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14-September-2008 18:02:44 - Retinal G protein coupled receptor Retinal G protein coupled receptor Identifiers Symbols RGR; External IDs OMIM: 600342 MGI: 1929473 HomoloGene: 37709 Gene ontology Molecular function: rhodopsin-like receptor activity receptor activity protein binding Cellular component: integral to plasma membrane membrane integral to membrane Biological process: signal transduction G-protein coupled receptor protein signaling pathway visual perception phototransduction protein-chromophore linkage response to stimulus RNA expression pattern More reference expression data Orthologs Human Mouse Entrez 5995 57811 Ensembl ENSG00000148604 ENSMUSG00000021804 Uniprot P47804 Q3UEX9 Refseq NM_001012720 mRNA NP_001012738 protein NM_021340 mRNA NP_067315 protein Location Chr 10: 85.99 - 86.01 Mb Chr 14: 35.95 - 35.96 Mb Pubmed search 1 2 Retinal G protein coupled receptor, also known as RGR, is a human gene.1 Defects in this gene are a cause of retinitis pigmentosa. The gene is a member of the rhodopsin-like receptor subfamily of GPCR. Like other opsins which bind retinaldehyde, it contains a conserved lysine residue in the seventh transmembrane domain. The protein presumably acts as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal, similar to retinochrome in invertebrates. The reverse isomerization occurs with rhodopsin in retinal photoreceptor cells. The protein is exclusively expressed in tissue adjacent to retinal photoreceptor cells, the retinal pigment epithelium and Mueller cells. This gene may be associated with autosomal recessive and autosomal dominant retinitis pigmentosa arRP and adRP, respectively. Alternative splicing results in multiple transcript variants encoding different isoforms.1 References ^ a b Entrez Gene: RGR retinal G protein coupled receptor. Further reading Jiang M, Shen D, Tao L, et al. 1995. Alternative splicing in human retinal mRNA transcripts of an opsin-related protein.. Exp. Eye Res. 60 4: 401-6. PMID 7789419. Shen D, Jiang M, Hao W, et al. 1994. A human opsin-related gene that encodes a retinaldehyde-binding protein.. Biochemistry 33 44: 13117-25. PMID 7947717. Chen XN, Korenberg JR, Jiang M, et al. 1996. Localization of the human RGR opsin gene to chromosome 10q23.. Hum. Genet. 97 6: 720-2. PMID 8641686. Morimura H, Saindelle-Ribeaudeau F, Berson EL, Dryja TP 1999. Mutations in RGR, encoding a light-sensitive opsin homologue, in patients with retinitis pigmentosa.. Nat. Genet. 23 4: 393-4. doi:10.1038/70496. PMID 10581022. Chen P, Lee TD, Fong HK 2001. Interaction of 11-cis-retinol dehydrogenase with the chromophore of retinal g protein-coupled receptor opsin.. J. Biol. Chem. 276 24: 21098-104. doi:10.1074/jbc.M010441200. PMID 11274198. Yang M, Fong HK 2002. Synthesis of the all-trans-retinal chromophore of retinal G protein-coupled receptor opsin in cultured pigment epithelial cells.. J. Biol. Chem. 277 5: 3318-24. doi:10.1074/jbc.M108946200. PMID 11723126. Strausberg RL, Feingold EA, Grouse LH, et al. 2003. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 99 26: 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. Bellingham J, Wells DJ, Foster RG 2003. In silico characterisation and chromosomal localisation of human RRH peropsin--implications for opsin evolution.. BMC Genomics 4 1: 3. PMID 12542842. Tarttelin EE, Bellingham J, Bibb LC, et al. 2003. Expression of opsin genes early in ocular development of humans and mice.. Exp. Eye Res. 76 3: 393-6. PMID 12573668. Bernal S, Calaf M, Garcia-Hoyos M, et al. 2003. Study of the involvement of the RGR, CRPB1, and CRB1 genes in the pathogenesis of autosomal recessive retinitis pigmentosa.. J. Med. Genet. 