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14-September-2008 18:02:44 - Rhodopsin-like receptors Rhodopsin-like receptors Identifiers Symbol 7tm_1 Pfam PF00001 InterPro IPR000276 PROSITE PDOC00211 SCOP 1f88 OPM family 6 OPM protein 1gzm Available PDB structures: 1U19 2R4R 2R4S 2RH1 1f88, 1hzx, 1l9h, 2g87, 2hpy, 2i35, 2i36, 2i37, 2j4y, 2ped Rhodopsin-like receptors are the largest group of G-protein coupled receptors. G-protein-coupled receptors, GPCRs, constitute a vast protein family that encompasses a wide range of functions including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups. GPCRs are usually described as superfamily because they embrace a group of families for which there are indications of evolutionary relationship, but between which there is no statistically significant similarity in sequence.1 The currently known superfamily members include the rhodopsin-like GPCRs, the secretin-like GPCRs, the cAMP receptors, the fungal mating pheromone receptors, and the metabotropic glutamate receptor family. There is a specialised database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone, neurotransmitter and light receptors, all of which transduce extracellular signals through interaction with guanine nucleotide-binding G proteins. Although their activating ligands vary widely in structure and character, the amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7 transmembrane TM helices.234 Rhodopsin-like GPCRs have been classified into the following 19 subgroups A1-A19 based on a phylogenetic analysis.5 Contents 1 Subfamily A1 2 Subfamily A2 3 Subfamily A3 4 Subfamily A4 5 Subfamily A5 6 Subfamily A6 7 Subfamily A7 8 Subfamily A8 9 Subfamily A9 10 Subfamily A10 11 Subfamily A11 12 Subfamily A12 13 Subfamily A13 14 Subfamily A14 15 Subfamily A15 16 Subfamily A16 17 Subfamily A17 18 Subfamily A18 19 Subfamily A19 20 Unclassified 21 References 22 External links Subfamily A1 Chemokine receptor IPR000355 Chemokine C-C motif receptor 1 CCR1, CKR1 Chemokine C-C motif receptor 2 CCR2, CKR2 Chemokine C-C motif receptor 3 CCR3, CKR3 Chemokine C-C motif receptor 4 CCR4, CKR4 Chemokine C-C motif receptor 5 CCR5, CKR5 Chemokine C-C motif receptor 8 CCR8, CKR8 Chemokine C-C motif receptor-like 2 CCRL2, CKRX chemokine C motif receptor 1 XCR1, CXC1 IPR005393 chemokine C-X3-C motif receptor 1 CX3CR1, C3X1 IPR005387 GPR137B GPR137B, TM7SF1 Subfamily A2 Chemokine receptor IPR000355 Chemokine C-C motif receptor-like 1 CCRL1 CCRL1, CCR11 Chemokine C-C motif receptor 6 CCR6, CKR6 Chemokine C-C motif receptor 7 CCR7, CKR7 Chemokine C-C motif receptor 9 CCR9, CKR9 Chemokine C-C motif receptor 10 CCR10, CKRA CXC chemokine receptors IPR001053 Chemokine C-X-C motif receptor 6 CXCR6, BONZO Chemokine C-X-C motif receptor 7 CXCR7, RDC1 IPR001416 Interleukin-8 IPR000174 IL8R IL8R-α IL8RA, CXCR1 IL8R-β IL8RB, CXCR2 Adrenomedullin receptor GPR182 Duffy blood group, chemokine receptor DARC, DUFF G Protein-coupled Receptor 30 GPER, CML2, GPCR estrogen receptor Subfamily A3 Angiotensin II receptor IPR000248 Angiotensin II receptor, type 1 AGTR1, AG2S Angiotensin II receptor, type 2 AGTR2, AG22 