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14-September-2008 18:02:45 - 6 Taste receptor, type 2, member 16 Identifiers Symbols TAS2R16; T2R16 External IDs OMIM: 604867 MGI: 2681247 HomoloGene: 9660 Gene ontology Molecular function: receptor activity G-protein coupled receptor activity taste receptor activity Cellular component: membrane integral to membrane Biological process: signal transduction G-protein coupled receptor protein signaling pathway response to stimulus sensory perception of taste RNA expression pattern More reference expression data Orthologs Human Mouse Entrez 50833 387347 Ensembl ENSG00000128519 ENSMUSG00000043865 Uniprot Q9NYV7 A0AUK2 Refseq NM_016945 mRNA NP_058641 protein NM_207022 mRNA NP_996905 protein Location Chr 7: 122.42 - 122.42 Mb Chr 6: 23.92 - 23.92 Mb Pubmed search 1 2 TAS2R16 taste receptor, type 2, member 16 is a human gene that encodes for a receptor that may play a role in the perception of bitterness. 12 Variants of this gene have been linked to an increased risk for alcohol dependence.3 The TAS2R16 gene is located on the long q arm of chromosome 7 at position 31.1 - 31.3, from base pair 122,228,764 to base pair 122,229,639. Contents 1 See also 2 References 3 Further reading 4 External links See also Taste receptor References ^ Bufe B, Hofmann T, Krautwurst D, Raguse JD, Meyerhof W 2002. The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides. Nat Genet 32 3: 397-401. doi:10.1038/ng1014. PMID 12379855. ^ Drewnowski A 2001. The science and complexity of bitter taste. Nutr Rev 59 6: 163-9. PMID 11444592. ^ Hinrichs AL, Wang JC, Bufe B, et al 2006. Functional variant in a bitter-taste receptor hTAS2R16 influences risk of alcohol dependence. Am. J. Hum. Genet. 78 1: 103-11. doi:10.1086/499253. PMID 16385453. Further reading Kinnamon SC 2000. A plethora of taste receptors.. Neuron 25 3: 507-10. PMID 10774719. Margolskee RF 2002. Molecular mechanisms of bitter and sweet taste transduction.. J. Biol. Chem. 277 1: 1-4. doi:10.1074/jbc.R100054200. PMID 11696554. Montmayeur JP, Matsunami H 2002. Receptors for bitter and sweet taste.. Curr. Opin. Neurobiol. 12 4: 366-71. PMID 12139982. Adler E, Hoon MA, Mueller KL, et al. 2000. A novel family of mammalian taste receptors.. Cell 100 6: 693-702. PMID 10761934. Chandrashekar J, Mueller KL, Hoon MA, et al. 2000. T2Rs function as bitter taste receptors.. Cell 100 6: 703-11. PMID 10761935. Firestein S 2000. The good taste of genomics.. Nature 404 6778: 552-3. doi:10.1038/35007167. PMID 10766221. Matsunami H, Montmayeur JP, Buck LB 2000. A family of candidate taste receptors in human and mouse.. Nature 404 6778: 601-4. doi:10.1038/35007072. PMID 10766242. Bufe B, Hofmann T, Krautwurst D, et al. 2002. The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides.. Nat. Genet. 32 3: 397-401. doi:10.1038/ng1014. PMID 12379855. Strausberg RL, Feingold EA, Grouse LH, et al. 2003. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 99 26: 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. Zhang Y, Hoon MA, Chandrashekar J, et al. 2003. Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways.. Cell 112 3: 293-301. PMID 12581520. Hillier LW, Fulton RS, Fulton LA, et al. 2003. The DNA sequence of human chromosome 7.. Nature 424 6945: 157-64. doi:10.1038/nature01782. PMID 12853948. Gerhard DS, Wagner L, Feingold EA, et al. 2004. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection MGC.. Genome Res. 14 10B: 2121-7. doi:10.1101/gr.2596504. PMID 15489334. Fischer A, Gilad Y, Man O, Pääbo S 2005. Evolution of bitter taste receptors in humans and apes.. Mol. Biol. Evol. 22 3: 432-6. doi:10.1093/molbev/msi027. PMID 15496549. Go Y, Satta Y, Takenaka O, Takahata N 2006. Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates.. Genetics 170 1: 313-26. doi:10.1534/genetics.104.037523. PMID 15744053. Mueller KL, Hoon MA, Erlenbach I, et al. 2005. The receptors and coding logic for bitter taste.. Nature 434 7030: 225-9. doi:10.1038/nature03352. PMID 15759003. Hinrichs AL, Wang JC, Bufe B, et al. 2006. Functional variant in a bitter-taste receptor hTAS2R16 influences risk of alcohol dependence.. Am. J. Hum. Genet. 78 1: 103-11. doi:10.1086/499253. PMID 16385453. Behrens M, Bartelt J, Reichling C, et al. 2006. Members of RTP and REEP gene families influence functional bitter taste receptor expression.. J. Biol. Chem. 281 29: 20650-9. doi:10.1074/jbc.M513637200. PMID 16720576. External links GeneCard for TAS2R16 MeSH TAS2R16+protein,+human This transmembrane receptor-related article is a stub. v d e Transmembrane receptor: G protein-coupled receptors Class A: Rhodopsin like Adrenergic α1 A, B, D, α2 A, B, C, β1, β2, β3 Eicosanoid CysLT 1, 2, LTB4 1, 2, FPRL1, OXE, Prostaglandin DP, EP 1, 2, 3, 4, PGF, Prostacyclin, Thromboxane Neuropeptide B/W 1, 2, FF 1, 2, S, Y 1, 2, 4, 5 Orphan GPR 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182 Purinergics Adenosine A1, A2a, A2b, A3, P2Y, 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14 Serotonin all but 5-HT3 5-HT1 A, B, D, E, F, 5-HT2 A, B, C, 5-HT 4, 5A, 6, 7 Other Acetylcholine M1, M2, M3, M4, M5 - Adrenomedullin - Anaphylatoxin C3a, C5a - Angiotensin 1, 2 - Apelin - Bile acid - Bombesin BRS3, GRPR, NMBR - Bradykinin B1, B2 - Cannabinoid CB1, CB2 - Chemokine - Cholecystokinin A, B - Dopamine D1, D2, D3, D4, D5 - EBI2 - Endothelin A, B - Estrogen - Formyl peptide 1, L1, L2 - Free fatty acid 1, 2, 3, 4 - FSH - Galanin 1, 2, 3 - Gonadotropin-releasing hormone 1, 2 - Ghrelin - Histamine H1, H2, H3, H4 - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid 1, 2, 3, 4, 5, 6, 7, 8 - MAS 1, 1L, D, E, F, G, X1, X2, X3, X4 - Melanocortin 1, 2, 3, 4, 5 - MCHR 1, 2 - Melatonin 1A, 1B- Motilin - neuromedin B, U 1, 2 - Neurotensin 1, 2 - Opioid Delta, Kappa, Mu, Nociceptin, but not Sigma - Olfactory - Opsin 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH - Orexin 1, 2 - Oxytocin - Oxoglutarate - PAF - Prokineticin 1, 2 - Prolactin-releasing peptide - Protease-activated 1, 2, 3, 4 - Relaxin 1, 2, 3, 4 - Somatostatin 1, 2, 3, 4, 5 - SREB - Succinate - TAAR 1, 2, 3, 5, 6, 8, 9 - Tachykinin 1, 2, 3 - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin 1A, 1B, 2 Class B: Secretin like Brain-specific angiogenesis inhibitor 1, 2, 3 - Cadherin 1, 2, 3 - Calcitonin - CD97 - Corticotropin-releasing hormone 1, 2 - EMR 1, 2, 3 - Glucagon GR, GIPR, GLP1R, GLP2R - Growth hormone releasing hormone - PACAPR1- GPR 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157 - Latrophilin 1, 2, 3, ELTD1 - Parathyroid hormone 1, 2 - Secretin - Vasoactive intestinal peptide 1, 2 Class C: Metabotropic glutamate / pheromone Calcium-sensing receptor - GABA B 1, 2 - Glutamate receptor Metabotropic glutamate 1, 2, 3, 4, 5, 6, 7, 8 - GPRC6A - GPR 156, 158, 179 - RAIG 1, 2, 3, 4 - Taste receptors TAS1R 1, 2, 3 TAS2R 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50 Frizzled / Smoothened Frizzled 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 - Smoothened Retrieved from http://en..org/wiki/TAS2R16 Categories: Genes on chromosome 7 | Human proteins | Transmembrane receptor stubs | Genes | G protein coupled receptorsHidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 8 July 2008, at 02:00
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