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14-September-2008 18:02:44 - F receptor Prostaglandin F receptor FP Identifiers Symbols PTGFR; FP; MGC120498; MGC46203 External IDs OMIM: 600563 MGI: 97796 HomoloGene: 741 Gene ontology Molecular function: rhodopsin-like receptor activity receptor activity prostaglandin F receptor activity thromboxane receptor activity Cellular component: integral to plasma membrane membrane integral to membrane Biological process: signal transduction G-protein coupled receptor protein signaling pathway parturition RNA expression pattern More reference expression data Orthologs Human Mouse Entrez 5737 19220 Ensembl ENSG00000122420 ENSMUSG00000028036 Uniprot P43088 Q60I90 Refseq NM_000959 mRNA NP_000950 protein NM_008966 mRNA NP_032992 protein Location Chr 1: 78.54 - 78.78 Mb Chr 3: 151.74 - 151.77 Mb Pubmed search 1 2 Prostaglandin F receptor FP is a receptor for Prostaglandin F2α. It is encoded by the gene PTGFR.1 It is a member of the G-protein coupled receptor family. Two transcript variants encoding different isoforms have been found for this gene.1 Contents 1 Functions 2 See also 3 References 4 Further reading Functions Main effects of prostaglandin binding to the receptor are: uterine contraction bronchoconstriction2 Via activation of this receptor, PGF2-alpha mediates luteolysis1, and may also be involved in modulating intraocular pressure and smooth muscle contraction in uterus and gastrointestinal tract sphincters3. Knockout studies in mice suggest that the interaction of PGF2-alpha with this receptor in ovarian luteal cells initiates luteolysis and thus induces parturition.4 See also Eicosanoid receptor References ^ a b c Entrez Gene: PTGFR prostaglandin F receptor FP. ^ Pharmacology, Rang, Dale, Ritter Moore, ISBN 0443071454, 5:th ed., Churchill Livingstone 2003 Page 234 ^ Signal transduction in lower esophageal sphincter circular muscle Piero Biancani, Ph.D. and Karen M. Harnett, Ph.D. ^ Sugimoto Y, Yamasaki A, Segi E, et al 1997. Failure of parturition in mice lacking the prostaglandin F receptor. Science 277 5326: 681-3. PMID 9235889. Further reading Duncan AM, Anderson LL, Funk CD, et al. 1995. Chromosomal localization of the human prostanoid receptor gene family.. Genomics 25 3: 740-2. PMID 7759114. Lake S, Gullberg H, Wahlqvist J, et al. 1995. Cloning of the rat and human prostaglandin F2 alpha receptors and the expression of the rat prostaglandin F2 alpha receptor.. FEBS Lett. 355 3: 317-25. PMID 7988697. Bastien L, Sawyer N, Grygorczyk R, et al. 1994. Cloning, functional expression, and characterization of the human prostaglandin E2 receptor EP2 subtype.. J. Biol. Chem. 269 16: 11873-7. PMID 8163486. Funk CD, Furci L, FitzGerald GA, et al. 1994. Cloning and expression of a cDNA for the human prostaglandin E receptor EP1 subtype.. J. Biol. Chem. 268 35: 26767-72. PMID 8253813. Abramovitz M, Boie Y, Nguyen T, et al. 1994. Cloning and expression of a cDNA for the human prostanoid FP receptor.. J. Biol. Chem. 269 4: 2632-6. PMID 8300593. Sugimoto Y, Yamasaki A, Segi E, et al. 1997. Failure of parturition in mice lacking the prostaglandin F receptor.. Science 277 5326: 681-3. PMID 9235889. Kunapuli P, Lawson JA, Rokach J, FitzGerald GA 1997. Functional characterization of the ocular prostaglandin f2alpha PGF2alpha receptor. Activation by the isoprostane, 12-iso-PGF2alpha.. J. Biol. Chem. 272 43: 27147-54. PMID 9341156. Betz R, Lagercrantz J, Kedra D, et al. 1999. Genomic structure, 5' flanking sequences, and precise localization in 1P31.1 of the human prostaglandin F receptor gene.. Biochem. Biophys. Res. Commun. 254 2: 413-6. doi:10.1006/bbrc.1998.9827. PMID 9918852. Kyveris A, Maruscak E, Senchyna M 2002. Optimization of RNA isolation from human ocular tissues and analysis of prostanoid receptor mRNA expression using RT-PCR.. Mol. Vis. 8: 51-8. PMID 11951086. Strausberg RL, Feingold EA, Grouse LH, et al. 2003. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 99 26: 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. Neuschäfer-Rube F, Engemaier E, Koch S, et al. 2003. Identification by site-directed mutagenesis of amino acids contributing to ligand-binding specificity or signal transduction properties of the human FP prostanoid receptor.. Biochem. J. 371 Pt 2: 443-9. doi:10.1042/BJ20021429. PMID 12519077. Zaragoza DB, Wilson R, Eyster K, Olson DM 2004. Cloning and characterization of the promoter region of the human prostaglandin F2alpha receptor gene.. Biochim. Biophys. Acta 1676 2: 193-202. PMID 14746914. Sales KJ, Milne SA, Williams AR, et al. 2004. Expression, localization, and signaling of prostaglandin F2 alpha receptor in human endometrial adenocarcinoma: regulation of proliferation by activation of the epidermal growth factor receptor and mitogen-activated protein kinase signaling pathways.. J. Clin. Endocrinol. Metab. 