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14-September-2008 18:02:44 - D2 receptor The correct title of this article is Prostaglandin D2 receptor. It appears incorrectly here because of technical restrictions. Prostaglandin D2 receptor DP Identifiers Symbols PTGDR; AS1; ASRT1; DP; MGC49004 External IDs OMIM: 604687 MGI: 102966 HomoloGene: 736 Gene ontology Molecular function: rhodopsin-like receptor activity prostaglandin J receptor activity receptor activity prostaglandin D receptor activity thromboxane receptor activity Cellular component: membrane integral to membrane Biological process: signal transduction G-protein coupled receptor protein signaling pathway RNA expression pattern More reference expression data Orthologs Human Mouse Entrez 5729 19214 Ensembl ENSG00000168229 ENSMUSG00000071489 Uniprot Q13258 Q8CCM3 Refseq NM_000953 mRNA NP_000944 protein NM_008962 mRNA NP_032988 protein Location Chr 14: 51.8 - 51.81 Mb Chr 14: 43.77 - 43.78 Mb Pubmed search 1 2 Prostaglandin D2 receptor DP, also known as PTGDR, is a receptor for prostaglandin D2, but also denotes the human gene encoding it.1 Contents 1 Mechanism 2 Function 3 See also 4 References 5 Further reading Mechanism It is a G-protein-coupled receptor. The activity of it is mainly mediated by G-S proteins that stimulate adenylate cyclase resulting in an elevation of intracellular cAMP and Ca2+. Function Knockout studies in mice suggest that the ligand of this receptor, prostaglandin D2 PGD2, functions as a mast cell-derived mediator to trigger asthmatic responses.1 It also causes vasodilation See also Eicosanoid receptor References ^ a b Entrez Gene: PTGDR prostaglandin D2 receptor DP. Further reading Boyce JA 2004. The role of mast cells in asthma.. Prostaglandins Leukot. Essent. Fatty Acids 69 2-3: 195-205. PMID 12895603. Chiba T, Kanda A, Ueki S, et al. 2007. Possible novel receptor for PGD2 on human bronchial epithelial cells.. Int. Arch. Allergy Immunol. 143 Suppl 1: 23-7. doi:10.1159/000101400. PMID 17541272. Senior J, Sangha R, Baxter GS, et al. 1992. In vitro characterization of prostanoid FP-, DP-, IP- and TP-receptors on the non-pregnant human myometrium.. Br. J. Pharmacol. 107 1: 215-21. PMID 1422574. Boie Y, Sawyer N, Slipetz DM, et al. 1995. Molecular cloning and characterization of the human prostanoid DP receptor.. J. Biol. Chem. 270 32: 18910-6. PMID 7642548. Ishikawa TO, Tamai Y, Rochelle JM, et al. 1997. Mapping of the genes encoding mouse prostaglandin D, E, and F and prostacyclin receptors.. Genomics 32 2: 285-8. doi:10.1006/geno.1996.0118. PMID 8833158. Kobayashi T, Ushikubi F, Narumiya S 2000. Amino acid residues conferring ligand binding properties of prostaglandin I and prostaglandin D receptors. Identification by site-directed mutagenesis.. J. Biol. Chem. 275 32: 24294-303. doi:10.1074/jbc.M002437200. PMID 10827082. Wright DH, Ford-Hutchinson AW, Chadee K, Metters KM 2001. The human prostanoid DP receptor stimulates mucin secretion in LS174T cells.. Br. J. Pharmacol. 131 8: 1537-45. doi:10.1038/sj.bjp.0703688. PMID 11139429. Gervais FG, Cruz RP, Chateauneuf A, et al. 2002. Selective modulation of chemokinesis, degranulation, and apoptosis in eosinophils through the PGD2 receptors CRTH2 and DP.. J. Allergy Clin. Immunol. 108 6: 982-8. doi:10.1067/mai.2001.119919. PMID 11742277. Noguchi E, Shibasaki M, Kamioka M, et al. 2002. New polymorphisms of haematopoietic prostaglandin D synthase and human prostanoid DP receptor genes.. Clin. Exp. Allergy 32 1: 93-6. PMID 12002745. Hakonarson H, Bjornsdottir US, Halapi E, et al. 2002. A major susceptibility gene for asthma maps to chromosome 14q24.. Am. J. Hum. Genet. 71 3: 483-91. PMID 12119603. Iwasaki M, Nagata K, Takano S, et al. 2002. Association of a new-type prostaglandin D2 receptor CRTH2 with circulating T helper 2 cells in patients with atopic dermatitis.. J. Invest. Dermatol. 119 3: 609-16. doi:10.1046/j.1523-1747.2002.01862.x. PMID 12230502. Strausberg RL, Feingold EA, Grouse LH, et al. 2003. