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14-September-2008 18:02:45 - Thromboxane receptor Thromboxane A2 receptor Identifiers Symbols TBXA2R; TXA2-R External IDs OMIM: 188070 MGI: 98496 HomoloGene: 825 Gene ontology Molecular function: rhodopsin-like receptor activity receptor activity thromboxane receptor activity thromboxane A2 receptor activity Cellular component: plasma membrane integral to plasma membrane membrane integral to membrane Biological process: muscle contraction signal transduction G-protein coupled receptor protein signaling pathway respiratory gaseous exchange RNA expression pattern More reference expression data Orthologs Human Mouse Entrez 6915 21390 Ensembl ENSG00000006638 ENSMUSG00000034881 Uniprot P21731 Q5FW61 Refseq NM_001060 mRNA NP_001051 protein NM_009325 mRNA NP_033351 protein Location Chr 19: 3.55 - 3.56 Mb Chr 10: 80.73 - 80.74 Mb Pubmed search 1 2 The thromboxane receptor is a protein on the surface of cells in the endothelium of blood vessels and in the placenta which interacts with the eicosanoid lipid thromboxane. It is a G-protein coupled receptors coupled to the G protein Gq.1 Contents 1 Gene 2 See also 3 References 4 Further reading Gene The gene responsible for the thromboxane receptor, TBXA2R is found on chromosome 19 and spans 15 kilobases. Thromboxane is a potent stimulator for platelet aggregation and clot formation and also plays a role in vascular tone. The thromboxane receptor is a member of the family of G protein-coupled receptors. Mutation of the receptor can lead to a bleeding disorder. See also Eicosanoid receptor References ^ Abe T, Takeuchi K, Takahashi N, Tsutsumi E, Taniyama Y, Abe K 1995. Rat kidney thromboxane receptor: molecular cloning, signal transduction, and intrarenal expression localization. J. Clin. Invest. 96 2: 657-64. PMID 7635958. Further reading Namba T, Narumiya S 1993. Thromboxane A2 receptor; structure, function and tissue distribution. Nippon Rinsho 51 1: 233-40. PMID 8433523. Murugappan S, Shankar H, Kunapuli SP 2005. Platelet receptors for adenine nucleotides and thromboxane A2.. Semin. Thromb. Hemost. 30 4: 411-8. doi:10.1055/s-2004-833476. PMID 15354262. Hirata M, Hayashi Y, Ushikubi F, et al. 1991. Cloning and expression of cDNA for a human thromboxane A2 receptor.. Nature 349 6310: 617-20. doi:10.1038/349617a0. PMID 1825698. Raychowdhury MK, Yukawa M, Collins LJ, et al. 1995. Alternative splicing produces a divergent cytoplasmic tail in the human endothelial thromboxane A2 receptor.. J. Biol. Chem. 270 12: 7011. PMID 7896853. Hirata T, Kakizuka A, Ushikubi F, et al. 1994. Arg60 to Leu mutation of the human thromboxane A2 receptor in a dominantly inherited bleeding disorder.. J. Clin. Invest. 94 4: 1662-7. PMID 7929844. D'Angelo DD, Davis MG, Ali S, Dorn GW 1994. Cloning and pharmacologic characterization of a thromboxane A2 receptor from K562 human chronic myelogenous leukemia cells.. J. Pharmacol. Exp. Ther. 271 2: 1034-41. PMID 7965765. Raychowdhury MK, Yukawa M, Collins LJ, et al. 1994. Alternative splicing produces a divergent cytoplasmic tail in the human endothelial thromboxane A2 receptor.. J. Biol. Chem. 269 30: 19256-61. PMID 8034687. Borg C, Lim CT, Yeomans DC, et al. 1994. Purification of rat brain, rabbit aorta, and human platelet thromboxane A2/prostaglandin H2 receptors by immunoaffinity chromatography employing anti-peptide and anti-receptor antibodies.. J. Biol. Chem. 269 8: 6109-16. PMID 8119956. Nüsing RM, Hirata M, Kakizuka A, et al. 1993. Characterization and chromosomal mapping of the human thromboxane A2 receptor gene.. J. Biol. Chem. 268 33: 25253-9. PMID 8227091. Funk CD, Furci L, Moran N, Fitzgerald GA 1994. Point mutation in the seventh hydrophobic domain of the human thromboxane A2 receptor allows discrimination between agonist and antagonist binding sites.. Mol. Pharmacol. 44 5: 934-9. PMID 8246916. Schwengel DA, Nouri N, Meyers DA, Levitt RC 1994. Linkage mapping of the human thromboxane A2 receptor TBXA2R to chromosome 19p13.3 using transcribed 3' untranslated DNA sequence polymorphisms.. Genomics 18 2: 212-5. doi:10.1006/geno.1993.1457. PMID 8288221. Offermanns S, Laugwitz KL, Spicher K, Schultz G 1994. G proteins of the G12 family are activated via thromboxane A2 and thrombin receptors in human platelets.. Proc. Natl. Acad. Sci. U.S.A. 91 2: 504-8. PMID 8290554. Hirata T, Ushikubi F, Kakizuka A, et al. 1996. Two thromboxane A2 receptor isoforms in human platelets. Opposite coupling to adenylyl cyclase with different sensitivity to Arg60 to Leu mutation.. J. Clin. Invest. 