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14-September-2008 18:02:45 - Thyrotropin receptor Thyroid stimulating hormone receptor Identifiers Symbols TSHR; LGR3; MGC75129; hTSHR-I External IDs OMIM: 603372 MGI: 98849 HomoloGene: 315 Gene ontology Molecular function: receptor activity thyroid-stimulating hormone receptor activity protein binding Cellular component: plasma membrane integral to plasma membrane Biological process: signal transduction G-protein signaling, coupled to cyclic nucleotide second messenger G-protein signaling, adenylate cyclase activating pathway cell-cell signaling positive regulation of cell proliferation adult locomotory behavior regulation of locomotion positive regulation of body size RNA expression pattern More reference expression data Orthologs Human Mouse Entrez 7253 22095 Ensembl ENSG00000165409 ENSMUSG00000020963 Uniprot P16473 Q562E4 Refseq NM_000369 mRNA NP_000360 protein NM_011648 mRNA NP_035778 protein Location Chr 14: 80.49 - 80.68 Mb Chr 12: 91.81 - 91.95 Mb Pubmed search 1 2 The thyrotropin receptor or TSH receptor is a gene and associated protein which responds to thyroid-stimulating hormone also known as thyrotropin, and stimulates the production of thyroxine T4 and triiodothyronine T3. The TSH receptor is a member of the G-protein coupled receptor superfamily of integral membrane proteins.1 It is primarily found on the surface of the thyroid epithelial cells. It should not be confused with thyrotropin-releasing hormone TRH or thyrotropin-releasing hormone receptor TRHR. Contents 1 See also 2 Further reading 3 External links 4 References See also Graves' disease Further reading Führer D, Wonerow P, Willgerodt H, Paschke R 1998. Identification of a new thyrotropin receptor germline mutation Leu629Phe in a family with neonatal onset of autosomal dominant nonautoimmune hyperthyroidism.. J. Clin. Endocrinol. Metab. 82 12: 4234-8. PMID 9398746. Farid NR, Kascur V, Balazs C 2000. The human thyrotropin receptor is highly mutable: a review of gain-of-function mutations.. Eur. J. Endocrinol. 143 1: 25-30. PMID 10870027. Szkudlinski MW, Fremont V, Ronin C, Weintraub BD 2002. Thyroid-stimulating hormone and thyroid-stimulating hormone receptor structure-function relationships.. Physiol. Rev. 82 2: 473-502. doi:10.1152/physrev.00031.2001. PMID 11917095. Tonacchera M, Vitti P, De Servi M, et al. 2004. Gain of function TSH receptor mutations and iodine deficiency: implications in iodine prophylaxis.. J. Endocrinol. Invest. 26 2 Suppl: 2-6. PMID 12762632. Arturi F, Scarpelli D, Coco A, et al. 2004. Thyrotropin receptor mutations and thyroid hyperfunctioning adenomas ten years after their first discovery: unresolved questions.. Thyroid 13 4: 341-3. doi:10.1089/105072503321669811. PMID 12804102. Vaidya B, Campbell V, Tripp JH, et al. 2004. Premature birth and low birth weight associated with nonautoimmune hyperthyroidism due to an activating thyrotropin receptor gene mutation.. Clin. Endocrinol. Oxf 60 6: 711-8. doi:10.1111/j.1365-2265.2004.02040.x. PMID 15163335. Takeshita A, Nagayama Y, Fujiyama K, et al. 1992. Molecular cloning and sequencing of an alternatively spliced form of the human thyrotropin receptor transcript.. Biochem. Biophys. Res. Commun. 