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14-September-2008 18:02:45 - hormone receptor Thyrotropin-releasing hormone receptor Identifiers Symbols TRHR; MGC141920 External IDs OMIM: 188545 MGI: 98824 HomoloGene: 20707 Gene ontology Molecular function: rhodopsin-like receptor activity receptor activity thyrotropin-releasing hormone receptor activity Cellular component: integral to plasma membrane membrane Biological process: signal transduction G-protein coupled receptor protein signaling pathway RNA expression pattern More reference expression data Orthologs Human Mouse Entrez 7201 22045 Ensembl ENSG00000174417 ENSMUSG00000038760 Uniprot P34981 Q32MS1 Refseq NM_003301 mRNA NP_003292 protein NM_013696 mRNA NP_038724 protein Location Chr 8: 110.17 - 110.2 Mb Chr 15: 44.03 - 44.06 Mb Pubmed search 1 2 The thyrotropin-releasing hormone receptor TRHR is a G protein-coupled receptor which binds the tripeptide thyrotropin releasing hormone.12 The TRHR are found in the brain and when bound by TRH result act through phospholipase C to increase intracellular inositol triphosphate. References ^ Yamada M, Monden T, Konaka S, Mori M 1993. Assignment of human thyrotropin-releasing hormone TRH receptor gene to chromosome 8. Somat. Cell Mol. Genet. 19 6: 577-80. PMID 8128317. ^ Gershengorn MC 1993. Thyrotropin-releasing hormone receptor: cloning and regulation of its expression. Recent Prog. Horm. Res. 48: 341-63. PMID 8382829. Further reading Short RE, James LF, Panter KE, et al. 1993. Effects of feeding ponderosa pine needles during pregnancy: comparative studies with bison, cattle, goats, and sheep.. J. Anim. Sci. 70 11: 3498-504. PMID 1459912. Yamada M, Iwasaki T, Satoh T, et al. 1996. Activation of the thyrotropin-releasing hormone TRH receptor by a direct precursor of TRH, TRH-Gly.. Neurosci. Lett. 196 1-2: 109-12. PMID 7501234. Hinuma S, Hosoya M, Ogi K, et al. 1994. Molecular cloning and functional expression of a human thyrotropin-releasing hormone TRH receptor gene.. Biochim. Biophys. Acta 1219 2: 251-9. PMID 7918619. Morrison N, Duthie SM, Boyd E, et al. 1994. Assignment of the gene encoding the human thyrotropin-releasing hormone receptor to 8q23 by fluorescence in situ hybridization.. Hum. Genet. 93 6: 716-8. PMID 8005602. Yamada M, Monden T, Konaka S, Mori M 1994. Assignment of human thyrotropin-releasing hormone TRH receptor gene to chromosome 8.. Somat. Cell Mol. Genet. 19 6: 577-80. PMID 8128317. Duthie SM, Taylor PL, Anderson L, et al. 1994. Cloning and functional characterisation of the human TRH receptor.. Mol. Cell. Endocrinol. 95 1-2: R11-5. PMID 8243797. Matre V, Karlsen HE, Wright MS, et al. 1993. Molecular cloning of a functional human thyrotropin-releasing hormone receptor.. Biochem. Biophys. Res. Commun. 195 1: 179-85. doi:10.1006/bbrc.1993.2027. PMID 8395824. Yamada M, Monden T, Satoh T, et al. 1993. Pituitary adenomas of patients with acromegaly express thyrotropin-releasing hormone receptor messenger RNA: cloning and functional expression of the human thyrotropin-releasing hormone receptor gene.. Biochem. Biophys. Res. Commun. 195 2: 737-45. doi:10.1006/bbrc.1993.2107. PMID 8396925. Iwasaki T, Yamada M, Satoh T, et al. 1996. Genomic organization and promoter function of the human thyrotropin-releasing hormone receptor gene.. J. Biol. Chem. 271 36: 22183-8. PMID 8703031. Cook JV, McGregor A, Lee T, et al. 1996. A disulfide bonding interaction role for cysteines in the extracellular domain of the thyrotropin-releasing hormone receptor.. Endocrinology 137 7: 2851-8. PMID 8770906. Collu R, Tang J, Castagné J, et al. 1997. A novel mechanism for isolated central hypothyroidism: inactivating mutations in the thyrotropin-releasing hormone receptor gene.. J. Clin. Endocrinol. Metab. 82 5: 1561-5. PMID 9141550. Petrou C, Tashjian AH 1999. The thyrotropin-releasing hormone-receptor complex and G11alpha are both internalised into clathrin-coated vesicles.. Cell. Signal. 10 8: 553-9. PMID 9794253. Matre V, Høvring PI, Orstavik S, et al. 1999. Structural and functional organization of the gene encoding the human thyrotropin-releasing hormone receptor.. J. Neurochem. 72 1: 40-50. PMID 9886052. Kroeger KM, Hanyaloglu AC, Seeber RM, et al. 2001. Constitutive and agonist-dependent homo-oligomerization of the thyrotropin-releasing hormone receptor. Detection in living cells using bioluminescence resonance energy transfer.. J. Biol. Chem. 276 16: 12736-43. doi:10.1074/jbc.M011311200. PMID 11278883. Zhu CC, Cook LB, Hinkle PM 2002. Dimerization and phosphorylation of thyrotropin-releasing hormone receptors are modulated by agonist stimulation.. J. Biol. Chem. 277 31: 28228-37. doi:10.1074/jbc.M204221200. PMID 12023974. Hanyaloglu AC, Seeber RM, Kohout TA, et al. 2003. Homo- and hetero-oligomerization of thyrotropin-releasing hormone TRH receptor subtypes. Differential regulation of beta-arrestins 1 and 2.. J. Biol. Chem. 277 52: 50422-30. doi:10.1074/jbc.M209340200. PMID 12393857. Strausberg RL, Feingold EA, Grouse LH, et al. 2003. