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14-September-2008 18:02:45 - R3 Taste receptor, type 1, member 3 Identifiers Symbols TAS1R3; T1R3 External IDs OMIM: 605865 MGI: 1933547 HomoloGene: 12890 Gene ontology Molecular function: receptor activity metabotropic glutamate, GABA-B-like receptor activity taste receptor activity protein heterodimerization activity Cellular component: membrane integral to membrane Biological process: signal transduction G-protein coupled receptor protein signaling pathway response to stimulus sensory perception of sweet taste sensory perception of umami taste Orthologs Human Mouse Entrez 83756 83771 Ensembl ENSG00000169962 ENSMUSG00000029072 Uniprot Q7RTX0 Q925D8 Refseq NM_152228 mRNA NP_689414 protein NM_031872 mRNA NP_114078 protein Location Chr 1: 1.26 - 1.26 Mb Chr 4: 154.7 - 154.71 Mb Pubmed search 1 2 Taste receptor, type 1, member 3, also known as TAS1R3, is a human gene.1 The TAS1R3 gene encodes the human homolog of mouse Sac, a major determinant of differences between sweet-sensitive and -insensitive mouse strains in their responsiveness to sucrose, saccharin, and other sweeteners.supplied by OMIM1 See also Taste receptor References ^ a b Entrez Gene: TAS1R3 taste receptor, type 1, member 3. Further reading Chandrashekar J, Hoon MA, Ryba NJ, Zuker CS 2007. The receptors and cells for mammalian taste.. Nature 444 7117: 288-94. doi:10.1038/nature05401. PMID 17108952. Montmayeur JP, Liberles SD, Matsunami H, Buck LB 2001. A candidate taste receptor gene near a sweet taste locus.. Nat. Neurosci. 4 5: 492-8. doi:10.1038/87440. PMID 11319557. Max M, Shanker YG, Huang L, et al. 2001. Tas1r3, encoding a new candidate taste receptor, is allelic to the sweet responsiveness locus Sac.. Nat. Genet. 28 1: 58-63. doi:10.1038/88270. PMID 11326277. Nelson G, Chandrashekar J, Hoon MA, et al. 2002. An amino-acid taste receptor.. Nature 416 6877: 199-202. doi:10.1038/nature726. PMID 11894099. Li X, Staszewski L, Xu H, et al. 2002. Human receptors for sweet and umami taste.. Proc. Natl. Acad. Sci. U.S.A. 99 7: 4692-6. doi:10.1073/pnas.072090199. PMID 11917125. Spadaccini R, Trabucco F, Saviano G, et al. 2003. The mechanism of interaction of sweet proteins with the T1R2-T1R3 receptor: evidence from the solution structure of G16A-MNEI.. J. Mol. Biol. 328 3: 683-92. PMID 12706725. Ariyasu T, Matsumoto S, Kyono F, et al. 2004. Taste receptor T1R3 is an essential molecule for the cellular recognition of the disaccharide trehalose.. In Vitro Cell. Dev. Biol. Anim. 39 1-2: 80-8. doi:10.1290/1543-706X20030390080:TRTIAE2.0.CO;2. PMID 12892531. Jiang P, Ji Q, Liu Z, et al. 2004. The cysteine-rich region of T1R3 determines responses to intensely sweet proteins.. J. Biol. Chem. 279 43: 45068-75. doi:10.1074/jbc.M406779200. PMID 15299024. Xu H, Staszewski L, Tang H, et al. 2005. Different functional roles of T1R subunits in the heteromeric taste receptors.. Proc. Natl. Acad. Sci. U.S.A. 101 39: 14258-63. doi:10.1073/pnas.0404384101. PMID 15353592. Taniguchi K 2005. Expression of the sweet receptor protein, T1R3, in the human liver and pancreas.. J. Vet. Med. Sci. 66 11: 1311-4. PMID 15585941. Jiang P, Cui M, Zhao B, et al. 2005. Lactisole interacts with the transmembrane domains of human T1R3 to inhibit sweet taste.. J. Biol. Chem. 280 15: 15238-46. doi:10.1074/jbc.M414287200. PMID 15668251. Galindo-Cuspinera V, Winnig M, Bufe B, et al. 2006. A TAS1R receptor-based