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14-September-2008 18:02:44 - Retinoic acid-inducible orphan G protein-coupled receptor G protein-coupled receptor, family C, group 5, member A Identifiers Symbol GPRC5A Alt. Symbols RAIG1, RAI3 Entrez 9052 HUGO 9836 OMIM 604138 RefSeq NM_003979 UniProt Q8NFJ5 Other data Locus Chr. 12 p13-p12.3 G protein coupled receptor, family C, group 5, member B Identifiers Symbol GPRC5B Alt. Symbols RAIG2 Entrez 51704 HUGO 13308 OMIM 605948 RefSeq NM_016235 UniProt Q9NZH0 Other data Locus Chr. 16 p12 G protein-coupled receptor, family C, group 5, member C Identifiers Symbol GPRC5C Alt. Symbols RAIG3 Entrez 55890 HUGO 13309 OMIM 605949 RefSeq NM_022036 UniProt Q9NQ84 Other data Locus Chr. 17 q25 G protein-coupled receptor, family C, group 5, member D Identifiers Symbol GPRC5D Entrez 55507 HUGO 13310 OMIM 607437 RefSeq NM_018654 UniProt Q9NZD1 Other data Locus Chr. 12 p13.3 The Retinoic Acid-Inducible orphan G-protein-coupled receptors RAIG are a group of four closely related G protein-coupled receptors whose expression is induced by retinoic acid.1234 The exact function of these proteins has not been determined but they may provide a mechanism by which retinoic acid can influence G protein signal transduction cascades. In addition, RAIG receptors interact with members of the frizzled class of G protein-coupled receptors and appear to activate the Wnt signaling pathway.5 References ^ Cheng Y, Lotan R 1998. Molecular cloning and characterization of a novel retinoic acid-inducible gene that encodes a putative G protein-coupled receptor. J. Biol. Chem. 273 52: 35008-15. PMID 9857033. ^ Bräuner-Osborne H, Krogsgaard-Larsen P 2000. Sequence and expression pattern of a novel human orphan G-protein-coupled receptor, GPRC5B, a family C receptor with a short amino-terminal domain. Genomics 65 2: 121-8. doi:10.1006/geno.2000.6164. PMID 10783259. ^ Robbins MJ, Michalovich D, Hill J, Calver AR, Medhurst AD, Gloger I, Sims M, Middlemiss DN, Pangalos MN 2000. Molecular cloning and characterization of two novel retinoic acid-inducible orphan G-protein-coupled receptors GPRC5B and GPRC5C. Genomics 67 1: 8-18. doi:10.1006/geno.2000.6226. PMID 10945465. ^ Bräuner-Osborne H, Jensen AA, Sheppard PO, Brodin B, Krogsgaard-Larsen P, O'Hara P 2001. Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D. Biochim. Biophys. Acta 1518 3: 237-48. PMID 11311935. ^ Harada Y, Yokota C, Habas R, Slusarski DC, He X 2007. Retinoic acid-inducible G protein-coupled receptors bind to frizzled receptors and may activate non-canonical Wnt signaling. Biochem. Biophys. Res. Commun. 358 4: 968-75. doi:10.1016/j.bbrc.2007.04.208. PMID 17521608. External links IUPHAR GPCR Database - GPRC5 receptors - RAIG1, RAIG2, RAIG3, RAIG4 MeSH GPRC5A+protein,+human MeSH GPRC5B+protein,+human MeSH GPRC5C+protein,+human This transmembrane receptor-related article is a stub. v d e Transmembrane receptor: G protein-coupled receptors Class A: Rhodopsin like Adrenergic α1 A, B, D, α2 A, B, C, β1, β2, β3 Eicosanoid CysLT 1, 2, LTB4 1, 2, FPRL1, OXE, Prostaglandin DP, EP 1, 2, 3, 4, PGF, Prostacyclin, Thromboxane Neuropeptide B/W 1, 2, FF 1, 2, S, Y 1, 2, 4, 5 Orphan GPR 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182 Purinergics Adenosine A1, A2a, A2b, A3, P2Y, 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14 Serotonin all but 5-HT3 5-HT1 A, B, D, E, F, 5-HT2 A, B, C, 5-HT 4, 5A, 6, 7 Other Acetylcholine M1, M2, M3, M4, M5 - Adrenomedullin - Anaphylatoxin C3a, C5a - Angiotensin 1, 2 - Apelin - Bile acid - Bombesin BRS3, GRPR, NMBR - Bradykinin B1, B2 - Cannabinoid CB1, CB2 - Chemokine - Cholecystokinin A, B - Dopamine D1, D2, D3, D4, D5 - EBI2 - Endothelin A, B - Estrogen - Formyl peptide 1, L1, L2 - Free fatty acid 1, 2, 3, 4 - FSH - Galanin 1, 2, 3 - Gonadotropin-releasing hormone 1, 2 - Ghrelin - Histamine H1, H2, H3, H4 - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid 1, 2, 3, 4, 5, 6, 7, 8 - MAS 1, 1L, D, E, F, G, X1, X2, X3, X4 - Melanocortin 1, 2, 3, 4, 5 - MCHR 1, 2 - Melatonin 1A, 1B- Motilin - neuromedin B, U 1, 2 - Neurotensin 1, 2 - Opioid Delta, Kappa, Mu, Nociceptin, but not Sigma - Olfactory - Opsin 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH - Orexin 1, 2 - Oxytocin - Oxoglutarate - PAF - Prokineticin 1, 2 - Prolactin-releasing peptide - Protease-activated 1, 2, 3, 4 - Relaxin 1, 2, 3, 4 - Somatostatin 1, 2, 3, 4, 5 - SREB - Succinate - TAAR 1, 2, 3, 5, 6, 8, 9 - Tachykinin 1, 2, 3 - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin 1A, 1B, 2 Class B: Secretin like Brain-specific angiogenesis inhibitor 1, 2, 3 - Cadherin 1, 2, 3 - Calcitonin - CD97 - Corticotropin-releasing hormone 1, 2 - EMR 1, 2, 3 - Glucagon GR, GIPR, GLP1R, GLP2R - Growth hormone releasing hormone - PACAPR1- GPR 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157 - Latrophilin 1, 2, 3, ELTD1 - Parathyroid hormone 1, 2 - Secretin - Vasoactive intestinal peptide 1, 2 Class C: Metabotropic glutamate / pheromone Calcium-sensing receptor - GABA B 1, 2 - Glutamate receptor Metabotropic glutamate 1, 2, 3, 4, 5, 6, 7, 8 - GPRC6A - GPR 156, 158, 179 - RAIG 1, 2, 3, 4 - Taste receptors TAS1R 1, 2, 3 TAS2R 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50 Frizzled / Smoothened Frizzled 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 - Smoothened Retrieved from http://en..org/wiki/Retinoic_acid-inducible_orphan_G_protein-coupled_receptor Categories: Genes on chromosome 12 | Genes on chromosome 16 | Genes on chromosome 17 | Transmembrane receptor stubs | G protein coupled receptorsHidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 15 June 2008, at 13:59
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