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14-September-2008 18:02:48 - Sheehan's syndrome Sheehan syndrome Classification and external resources ICD-10 E23.0 ICD-9 253.2 DiseasesDB 11998 MedlinePlus 001175 eMedicine med/1914 MeSH D007018 Sheehan syndrome, also known as postpartum hypopituitarism or postpartum pituitary necrosis, is hypopituitarism decreased functioning of the pituitary gland, caused by necrosis due to blood loss and hypovolemic shock during and after childbirth. Contents 1 Causes 2 Pathophysiology 3 Eponym 4 References 5 External links Causes It is a rare complication of pregnancy, usually occurring after excessive blood loss; the presence of disseminated intravascular coagulation i.e., in amniotic fluid embolism or HELLP syndrome also appears to be a factor in its development. Pathophysiology Hypertrophy and hyperplasia of lactotrophs during pregnancy results in the enlargement of the anterior pituitary, without a corresponding increase in blood supply. Secondly, the anterior pituitary is supplied by a low pressure portal venous system.1 These vulnerabilities, when affected by major hemorrhage or hypotension during the peripartum period, can result in ischaemia of the affected pituitary regions leading to necrosis. The posterior pituitary is usually not affected due to its direct arterial supply. Eponym It is named for Harold Sheehan.23 References ^ http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=endocrinpart=A1257 under heading Sheehan's syndrome ^ synd/2009 at Who Named It ^ H. L. Sheehan. Post-partum necrosis of anterior pituitary. The Journal of Pathology and Bacteriology, Chichester, 1937, 45: 189-214. External links Pathology at vcu.edu v d e Endocrine pathology: endocrine diseases E00-35, 240-259 Pancreas/ glucose metabolism Diabetes mellitus types: type 1, type 2, MODY, complications: coma, angiopathy, ketoacidosis, nephropathy, neuropathy, retinopathy Hypoglycemia - Hyperinsulinism - Zollinger-Ellison syndrome - insulin receptor Rabson-Mendenhall syndrome - Insulin resistance Hypothalamic/ pituitary axes Pituitary Hyperpituitarism Acromegaly, Hyperprolactinaemia, SIADH Hypopituitarism Sheehan's syndrome, Kallmann syndrome, Growth hormone deficiency, Diabetes insipidus Adiposogenital dystrophy - Empty sella syndrome - Pituitary apoplexy - ACTH deficiency Thyroid Hypothyroidism Iodine deficiency, Cretinism, Congenital hypothyroidism, Goitre, Myxedema Hyperthyroidism Graves disease, Toxic multinodular goitre, Teratoma with thyroid tissue or Struma ovarii Thyroiditis De Quervain's thyroiditis, Hashimoto's thyroiditis, Riedel's thyroiditis Euthyroid sick syndrome - Thyroid hormone resistance - Thyroid nodule Parathyroid Hypoparathyroidism Pseudohypoparathyroidism - Hyperparathyroidism Primary, Secondary, Tertiary Adrenal Adrenocortical hyperfunction: Cushing's syndrome Nelson's syndrome, Pseudo-Cushing's syndrome - Hyperaldosteronism Conn syndrome, Bartter syndrome CAH Lipoid, 3β, 11β, 17α, 21α Adrenal insufficiency Addison's disease, Waterhouse-Friderichsen syndrome - Hypoaldosteronism Gonads ovarian Polycystic ovary syndrome, Premature ovarian failure testicular 5-alpha-reductase deficiency, 17-beta-hydroxysteroid dehydrogenase deficiency general Hypogonadism, Delayed puberty, Precocious puberty Other Androgen insensitivity syndrome - Autoimmune polyendocrine syndrome - Carcinoid syndrome - Gigantism - Short stature Laron syndrome, Psychogenic dwarfism - Multiple endocrine neoplasia 1, 2 - Progeria - Woodhouse-Sakati syndrome - thymus Abscess of thymus, Thymus hyperplasia see also congenital, neoplasia This disease article is a stub. Retrieved from http://en..org/wiki/Sheehan%27s_syndrome Categories: Disease stubs | Neuroendocrinology | Obstetrics Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages Deutsch Español Français Hrvatski Italiano 日本語 Polski Português РуÑ?Ñ?кий This page was last modified on 3 August 2008, at 20:15
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