Sierra Acai Company
Sierra Acai Company
Open 7 Days a Week
MonaVie Independent Distributor
Distributor Training
Shop Online
Enroll Now
Buy Wholesale and maintain an Active status for 2 months and we will refund your $39 Distributor Fee
Friends
Buy Wholesale and maintain an Active status for 2 months and we will refund your $39 Distributor Fee
14-September-2008 18:02:45 - Urotensin-II receptor Urotensin 2 receptor Identifiers Symbols UTS2R; GPR14; UTR; UTR2 External IDs OMIM: 600896 MGI: 2183450 HomoloGene: 10345 Gene ontology Molecular function: rhodopsin-like receptor activity urotensin II receptor activity receptor activity Cellular component: membrane integral to membrane Biological process: signal transduction G-protein coupled receptor protein signaling pathway circulation Orthologs Human Mouse Entrez 2837 217369 Ensembl ENSG00000181408 ENSMUSG00000039321 Uniprot Q9UKP6 Q05AD1 Refseq NM_018949 mRNA NP_061822 protein NM_145440 mRNA NP_663415 protein Location Chr 17: 77.93 - 77.93 Mb Chr 11: 120.98 - 120.98 Mb Pubmed search 1 2 The urotensin-II receptor also referred to as the hypocretin receptor is a G-protein coupled receptor which binds the peptide hormone urotensin-II.1 References ^ Douglas SA, Dhanak D, Johns DG 2004. From 'gills to pills': urotensin-II as a regulator of mammalian cardiorenal function. Trends Pharmacol. Sci. 25 2: 76-85. doi:10.1016/j.tips.2003.12.005. PMID 15102493. Further reading Marchese A, Heiber M, Nguyen T, et al. 1996. Cloning and chromosomal mapping of three novel genes, GPR9, GPR10, and GPR14, encoding receptors related to interleukin 8, neuropeptide Y, and somatostatin receptors.. Genomics 29 2: 335-44. PMID 8666380. Coulouarn Y, Lihrmann I, Jegou S, et al. 1999. Cloning of the cDNA encoding the urotensin II precursor in frog and human reveals intense expression of the urotensin II gene in motoneurons of the spinal cord.. Proc. Natl. Acad. Sci. U.S.A. 95 26: 15803-8. PMID 9861051. Ames RS, Sarau HM, Chambers JK, et al. 1999. Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14.. Nature 401 6750: 282-6. doi:10.1038/45809. PMID 10499587. Liu Q, Pong SS, Zeng Z, et al. 2000. Identification of urotensin II as the endogenous ligand for the orphan G-protein-coupled receptor GPR14.. Biochem. Biophys. Res. Commun. 266 1: 174-8. doi:10.1006/bbrc.1999.1796. PMID 10581185. Protopopov A, Kashuba V, Podowski R, et al. 2000. Assignment of the GPR14 gene coding for the G-protein-coupled receptor 14 to human chromosome 17q25.3 by fluorescent in situ hybridization.. Cytogenet. Cell Genet. 88 3-4: 312-3. PMID 10828617. Maguire JJ, Kuc RE, Davenport AP 2001. Orphan-receptor ligand human urotensin II: receptor localization in human tissues and comparison of vasoconstrictor responses with endothelin-1.. Br. J. Pharmacol. 131 3: 441-6. doi:10.1038/sj.bjp.0703601. PMID 11015293. Sugo T, Murakami Y, Shimomura Y, et al. 2003. Identification of urotensin II-related peptide as the urotensin II-immunoreactive molecule in the rat brain.. Biochem. Biophys. Res. Commun. 310 3: 860-8. PMID 14550283. Birker-Robaczewska M, Boukhadra C, Studer R, et al. 2004. The expression of urotensin II receptor U2R is up-regulated by interferon-gamma.. J. Recept. Signal Transduct. Res. 23 4: 289-305. PMID 14753294. Bousette N, Patel L, Douglas SA, et al. 2004. Increased expression of urotensin II and its cognate receptor GPR14 in atherosclerotic lesions of the human aorta.. Atherosclerosis 176 1: 117-23. doi:10.1016/j.atherosclerosis.2004.03.023. PMID 15306183. Suzuki S, Wenyi Z, Hirai M, et al. 2005. Genetic variations at urotensin II and urotensin II receptor genes and risk of type 2 diabetes mellitus in Japanese.. Peptides 25 10: 1803-8. doi:10.1016/j.peptides.2004.03.030. PMID 15476949. Qi JS, Minor LK, Smith C, et al. 2005. Characterization of functional urotensin II receptors in human skeletal muscle myoblasts: comparison with angiotensin II receptors.. Peptides 26 4: 683-90. doi:10.1016/j.peptides.2004.11.018. PMID 15752584. Lehner U, Velić A, Schroter R, et al. 2007. Ligands and signaling of the G-protein-coupled receptor GPR14, expressed in human kidney cells.. Cell. Physiol. Biochem. 