Sierra Acai Company
Sierra Acai Company
Open 7 Days a Week
MonaVie Independent Distributor
Distributor Training
Shop Online
Enroll Now
Buy Wholesale and maintain an Active status for 2 months and we will refund your $39 Distributor Fee
Friends
Buy Wholesale and maintain an Active status for 2 months and we will refund your $39 Distributor Fee
14-September-2008 18:02:45 - Taste receptor, type 2, member 3 Identifiers Symbols TAS2R3; T2R3 External IDs OMIM: 604868 MGI: 3606604 HomoloGene: 23231 Gene ontology Molecular function: receptor activity G-protein coupled receptor activity taste receptor activity Cellular component: membrane integral to membrane Biological process: signal transduction G-protein coupled receptor protein signaling pathway response to stimulus sensory perception of taste RNA expression pattern More reference expression data Orthologs Human Mouse Entrez 50831 574417 Ensembl ENSG00000127362 ENSMUSG00000052850 Uniprot Q9NYW6 Q7TQA7 Refseq NM_016943 mRNA NP_058639 protein NM_001025385 mRNA NP_001020556 protein Location Chr 7: 141.11 - 141.11 Mb Chr 6: 40.42 - 40.42 Mb Pubmed search 1 2 Taste receptor, type 2, member 3, also known as TAS2R3, is a human gene.1 This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. These apparently intronless taste receptor genes encode a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception.1 See also Taste receptor References ^ a b Entrez Gene: TAS2R3 taste receptor, type 2, member 3. Further reading Kinnamon SC 2000. A plethora of taste receptors.. Neuron 25 3: 507-10. PMID 10774719. Margolskee RF 2002. Molecular mechanisms of bitter and sweet taste transduction.. J. Biol. Chem. 277 1: 1-4. doi:10.1074/jbc.R100054200. PMID 11696554. Montmayeur JP, Matsunami H 2002. Receptors for bitter and sweet taste.. Curr. Opin. Neurobiol. 12 4: 366-71. PMID 12139982. Adler E, Hoon MA, Mueller KL, et al. 2000. A novel family of mammalian taste receptors.. Cell 100 6: 693-702. PMID 10761934. Chandrashekar J, Mueller KL, Hoon MA, et al. 2000. T2Rs function as bitter taste receptors.. Cell 100 6: 703-11. PMID 10761935. Firestein S 2000. The good taste of genomics.. Nature 404 6778: 552-3. doi:10.1038/35007167. PMID 10766221. Matsunami H, Montmayeur JP, Buck LB 2000. A family of candidate taste receptors in human and mouse.. Nature 404 6778: 601-4. doi:10.1038/35007072. PMID 10766242. Ueda T, Ugawa S, Ishida Y, et al. 2001. Identification of coding single-nucleotide polymorphisms in human taste receptor genes involving bitter tasting.. Biochem. Biophys. Res. Commun. 285 1: 147-51. doi:10.1006/bbrc.2001.5136. PMID 11437385. Strausberg RL, Feingold EA, Grouse LH, et al. 2003. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 99 26: 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. Zhang Y, Hoon MA, Chandrashekar J, et al. 2003. Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways.. Cell 112 3: 293-301. PMID 12581520. Scherer SW, Cheung J, MacDonald JR, et al. 2003. Human chromosome 7: DNA sequence and biology.. Science 300 5620: 767-72. doi:10.1126/science.1083423. PMID 12690205. Hillier LW, Fulton RS, Fulton LA, et al. 2003. The DNA sequence of human chromosome 7.. Nature 424 6945: 157-64. doi:10.1038/nature01782. PMID 12853948. Gerhard DS, Wagner L, Feingold EA, et al. 2004. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection MGC.. Genome Res. 14 10B: 2121-7. doi:10.1101/gr.2596504. PMID 15489334. Fischer A, Gilad Y, Man O, Pääbo S 2005. Evolution of bitter taste receptors in humans and apes.. Mol. Biol. Evol. 22 3: 432-6. doi:10.1093/molbev/msi027. PMID 15496549. Go Y, Satta Y, Takenaka O, Takahata N 2006. Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates.. Genetics 170 1: 313-26. doi:10.1534/genetics.104.037523. PMID 15744053. This transmembrane receptor-related article is a stub. This article incorporates text from the United States National Library of Medicine, which is in the public domain. v d e Transmembrane receptor: G protein-coupled receptors Class A: Rhodopsin like Adrenergic α1 A, B, D, α2 A, B, C, β1, β2, β3 Eicosanoid CysLT 1, 2, LTB4 1, 2, FPRL1, OXE, Prostaglandin DP, EP 1, 2, 3, 4, PGF, Prostacyclin, Thromboxane Neuropeptide B/W 1, 2, FF 1, 2, S, Y 1, 2, 4, 5 Orphan GPR 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182 Purinergics Adenosine A1, A2a, A2b, A3, P2Y, 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14 Serotonin all but 5-HT3 5-HT1 A, B, D, E, F, 5-HT2 A, B, C, 5-HT 4, 5A, 6, 7 Other Acetylcholine M1, M2, M3, M4, M5 - Adrenomedullin - Anaphylatoxin C3a, C5a - Angiotensin 1, 2 - Apelin - Bile acid - Bombesin BRS3, GRPR, NMBR - Bradykinin B1, B2 - Cannabinoid CB1, CB2 - Chemokine - Cholecystokinin A, B - Dopamine D1, D2, D3, D4, D5 - EBI2 - Endothelin A, B - Estrogen - Formyl peptide 1, L1, L2 - Free fatty acid 1, 2, 3, 4 - FSH - Galanin 1, 2, 3 - Gonadotropin-releasing hormone 1, 2 - Ghrelin - Histamine H1, H2, H3, H4 - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid 1, 2, 3, 4, 5, 6, 7, 8 - MAS 1, 1L, D, E, F, G, X1, X2, X3, X4 - Melanocortin 1, 2, 3, 4, 5 - MCHR 1, 2 - Melatonin 1A, 1B- Motilin - neuromedin B, U 1, 2 - Neurotensin 1, 2 - Opioid Delta, Kappa, Mu, Nociceptin, but not Sigma - Olfactory - Opsin 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH - Orexin 1, 2 - Oxytocin - Oxoglutarate - PAF - Prokineticin 1, 2 - Prolactin-releasing peptide - Protease-activated 1, 2, 3, 4 - Relaxin 1, 2, 3, 4 - Somatostatin 1, 2, 3, 4, 5 - SREB - Succinate - TAAR 1, 2, 3, 5, 6, 8, 9 - Tachykinin 1, 2, 3 - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin 1A, 1B, 2 Class B: Secretin like Brain-specific angiogenesis inhibitor 1, 2, 3 - Cadherin 1, 2, 3 - Calcitonin - CD97 - Corticotropin-releasing hormone 1, 2 - EMR 1, 2, 3 - Glucagon GR, GIPR, GLP1R, GLP2R - Growth hormone releasing hormone - PACAPR1- GPR 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157 - Latrophilin 1, 2, 3, ELTD1 - Parathyroid hormone 1, 2 - Secretin - Vasoactive intestinal peptide 1, 2 Class C: Metabotropic glutamate / pheromone Calcium-sensing receptor - GABA B 1, 2 - Glutamate receptor Metabotropic glutamate 1, 2, 3, 4, 5, 6, 7, 8 - GPRC6A - GPR 156, 158, 179 - RAIG 1, 2, 3, 4 - Taste receptors TAS1R 1, 2, 3 TAS2R 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50 Frizzled / Smoothened Frizzled 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 - Smoothened Retrieved from http://en..org/wiki/TAS2R3 Categories: Genes on chromosome 7 | Human proteins | Transmembrane receptor stubs | G protein coupled receptorsHidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 9 July 2008, at 05:54
39 Reasons to Drink Acai Juice Every Day
What is MonaVie - Watch the 8-minute video
Discovering MonaVie Video
The Power of You Video
Effects of MonaVie Active on Antioxidant Capacity in Humans
Log into your Wholesale MonaVie Account
So many of us do not eat a balanced diet, get enough sleep, have too much stress, or are impacted with toxins and pollutants. Drinking 2 ounces of MonaVie twice a day will help your body detoxify as well as build your immune system. Its the smartest thing you can do for yourself, so start today. Buying MonaVie through our company guarantees you support 7 days a week and, if you would like to share MonaVie with your family and friends we will guide you from start to finish.
1. Click on Enroll Now (30 - 55% off retail price)
2. Pay $39 for your Wholesale ID number.
3. NO minimum order required.
4. MonaVie is delivered to your door in 3 to 5 days.