Apelin receptor AGTRL1, APJ IPR003904 Bradykinin receptor IPR000496 Bradykinin receptor B1 BDKRB1, BRB1 Bradykinin receptor B2 BDKRB2, BRB2 GPR15 GPR15, GPRF GPR25 GPR25 Subfamily A4 Opioid receptor IPR001418 delta Opioid receptor OPRD1, OPRD kappa Opioid receptor OPRK1, OPRK mu Opioid receptor OPRM1, OPRM Nociceptin receptor OPRL1, OPRX Somatostatin receptor IPR000586 Somatostatin receptor 1 SSTR1, SSR1 Somatostatin receptor 2 SSTR2, SSR2 Somatostatin receptor 3 SSTR3, SSR3 Somatostatin receptor 4 SSTR4, SSR4 Somatostatin receptor 5 SSTR5, SSR5 GPCR neuropeptide receptor IPR009150 Neuropeptides B/W receptor 1 NPBWR1, GPR7 Neuropeptides B/W receptor 2 NPBWR2, GPR8 GPR1 orphan receptor GPR1 IPR002275 DEZ orphan receptor IPR002258 Subfamily A5 Galanin receptor IPR000405 Galanin receptor 1 GALR1, GALR Galanin receptor 2 GALR2, GALS Galanin receptor 3 GALR3, GALT Cysteinyl leukotriene receptor IPR004071 Cysteinyl leukotriene receptor 1 CYSLTR1 Cysteinyl leukotriene receptor 2 CYSLTR2 Leukotriene B4 receptor IPR003981 Leukotriene B4 receptor LTB4R, P2Y7 Leukotriene B4 receptor 2 LTB4R2 Relaxin receptor IPR008112 Relaxin/insulin-like family peptide receptor 1 RXFP1, LGR7 Relaxin/insulin-like family peptide receptor 2 RXFP2, GPR106 Relaxin/insulin-like family peptide receptor 3 RXFP3, SALPR Relaxin/insulin-like family peptide receptor 4 RXFP4, GPR100/GPR142 KiSS1-derived peptide receptor GPR54 KISS1R IPR008103 Melanin-concentrating hormone receptor 1 MCHR1, GPRO IPR008361 Urotensin-II receptor UTS2R, UR2R IPR000670 Subfamily A6 GPR40-related receptor IPR013312 Free fatty acid receptor 1 FFAR1, GPR40 Free fatty acid receptor 2 FFAR2, GPR43 Free fatty acid receptor 3 FFAR3, GPR41 GPR42 GPR42, FFAR1L P2 purinoceptor IPR002286 Purinergic receptor P2Y1 P2RY1 Purinergic receptor P2Y2 P2RY2 Purinergic receptor P2Y4 P2RY4 Purinergic receptor P2Y6 P2RY6 Purinergic receptor P2Y11 P2RY11 GPR31 GPR31, GPRV GPR81 GPR81 GPR82 GPR82 GPR109B GPR109B, HM74 Oxoglutarate alpha-ketoglutarate receptor 1 OXGR1, GPR80 Succinate receptor 1 SUCNR1, GPR91 Subfamily A7 P2 purinoceptor IPR002286 Purinergic receptor P2Y5 P2RY5, P2Y5 IPR002188 Purinergic receptor P2Y10 P2RY10, P2Y10 Protease-activated receptor IPR003912 Coagulation factor II thrombin receptor-like 1 F2RL1, PAR2 Coagulation factor II thrombin receptor-like 2 F2RL2, PAR3 Epstein-Barr virus induced gene 2 lymphocyte-specific G protein-coupled receptor EBI2 GPR4 GPR4 IPR002276 GPR17 GPR17, GPRH GPR18 GPR18, GPRI GPR20 GPR20, GPRK GPR23 GPR23, P2RY9, P2Y9 GPR35 GPR35 GPR55 GPR55 GPR65 GPR65 IPR005464 GPR68 GPR68 IPR005389 GPR92 GPR92 GPR132 132, G2A IPR005388 Coagulation factor II receptor F2R, THRR Subfamily A8 P2 purinoceptor IPR002286 Purinergic receptor P2Y12 P2RY12 Purinergic receptor P2Y13 P2RY13, GPR86 IPR008109 Purinergic receptor P2Y14 P2RY14, UDP-glucose receptor, KI01 IPR005466 GPR34 GPR34 GPR87 GPR87 GPR171 GPR171, H963 Platelet-activating factor receptor PTAFR, PAFR IPR002282 Subfamily A9 Cannabinoid receptor IPR002230 Cannabinoid receptor 1 brain CNR1, CB1R Cannabinoid receptor 2 macrophage CNR2, CB2R Lysophosphatidic acid receptor IPR004065 Endothelial