Sierra Acai Company
Sierra Acai Company
Open 7 Days a Week
MonaVie Independent Distributor
Distributor Training
Shop Online
Enroll Now
Buy Wholesale and maintain an Active status for 2 months and we will refund your $39 Distributor Fee
Friends
Buy Wholesale and maintain an Active status for 2 months and we will refund your $39 Distributor Fee
14-September-2008 18:02:44 - Prolactin-releasing peptide receptor Prolactin releasing hormone receptor Identifiers Symbols PRLHR; GPR10; GR3; MGC126539; MGC126541; PrRPR External IDs OMIM: 600895 MGI: 2135956 HomoloGene: 3134 Gene ontology Molecular function: rhodopsin-like receptor activity receptor activity neuropeptide Y receptor activity Cellular component: integral to plasma membrane membrane Biological process: signal transduction G-protein coupled receptor protein signaling pathway female pregnancy feeding behavior hormone metabolic process Orthologs Human Mouse Entrez 2834 226278 Ensembl ENSG00000119973 ENSMUSG00000045052 Uniprot P49683 Q059H6 Refseq NM_004248 mRNA NP_004239 protein NM_201615 mRNA NP_963909 protein Location Chr 10: 120.34 - 120.34 Mb Chr 19: 60.52 - 60.52 Mb Pubmed search 1 2 The prolactin-releasing hormone receptor PRLHR is a G-protein coupled receptor1 that binds the prolactin releasing hormone.2 PRLHR is a 7-transmembrane domain receptor for prolactin-releasing hormone PRLH; MIM 602663 that is highly expressed in anterior pituitary Ozawa et al., 2002.supplied by OMIM3 References ^ Marchese A, Heiber M, Nguyen T, Heng HH, Saldivia VR, Cheng R, Murphy PM, Tsui LC, Shi X, Gregor P 1995. Cloning and chromosomal mapping of three novel genes, GPR9, GPR10, and GPR14, encoding receptors related to interleukin 8, neuropeptide Y, and somatostatin receptors. Genomics 29 2: 335-44. PMID 8666380. ^ Hinuma S, Habata Y, Fujii R, Kawamata Y, Hosoya M, Fukusumi S, Kitada C, Masuo Y, Asano T, Matsumoto H, Sekiguchi M, Kurokawa T, Nishimura O, Onda H, Fujino M 1998. A prolactin-releasing peptide in the brain. Nature 393 6682: 272-6. doi:10.1038/30515. PMID 9607765. ^ Entrez Gene: PRLHR prolactin releasing hormone receptor. Further reading Hinuma S, Onda H, Fujino M 1999. The quest for novel bioactive peptides utilizing orphan seven-transmembrane-domain receptors.. J. Mol. Med. 77 6: 495-504. PMID 10475064. Marchese A, Heiber M, Nguyen T, et al. 1996. Cloning and chromosomal mapping of three novel genes, GPR9, GPR10, and GPR14, encoding receptors related to interleukin 8, neuropeptide Y, and somatostatin receptors.. Genomics 29 2: 335-44. PMID 8666380. Hinuma S, Habata Y, Fujii R, et al. 1998. A prolactin-releasing peptide in the brain.. Nature 393 6682: 272-6. doi:10.1038/30515. PMID 9607765. Fujii R, Fukusumi S, Hosoya M, et al. 1999. Tissue distribution of prolactin-releasing peptide PrRP and its receptor.. Regul. Pept. 83 1: 1-10. PMID 10498338. Langmead CJ, Szekeres PG, Chambers JK, et al. 2000. Characterization of the binding of 125I-human prolactin releasing peptide PrRP to GPR10, a novel G protein coupled receptor.. Br. J. Pharmacol. 131 4: 683-8. doi:10.1038/sj.bjp.0703617. PMID 11030716. Lin SH, Arai AC, Wang Z, et al. 2001. The carboxyl terminus of the prolactin-releasing peptide receptor interacts with PDZ domain proteins involved in alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor clustering.. Mol. Pharmacol. 60 5: 916-23. PMID 11641419. Ozawa A, Yamada M, Satoh T, et al. 2002. Transcriptional regulation of the human PRL-releasing peptide PrRP receptor gene by a dopamine 2 Receptor agonist: cloning and characterization of the human PrRP receptor gene and its promoter region.. Mol. Endocrinol. 16 4: 785-98. PMID 11923475. Takahashi K, Totsune K, Murakami O, et al. 2003. Expression of prolactin-releasing peptide and its receptor in the human adrenal glands and tumor tissues of adrenocortical tumors, pheochromocytomas and neuroblastomas.. Peptides 23 6: 1135-40. PMID 12126742. Kemp DM, Lin JC, Ubeda M, Habener JF 2002. NRSF/REST confers transcriptional repression of the GPR10 gene via a putative NRSE/RE-1 located in the 5' promoter region.. FEBS Lett. 531 2: 193-8. PMID 12417311. Strausberg RL, Feingold EA, Grouse LH, et al. 2003. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 99 26: 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. Bhattacharyya S, Luan J, Challis B, et al. 2003. Association of polymorphisms in GPR10, the gene encoding the prolactin-releasing peptide receptor with blood pressure, but not obesity, in a U.K. Caucasian population.. Diabetes 52 5: 1296-9. PMID 12716769. Deloukas P, Earthrowl ME, Grafham DV, et al. 2004. The DNA sequence and comparative analysis of human chromosome 10.. Nature 429 6990: 375-81. doi:10.1038/nature02462. PMID 15164054. Gerhard DS, Wagner L, Feingold EA, et al. 2004. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection MGC.. Genome Res. 14 10B: 2121-7. doi:10.1101/gr.2596504. PMID 15489334. Ellacott KL, Donald EL, Clarkson P, et al. 2005. Characterization of a naturally-occurring polymorphism in the UHR-1 gene encoding the putative rat prolactin-releasing peptide receptor.. Peptides 26 4: 675-81. doi:10.1016/j.peptides.2004.11.020. PMID 15752583. Lagerström MC, Fredriksson R, Bjarnadóttir TK, et al. 2005. Origin of the prolactin-releasing hormone PRLH receptors: evidence of coevolution between PRLH and a redundant neuropeptide Y receptor during vertebrate evolution.. Genomics 85 6: 688-703. doi:10.1016/j.ygeno.2005.02.007. PMID 15885496. Kimura K, Wakamatsu A, Suzuki Y, et al. 2006. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.. Genome Res. 16 1: 55-65. doi:10.1101/gr.4039406. PMID 16344560. External links IUPHAR GPCR Database - Prolactin-releasing peptide receptor MeSH PRLHR+protein,+human This transmembrane receptor-related article is a stub. This article incorporates text from the United States National Library of Medicine, which is in the public domain. v d e Transmembrane receptor: G protein-coupled receptors Class A: Rhodopsin like Adrenergic α1 A, B, D, α2 A, B, C, β1, β2, β3 Eicosanoid CysLT 1, 2, LTB4 1, 2, FPRL1, OXE, Prostaglandin DP, EP 1, 2, 3, 4, PGF, Prostacyclin, Thromboxane Neuropeptide B/W 1, 2, FF 1, 2, S, Y 1, 2, 4, 5 Orphan GPR 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182 Purinergics Adenosine A1, A2a, A2b, A3, P2Y, 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14 Serotonin all but 5-HT3 5-HT1 A, B, D, E, F, 5-HT2 A, B, C, 5-HT 4, 5A, 6, 7 Other Acetylcholine M1, M2, M3, M4, M5 - Adrenomedullin - Anaphylatoxin C3a, C5a - Angiotensin 1, 2 - Apelin - Bile acid - Bombesin BRS3, GRPR, NMBR - Bradykinin B1, B2 - Cannabinoid CB1, CB2 - Chemokine - Cholecystokinin A, B - Dopamine D1, D2, D3, D4, D5 - EBI2 - Endothelin A, B - Estrogen - Formyl peptide 1, L1, L2 - Free fatty acid 1, 2, 3, 4 - FSH - Galanin 1, 2, 3 - Gonadotropin-releasing hormone 1, 2 - Ghrelin - Histamine H1, H2, H3, H4 - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid 1, 2, 3, 4, 5, 6, 7, 8 - MAS 1, 1L, D, E, F, G, X1, X2, X3, X4 - Melanocortin 1, 2, 3, 4, 5 - MCHR 1, 2 - Melatonin 1A, 1B- Motilin - neuromedin B, U 1, 2 - Neurotensin 1, 2 - Opioid Delta, Kappa, Mu, Nociceptin, but not Sigma - Olfactory - Opsin 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH - Orexin 1, 2 - Oxytocin - Oxoglutarate - PAF - Prokineticin 1, 2 - Prolactin-releasing peptide - Protease-activated 1, 2, 3, 4 - Relaxin 1, 2, 3, 4 - Somatostatin 1, 2, 3, 4, 5 - SREB - Succinate - TAAR 1, 2, 3, 5, 6, 8, 9 - Tachykinin 1, 2, 3 - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin 1A, 1B, 2 Class B: Secretin like Brain-specific angiogenesis inhibitor 1, 2, 3 - Cadherin 1, 2, 3 - Calcitonin - CD97 - Corticotropin-releasing hormone 1, 2 - EMR 1, 2, 3 - Glucagon GR, GIPR, GLP1R, GLP2R - Growth hormone releasing hormone - PACAPR1- GPR 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157 - Latrophilin 1, 2, 3, ELTD1 - Parathyroid hormone 1, 2 - Secretin - Vasoactive intestinal peptide 1, 2 Class C: Metabotropic glutamate / pheromone Calcium-sensing receptor - GABA B 1, 2 - Glutamate receptor Metabotropic glutamate 1, 2, 3, 4, 5, 6, 7, 8 - GPRC6A - GPR 156, 158, 179 - RAIG 1, 2, 3, 4 - Taste receptors TAS1R 1, 2, 3 TAS2R 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50 Frizzled / Smoothened Frizzled 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 - Smoothened Retrieved from http://en..org/wiki/Prolactin-releasing_peptide_receptor Categories: Genes on chromosome 10 | Human proteins | Transmembrane receptor stubs | G protein coupled receptorsHidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 8 July 2008, at 06:40
39 Reasons to Drink Acai Juice Every Day
What is MonaVie - Watch the 8-minute video
Discovering MonaVie Video
The Power of You Video
Effects of MonaVie Active on Antioxidant Capacity in Humans
Log into your Wholesale MonaVie Account
So many of us do not eat a balanced diet, get enough sleep, have too much stress, or are impacted with toxins and pollutants. Drinking 2 ounces of MonaVie twice a day will help your body detoxify as well as build your immune system. Its the smartest thing you can do for yourself, so start today. Buying MonaVie through our company guarantees you support 7 days a week and, if you would like to share MonaVie with your family and friends we will guide you from start to finish.
1. Click on Enroll Now (30 - 55% off retail price)
2. Pay $39 for your Wholesale ID number.
3. NO minimum order required.
4. MonaVie is delivered to your door in 3 to 5 days.