188 3: 1214-9. PMID 1445355. Graves PN, Tomer Y, Davies TF 1992. Cloning and sequencing of a 1.3 KB variant of human thyrotropin receptor mRNA lacking the transmembrane domain.. Biochem. Biophys. Res. Commun. 187 2: 1135-43. PMID 1530609. Loosfelt H, Pichon C, Jolivet A, et al. 1992. Two-subunit structure of the human thyrotropin receptor.. Proc. Natl. Acad. Sci. U.S.A. 89 9: 3765-9. PMID 1570295. Nagayama Y, Russo D, Wadsworth HL, et al. 1991. Eleven amino acids Lys-201 to Lys-211 and 9 amino acids Gly-222 to Leu-230 in the human thyrotropin receptor are involved in ligand binding.. J. Biol. Chem. 266 23: 14926-30. PMID 1651314. Murakami M, Mori M 1990. Identification of immunogenic regions in human thyrotropin receptor for immunoglobulin G of patients with Graves' disease.. Biochem. Biophys. Res. Commun. 171 1: 512-8. PMID 1697467. Heldin NE, Gustavsson B, Westermark K, Westermark B 1992. A somatic point mutation in a putative ligand binding domain of the TSH receptor in a patient with autoimmune hyperthyroidism.. J. Clin. Endocrinol. Metab. 73 6: 1374-6. PMID 1955520. Libert F, Passage E, Lefort A, et al. 1991. Localization of human thyrotropin receptor gene to chromosome region 14q3 by in situ hybridization.. Cytogenet. Cell Genet. 54 1-2: 82-3. PMID 2249482. Frazier AL, Robbins LS, Stork PJ, et al. 1991. Isolation of TSH and LH/CG receptor cDNAs from human thyroid: regulation by tissue specific splicing.. Mol. Endocrinol. 4 8: 1264-76. PMID 2293030. Misrahi M, Loosfelt H, Atger M, et al. 1990. Cloning, sequencing and expression of human TSH receptor.. Biochem. Biophys. Res. Commun. 166 1: 394-403. PMID 2302212. Nagayama Y, Kaufman KD, Seto P, Rapoport B 1990. Molecular cloning, sequence and functional expression of the cDNA for the human thyrotropin receptor.. Biochem. Biophys. Res. Commun. 165 3: 1184-90. PMID 2558651. Libert F, Lefort A, Gerard C, et al. 1990. Cloning, sequencing and expression of the human thyrotropin TSH receptor: evidence for binding of autoantibodies.. Biochem. Biophys. Res. Commun. 165 3: 1250-5. PMID 2610690. Cuddihy RM, Bryant WP, Bahn RS 1996. Normal function in vivo of a homozygotic polymorphism in the human thyrotropin receptor.. Thyroid 5 4: 255-7. PMID 7488864. Bahn RS, Dutton CM, Heufelder AE, Sarkar G 1994. A genomic point mutation in the extracellular domain of the thyrotropin receptor in patients with Graves' ophthalmopathy.. J. Clin. Endocrinol. Metab. 78 2: 256-60. PMID 7508946. Sunthornthepvarakui T, Gottschalk ME, Hayashi Y, Refetoff S 1995. Brief report: resistance to thyrotropin caused by mutations in the thyrotropin-receptor gene.. N. Engl. J. Med. 332 3: 155-60. PMID 7528344. External links IUPHAR GPCR Database - TSH receptor MeSH Thyrotropin+Receptors GRIS: Glycoprotein-hormone Receptor Information System References ^ Farid NR, Szkudlinski MW 2004. Minireview: structural and functional evolution of the thyrotropin receptor. Endocrinology 145 9: 4048-57. doi:10.1210/en.2004-0437. PMID 15231707. This transmembrane receptor-related article is a stub. v d e Transmembrane receptor: G protein-coupled receptors Class A: Rhodopsin like Adrenergic α1 A, B, D, α2 