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14-September-2008 18:02:45 - UniProt Redirected from Uniprot UniProt is the universal protein resource, a central repository of protein data created by combining Swiss-Prot, TrEMBL and PIR. This makes it the world's most comprehensive resource on protein information. Contents 1 The UniProt Consortium 2 The Roots of UniProt Databases 3 Organization of UniProt Databases 4 Funding for UniProt 5 External references The UniProt Consortium The UniProt Consortium comprises the European Bioinformatics Institute EBI, the Swiss Institute of Bioinformatics SIB, and the Protein Information Resource PIR. EBI, located at the Wellcome Trust Genome Campus in Hinxton, UK, hosts a large resource of bioinformatics databases and services. SIB, located in Geneva, Switzerland, maintains the ExPASy Expert Protein Analysis System servers that are a central resource for proteomics tools and databases. PIR, hosted by the National Biomedical Research Foundation NBRF at the Georgetown University Medical Center in Washington, DC, USA, is heir to the oldest protein sequence database, Margaret Dayhoff's Atlas of Protein Sequence and Structure. In 2002, EBI, SIB, and PIR joined forces as the UniProt Consortium. The Roots of UniProt Databases Each consortium member is heavily involved in protein database maintenance and annotation. Until recently, EBI and SIB together produced Swiss-Prot and TrEMBL, while PIR produced the Protein Sequence Database PIR-PSD. These databases coexisted with differing protein sequence coverage and annotation priorities. Swiss-Prot is recognized as the gold standard of protein annotation, with extensive cross-references, literature citations, and computational analyses provided by expert curators. Recognizing that sequence data were being generated at a pace exceeding Swiss-Prot's ability to keep up, TrEMBL Translated EMBL Nucleotide Sequence Data Library was created to provide automated annotations for those proteins not in Swiss-Prot. Meanwhile, PIR maintained the PIR-PSD and related databases, including iProClass, a database of protein sequences and curated families. The consortium members - all dedicated to the same goal of providing expansive and meaningful protein annotation, and all with solid foundations stemming from decades of activity - decided to pool their overlapping and, importantly, their complementary resources, efforts, and expertise. The UniProt databases build upon these solid foundations. Organization of UniProt Databases UniProt provides four core database: The UniProt Knowledgebase UniProtKB is the central database of protein sequences with accurate, consistent, and rich sequence and functional annotation. The UniProt Reference Clusters UniRef databases provide non-redundant reference data collections based on the UniProt knowledgebase in order to obtain complete coverage of sequence space at several resolutions. The UniProt Metagenomics and Environmental Sequences database UniMES is a repository specifically developed for metagenomic and environmental sequence data. The UniProt Archive UniParc provides a stable, comprehensive sequence collection without redundant sequences by storing the complete body of publicly available protein sequence data. Funding for UniProt UniProt is mainly supported by the National Institutes of Health NIH grant 2 U01 HG02712-05. Additional support for the EBI's involvement in UniProt comes from the European Commission EC's FELICS grant 021902RII3 and from the NIH GO grant 2P41HG02273-07. Swiss-Prot activities at the SIB are supported by the Swiss Federal Government through the Federal Office of Education and Science, by the European Commission FELICS grant 021902RII3 and by the PATRIC BRC NIH/NIAID contract HHSN 266200400035C. PIR activities are also supported by the NIH grants and contracts HHSN266200400061C, NCI-caBIG, and 1R01GM080646-01, and the National Science Foundation NSF grant IIS-0430743. External references www.uniprot.org v d e Databases supported by Bioinformatic Harvester NCBI-BLAST · CDD · Ensembl · Entrez · Flybase · Flymine · GFP-cDNA · Genome browser · GeneCard · Google Scholar · GoPubMed · HomoloGene · iHOP · IPI · OMIM · MGI · Mitocheck · PSORT · PolyMeta · RGD · UniProt · SOURCE · SOSUI · RZPD · Sciencenet · STRING · SMART · TAIR · WikiProfessional · ZFIN v d e Major subfields of biology Anatomy · Astrobiology · Biochemistry · Bioinformatics · Biostatistics · Botany · Cell biology · Chronobiology · Developmental biology · Ecology · Epidemiology · Evolutionary biology · Genetics · Genomics · Human biology · Immunology · Marine biology · Microbiology · Molecular biology · Neuroscience · Nutrition · Origin of life · Paleontology · Parasitology · Pathology · Physiology · Systems biology · Taxonomy · Zoology Retrieved from http://en..org/wiki/UniProt Categories: Bioinformatics databases Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages Deutsch Español This page was last modified on 16 July 2008, at 12:01
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