97 4: 949-56. PMID 8613548. Kinsella BT, O'Mahony DJ, Fitzgerald GA 1997. The human thromboxane A2 receptor alpha isoform TP alpha functionally couples to the G proteins Gq and G11 in vivo and is activated by the isoprostane 8-epi prostaglandin F2 alpha.. J. Pharmacol. Exp. Ther. 281 2: 957-64. PMID 9152406. Becker KP, Garnovskaya M, Gettys T, Halushka PV 1999. Coupling of thromboxane A2 receptor isoforms to Galpha13: effects on ligand binding and signalling.. Biochim. Biophys. Acta 1450 3: 288-96. PMID 10395940. Barr CL, Wigg KG, Pakstis AJ, et al. 1999. Genome scan for linkage to Gilles de la Tourette syndrome.. Am. J. Med. Genet. 88 4: 437-45. PMID 10402514. Zhou H, Yan F, Tai HH 2001. Phosphorylation and desensitization of the human thromboxane receptor-alpha by G protein-coupled receptor kinases.. J. Pharmacol. Exp. Ther. 298 3: 1243-51. PMID 11504827. Vezza R, Mezzasoma AM, Venditti G, Gresele P 2002. Prostaglandin endoperoxides and thromboxane A2 activate the same receptor isoforms in human platelets.. Thromb. Haemost. 87 1: 114-21. PMID 11848439. Turek JW, Halmos T, Sullivan NL, et al. 2002. Mapping of a ligand-binding site for the human thromboxane A2 receptor protein.. J. Biol. Chem. 277 19: 16791-7. doi:10.1074/jbc.M105872200. PMID 11877412. This transmembrane receptor-related article is a stub. v d e Transmembrane receptor: G protein-coupled receptors Class A: Rhodopsin like Adrenergic α1 A, B, D, α2 A, B, C, β1, β2, β3 Eicosanoid CysLT 1, 2, LTB4 1, 2, FPRL1, OXE, Prostaglandin DP, EP 1, 2, 3, 4, PGF, Prostacyclin, Thromboxane Neuropeptide B/W 1, 2, FF 1, 2, S, Y 1, 2, 4, 5 Orphan GPR 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182 Purinergics Adenosine A1, A2a, A2b, A3, P2Y, 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14 Serotonin all but 5-HT3 5-HT1 A, B, D, E, F, 5-HT2 A, B, C, 5-HT 4, 5A, 6, 7 Other Acetylcholine M1, M2, M3, M4, M5 - Adrenomedullin - Anaphylatoxin C3a, C5a - Angiotensin 1, 2 - Apelin - Bile acid - Bombesin BRS3, GRPR, NMBR - Bradykinin B1, B2 - Cannabinoid CB1, CB2 - Chemokine - Cholecystokinin A, B - Dopamine D1, D2, D3, D4, D5 - EBI2 - Endothelin A, B - Estrogen - Formyl peptide 1, L1, L2 - Free fatty acid 1, 2, 3, 4 - FSH - Galanin 1, 2, 3 - Gonadotropin-releasing hormone 1, 2 - Ghrelin - Histamine H1, H2, H3, H4 - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid 1, 2, 3, 4, 5, 6, 7, 8 - MAS 1, 1L, D, E, F, G, X1, X2, X3, X4 - Melanocortin 1, 2, 3, 4, 5 - MCHR 1, 2 - Melatonin 1A, 1B- Motilin - neuromedin B, U 1, 2 - Neurotensin 1, 2 - Opioid Delta, Kappa, Mu, Nociceptin, but not Sigma - Olfactory - Opsin 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH - Orexin 1, 2 - Oxytocin - Oxoglutarate - PAF - Prokineticin 1, 2 - Prolactin-releasing peptide - Protease-activated 1, 2, 3, 4 - Relaxin 1, 2, 3, 4 - Somatostatin 1, 2, 3, 4, 5 - SREB - Succinate - TAAR 1, 2, 3, 5, 6, 8, 9 - Tachykinin 1, 2, 3 - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin 1A, 1B, 2 Class B: Secretin like Brain-specific angiogenesis inhibitor 1, 2, 3 - Cadherin 1, 2, 3 - Calcitonin - CD97 - Corticotropin-releasing hormone 1, 2 - EMR 1, 2, 3 - Glucagon GR, GIPR, GLP1R, GLP2R - Growth hormone releasing hormone - PACAPR1- GPR 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157 - Latrophilin 1, 2, 3, ELTD1 - Parathyroid hormone 1, 2 - Secretin - Vasoactive intestinal peptide 1, 2 Class C: Metabotropic glutamate / pheromone Calcium-sensing receptor - GABA B 1, 2 - Glutamate receptor Metabotropic glutamate 1, 2, 3, 4, 5, 6, 7, 8 - GPRC6A - GPR 156, 158, 179 - RAIG 1, 2, 3, 4 - Taste receptors TAS1R 1, 2, 3 TAS2R 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50 Frizzled / Smoothened Frizzled 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 - Smoothened Retrieved from http://en..org/wiki/Thromboxane_receptor Categories: Genes on chromosome 19 | Human proteins | Transmembrane receptor stubs | G protein coupled receptorsHidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 8 July 2008, at 03:05
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