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14-September-2008 18:02:48 - Thyroxine Thyroxine Identifiers CAS number 7488-70-2 PubChem 853 MeSH Thyroxine SMILES NCCc1ccIcOc2ccIcO cIc2cIc1CO=O Properties Molecular formula C15H11I4NO4 Molar mass 776.87 Except where noted otherwise, data are given for materials in their standard state at 25 °C, 100 kPa Infobox references Thyroxine, or 3,5,3',5'-tetra-iodothyronine often abbreviated as T4, a form of thyroid hormones is the major hormone secreted by the follicular cells of the thyroid gland. T4 is transported in blood, with 99.95% of the secreted T4 being protein bound, principally to thyroxine-binding globulin TBG, and, to a lesser extent, to transthyretin and serum albumin. T4 is involved in controlling the rate of metabolic processes in the body and influencing physical development. Note: Thyroxine is a prohormone and a reservoir for the active thyroid hormone triiodothyronine T3. T4 is converted in the tissues by deiodinases to T3. The D isomer is called Dextrothyroxine1 and is used as a lipid modifying agent.2 The half-life of thyroxine once released into the blood circulatory system is about 1 week. The hormone was synthesised in 1927 by British chemists Charles Robert Harington and George Barger. Reactions Transformations Transformations References ^ MeSH Dextrothyroxine ^ C10AX01 v d e Endocrine system: hormones/endocrine glands Peptide hormones, Steroid hormones Hypothalamic-pituitary Hypothalamus: TRH, CRH , GnRH, GHRH, somatostatin, dopamine - Posterior pituitary: vasopressin, oxytocin - Anterior pituitary: α FSH, LH, TSH, GH, prolactin, POMC ACTH, MSH, endorphins, lipotropin Adrenal axis Adrenal medulla: epinephrine, norepinephrine - Adrenal cortex: aldosterone, cortisol, DHEA Thyroid axis Thyroid: thyroid hormone T3 and T4 - calcitonin - Parathyroid: PTH Gonadal axis Testis: testosterone, AMH, inhibin - Ovary: estradiol, progesterone, inhibin/activin, relaxin pregnancy Other end. glands Pancreas: glucagon, insulin, somatostatin - Pineal gland: melatonin Non-end. glands Placenta: hCG, HPL, estrogen, progesterone - Kidney: renin, EPO, calcitriol, prostaglandin - Heart atrium: ANP - Stomach: gastrin, ghrelin - Duodenum: CCK, GIP, secretin, motilin, VIP - Ileum: enteroglucagon - Adipose tissue: leptin, adiponectin, resistin - Thymus: Thymosin - Thymopoietin - Thymulin - Skeleton: Osteocalcin - Liver/other: Insulin-like growth factor IGF-1, IGF-2 Target-derived NGF, BDNF, NT-3 Retrieved from http://en..org/wiki/Thyroxine Categories: Thyroid hormones | Iodinated tyrosine derivatives Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages العربية БългарÑ?ки ÄŒesky Dansk Deutsch Þ‹Þ¨ÞˆÞ¬Þ€Þ¨Þ„Þ¦Þ?Þ° Eesti Español Français Italiano עברית Lietuvių Nederlands 日本語 ‪Norsk bokmÃ¥l‬ Polski Português SlovenÄ?ina Suomi Svenska Türkçe 䏿–‡ This page was last modified on 13 August 2008, at 17:28
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