40 7: e89. PMID 12843338. Gerhard DS, Wagner L, Feingold EA, et al. 2004. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection MGC.. Genome Res. 14 10B: 2121-7. doi:10.1101/gr.2596504. PMID 15489334. Rual JF, Venkatesan K, Hao T, et al. 2005. Towards a proteome-scale map of the human protein-protein interaction network.. Nature 437 7062: 1173-8. doi:10.1038/nature04209. PMID 16189514. Zhu L, Imanishi Y, Filipek S, et al. 2006. Autosomal recessive retinitis pigmentosa and E150K mutation in the opsin gene.. J. Biol. Chem. 281 31: 22289-98. doi:10.1074/jbc.M602664200. PMID 16737970. Lin MY, Kochounian H, Moore RE, et al. 2007. Deposition of exon-skipping splice isoform of human retinal G protein-coupled receptor from retinal pigment epithelium into Bruch's membrane.. Mol. Vis. 13: 1203-14. PMID 17679941. This transmembrane receptor-related article is a stub. This article incorporates text from the United States National Library of Medicine, which is in the public domain. v d e Transmembrane receptor: G protein-coupled receptors Class A: Rhodopsin like Adrenergic α1 A, B, D, α2 A, B, C, β1, β2, β3 Eicosanoid CysLT 1, 2, LTB4 1, 2, FPRL1, OXE, Prostaglandin DP, EP 1, 2, 3, 4, PGF, Prostacyclin, Thromboxane Neuropeptide B/W 1, 2, FF 1, 2, S, Y 1, 2, 4, 5 Orphan GPR 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182 Purinergics Adenosine A1, A2a, A2b, A3, P2Y, 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14 Serotonin all but 5-HT3 5-HT1 A, B, D, E, F, 5-HT2 A, B, C, 5-HT 4, 5A, 6, 7 Other Acetylcholine M1, M2, M3, M4, M5 - Adrenomedullin - Anaphylatoxin C3a, C5a - Angiotensin 1, 2 - Apelin - Bile acid - Bombesin BRS3, GRPR, NMBR - Bradykinin B1, B2 - Cannabinoid CB1, CB2 - Chemokine - Cholecystokinin A, B - Dopamine D1, D2, D3, D4, D5 - EBI2 - Endothelin A, B - Estrogen - Formyl peptide 1, L1, L2 - Free fatty acid 1, 2, 3, 4 - FSH - Galanin 1, 2, 3 - Gonadotropin-releasing hormone 1, 2 - Ghrelin - Histamine H1, H2, H3, H4 - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid 1, 2, 3, 4, 5, 6, 7, 8 - MAS 1, 1L, D, E, F, G, X1, X2, X3, X4 - Melanocortin 1, 2, 3, 4, 5 - MCHR 1, 2 - Melatonin 1A, 1B- Motilin - neuromedin B, U 1, 2 - Neurotensin 1, 2 - Opioid Delta, Kappa, Mu, Nociceptin, but not Sigma - Olfactory - Opsin 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH - Orexin 1, 2 - Oxytocin - Oxoglutarate - PAF - Prokineticin 1, 2 - Prolactin-releasing peptide - Protease-activated 1, 2, 3, 4 - Relaxin 1, 2, 3, 4 - Somatostatin 1, 2, 3, 4, 5 - SREB - Succinate - TAAR 1, 2, 3, 5, 6, 8, 9 - Tachykinin 1, 2, 3 - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin 1A, 1B, 2 Class B: Secretin like Brain-specific angiogenesis inhibitor 1, 2, 3 - Cadherin 1, 2, 3 - Calcitonin - CD97 - Corticotropin-releasing hormone 1, 2 - EMR 1, 2, 3 - Glucagon GR, GIPR, GLP1R, GLP2R - Growth hormone releasing hormone - PACAPR1- GPR 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157 - Latrophilin 1, 2, 3, ELTD1 - Parathyroid hormone 1, 2 - Secretin - Vasoactive intestinal peptide 1, 2 Class C: Metabotropic glutamate / pheromone Calcium-sensing receptor - GABA B 1, 2 - Glutamate receptor Metabotropic glutamate 1, 2, 3, 4, 5, 6, 7, 8 - GPRC6A - GPR 156, 158, 179 - RAIG 1, 2, 3, 4 - Taste receptors TAS1R 1, 2, 3 TAS2R 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50 Frizzled / Smoothened Frizzled 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 - Smoothened Retrieved from http://en..org/wiki/Retinal_G_protein_coupled_receptor Categories: Genes on chromosome 10 | Human proteins | Transmembrane receptor stubs | G protein coupled receptorsHidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 9 July 2008, at 06:10
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