differentiation gene 2 EDG2 Endothelial differentiation gene 4 EDG4 Endothelial differentiation gene 7 EDG7 Sphingosine 1-phosphate receptor IPR004061 Endothelial differentiation gene 1 EDG1 Endothelial differentiation gene 3 EDG3 Endothelial differentiation gene 5 EDG5 Endothelial differentiation gene 6 EDG6 Endothelial differentiation gene 8 EDG8 Melanocortin/ACTH receptor IPR001671 Melanocortin 1 receptor MC1R, MSHR Melanocortin 3 receptor MC3R Melanocortin 4 receptor MC4R Melanocortin 5 receptor MC5R ACTH receptor MC2R, ACTR GPR3 GPR3 GPR6 GPR6 GPR12 GPR12, GPRC Subfamily A10 Opsins IPR0017606 Rhodopsin RHO, OPSD Opsin 1 cone pigments, short-wave-sensitive color blindness, tritan OPN1SW, OPSB blue-sensitive opsin Opsin 1 cone pigments, medium-wave-sensitive color blindness, deutan OPN1MW, OPSG green-sensitive opsin Opsin 1 cone pigments, long-wave-sensitive color blindness, protan OPN1LW, OPSR red-sensitive opsin Retinal G protein coupled receptor RGR Retinal pigment epithelium-derived rhodopsin homolog RRH, OPSX visual pigment-like receptor opsin IPR001793 Subfamily A11 Eicosanoid receptor IPR008365 Prostaglandin D2 receptor PTGDR, PD2R Prostaglandin E1 receptor PTGER1, PE21 Prostaglandin E2 receptor PTGER2, PE22 Prostaglandin E3 receptor PTGER3, PE23 Prostaglandin E4 receptor PTGER4, PE24 Prostaglandin F receptor PTGFR, PF2R Prostaglandin I2 prostacyclin receptor PTGIR, PI2R Thromboxane A2 receptor TBXA2R, TA2R Subfamily A12 Cholecystokinin receptor IPR009126 Cholecystokinin A receptor CCKAR, CCKR Cholecystokinin B receptor CCKBR, GASR Neuropeptide FF receptor IPR005395 Neuropeptide FF receptor 1 NPFFR1, FF1R Neuropeptide FF receptor 2 NPFFR2, FF2R Orexin receptor IPR000204 Hypocretin orexin receptor 1 HCRTR1, OX1R Hypocretin orexin receptor 2 HCRTR2, OX2R Vasopressin receptor IPR001817 Arginine vasopressin receptor 1A AVPR1A, V1AR Arginine vasopressin receptor 1B AVPR1B, V1BR Arginine vasopressin receptor 2 AVPR2, V2R Gonadotrophin releasing hormone receptor GNRHR, GRHR IPR001658 GPR22 GPR22, GPRM GPR103 GPR103 GPR176 GPR176, GPR Subfamily A13 Melatonin receptor IPR000025 Melatonin receptor 1A MTNR1A, ML1A Melatonin receptor 1B MTNR1B, ML1B Neurokinin receptor IPR001681 Tachykinin receptor 1 TACR1, NK1R Tachykinin receptor 2 TACR2, NK2R Tachykinin receptor 3 TACR3, NK3R Neuropeptide Y receptor IPR000611 Neuropeptide Y receptor Y1 NPY1R, NY1R Neuropeptide Y receptor Y2 NPY2R, NY2R Pancreatic polypeptide receptor 1 PPYR1, NY4R Neuropeptide Y receptor Y5 NPY5R, NY5R Prolactin-releasing peptide receptor PRLHR, GPRA IPR001402 Prokineticin receptor 1 PROKR1, GPR73 GPR19 GPR19, GPRJ GPR50 GPR50, ML1X GPR75 GPR75 GPR83 GPR83, GPR72 Subfamily A14 Bombesin receptor IPR001556 Bombesin-like receptor 3 BRS3 Neuromedin B receptor NMBR Gastrin-releasing peptide receptor GRPR Endothelin receptor IPR000499 Endothelin receptor type A EDNRA, ET1R Endothelin receptor type B EDNRB, ETBR GPR37 GPR37, ETBR-LP2 IPR003909 Neuromedin U receptor IPR005390 Neuromedin U receptor 1 NMUR1 Neuromedin U receptor 2 NMU2R Neurotensin receptor IPR003984 Neurotensin receptor 1 NTSR1, NTR1 Neurotensin receptor 2 