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14-September-2008 18:02:48 - oligopeptide reabsorption Renal oligopeptide reabsorption is the part of renal physiology that deals with the retrieval of filtered oligopeptides, preventing them from disappearing from the body through the urine. Almost all reabsorption takes place in the proximal tubule. Practically nothing is left in the final urine. Longer oligopeptides, such as angiotensin1 and glutathione1 are degraded by enzymes on the brush border, while shorter ones, such as carnosine1, are transported across the apical membrane as a whole by the PepT 1 transporter, and degraded inside the proximal tubule cell. Overview table Characteristics of oligopeptide reabsorption Characteristic proximal tubule loop of Henle Distal convoluted tubule Collecting duct system S1 S2 S3 reabsorption % 991 Beyond the proximal tubule: 1%1 reabsorption mmoles/day Concentration apical transport proteins sodium-amino acid symporter1 PepT 1 for short peptides, n=2 to 41 basolateral transport proteins amino acid transporter1 Other reabsorption features References ^ a b c d e f g h Walter F., PhD. Boron. Medical Physiology: A Cellular And Molecular Approaoch. Elsevier/Saunders. ISBN 1-4160-2328-3. Page 798 v d e Urinary system, physiology: renal physiology and acid base physiology Filtration Renal blood flow - Ultrafiltration - Countercurrent exchange Hormones affecting filtration Antidiuretic hormone ADH - Aldosterone - Atrial natriuretic peptide Secretion/clearance Pharmacokinetics - Clearance of medications Reabsorption Solvent drag - Na+ - Cl- - urea - glucose - oligopeptides - protein Endocrine Renin - Erythropoietin EPO - Calcitriol Active vitamin D - Prostaglandins Assessing Renal function/ Measures of dialysis Glomerular filtration rate - Creatinine clearance - Renal clearance ratio - Urea reduction ratio - Kt/V - Standardized Kt/V - Hemodialysis product - PAH clearance Effective renal plasma flow - Extraction ratio Acid base physiology Fluid balance - Darrow Yannet diagram - Body water - Interstitial fluid - Extracellular fluid - Intracellular fluid/Cytosol - Plasma - Transcellular fluid - Base excess - Davenport diagram - Anion gap - Arterial blood gas Buffering/compensation Bicarbonate buffering system - Respiratory compensation - Renal compensation Retrieved from http://en..org/wiki/Renal_oligopeptide_reabsorption Categories: Physiology Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 28 December 2007, at 10:20
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