20 1-4: 181-92. doi:10.1159/000104165. PMID 17595527. Segain JP, Rolli-Derkinderen M, Gervois N, et al. 2007. Urotensin II is a new chemotactic factor for UT receptor-expressing monocytes.. J. Immunol. 179 2: 901-9. PMID 17617581. External links IUPHAR GPCR Database - Urotensin receptor MeSH UTS2R+protein,+human This transmembrane receptor-related article is a stub. v d e Transmembrane receptor: G protein-coupled receptors Class A: Rhodopsin like Adrenergic α1 A, B, D, α2 A, B, C, β1, β2, β3 Eicosanoid CysLT 1, 2, LTB4 1, 2, FPRL1, OXE, Prostaglandin DP, EP 1, 2, 3, 4, PGF, Prostacyclin, Thromboxane Neuropeptide B/W 1, 2, FF 1, 2, S, Y 1, 2, 4, 5 Orphan GPR 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182 Purinergics Adenosine A1, A2a, A2b, A3, P2Y, 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14 Serotonin all but 5-HT3 5-HT1 A, B, D, E, F, 5-HT2 A, B, C, 5-HT 4, 5A, 6, 7 Other Acetylcholine M1, M2, M3, M4, M5 - Adrenomedullin - Anaphylatoxin C3a, C5a - Angiotensin 1, 2 - Apelin - Bile acid - Bombesin BRS3, GRPR, NMBR - Bradykinin B1, B2 - Cannabinoid CB1, CB2 - Chemokine - Cholecystokinin A, B - Dopamine D1, D2, D3, D4, D5 - EBI2 - Endothelin A, B - Estrogen - Formyl peptide 1, L1, L2 - Free fatty acid 1, 2, 3, 4 - FSH - Galanin 1, 2, 3 - Gonadotropin-releasing hormone 1, 2 - Ghrelin - Histamine H1, H2, H3, H4 - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid 1, 2, 3, 4, 5, 6, 7, 8 - MAS 1, 1L, D, E, F, G, X1, X2, X3, X4 - Melanocortin 1, 2, 3, 4, 5 - MCHR 1, 2 - Melatonin 1A, 1B- Motilin - neuromedin B, U 1, 2 - Neurotensin 1, 2 - Opioid Delta, Kappa, Mu, Nociceptin, but not Sigma - Olfactory - Opsin 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH - Orexin 1, 2 - Oxytocin - Oxoglutarate - PAF - Prokineticin 1, 2 - Prolactin-releasing peptide - Protease-activated 1, 2, 3, 4 - Relaxin 1, 2, 3, 4 - Somatostatin 1, 2, 3, 4, 5 - SREB - Succinate - TAAR 1, 2, 3, 5, 6, 8, 9 - Tachykinin 1, 2, 3 - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin 1A, 1B, 2 Class B: Secretin like Brain-specific angiogenesis inhibitor 1, 2, 3 - Cadherin 1, 2, 3 - Calcitonin - CD97 - Corticotropin-releasing hormone 1, 2 - EMR 1, 2, 3 - Glucagon GR, GIPR, GLP1R, GLP2R - Growth hormone releasing hormone - PACAPR1- GPR 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157 - Latrophilin 1, 2, 3, ELTD1 - Parathyroid hormone 1, 2 - Secretin - Vasoactive intestinal peptide 1, 2 Class C: Metabotropic glutamate / pheromone Calcium-sensing receptor - GABA B 1, 2 - Glutamate receptor Metabotropic glutamate 1, 2, 3, 4, 5, 6, 7, 8 - GPRC6A - GPR 156, 158, 179 - RAIG 1, 2, 3, 4 - Taste receptors TAS1R 1, 2, 3 TAS2R 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50 Frizzled / Smoothened Frizzled 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 - Smoothened Retrieved from http://en..org/wiki/Urotensin-II_receptor Categories: Genes on chromosome 17 | Human proteins | Transmembrane receptor stubs | G protein coupled receptorsHidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 8 July 2008, at 05:37
39 Reasons to Drink Acai Juice Every Day
What is MonaVie - Watch the 8-minute video
Discovering MonaVie Video
The Power of You Video
Effects of MonaVie Active on Antioxidant Capacity in Humans
Log into your Wholesale MonaVie Account
So many of us do not eat a balanced diet, get enough sleep, have too much stress, or are impacted with toxins and pollutants. Drinking 2 ounces of MonaVie twice a day will help your body detoxify as well as build your immune system. Its the smartest thing you can do for yourself, so start today. Buying MonaVie through our company guarantees you support 7 days a week and, if you would like to share MonaVie with your family and friends we will guide you from start to finish.
1. Click on Enroll Now (30 - 55% off retail price)
2. Pay $39 for your Wholesale ID number.
3. NO minimum order required.
4. MonaVie is delivered to your door in 3 to 5 days.