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 99 26: 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. Moreland RB, Nehra A, Kim NN, et al. 2003. Expression of functional prostaglandin D DP receptors in human corpus cavernosum smooth muscle.. Int. J. Impot. Res. 14 6: 446-52. doi:10.1038/sj.ijir.3900900. PMID 12494276. Faveeuw C, Gosset P, Bureau F, et al. 2003. Prostaglandin D2 inhibits the production of interleukin-12 in murine dendritic cells through multiple signaling pathways.. Eur. J. Immunol. 33 4: 889-98. doi:10.1002/eji.200323330. PMID 12672054. Angeli V, Staumont D, Charbonnier AS, et al. 2004. Activation of the D prostanoid receptor 1 regulates immune and skin allergic responses.. J. Immunol. 172 6: 3822-9. PMID 15004188. Gerhard DS, Wagner L, Feingold EA, et al. 2004. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection MGC.. Genome Res. 14 10B: 2121-7. doi:10.1101/gr.2596504. PMID 15489334. Oguma T, Palmer LJ, Birben E, et al. 2004. Role of prostanoid DP receptor variants in susceptibility to asthma.. N. Engl. J. Med. 351 17: 1752-63. doi:10.1056/NEJMoa031785. PMID 15496624. Spik I, Brénuchon C, Angéli V, et al. 2005. Activation of the prostaglandin D2 receptor DP2/CRTH2 increases allergic inflammation in mouse.. J. Immunol. 174 6: 3703-8. PMID 15749909. Hirano Y, Shichijo M, Deguchi M, et al. 2007. Synergistic effect of PGD2 via prostanoid DP receptor on TNF-alpha-induced production of MCP-1 and IL-8 in human monocytic THP-1 cells.. Eur. J. Pharmacol. 560 1: 81-8. doi:10.1016/j.ejphar.2007.01.003. PMID 17307163. This transmembrane receptor-related article is a stub. This article incorporates text from the United States National Library of Medicine, which is in the public domain. v d e Transmembrane receptor: G protein-coupled receptors Class A: Rhodopsin like Adrenergic α1 A, B, D, α2 A, B, C, β1, β2, β3 Eicosanoid CysLT 1, 2, LTB4 1, 2, FPRL1, OXE, Prostaglandin DP, EP 1, 2, 3, 4, PGF, Prostacyclin, Thromboxane Neuropeptide B/W 1, 2, FF 1, 2, S, Y 1, 2, 4, 5 Orphan GPR 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182 Purinergics Adenosine A1, A2a, A2b, A3, P2Y, 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14 Serotonin all but 5-HT3 5-HT1 A, B, D, E, F, 5-HT2 A, B, C, 5-HT 4, 5A, 6, 7 Other Acetylcholine M1, M2, M3, M4, M5 - Adrenomedullin - Anaphylatoxin C3a, C5a - Angiotensin 1, 2 - Apelin - Bile acid - Bombesin BRS3, GRPR, NMBR - Bradykinin B1, B2 - Cannabinoid CB1, CB2 - Chemokine - Cholecystokinin A, B - Dopamine D1, D2, D3, D4, D5 - EBI2 - Endothelin A, B - Estrogen - Formyl peptide 1, L1, L2 - Free fatty acid 1, 2, 3, 4 - FSH - Galanin 1, 2, 3 - Gonadotropin-releasing hormone 1, 2 - Ghrelin - Histamine H1, H2, H3, H4 - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid 1, 2, 3, 4, 5, 6, 7, 8 - MAS 1, 1L, D, E, F, G, X1, X2, X3, X4 - Melanocortin 1, 2, 3, 4, 5 - MCHR 1, 2 - Melatonin 1A, 1B- Motilin - neuromedin B, U 1, 2 - Neurotensin 1, 2 - Opioid Delta, Kappa, Mu, Nociceptin, but not Sigma - Olfactory - Opsin 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH - Orexin 1, 2 - Oxytocin - Oxoglutarate - PAF - Prokineticin 1, 2 - Prolactin-releasing peptide - Protease-activated 1, 2, 3, 4 - Relaxin 1, 2, 3, 4 - Somatostatin 1, 2, 3, 4, 5 - SREB - Succinate - TAAR 1, 2, 3, 5, 6, 8, 9 - Tachykinin 1, 2, 3 - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin 1A, 1B, 2 Class B: Secretin like Brain-specific angiogenesis inhibitor 1, 2, 3 - Cadherin 1, 2, 3 - Calcitonin - CD97 - Corticotropin-releasing hormone 1, 2 - EMR 1, 2, 3 - Glucagon GR, GIPR, GLP1R, GLP2R - Growth hormone releasing hormone - PACAPR1- GPR 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157 - Latrophilin 1, 2, 3, ELTD1 - Parathyroid hormone 1, 2 - Secretin - Vasoactive intestinal peptide 1, 2 Class C: Metabotropic glutamate / pheromone Calcium-sensing receptor - GABA B 1, 2 - Glutamate receptor Metabotropic glutamate 1, 2, 3, 4, 5, 6, 7, 8 - GPRC6A - GPR 156, 158, 179 - RAIG 1, 2, 3, 4 - Taste receptors TAS1R 1, 2, 3 TAS2R 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50 Frizzled / Smoothened Frizzled 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 - Smoothened Retrieved from http://en..org/wiki/Prostaglandin_D2_receptor Categories: Genes on chromosome 14 | Human proteins | Transmembrane receptor stubs | G protein coupled receptorsHidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 8 July 2008, at 04:44
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