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14-September-2008 18:02:44 - receptor Secretin receptor Identifiers Symbols SCTR; SR External IDs OMIM: 182098 HomoloGene: 68290 Gene ontology Molecular function: receptor activity G-protein coupled receptor activity vasoactive intestinal polypeptide receptor activity secretin receptor activity Cellular component: integral to plasma membrane membrane Biological process: signal transduction G-protein coupled receptor protein signaling pathway digestion excretion RNA expression pattern More reference expression data Orthologs Human Mouse Entrez 6344 n/a Ensembl ENSG00000080293 n/a Uniprot P47872 n/a Refseq NM_002980 mRNA NP_002971 protein n/a mRNA n/a protein Location Chr 2: 119.91 - 120 Mb n/a Pubmed search 1 n/a Human secretin receptor gene name SCTR is a G protein-coupled receptor which binds secretin and is the leading member i.e., first cloned of the class B GPCR subfamily.1 References ^ Dong M, Miller LJ 2002. Molecular pharmacology of the secretin receptor. Recept. Channels 8 3-4: 189-200. PMID 12529936. Further reading Ulrich CD, Holtmann M, Miller LJ 1998. Secretin and vasoactive intestinal peptide receptors: members of a unique family of G protein-coupled receptors.. Gastroenterology 114 2: 382-97. PMID 9453500. Felley CP, Qian JM, Mantey S, et al. 1993. Chief cells possess a receptor with high affinity for PACAP and VIP that stimulates pepsinogen release.. Am. J. Physiol. 263 6 Pt 1: G901-7. PMID 1335692. Ishihara T, Nakamura S, Kaziro Y, et al. 1991. Molecular cloning and expression of a cDNA encoding the secretin receptor.. EMBO J. 10 7: 1635-41. PMID 1646711. Robberecht P, De Neef P, Waelbroeck M, et al. 1988. Secretin receptors in human pancreatic membranes.. Pancreas 3 5: 529-35. PMID 3186683. Chow BK 1995. Molecular cloning and functional characterization of a human secretin receptor.. Biochem. Biophys. Res. Commun. 212 1: 204-11. doi:10.1006/bbrc.1995.1957. PMID 7612008. Patel DR, Kong Y, Sreedharan SP 1995. Molecular cloning and expression of a human secretin receptor.. Mol. Pharmacol. 47 3: 467-73. PMID 7700244. Holtmann MH, Hadac EM, Miller LJ 1995. Critical contributions of amino-terminal extracellular domains in agonist binding and activation of secretin and vasoactive intestinal polypeptide receptors. Studies of chimeric receptors.. J. Biol. Chem. 270 24: 14394-8. PMID 7782300. Jiang S, Ulrich C 1995. Molecular cloning and functional expression of a human pancreatic secretin receptor.. Biochem. Biophys. Res. Commun. 207 3: 883-90. PMID 7864894. Sreedharan SP, Patel DR, Huang JX, Goetzl EJ 1993. Cloning and functional expression of a human neuroendocrine vasoactive intestinal peptide receptor.. Biochem. Biophys. Res. Commun. 193 2: 546-53. doi:10.1006/bbrc.1993.1658. PMID 8390245. Mark HF, Chow BK 1996. Localization of the gene encoding the secretin receptor, SCTR, on human chromosome 2q14.1 by fluorescence in situ hybridization and chromosome morphometry.. Genomics 29 3: 817-8. doi:10.1006/geno.1995.9922. PMID 8575789. Vilardaga JP, di Paolo E, de Neef P, et al. 1996. Lysine 173 residue within the first exoloop of rat secretin receptor is involved in carboxylate moiety recognition of Asp 3 in secretin.. Biochem. Biophys. Res. Commun. 218 3: 842-6. doi:10.1006/bbrc.1996.0150. PMID 8579602. Chow BK 1998. Functional antagonism of the human secretin receptor by a recombinant protein encoding the N-terminal ectodomain of the receptor.. Receptors signal transduction 7 3: 143-50. PMID 9440501. Shetzline MA, Premont RT, Walker JK, et al. 1998. A role for receptor kinases in the regulation of class II G protein-coupled receptors. Phosphorylation and desensitization of the secretin receptor.. J. Biol. Chem. 273 12: 6756-62. PMID 9506976. Ho PK, Fong RS, Kai HS, et al. 1999. The human secretin receptor gene: genomic organization and promoter characterization.. FEBS Lett. 455 3: 209-14. PMID 10437774. Pang RT, Ng SS, Cheng CH, et al. 1999. Role of N-linked glycosylation on the function and expression of the human secretin receptor.. Endocrinology 140 11: 5102-11. PMID 10537138. Chan KY, Pang RT, Chow BK 2001. Functional segregation of the highly conserved basic motifs within the third endoloop of the human secretin receptor.. Endocrinology 142 9: 3926-34. PMID 11517171. Strausberg RL, Feingold EA, Grouse LH, et al. 2003. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 99 26: 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. Pang RT, Lee LT, Ng SS, et al. 2004. CpG methylation and transcription factors Sp1 and Sp3 regulate the expression of the human secretin receptor gene.. Mol. Endocrinol. 18 2: 471-83. doi:10.1210/me.2003-0245. PMID 14645499. Ota T, Suzuki Y, Nishikawa T, et al. 2004. Complete sequencing and characterization of 21,243 full-length human cDNAs.. Nat. Genet. 36 1: 40-5. doi:10.1038/ng1285. PMID 14702039. External links IUPHAR GPCR Database - Secretin receptor MeSH secretin+receptor This transmembrane receptor-related article is a stub. v d e Transmembrane receptor: G protein-coupled receptors Class A: Rhodopsin like Adrenergic α1 A, B, D, α2 A, B, C, β1, β2, β3 Eicosanoid CysLT 1, 2, LTB4 1, 2, FPRL1, OXE, Prostaglandin DP, EP 1, 2, 3, 4, PGF, Prostacyclin, Thromboxane Neuropeptide B/W 1, 2, FF 1, 2, S, Y 1, 2, 4, 5 Orphan GPR 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182 Purinergics Adenosine A1, A2a, A2b, A3, P2Y, 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14 Serotonin all but 5-HT3 5-HT1 A, B, D, E, F, 5-HT2 A, B, C, 5-HT 4, 5A, 6, 7 Other Acetylcholine M1, M2, M3, M4, M5 - Adrenomedullin - Anaphylatoxin C3a, C5a - Angiotensin 1, 2 - Apelin - Bile acid - Bombesin BRS3, GRPR, NMBR - Bradykinin B1, B2 - Cannabinoid CB1, CB2 - Chemokine - Cholecystokinin A, B - Dopamine D1, D2, D3, D4, D5 - EBI2 - Endothelin A, B - Estrogen - Formyl peptide 1, L1, L2 - Free fatty acid 1, 2, 3, 4 - FSH - Galanin 1, 2, 3 - Gonadotropin-releasing hormone 1, 2 - Ghrelin - Histamine H1, H2, H3, H4 - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid 1, 2, 3, 4, 5, 6, 7, 8 - MAS 1, 1L, D, E, F, G, X1, X2, X3, X4 - Melanocortin 1, 2, 3, 4, 5 - MCHR 1, 2 - Melatonin 1A, 1B- Motilin - neuromedin B, U 1, 2 - Neurotensin 1, 2 - Opioid Delta, Kappa, Mu, Nociceptin, but not Sigma - Olfactory - Opsin 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH - Orexin 1, 2 - Oxytocin - Oxoglutarate - PAF - Prokineticin 1, 2 - Prolactin-releasing peptide - Protease-activated 1, 2, 3, 4 - Relaxin 1, 2, 3, 4 - Somatostatin 1, 2, 3, 4, 5 - SREB - Succinate - TAAR 1, 2, 3, 5, 6, 8, 9 - Tachykinin 1, 2, 3 - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin 1A, 1B, 2 Class B: Secretin like Brain-specific angiogenesis inhibitor 1, 2, 3 - Cadherin 1, 2, 3 - Calcitonin - CD97 - Corticotropin-releasing hormone 1, 2 - EMR 1, 2, 3 - Glucagon GR, GIPR, GLP1R, GLP2R - Growth hormone releasing hormone - PACAPR1- GPR 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157 - Latrophilin 1, 2, 3, ELTD1 - Parathyroid hormone 1, 2 - Secretin - Vasoactive intestinal peptide 1, 2 Class C: Metabotropic glutamate / pheromone Calcium-sensing receptor - GABA B 1, 2 - Glutamate receptor Metabotropic glutamate 1, 2, 3, 4, 5, 6, 7, 8 - GPRC6A - GPR 156, 158, 179 - RAIG 1, 2, 3, 4 - Taste receptors TAS1R 1, 2, 3 TAS2R 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50 Frizzled / Smoothened Frizzled 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 - Smoothened Retrieved from http://en..org/wiki/Secretin_receptor Categories: Genes on chromosome 2 | Human proteins | Transmembrane receptor stubs | G protein coupled receptorsHidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 8 July 2008, at 03:58
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