A, B, C, β1, β2, β3 Eicosanoid CysLT 1, 2, LTB4 1, 2, FPRL1, OXE, Prostaglandin DP, EP 1, 2, 3, 4, PGF, Prostacyclin, Thromboxane Neuropeptide B/W 1, 2, FF 1, 2, S, Y 1, 2, 4, 5 Orphan GPR 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182 Purinergics Adenosine A1, A2a, A2b, A3, P2Y, 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14 Serotonin all but 5-HT3 5-HT1 A, B, D, E, F, 5-HT2 A, B, C, 5-HT 4, 5A, 6, 7 Other Acetylcholine M1, M2, M3, M4, M5 - Adrenomedullin - Anaphylatoxin C3a, C5a - Angiotensin 1, 2 - Apelin - Bile acid - Bombesin BRS3, GRPR, NMBR - Bradykinin B1, B2 - Cannabinoid CB1, CB2 - Chemokine - Cholecystokinin A, B - Dopamine D1, D2, D3, D4, D5 - EBI2 - Endothelin A, B - Estrogen - Formyl peptide 1, L1, L2 - Free fatty acid 1, 2, 3, 4 - FSH - Galanin 1, 2, 3 - Gonadotropin-releasing hormone 1, 2 - Ghrelin - Histamine H1, H2, H3, H4 - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid 1, 2, 3, 4, 5, 6, 7, 8 - MAS 1, 1L, D, E, F, G, X1, X2, X3, X4 - Melanocortin 1, 2, 3, 4, 5 - MCHR 1, 2 - Melatonin 1A, 1B- Motilin - neuromedin B, U 1, 2 - Neurotensin 1, 2 - Opioid Delta, Kappa, Mu, Nociceptin, but not Sigma - Olfactory - Opsin 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH - Orexin 1, 2 - Oxytocin - Oxoglutarate - PAF - Prokineticin 1, 2 - Prolactin-releasing peptide - Protease-activated 1, 2, 3, 4 - Relaxin 1, 2, 3, 4 - Somatostatin 1, 2, 3, 4, 5 - SREB - Succinate - TAAR 1, 2, 3, 5, 6, 8, 9 - Tachykinin 1, 2, 3 - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin 1A, 1B, 2 Class B: Secretin like Brain-specific angiogenesis inhibitor 1, 2, 3 - Cadherin 1, 2, 3 - Calcitonin - CD97 - Corticotropin-releasing hormone 1, 2 - EMR 1, 2, 3 - Glucagon GR, GIPR, GLP1R, GLP2R - Growth hormone releasing hormone - PACAPR1- GPR 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157 - Latrophilin 1, 2, 3, ELTD1 - Parathyroid hormone 1, 2 - Secretin - Vasoactive intestinal peptide 1, 2 Class C: Metabotropic glutamate / pheromone Calcium-sensing receptor - GABA B 1, 2 - Glutamate receptor Metabotropic glutamate 1, 2, 3, 4, 5, 6, 7, 8 - GPRC6A - GPR 156, 158, 179 - RAIG 1, 2, 3, 4 - Taste receptors TAS1R 1, 2, 3 TAS2R 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50 Frizzled / Smoothened Frizzled 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 - Smoothened v d e Neuropeptide receptors Hypothalamic hormone receptors CRH - FSH - LHRH - TRH - Somatostatin Pituitary hormone receptors Vasopressin 1A, 1B, 2 - Oxytocin - LHCG - Type I cytokine receptor GH, Prolactin - TSH Other hormone receptors Atrial natriuretic factor - Calcitonin - Cholecystokinin A, B - VIP Opioid receptors Delta - Kappa - Mu - Sigma 1, 2 - Nociceptin Other neuropeptide receptors Angiotensin - Bradykinin B1, B2 / Tachykinin TACR1 - Calcitonin gene-related peptide - Galanin - GPCR neuropeptide B/W, FF, S, Y - Neurotensin Retrieved from http://en..org/wiki/Thyrotropin_receptor Categories: Genes on chromosome 14 | Human proteins | Transmembrane receptor stubs | Cell signaling | Signal transduction | G protein coupled receptorsHidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 30 July 2008, at 18:16
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