NTSR2, NTR2 Thyrotropin-releasing hormone receptor TRHR, TRFR IPR009144 Growth hormone secretagogue receptor GHSR IPR003905 GPR39 GPR39 Motilin receptor MLNR, GPR38 Subfamily A15 5-Hydroxytryptamine 5-HT receptor IPR002231 5-HT2A HTR2A, 5H2A 5-HT2B HTR2B, 5H2B 5-HT2C HTR2C, 5H2C 5-HT6 HTR6, 5H6 IPR002232 Adrenergic receptor IPR002233 Alpha1A ADRA1A, A1AA Alpha1B ADRA1B, A1AB Alpha1D ADRA1D, A1AD Alpha2A ADRA2A, A2AA Alpha2B ADRA2B, A2AB Alpha2C ADRA2C, A2AC Beta1 ADRB1, B1AR Beta2 ADRB2, B2AR Beta3 ADRB3, B3AR Dopamine receptor IPR000929 D1 DRD1, DADR D2 DRD2, D2DR D3 DRD3, D3DR D4 DRD4, D4DR D5 DRD5, DBDR Octopamine receptor IPR002002 Trace amine receptor IPR009132 TAAR2 TAAR2, GPR58 TAAR3 TAAR3, GPR57 TAAR5 TAAR5, PNR TAAR8 TAAR8, GPR102 Histamine H2 receptor HRH2, HH2R IPR000503 Subfamily A16 Histamine H1 receptor HRH1, HH1R IPR000921 Histamine H3 receptor HRH3 IPR003980 Histamine H4 receptor HRH4 IPR008102 Adenosine receptor IPR001634 A1 ADORA1, AA1R A2a ADORA2A, AA2A A2b ADORA2B, AA2B A3 ADORA3, AA3R Muscarinic acetylcholine receptor IPR000995 M1 CHRM1, ACM1 M2 CHRM2, ACM2 M3 CHRM3, ACM3 M4 CHRM4, ACM4 M5 CHRM5, ACM5 GPR21 GPR21, GPRL GPR27 GPR27 GPR45 GPR45, PSP24 GPR52 GPR52 GPR61 GPR61 GPR62 GPR62 GPR63 GPR63 GPR78 GPR78 GPR84 GPR84 GPR85 GPR85 GPR88 GPR88 GPR101 GPR101 GPR161 GPR161, RE2 GPR173 GPR173, SREB3 Subfamily A17 5-Hydroxytryptamine 5-HT receptor IPR002231 5-HT1A HTR1A, 5H1A 5-HT1B HTR1B, 5H1B 5-HT1D HTR1D, 5H1D 5-HT1E HTR1E, 5H1E 5-HT1F HTR1F, 5H1F 5-HT4 HTR4 IPR001520 5-HT5A HTR5A, 5H5A 5-HT7 HTR7, 5H7 IPR001069 Subfamily A18 Anaphylatoxin receptors IPR002234 C3a receptor C3AR1, C3AR C5a receptor C5AR1, C5AR Chemokine-like receptor 1 CMKLR1, CML1 Formyl peptide receptor IPR000826 Formyl peptide receptor 1 FPR1, FMLR Formyl peptide receptor-like 1 FPRL1, FML2 Formyl peptide receptor-like 2 FPRL2, FML1 MAS1 oncogene IPR000820 MAS1 MAS1, MAS MAS1L MAS1L, MRG GPR1 GPR1 GPR32 GPR32, GPRW GPR44 GPR44 GPR77 GPR77, C5L2 Subfamily A19 Glycoprotein hormone receptor IPR002131 FSH-receptor FSHR Luteinizing hormone/choriogonadotropin receptor LHCGR, LSHR Thyrotropin receptor TSHR Leucine-rich repeat-containing G protein-coupled receptor 4 LGR4 , GPR48 Leucine-rich repeat-containing G protein-coupled receptor 5 LGR5 , GPR49 Unclassified Olfactory receptor IPR000725 Vomeronasal receptor IPR004072 VN1R1 VN1R2 VN1R3 VN1R4 VN1R5 References ^ Attwood TK, Findlay JB 1994. Fingerprinting G-protein-coupled receptors. Protein Eng. 7 2: 195-203. doi:10.1093/protein/7.2.195. PMID 8170923. ^ Birnbaumer L 1990. G proteins in signal transduction. Annu. Rev. Pharmacol. Toxicol. 30: 675-705. doi:10.1146/annurev.pa.30.040190.003331. PMID 2111655. ^ Gilman AG, Casey PJ 1988. G protein involvement in receptor-effector coupling. J. Biol. Chem. 263 6: 2577-2580. PMID 2830256. ^ Attwood TK, Findlay JB 1993. Design of a discriminating fingerprint for G-protein-coupled receptors. Protein Eng. 6 2: 167-176. doi:10.1093/protein/6.2.167. PMID 8386361. ^ Joost P, Methner A 2002. Phylogenetic analysis of 277 human G-protein-coupled receptors as a tool for the prediction of orphan receptor ligands. Genome Biol 3 