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14-September-2008 18:02:45 - 3 Tachykinin receptor 3 Identifiers Symbols TACR3; MGC148060; MGC148061; NK3R; TAC3RL External IDs OMIM: 162332 MGI: 892968 HomoloGene: 824 Gene ontology Molecular function: rhodopsin-like receptor activity receptor activity tachykinin receptor activity Cellular component: plasma membrane integral to plasma membrane Biological process: signal transduction tachykinin signaling pathway RNA expression pattern More reference expression data Orthologs Human Mouse Entrez 6870 21338 Ensembl ENSG00000169836 ENSMUSG00000028172 Uniprot P29371 Q6NXX1 Refseq NM_001059 mRNA NP_001050 protein NM_021382 mRNA NP_067357 protein Location Chr 4: 104.73 - 104.86 Mb Chr 3: 134.77 - 134.87 Mb Pubmed search 1 2 Tachykinin receptor 3, also known as TACR3, is a human gene.1 This gene belongs to a family of genes that function as receptors for Babies. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neurokinin 3, also referred to as neurokinin B.1 See also Tachykinin receptor References ^ a b Entrez Gene: TACR3 tachykinin receptor 3. Further reading Khawaja AM, Rogers DF 1996. Tachykinins: receptor to effector.. Int. J. Biochem. Cell Biol. 28 7: 721-38. PMID 8925404. Advenier C, Lagente V, Boichot E 1997. The role of tachykinin receptor antagonists in the prevention of bronchial hyperresponsiveness, airway inflammation and cough.. Eur. Respir. J. 10 8: 1892-906. PMID 9272936. Buell G, Schulz MF, Arkinstall SJ, et al. 1992. Molecular characterisation, expression and localisation of human neurokinin-3 receptor.. FEBS Lett. 299 1: 90-5. PMID 1312036. Takahashi K, Tanaka A, Hara M, Nakanishi S 1992. The primary structure and gene organization of human substance P and neuromedin K receptors.. Eur. J. Biochem. 204 3: 1025-33. PMID 1312928. Xie GX, Miyajima A, Goldstein A 1992. Expression cloning of cDNA encoding a seven-helix receptor from human placenta with affinity for opioid ligands.. Proc. Natl. Acad. Sci. U.S.A. 89 9: 4124-8. PMID 1315051. Huang RR, Cheung AH, Mazina KE, et al. 1992. cDNA sequence and heterologous expression of the human neurokinin-3 receptor.. Biochem. Biophys. Res. Commun. 184 2: 966-72. PMID 1374246. Dion S, Corcos J, Carmel M, et al. 1988. Substance P and neurokinins as stimulants of the human isolated urinary bladder.. Neuropeptides 11 2: 83-7. PMID 2452993. Krause JE, Staveteig PT, Mentzer JN, et al. 1997. Functional expression of a novel human neurokinin-3 receptor homolog that binds 3Hsenktide and 125I-MePhe7neurokinin B, and is responsive to tachykinin peptide agonists.. Proc. Natl. Acad. Sci. U.S.A. 94 1: 310-5. PMID 8990205. Brunelleschi S, Bordin G, Colangelo D, Viano I 1999. Tachykinin receptors on human monocytes: their involvement in rheumatoid arthritis.. Neuropeptides 32 3: 215-23. PMID 10189055. Page NM, Woods RJ, Gardiner SM, et al. 2000. Excessive placental secretion of neurokinin B during the third trimester causes pre-eclampsia.. Nature 405 6788: 797-800. doi:10.1038/35015579. PMID 10866201. Bellucci F, Carini F, Catalani C, et al. 2002. Pharmacological profile of the novel mammalian tachykinin, hemokinin 1.. Br. J. Pharmacol. 135 1: 266-74. doi:10.1038/sj.bjp.0704443. PMID 11786503. Strausberg RL, Feingold EA, Grouse LH, et al. 2003. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 99 26: 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. Graham GJ, Stevens JM, Page NM, et al. 2005. Tachykinins regulate the function of platelets.. Blood 104 4: 1058-65. doi:10.1182/blood-2003-11-3979. PMID 15130944. Gerhard DS, Wagner L, Feingold EA, et al. 2004. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection MGC.. Genome Res. 14 10B: 2121-7. doi:10.1101/gr.2596504. PMID 15489334. Page NM, Dakour J, Morrish DW 2006. Gene regulation of neurokinin B and its receptor NK3 in late pregnancy and pre-eclampsia.. Mol. Hum. Reprod. 12 7: 427-33. doi:10.1093/molehr/gal025. PMID 16709596. This transmembrane receptor-related article is a stub. This article incorporates text from the United States National Library of Medicine, which is in the public domain. v d e Transmembrane receptor: G protein-coupled receptors Class A: Rhodopsin like Adrenergic α1 A, B, D, α2 A, B, C, β1, β2, β3 Eicosanoid CysLT 1, 2, LTB4 1, 2, FPRL1, OXE, Prostaglandin DP, EP 1, 2, 3, 4, PGF, Prostacyclin, Thromboxane Neuropeptide B/W 1, 2, FF 1, 2, S, Y 1, 2, 4, 5 Orphan GPR 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182 Purinergics Adenosine A1, A2a, A2b, A3, P2Y, 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14 Serotonin all but 5-HT3 5-HT1 A, B, D, E, F, 5-HT2 A, B, C, 5-HT 4, 5A, 6, 7 Other Acetylcholine M1, M2, M3, M4, M5 - Adrenomedullin - Anaphylatoxin C3a, C5a - Angiotensin 1, 2 - Apelin - Bile acid - Bombesin BRS3, GRPR, NMBR - Bradykinin B1, B2 - Cannabinoid CB1, CB2 - Chemokine - Cholecystokinin A, B - Dopamine D1, D2, D3, D4, D5 - EBI2 - Endothelin A, B - Estrogen - Formyl peptide 1, L1, L2 - Free fatty acid 1, 2, 3, 4 - FSH - Galanin 1, 2, 3 - Gonadotropin-releasing hormone 1, 2 - Ghrelin - Histamine H1, H2, H3, H4 - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid 1, 2, 3, 4, 5, 6, 7, 8 - MAS 1, 1L, D, E, F, G, X1, X2, X3, X4 - Melanocortin 1, 2, 3, 4, 5 - MCHR 1, 2 - Melatonin 1A, 1B- Motilin - neuromedin B, U 1, 2 - Neurotensin 1, 2 - Opioid Delta, Kappa, Mu, Nociceptin, but not Sigma - Olfactory - Opsin 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH - Orexin 1, 2 - Oxytocin - Oxoglutarate - PAF - Prokineticin 1, 2 - Prolactin-releasing peptide - Protease-activated 1, 2, 3, 4 - Relaxin 1, 2, 3, 4 - Somatostatin 1, 2, 3, 4, 5 - SREB - Succinate - TAAR 1, 2, 3, 5, 6, 8, 9 - Tachykinin 1, 2, 3 - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin 1A, 1B, 2 Class B: Secretin like Brain-specific angiogenesis inhibitor 1, 2, 3 - Cadherin 1, 2, 3 - Calcitonin - CD97 - Corticotropin-releasing hormone 1, 2 - EMR 1, 2, 3 - Glucagon GR, GIPR, GLP1R, GLP2R - Growth hormone releasing hormone - PACAPR1- GPR 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157 - Latrophilin 1, 2, 3, ELTD1 - Parathyroid hormone 1, 2 - Secretin - Vasoactive intestinal peptide 1, 2 Class C: Metabotropic glutamate / pheromone Calcium-sensing receptor - GABA B 1, 2 - Glutamate receptor Metabotropic glutamate 1, 2, 3, 4, 5, 6, 7, 8 - GPRC6A - GPR 156, 158, 179 - RAIG 1, 2, 3, 4 - Taste receptors TAS1R 1, 2, 3 TAS2R 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50 Frizzled / Smoothened Frizzled 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 - Smoothened Retrieved from http://en..org/wiki/Tachykinin_receptor_3 Categories: Genes on chromosome 4 | Human proteins | Transmembrane receptor stubs | G protein coupled receptorsHidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 8 July 2008, at 12:08

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