explanation of sweet 'water-taste'.. Nature 441 7091: 354-7. doi:10.1038/nature04765. PMID 16633339. Gregory SG, Barlow KF, McLay KE, et al. 2006. The DNA sequence and biological annotation of human chromosome 1.. Nature 441 7091: 315-21. doi:10.1038/nature04727. PMID 16710414. Behrens M, Bartelt J, Reichling C, et al. 2006. Members of RTP and REEP gene families influence functional bitter taste receptor expression.. J. Biol. Chem. 281 29: 20650-9. doi:10.1074/jbc.M513637200. PMID 16720576. Koizumi A, Nakajima K, Asakura T, et al. 2007. Taste-modifying sweet protein, neoculin, is received at human T1R3 amino terminal domain.. Biochem. Biophys. Res. Commun. 358 2: 585-9. doi:10.1016/j.bbrc.2007.04.171. PMID 17499612. This transmembrane receptor-related article is a stub. This article incorporates text from the United States National Library of Medicine, which is in the public domain. v d e Transmembrane receptor: G protein-coupled receptors Class A: Rhodopsin like Adrenergic α1 A, B, D, α2 A, B, C, β1, β2, β3 Eicosanoid CysLT 1, 2, LTB4 1, 2, FPRL1, OXE, Prostaglandin DP, EP 1, 2, 3, 4, PGF, Prostacyclin, Thromboxane Neuropeptide B/W 1, 2, FF 1, 2, S, Y 1, 2, 4, 5 Orphan GPR 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182 Purinergics Adenosine A1, A2a, A2b, A3, P2Y, 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14 Serotonin all but 5-HT3 5-HT1 A, B, D, E, F, 5-HT2 A, B, C, 5-HT 4, 5A, 6, 7 Other Acetylcholine M1, M2, M3, M4, M5 - Adrenomedullin - Anaphylatoxin C3a, C5a - Angiotensin 1, 2 - Apelin - Bile acid - Bombesin BRS3, GRPR, NMBR - Bradykinin B1, B2 - Cannabinoid CB1, CB2 - Chemokine - Cholecystokinin A, B - Dopamine D1, D2, D3, D4, D5 - EBI2 - Endothelin A, B - Estrogen - Formyl peptide 1, L1, L2 - Free fatty acid 1, 2, 3, 4 - FSH - Galanin 1, 2, 3 - Gonadotropin-releasing hormone 1, 2 - Ghrelin - Histamine H1, H2, H3, H4 - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid 1, 2, 3, 4, 5, 6, 7, 8 - MAS 1, 1L, D, E, F, G, X1, X2, X3, X4 - Melanocortin 1, 2, 3, 4, 5 - MCHR 1, 2 - Melatonin 1A, 1B- Motilin - neuromedin B, U 1, 2 - Neurotensin 1, 2 - Opioid Delta, Kappa, Mu, Nociceptin, but not Sigma - Olfactory - Opsin 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH - Orexin 1, 2 - Oxytocin - Oxoglutarate - PAF - Prokineticin 1, 2 - Prolactin-releasing peptide - Protease-activated 1, 2, 3, 4 - Relaxin 1, 2, 3, 4 - Somatostatin 1, 2, 3, 4, 5 - SREB - Succinate - TAAR 1, 2, 3, 5, 6, 8, 9 - Tachykinin 1, 2, 3 - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin 1A, 1B, 2 Class B: Secretin like Brain-specific angiogenesis inhibitor 1, 2, 3 - Cadherin 1, 2, 3 - Calcitonin - CD97 - Corticotropin-releasing hormone 1, 2 - EMR 1, 2, 3 - Glucagon GR, GIPR, GLP1R, GLP2R - Growth hormone releasing hormone - PACAPR1- GPR 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157 - Latrophilin 1, 2, 3, ELTD1 - Parathyroid hormone 1, 2 - Secretin - Vasoactive intestinal peptide 1, 2 Class C: Metabotropic glutamate / pheromone Calcium-sensing receptor - GABA B 1, 2 - Glutamate receptor Metabotropic glutamate 1, 2, 3, 4, 5, 6, 7, 8 - GPRC6A - GPR 156, 158, 179 - RAIG 1, 2, 3, 4 - Taste receptors TAS1R 1, 2, 3 TAS2R 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50 Frizzled / Smoothened Frizzled 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 - Smoothened Retrieved from http://en..org/wiki/TAS1R3
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