11: research0063.1-0063.16. doi:10.1186/gb-2002-3-11-research0063. PMID 12429062. ^ Terakita A 2005. The opsins. Genome Biol. 6 3: 213. doi:10.1186/gb-2005-6-3-213. PMID 15774036. External links Vriend G, Horn F, Oliveira L, Bywater RP, Cohen FE. GPCRDB G Protein-Coupled Receptor Data Base: sequence-derived data.. Retrieved on 2007-12-10.1 This database includes multiple sequence alignments of all GPCR families and sub-families. v d e Transmembrane receptor: G protein-coupled receptors Class A: Rhodopsin like Adrenergic α1 A, B, D, α2 A, B, C, β1, β2, β3 Eicosanoid CysLT 1, 2, LTB4 1, 2, FPRL1, OXE, Prostaglandin DP, EP 1, 2, 3, 4, PGF, Prostacyclin, Thromboxane Neuropeptide B/W 1, 2, FF 1, 2, S, Y 1, 2, 4, 5 Orphan GPR 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182 Purinergics Adenosine A1, A2a, A2b, A3, P2Y, 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14 Serotonin all but 5-HT3 5-HT1 A, B, D, E, F, 5-HT2 A, B, C, 5-HT 4, 5A, 6, 7 Other Acetylcholine M1, M2, M3, M4, M5 - Adrenomedullin - Anaphylatoxin C3a, C5a - Angiotensin 1, 2 - Apelin - Bile acid - Bombesin BRS3, GRPR, NMBR - Bradykinin B1, B2 - Cannabinoid CB1, CB2 - Chemokine - Cholecystokinin A, B - Dopamine D1, D2, D3, D4, D5 - EBI2 - Endothelin A, B - Estrogen - Formyl peptide 1, L1, L2 - Free fatty acid 1, 2, 3, 4 - FSH - Galanin 1, 2, 3 - Gonadotropin-releasing hormone 1, 2 - Ghrelin - Histamine H1, H2, H3, H4 - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid 1, 2, 3, 4, 5, 6, 7, 8 - MAS 1, 1L, D, E, F, G, X1, X2, X3, X4 - Melanocortin 1, 2, 3, 4, 5 - MCHR 1, 2 - Melatonin 1A, 1B- Motilin - neuromedin B, U 1, 2 - Neurotensin 1, 2 - Opioid Delta, Kappa, Mu, Nociceptin, but not Sigma - Olfactory - Opsin 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH - Orexin 1, 2 - Oxytocin - Oxoglutarate - PAF - Prokineticin 1, 2 - Prolactin-releasing peptide - Protease-activated 1, 2, 3, 4 - Relaxin 1, 2, 3, 4 - Somatostatin 1, 2, 3, 4, 5 - SREB - Succinate - TAAR 1, 2, 3, 5, 6, 8, 9 - Tachykinin 1, 2, 3 - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin 1A, 1B, 2 Class B: Secretin like Brain-specific angiogenesis inhibitor 1, 2, 3 - Cadherin 1, 2, 3 - Calcitonin - CD97 - Corticotropin-releasing hormone 1, 2 - EMR 1, 2, 3 - Glucagon GR, GIPR, GLP1R, GLP2R - Growth hormone releasing hormone - PACAPR1- GPR 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157 - Latrophilin 1, 2, 3, ELTD1 - Parathyroid hormone 1, 2 - Secretin - Vasoactive intestinal peptide 1, 2 Class C: Metabotropic glutamate / pheromone Calcium-sensing receptor - GABA B 1, 2 - Glutamate receptor Metabotropic glutamate 1, 2, 3, 4, 5, 6, 7, 8 - GPRC6A - GPR 156, 158, 179 - RAIG 1, 2, 3, 4 - Taste receptors TAS1R 1, 2, 3 TAS2R 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50 Frizzled / Smoothened Frizzled 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 - Smoothened Retrieved from http://en..org/wiki/Rhodopsin-like_receptors Categories: G protein coupled receptors | Protein domains | Protein familiesHidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 2 July 2008, at 18:36
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