89 2: 986-93. PMID 14764825. Vielhauer GA, Fujino H, Regan JW 2004. Cloning and localization of hFPS: a six-transmembrane mRNA splice variant of the human FP prostanoid receptor.. Arch. Biochem. Biophys. 421 2: 175-85. PMID 14984197. Jin P, Fu GK, Wilson AD, et al. 2004. PCR isolation and cloning of novel splice variant mRNAs from known drug target genes.. Genomics 83 4: 566-71. doi:10.1016/j.ygeno.2003.09.023. PMID 15028279. Sugino N, Karube-Harada A, Taketani T, et al. 2004. Withdrawal of ovarian steroids stimulates prostaglandin F2alpha production through nuclear factor-kappaB activation via oxygen radicals in human endometrial stromal cells: potential relevance to menstruation.. J. Reprod. Dev. 50 2: 215-25. PMID 15118249. Gerhard DS, Wagner L, Feingold EA, et al. 2004. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection MGC.. Genome Res. 14 10B: 2121-7. doi:10.1101/gr.2596504. PMID 15489334. Scott G, Jacobs S, Leopardi S, et al. 2005. Effects of PGF2alpha on human melanocytes and regulation of the FP receptor by ultraviolet radiation.. Exp. Cell Res. 304 2: 407-16. doi:10.1016/j.yexcr.2004.11.016. PMID 15748887. Mandal AK, Ray R, Zhang Z, et al. 2005. Uteroglobin inhibits prostaglandin F2alpha receptor-mediated expression of genes critical for the production of pro-inflammatory lipid mediators.. J. Biol. Chem. 280 38: 32897-904. doi:10.1074/jbc.M502375200. PMID 16061484. Hébert RL, Carmosino M, Saito O, et al. 2005. Characterization of a rabbit kidney prostaglandin F2alpha receptor exhibiting Gi-restricted signaling that inhibits water absorption in the collecting duct.. J. Biol. Chem. 280 41: 35028-37. doi:10.1074/jbc.M505852200. PMID 16096282. This transmembrane receptor-related article is a stub. This article incorporates text from the United States National Library of Medicine, which is in the public domain. v d e Transmembrane receptor: G protein-coupled receptors Class A: Rhodopsin like Adrenergic α1 A, B, D, α2 A, B, C, β1, β2, β3 Eicosanoid CysLT 1, 2, LTB4 1, 2, FPRL1, OXE, Prostaglandin DP, EP 1, 2, 3, 4, PGF, Prostacyclin, Thromboxane Neuropeptide B/W 1, 2, FF 1, 2, S, Y 1, 2, 4, 5 Orphan GPR 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182 Purinergics Adenosine A1, A2a, A2b, A3, P2Y, 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14 Serotonin all but 5-HT3 5-HT1 A, B, D, E, F, 5-HT2 A, B, C, 5-HT 4, 5A, 6, 7 Other Acetylcholine M1, M2, M3, M4, M5 - Adrenomedullin - Anaphylatoxin C3a, C5a - Angiotensin 1, 2 - Apelin - Bile acid - Bombesin BRS3, GRPR, NMBR - Bradykinin B1, B2 - Cannabinoid CB1, CB2 - Chemokine - Cholecystokinin A, B - Dopamine D1, D2, D3, D4, D5 - EBI2 - Endothelin A, B - Estrogen - Formyl peptide 1, L1, L2 - Free fatty acid 1, 2, 3, 4 - FSH - Galanin 1, 2, 3 - Gonadotropin-releasing hormone 1, 2 - Ghrelin - Histamine H1, H2, H3, H4 - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid 1, 2, 3, 4, 5, 6, 7, 8 - MAS 1, 1L, D, E, F, G, X1, X2, X3, X4 - Melanocortin 1, 2, 3, 4, 5 - MCHR 1, 2 - Melatonin 1A, 1B- Motilin - neuromedin B, U 1, 2 - Neurotensin 1, 2 - Opioid Delta, Kappa, Mu, Nociceptin, but not Sigma - Olfactory - Opsin 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH - Orexin 1, 2 - Oxytocin - Oxoglutarate - PAF - Prokineticin 1, 2 - Prolactin-releasing peptide - Protease-activated 1, 2, 3, 4 - Relaxin 1, 2, 3, 4 - Somatostatin 1, 2, 3, 4, 5 - SREB - Succinate - TAAR 1, 2, 3, 5, 6, 8, 9 - Tachykinin 1, 2, 3 - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin 1A, 1B, 2 Class B: Secretin like Brain-specific angiogenesis inhibitor 1, 2, 3 - Cadherin 1, 2, 3 - Calcitonin - CD97 - Corticotropin-releasing hormone 1, 2 - EMR 1, 2, 3 - Glucagon GR, GIPR, GLP1R, GLP2R - Growth hormone releasing hormone - PACAPR1- GPR 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157 - Latrophilin 1, 2, 3, ELTD1 - Parathyroid hormone 1, 2 - Secretin - Vasoactive intestinal peptide 1, 2 Class C: Metabotropic glutamate / pheromone Calcium-sensing receptor - GABA B 1, 2 - Glutamate receptor Metabotropic glutamate 1, 2, 3, 4, 5, 6, 7, 8 - GPRC6A - GPR 156, 158, 179 - RAIG 1, 2, 3, 4 - Taste receptors TAS1R 1, 2, 3 TAS2R 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50 Frizzled / Smoothened Frizzled 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 - Smoothened Retrieved from http://en..org/wiki/Prostaglandin_F_receptor Categories: Genes on chromosome 1 | Human proteins | Transmembrane receptor stubs | G protein coupled receptorsHidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 8 July 2008, at 13
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