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14-September-2008 18:02:45 - 8 Taste receptor, type 2, member 38 Identifiers Symbols TAS2R38; PTC; T2R61 External IDs OMIM: 607751 MGI: 2681306 HomoloGene: 47976 Gene ontology Molecular function: receptor activity G-protein coupled receptor activity Cellular component: membrane integral to membrane Biological process: signal transduction G-protein coupled receptor protein signaling pathway response to stimulus sensory perception of taste Orthologs Human Mouse Entrez 5726 387513 Ensembl ENSG00000183609 ENSMUSG00000058250 Uniprot P59533 A0PK79 Refseq NM_176817 mRNA NP_789787 protein NM_001001451 mRNA NP_001001451 protein Location Chr 7: 141.32 - 141.32 Mb Chr 6: 40.54 - 40.54 Mb Pubmed search 1 2 TAS2R38 is a bitter taste receptor12 which facilitates the tasting of phenylthiocarbamide PTC3 and propylthiouracil PROP, 4, although it does not explain supertasting 5. Contents 1 References 2 Further reading 3 See also 4 External links References ^ Conte C, Ebeling M, Marcuz A, Nef P, Andres-Barquin PJ 2002. Identification and characterization of human taste receptor genes belonging to the TAS2R family. Cytogenet. Genome Res. 98 1: 45-53. doi:10.1159/000068546. PMID 12584440. ^ Drayna D, Coon H, Kim UK, Elsner T, Cromer K, Otterud B, Baird L, Peiffer AP, Leppert M 2003. Genetic analysis of a complex trait in the Utah Genetic Reference Project: a major locus for PTC taste ability on chromosome 7q and a secondary locus on chromosome 16p. Hum. Genet. 112 5-6: 567-72. doi:10.1007/s00439-003-0911-y. PMID 12624758. ^ Prodi DA, Drayna D, Forabosco P, Palmas MA, Maestrale GB, Piras D, Pirastu M, Angius A 2004. Bitter taste study in a sardinian genetic isolate supports the association of phenylthiocarbamide sensitivity to the TAS2R38 bitter receptor gene. Chem. Senses 29 8: 697-702. doi:10.1093/chemse/bjh074. PMID 15466815. ^ Duffy VB, Davidson AC, Kidd JR, Kidd KK, Speed WC, Pakstis AJ, Reed DR, Snyder DJ, Bartoshuk LM 2004. Bitter receptor gene TAS2R38, 6-n-propylthiouracil PROP bitterness and alcohol intake. Alcohol. Clin. Exp. Res. 28 11: 1629-37. doi:10.1097/01.ALC.0000145789.55183.D4.. PMID 15547448. ^ Hayes JE, Bartoshuk LM, Kidd JR, Duffy VB 2008. Supertasting and PROP Bitterness Depends on More Than the TAS2R38 Gene. Chem Senses 33 3: 255-65. doi:10.1093/chemse/bjm084. PMID 18209019. Further reading Margolskee RF 2002. Molecular mechanisms of bitter and sweet taste transduction.. J. Biol. Chem. 277 1: 1-4. doi:10.1074/jbc.R100054200. PMID 11696554. Montmayeur JP, Matsunami H 2002. Receptors for bitter and sweet taste.. Curr. Opin. Neurobiol. 12 4: 366-71. PMID 12139982. Kim UK, Drayna D 2005. Genetics of individual differences in bitter taste perception: lessons from the PTC gene.. Clin. Genet. 67 4: 275-80. doi:10.1111/j.1399-0004.2004.00361.x. PMID 15733260. Anne-Spence M, Falk CT, Neiswanger K, et al. 1984. Estimating the recombination frequency for the PTC-Kell linkage.. Hum. Genet. 67 2: 183-6. PMID 6745938. Bufe B, Hofmann T, Krautwurst D, et al. 2002. The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides.. Nat. Genet. 32 3: 397-401. doi:10.1038/ng1014. PMID 12379855. Strausberg RL, Feingold EA, Grouse LH, et al. 2003. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 99 26: 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. Zhang Y, Hoon MA, Chandrashekar J, et al. 2003. Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways.. Cell 112 3: 293-301. PMID 12581520. Conte C, Ebeling M, Marcuz A, et al. 2003. Identification and characterization of human taste receptor genes belonging to the TAS2R family.. Cytogenet. Genome Res. 98 1: 45-53. doi:10.1159/000068546. PMID 12584440. Kim UK, Jorgenson E, Coon H, et al. 2003. Positional cloning of the human quantitative trait locus underlying taste sensitivity to phenylthiocarbamide.. Science 299 5610: 1221-5. doi:10.1126/science.1080190. PMID 12595690. Drayna D, Coon H, Kim UK, et al. 2003. Genetic analysis of a complex trait in the Utah Genetic Reference Project: a major locus for PTC taste ability on chromosome 7q and a secondary locus on chromosome 16p.. Hum. Genet. 