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14-September-2008 18:02:45 - 0 Taste receptor, type 2, member 50 Identifiers Symbols TAS2R50; MGC138305; T2R51 External IDs OMIM: 609627 HomoloGene: 88474 Gene ontology Molecular function: receptor activity G-protein coupled receptor activity Cellular component: membrane integral to membrane Biological process: signal transduction G-protein coupled receptor protein signaling pathway response to stimulus sensory perception of taste Orthologs Human Mouse Entrez 259296 n/a Refseq NM_176890 mRNA NP_795371 protein n/a mRNA n/a protein Pubmed search 1 n/a Taste receptor, type 2, member 50, also known as TAS2R50, is a human gene.1 TAS2R50 belongs to the large TAS2R receptor family. TAS2Rs are expressed on the surface of taste receptor cells and mediate the perception of bitterness through a G protein-coupled second messenger pathway Conte et al., 2002. See also TAS2R10 MIM 604791.supplied by OMIM1 See also Taste receptor References ^ a b Entrez Gene: TAS2R50 taste receptor, type 2, member 50. Further reading Margolskee RF 2002. Molecular mechanisms of bitter and sweet taste transduction.. J. Biol. Chem. 277 1: 1-4. doi:10.1074/jbc.R100054200. PMID 11696554. Montmayeur JP, Matsunami H 2002. Receptors for bitter and sweet taste.. Curr. Opin. Neurobiol. 12 4: 366-71. PMID 12139982. Bufe B, Hofmann T, Krautwurst D, et al. 2002. The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides.. Nat. Genet. 32 3: 397-401. doi:10.1038/ng1014. PMID 12379855. Strausberg RL, Feingold EA, Grouse LH, et al. 2003. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 99 26: 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. Zhang Y, Hoon MA, Chandrashekar J, et al. 2003. Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways.. Cell 112 3: 293-301. PMID 12581520. Conte C, Ebeling M, Marcuz A, et al. 2003. Identification and characterization of human taste receptor genes belonging to the TAS2R family.. Cytogenet. Genome Res. 98 1: 45-53. doi:10.1159/000068546. PMID 12584440. Gerhard DS, Wagner L, Feingold EA, et al. 2004. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection MGC.. Genome Res. 14 10B: 2121-7. doi:10.1101/gr.2596504. PMID 15489334. Fischer A, Gilad Y, Man O, Pääbo S 2005. Evolution of bitter taste receptors in humans and apes.. Mol. Biol. Evol. 22 3: 432-6. doi:10.1093/molbev/msi027. PMID 15496549. Go Y, Satta Y, Takenaka O, Takahata N 2006. Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates.. Genetics 170 1: 313-26. doi:10.1534/genetics.104.037523. PMID 15744053. Shiffman D, Ellis SG, Rowland CM, et al. 2005. Identification of four gene variants associated with myocardial infarction.. Am. J. Hum. Genet. 77 4: 596-605. doi:10.1086/491674. PMID 16175505. This transmembrane receptor-related article is a stub. This article incorporates text from the United States National Library of Medicine, which is in the public domain. v d e Transmembrane receptor: G protein-coupled receptors Class A: Rhodopsin like Adrenergic α1 A, B, D, α2 A, B, C, β1, β2, β3 Eicosanoid CysLT 1, 2, LTB4 1, 2, FPRL1, OXE, Prostaglandin DP, EP 1, 2, 3, 4, PGF, Prostacyclin, Thromboxane Neuropeptide B/W 1, 2, FF 1, 2, S, Y 1, 2, 4, 5 Orphan GPR 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182 Purinergics Adenosine A1, A2a, A2b, A3, P2Y, 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14 Serotonin all but 5-HT3 5-HT1 A, B, D, E, F, 5-HT2 A, B, C, 5-HT 4, 5A, 6, 7 Other Acetylcholine M1, M2, M3, M4, M5 - Adrenomedullin - Anaphylatoxin C3a, C5a - Angiotensin 1, 2 - Apelin - Bile acid - Bombesin BRS3, GRPR, NMBR - Bradykinin B1, B2 - Cannabinoid CB1, CB2 - Chemokine - Cholecystokinin A, B - Dopamine D1, D2, D3, D4, D5 - EBI2 - Endothelin A, B - Estrogen - Formyl peptide 1, L1, L2 - Free fatty acid 1, 2, 3, 4 - FSH - Galanin 1, 2, 3 - Gonadotropin-releasing hormone 1, 2 - Ghrelin - Histamine H1, H2, H3, H4 - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid 1, 2, 3, 4, 5, 6, 7, 8 - MAS 1, 1L, D, E, F, G, X1, X2, X3, X4 - Melanocortin 1, 2, 3, 4, 5 - MCHR 1, 2 - Melatonin 1A, 1B- Motilin - neuromedin B, U 1, 2 - Neurotensin 1, 2 - Opioid Delta, Kappa, Mu, Nociceptin, but not Sigma - Olfactory - Opsin 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH - Orexin 1, 2 - Oxytocin - Oxoglutarate - PAF - Prokineticin 1, 2 - Prolactin-releasing peptide - Protease-activated 1, 2, 3, 4 - Relaxin 1, 2, 3, 4 - Somatostatin 1, 2, 3, 4, 5 - SREB - Succinate - TAAR 1, 2, 3, 5, 6, 8, 9 - Tachykinin 1, 2, 3 - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin 1A, 1B, 2 Class B: Secretin like Brain-specific angiogenesis inhibitor 1, 2, 3 - Cadherin 1, 2, 3 - Calcitonin - CD97 - Corticotropin-releasing hormone 1, 2 - EMR 1, 2, 3 - Glucagon GR, GIPR, GLP1R, GLP2R - Growth hormone releasing hormone - PACAPR1- GPR 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157 - Latrophilin 1, 2, 3, ELTD1 - Parathyroid hormone 1, 2 - Secretin - Vasoactive intestinal peptide 1, 2 Class C: Metabotropic glutamate / pheromone Calcium-sensing receptor - GABA B 1, 2 - Glutamate receptor Metabotropic glutamate 1, 2, 3, 4, 5, 6, 7, 8 - GPRC6A - GPR 156, 158, 179 - RAIG 1, 2, 3, 4 - Taste receptors TAS1R 1, 2, 3 TAS2R 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50 Frizzled / Smoothened Frizzled 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 - Smoothened Retrieved from http://en..org/wiki/TAS2R50 Categories: Human proteins | Transmembrane receptor stubs | G protein coupled receptorsHidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 9 July 2008, at 06:04
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