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 99 26: 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. Cook LB, Zhu CC, Hinkle PM 2004. Thyrotropin-releasing hormone receptor processing: role of ubiquitination and proteasomal degradation.. Mol. Endocrinol. 17 9: 1777-91. doi:10.1210/me.2003-0073. PMID 12805411. Igarashi-Migitaka J, Yamada S, Hara M, et al. 2004. Gene expression study of thyrotropin releasing hormone TRH receptor using RT-PCR: relationship to clinical and immunohistochemical phenotypes in a series of human pituitary adenomas.. Endocr. J. 50 4: 459-67. PMID 14599121. Cook LB, Hinkle PM 2004. Fate of internalized thyrotropin-releasing hormone receptors monitored with a timer fusion protein.. Endocrinology 145 7: 3095-100. doi:10.1210/en.2004-0304. PMID 15117874. External links IUPHAR GPCR Database - Thyrotropin-releasing hormone receptor MeSH Receptors,+Thyrotropin-Releasing+Hormone v d e Transmembrane receptor: G protein-coupled receptors Class A: Rhodopsin like Adrenergic α1 A, B, D, α2 A, B, C, β1, β2, β3 Eicosanoid CysLT 1, 2, LTB4 1, 2, FPRL1, OXE, Prostaglandin DP, EP 1, 2, 3, 4, PGF, Prostacyclin, Thromboxane Neuropeptide B/W 1, 2, FF 1, 2, S, Y 1, 2, 4, 5 Orphan GPR 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182 Purinergics Adenosine A1, A2a, A2b, A3, P2Y, 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14 Serotonin all but 5-HT3 5-HT1 A, B, D, E, F, 5-HT2 A, B, C, 5-HT 4, 5A, 6, 7 Other Acetylcholine M1, M2, M3, M4, M5 - Adrenomedullin - Anaphylatoxin C3a, C5a - Angiotensin 1, 2 - Apelin - Bile acid - Bombesin BRS3, GRPR, NMBR - Bradykinin B1, B2 - Cannabinoid CB1, CB2 - Chemokine - Cholecystokinin A, B - Dopamine D1, D2, D3, D4, D5 - EBI2 - Endothelin A, B - Estrogen - Formyl peptide 1, L1, L2 - Free fatty acid 1, 2, 3, 4 - FSH - Galanin 1, 2, 3 - Gonadotropin-releasing hormone 1, 2 - Ghrelin - Histamine H1, H2, H3, H4 - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid 1, 2, 3, 4, 5, 6, 7, 8 - MAS 1, 1L, D, E, F, G, X1, X2, X3, X4 - Melanocortin 1, 2, 3, 4, 5 - MCHR 1, 2 - Melatonin 1A, 1B- Motilin - neuromedin B, U 1, 2 - Neurotensin 1, 2 - Opioid Delta, Kappa, Mu, Nociceptin, but not Sigma - Olfactory - Opsin 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH - Orexin 1, 2 - Oxytocin - Oxoglutarate - PAF - Prokineticin 1, 2 - Prolactin-releasing peptide - Protease-activated 1, 2, 3, 4 - Relaxin 1, 2, 3, 4 - Somatostatin 1, 2, 3, 4, 5 - SREB - Succinate - TAAR 1, 2, 3, 5, 6, 8, 9 - Tachykinin 1, 2, 3 - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin 1A, 1B, 2 Class B: Secretin like Brain-specific angiogenesis inhibitor 1, 2, 3 - Cadherin 1, 2, 3 - Calcitonin - CD97 - Corticotropin-releasing hormone 1, 2 - EMR 1, 2, 3 - Glucagon GR, GIPR, GLP1R, GLP2R - Growth hormone releasing hormone - PACAPR1- GPR 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157 - Latrophilin 1, 2, 3, ELTD1 - Parathyroid hormone 1, 2 - Secretin - Vasoactive intestinal peptide 1, 2 Class C: Metabotropic glutamate / pheromone Calcium-sensing receptor - GABA B 1, 2 - Glutamate receptor Metabotropic glutamate 1, 2, 3, 4, 5, 6, 7, 8 - GPRC6A - GPR 156, 158, 179 - RAIG 1, 2, 3, 4 - Taste receptors TAS1R 1, 2, 3 TAS2R 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50 Frizzled / Smoothened Frizzled 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 - Smoothened v d e Neuropeptide receptors Hypothalamic hormone receptors CRH - FSH - LHRH - TRH - Somatostatin Pituitary hormone receptors Vasopressin 1A, 1B, 2 - Oxytocin - LHCG - Type I cytokine receptor GH, Prolactin - TSH Other hormone receptors Atrial natriuretic factor - Calcitonin - Cholecystokinin A, B - VIP Opioid receptors Delta - Kappa - Mu - Sigma 1, 2 - Nociceptin Other neuropeptide receptors Angiotensin - Bradykinin B1, B2 / Tachykinin TACR1 - Calcitonin gene-related peptide - Galanin - GPCR neuropeptide B/W, FF, S, Y - Neurotensin This transmembrane receptor-related article is a stub. Retrieved from http://en..org/wiki/Thyrotropin-releasing_hormone_receptor Categories: Genes on chromosome 8 | Human proteins | Cell signaling | Signal transduction | G protein coupled receptors | Transmembrane receptor stubsHidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 8 July 2008, at 02:54
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