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14-September-2008 18:02:44 - Relaxin receptor relaxin/insulin-like family peptide receptor 1 Identifiers Symbol RXFP1 Alt. Symbols LGR7 Entrez 59350 HUGO 19718 OMIM 606654 RefSeq NM_021634 UniProt Q9HBX9 Other data Locus Chr. 4 q31.3 relaxin/insulin-like family peptide receptor 2 Identifiers Symbol RXFP2 Alt. Symbols LGR8, GREAT, GPR106, INSL3R Entrez 122042 HUGO 17318 OMIM 606655 RefSeq NM_130806 UniProt Q8WXD0 Other data Locus Chr. 13 q12.3 relaxin/insulin-like family peptide receptor 3 Identifiers Symbol RXFP3 Alt. Symbols RLN3R1, SALPR, GPCR135 Entrez 51289 HUGO 24883 OMIM 609445 RefSeq NM_016568 UniProt Q9NSD7 Other data Locus Chr. 5 p15.1-p14 relaxin/insulin-like family peptide receptor 4 Identifiers Symbol RXFP4 Alt. Symbols GPR100, GPCR142, RLN3R2 Entrez 339403 HUGO 14666 OMIM 609043 RefSeq NM_181885 UniProt Q8TDU9 Other data Locus Chr. 1 q22 The relaxin receptors are a subclass of four closely related G protein-coupled receptors that bind relaxin peptide hormones.12 Below is list of human relaxin receptors, their endogenous peptide hormones, and what down stream enzymes are activated or inhibited by the receptor. receptor/gene ligands activates inhibits RXFP1 Relaxin 1, Relaxin 2, Relaxin 3 adenylate cyclase, protein kinase A, protein kinase C, phosphatidylinositol 3-kinase, extracellular signal-regulated kinases Erk1/2 RXFP2 Relaxin 1, Relaxin 2, INSL3 adenylate cyclase RXFP3 Relaxin 3 Erk1/2 signaling adenylate cyclase RXFP4 Relaxin 3, INSL3 adenylate cyclase References ^ Bathgate RA, Ivell R, Sanborn BM, Sherwood OD, Summers RJ 2006. International Union of Pharmacology LVII: recommendations for the nomenclature of receptors for relaxin family peptides. Pharmacol. Rev. 58 1: 7-31. doi:10.1124/pr.58.1.9. PMID 16507880. ^ Halls ML, van der Westhuizen ET, Bathgate RA, Summers RJ 2007. Relaxin family peptide receptors--former orphans reunite with their parent ligands to activate multiple signalling pathways. Br. J. Pharmacol. 150 6: 677-91. doi:10.1038/sj.bjp.0707140. PMID 17293890. External links IUPHAR GPCR Database - Relaxin family peptide receptors MeSH relaxin+receptors This transmembrane receptor-related article is a stub. v d e Transmembrane receptor: G protein-coupled receptors Class A: Rhodopsin like Adrenergic α1 A, B, D, α2 A, B, C, β1, β2, β3 Eicosanoid CysLT 1, 2, LTB4 1, 2, FPRL1, OXE, Prostaglandin DP, EP 1, 2, 3, 4, PGF, Prostacyclin, Thromboxane Neuropeptide B/W 1, 2, FF 1, 2, S, Y 1, 2, 4, 5 Orphan GPR 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182 Purinergics Adenosine A1, A2a, A2b, A3, P2Y, 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14 Serotonin all but 5-HT3 5-HT1 A, B, D, E, F, 5-HT2 A, B, C, 5-HT 4, 5A, 6, 7 Other Acetylcholine M1, M2, M3, M4, M5 - Adrenomedullin - Anaphylatoxin C3a, C5a - Angiotensin 1, 2 - Apelin - Bile acid - Bombesin BRS3, GRPR, NMBR - Bradykinin B1, B2 - Cannabinoid CB1, CB2 - Chemokine - Cholecystokinin A, B - Dopamine D1, D2, D3, D4, D5 - EBI2 - Endothelin A, B - Estrogen - Formyl peptide 1, L1, L2 - Free fatty acid 1, 2, 3, 4 - FSH - Galanin 1, 2, 3 - Gonadotropin-releasing hormone 1, 2 - Ghrelin - Histamine H1, H2, H3, H4 - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid 1, 2, 3, 4, 5, 6, 7, 8 - MAS 1, 1L, D, E, F, G, X1, X2, X3, X4 - Melanocortin 1, 2, 3, 4, 5 - MCHR 1, 2 - Melatonin 1A, 1B- Motilin - neuromedin B, U 1, 2 - Neurotensin 1, 2 - Opioid Delta, Kappa, Mu, Nociceptin, but not Sigma - Olfactory - Opsin 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH - Orexin 1, 2 - Oxytocin - Oxoglutarate - PAF - Prokineticin 1, 2 - Prolactin-releasing peptide - Protease-activated 1, 2, 3, 4 - Relaxin 1, 2, 3, 4 - Somatostatin 1, 2, 3, 4, 5 - SREB - Succinate - TAAR 1, 2, 3, 5, 6, 8, 9 - Tachykinin 1, 2, 3 - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin 1A, 1B, 2 Class B: Secretin like Brain-specific angiogenesis inhibitor 1, 2, 3 - Cadherin 1, 2, 3 - Calcitonin - CD97 - Corticotropin-releasing hormone 1, 2 - EMR 1, 2, 3 - Glucagon GR, GIPR, GLP1R, GLP2R - Growth hormone releasing hormone - PACAPR1- GPR 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157 - Latrophilin 1, 2, 3, ELTD1 - Parathyroid hormone 1, 2 - Secretin - Vasoactive intestinal peptide 1, 2 Class C: Metabotropic glutamate / pheromone Calcium-sensing receptor - GABA B 1, 2 - Glutamate receptor Metabotropic glutamate 1, 2, 3, 4, 5, 6, 7, 8 - GPRC6A - GPR 156, 158, 179 - RAIG 1, 2, 3, 4 - Taste receptors TAS1R 1, 2, 3 TAS2R 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50 Frizzled / Smoothened Frizzled 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 - Smoothened Retrieved from http://en..org/wiki/Relaxin_receptor Categories: Genes on chromosome 4 | Genes on chromosome 13 | Genes on chromosome 5 | Genes on chromosome 1 | Transmembrane receptor stubs | G protein coupled receptorsHidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 15 June 2008, at 13:5
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