112 5-6: 567-72. doi:10.1007/s00439-003-0911-y. PMID 12624758. Scherer SW, Cheung J, MacDonald JR, et al. 2003. Human chromosome 7: DNA sequence and biology.. Science 300 5620: 767-72. doi:10.1126/science.1083423. PMID 12690205. Wooding S, Kim UK, Bamshad MJ, et al. 2004. Natural selection and molecular evolution in PTC, a bitter-taste receptor gene.. Am. J. Hum. Genet. 74 4: 637-46. doi:10.1086/383092. PMID 14997422. Pronin AN, Tang H, Connor J, Keung W 2005. Identification of ligands for two human bitter T2R receptors.. Chem. Senses 29 7: 583-93. doi:10.1093/chemse/bjh064. PMID 15337684. Prodi DA, Drayna D, Forabosco P, et al. 2005. Bitter taste study in a sardinian genetic isolate supports the association of phenylthiocarbamide sensitivity to the TAS2R38 bitter receptor gene.. Chem. Senses 29 8: 697-702. doi:10.1093/chemse/bjh074. PMID 15466815. Gerhard DS, Wagner L, Feingold EA, et al. 2004. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection MGC.. Genome Res. 14 10B: 2121-7. doi:10.1101/gr.2596504. PMID 15489334. Fischer A, Gilad Y, Man O, Pääbo S 2005. Evolution of bitter taste receptors in humans and apes.. Mol. Biol. Evol. 22 3: 432-6. doi:10.1093/molbev/msi027. PMID 15496549. Go Y, Satta Y, Takenaka O, Takahata N 2006. Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates.. Genetics 170 1: 313-26. doi:10.1534/genetics.104.037523. PMID 15744053. See also Supertaster External links MeSH TAS2R38+protein,+human This transmembrane receptor-related article is a stub. v d e Transmembrane receptor: G protein-coupled receptors Class A: Rhodopsin like Adrenergic α1 A, B, D, α2 A, B, C, β1, β2, β3 Eicosanoid CysLT 1, 2, LTB4 1, 2, FPRL1, OXE, Prostaglandin DP, EP 1, 2, 3, 4, PGF, Prostacyclin, Thromboxane Neuropeptide B/W 1, 2, FF 1, 2, S, Y 1, 2, 4, 5 Orphan GPR 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182 Purinergics Adenosine A1, A2a, A2b, A3, P2Y, 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14 Serotonin all but 5-HT3 5-HT1 A, B, D, E, F, 5-HT2 A, B, C, 5-HT 4, 5A, 6, 7 Other Acetylcholine M1, M2, M3, M4, M5 - Adrenomedullin - Anaphylatoxin C3a, C5a - Angiotensin 1, 2 - Apelin - Bile acid - Bombesin BRS3, GRPR, NMBR - Bradykinin B1, B2 - Cannabinoid CB1, CB2 - Chemokine - Cholecystokinin A, B - Dopamine D1, D2, D3, D4, D5 - EBI2 - Endothelin A, B - Estrogen - Formyl peptide 1, L1, L2 - Free fatty acid 1, 2, 3, 4 - FSH - Galanin 1, 2, 3 - Gonadotropin-releasing hormone 1, 2 - Ghrelin - Histamine H1, H2, H3, H4 - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid 1, 2, 3, 4, 5, 6, 7, 8 - MAS 1, 1L, D, E, F, G, X1, X2, X3, X4 - Melanocortin 1, 2, 3, 4, 5 - MCHR 1, 2 - Melatonin 1A, 1B- Motilin - neuromedin B, U 1, 2 - Neurotensin 1, 2 - Opioid Delta, Kappa, Mu, Nociceptin, but not Sigma - Olfactory - Opsin 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH - Orexin 1, 2 - Oxytocin - Oxoglutarate - PAF - Prokineticin 1, 2 - Prolactin-releasing peptide - Protease-activated 1, 2, 3, 4 - Relaxin 1, 2, 3, 4 - Somatostatin 1, 2, 3, 4, 5 - SREB - Succinate - TAAR 1, 2, 3, 5, 6, 8, 9 - Tachykinin 1, 2, 3 - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin 1A, 1B, 2 Class B: Secretin like Brain-specific angiogenesis inhibitor 1, 2, 3 - Cadherin 1, 2, 3 - Calcitonin - CD97 - Corticotropin-releasing hormone 1, 2 - EMR 1, 2, 3 - Glucagon GR, GIPR, GLP1R, GLP2R - Growth hormone releasing hormone - PACAPR1- GPR 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157 - Latrophilin 1, 2, 3, ELTD1 - Parathyroid hormone 1, 2 - Secretin - Vasoactive intestinal peptide 1, 2 Class C: Metabotropic glutamate / pheromone Calcium-sensing receptor - GABA B 1, 2 - Glutamate receptor Metabotropic glutamate 1, 2, 3, 4, 5, 6, 7, 8 - GPRC6A - GPR 156, 158, 179 - RAIG 1, 2, 3, 4 - Taste receptors TAS1R 1, 2, 3 TAS2R 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50 Frizzled / Smoothened Frizzled 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 - Smoothened Retrieved from http://en..org/wiki/TAS2R38 Categories: Genes on chromosome 7 | Human proteins | Transmembrane receptor stubs | Genes | G protein coupled receptorsHidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 8 July 2008, at 05:06
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