, 3, 5, 6, 8, 9 - Tachykinin 1, 2, 3 - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin 1A, 1B, 2 Class B: Secretin like Brain-specific angiogenesis inhibitor 1, 2, 3 - Cadherin 1, 2, 3 - Calcitonin - CD97 - Corticotropin-releasing hormone 1, 2 - EMR 1, 2, 3 - Glucagon GR, GIPR, GLP1R, GLP2R - Growth hormone releasing hormone - PACAPR1- GPR 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157 - Latrophilin 1, 2, 3, ELTD1 - Parathyroid hormone 1, 2 - Secretin - Vasoactive intestinal peptide 1, 2 Class C: Metabotropic glutamate / pheromone Calcium-sensing receptor - GABA B 1, 2 - Glutamate receptor Metabotropic glutamate 1, 2, 3, 4, 5, 6, 7, 8 - GPRC6A - GPR 156, 158, 179 - RAIG 1, 2, 3, 4 - Taste receptors TAS1R 1, 2, 3 TAS2R 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50 Frizzled / Smoothened Frizzled 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 - Smoothened Retrieved from http://en..org/wiki/Platelet-activating_factor_receptor Categories: Genes on chromosome 1 | Human proteins | Transmembrane receptor stubs | G protein coupled receptorsHidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 8 July 2008, at 05:38
39 Reasons to Drink Acai Juice Every Day
What is MonaVie - Watch the 8-minute video
Discovering MonaVie Video
The Power of You Video
Effects of MonaVie Active on Antioxidant Capacity in Humans
Log into your Wholesale MonaVie Account
So many of us do not eat a balanced diet, get enough sleep, have too much stress, or are impacted with toxins and pollutants. Drinking 2 ounces of MonaVie twice a day will help your body detoxify as well as build your immune system. Its the smartest thing you can do for yourself, so start today. Buying MonaVie through our company guarantees you support 7 days a week and, if you would like to share MonaVie with your family and friends we will guide you from start to finish.
1. Click on Enroll Now (30 - 55% off retail price)
2. Pay $39 for your Wholesale ID number.
3. NO minimum order required.
4. MonaVie is delivered to your door in 3 to 5 days.