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14-September-2008 18:02:45 - VIPR2 Vasoactive intestinal peptide receptor 2 Identifiers Symbols VIPR2; FLJ16511; VPAC2 External IDs OMIM: 601970 MGI: 107166 HomoloGene: 2540 Gene ontology Molecular function: receptor activity G-protein coupled receptor activity vasoactive intestinal polypeptide receptor activity Cellular component: plasma membrane integral to plasma membrane membrane Biological process: signal transduction G-protein coupled receptor protein signaling pathway cell-cell signaling RNA expression pattern More reference expression data Orthologs Human Mouse Entrez 7434 22355 Ensembl ENSG00000106018 n/a Uniprot P41587 n/a Refseq NM_003382 mRNA NP_003373 protein XM_987059 mRNA XP_992153 protein Location Chr 7: 158.51 - 158.63 Mb n/a Pubmed search 1 2 Vasoactive intestinal peptide receptor 2, also known as VIPR2, is a human gene.1 Vasoactive intestinal peptide VIP; MIM 192320 and pituitary adenylate cyclase activating polypeptide PACAP; MIM 102980 are homologous peptides that function as neurotransmitters and neuroendocrine hormones. While the receptors for VIP and PACAP share homology, they differ in their substrate specificities and expression patterns. See VIPR1 MIM 192321 and ADCYAP1R1MIM 102981.supplied by OMIM1 See also Vasoactive intestinal peptide receptor References ^ a b Entrez Gene: VIPR2 vasoactive intestinal peptide receptor 2. Further reading Goetzl EJ, Pankhaniya RR, Gaufo GO, et al. 1998. Selectivity of effects of vasoactive intestinal peptide on macrophages and lymphocytes in compartmental immune responses.. Ann. N. Y. Acad. Sci. 840: 540-50. PMID 9629281. Adamou JE, Aiyar N, Van Horn S, Elshourbagy NA 1995. Cloning and functional characterization of the human vasoactive intestinal peptide VIP-2 receptor.. Biochem. Biophys. Res. Commun. 209 2: 385-92. PMID 7733904. Svoboda M, Tastenoy M, Van Rampelbergh J, et al. 1995. Molecular cloning and functional characterization of a human VIP receptor from SUP-T1 lymphoblasts.. Biochem. Biophys. Res. Commun. 205 3: 1617-24. PMID 7811244. Inagaki N, Yoshida H, Mizuta M, et al. 1994. Cloning and functional characterization of a third pituitary adenylate cyclase-activating polypeptide receptor subtype expressed in insulin-secreting cells.. Proc. Natl. Acad. Sci. U.S.A. 91 7: 2679-83. PMID 8146174. Xia M, Gaufo GO, Wang Q, et al. 1996. Transduction of specific inhibition of HuT 78 human T cell chemotaxis by type I vasoactive intestinal peptide receptors.. J. Immunol. 157 3: 1132-8. PMID 8757618. Wei Y, Mojsov S 1997. Tissue specific expression of different human receptor types for pituitary adenylate cyclase activating polypeptide and vasoactive intestinal polypeptide: implications for their role in human physiology.. J. Neuroendocrinol. 8 11: 811-7. PMID 8933357. Mackay M, Fantes J, Scherer S, et al. 1997. Chromosomal localization in mouse and human of the vasoactive intestinal peptide receptor type 2 gene: a possible contributor to the holoprosencephaly 3 phenotype.. Genomics 37 3: 345-53. PMID 8938447. Nicole P, Du K, Couvineau A, Laburthe M 1998. Site-directed mutagenesis of human vasoactive intestinal peptide receptor subtypes VIP1 and VIP2: evidence for difference in the structure-function relationship.. J. Pharmacol. Exp. Ther. 284 2: 744-50. PMID 9454823. Dewit D, Gourlet P, Amraoui Z, et al. 1998. The vasoactive intestinal peptide analogue RO25-1553 inhibits the production of TNF and IL-12 by LPS-activated monocytes.. Immunol. Lett. 60 1: 57-60. PMID 9541464. Lutz EM, Shen S, Mackay M, et al. 1999. Structure of the human VIPR2 gene for vasoactive intestinal peptide receptor type 2.. FEBS Lett. 458 2: 197-203. PMID 10481065. Busto R, Prieto JC, Bodega G, et al. 2000. Immunohistochemical localization and distribution of VIP/PACAP receptors in human lung.. Peptides 21 2: 265-9. PMID 10764955. Nicole P, Lins L, Rouyer-Fessard C, et al. 2000. Identification of key residues for interaction of vasoactive intestinal peptide with human VPAC1 and VPAC2 receptors and development of a highly selective VPAC1 receptor agonist. Alanine scanning and molecular modeling of the peptide.. J. Biol. Chem. 275 31: 24003-12. doi:10.1074/jbc.M002325200. PMID 10801840. Bajo AM, Juarranz MG, Valenzuela P, et al. 2001. Expression of vasoactive intestinal peptide VIP receptors in human uterus.. Peptides 21 9: 1383-8. PMID 11072126. Lara-Marquez M, O'Dorisio M, O'Dorisio T, et al. 2001. Selective gene expression and activation-dependent regulation of vasoactive intestinal peptide receptor type 1 and type 2 in human T cells.. J. Immunol. 166 4: 2522-30. PMID 11160313. Lara-Marquez ML, O'Dorisio MS, Karacay B 2001. Vasoactive intestinal peptide VIP receptor type 2 VPAC2 is the predominant receptor expressed in human thymocytes.. Ann. N. Y. Acad. Sci. 921: 45-54. PMID 11193874. Groneberg DA, Hartmann P, Dinh QT, Fischer A 2001. Expression and distribution of vasoactive intestinal polypeptide receptor VPAC2 mRNA in human airways.. Lab. Invest. 81 5: 749-55. PMID 11351046. Juarranz MG, Bolaños O, Gutiérrez-Cañas I, et al. 2002. Neuroendocrine differentiation of the LNCaP prostate cancer cell line maintains the expression and function of VIP and PACAP receptors.. Cell. Signal. 13 12: 887-94. PMID 11728828. Fischer TC, Dinh QT, Peiser C, et al. 2002. Simultaneous detection of receptor mRNA and ligand protein in human skin tissues.. J. Cutan. Pathol. 29 2: 65-71. PMID 12150135. Strausberg RL, Feingold EA, Grouse LH, et al. 2003. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 99 26: 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. This transmembrane receptor-related article is a stub. This article incorporates text from the United States National Library of Medicine, which is in the public domain. v d e Transmembrane receptor: G protein-coupled receptors Class A: Rhodopsin like Adrenergic α1 A, B, D, α2 A, B, C, β1, β2, β3 Eicosanoid CysLT 1, 2, LTB4 1, 2, FPRL1, OXE, Prostaglandin DP, EP 1, 2, 3, 4, PGF, Prostacyclin, Thromboxane Neuropeptide B/W 1, 2, FF 1, 2, S, Y 1, 2, 4, 5 Orphan GPR 1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182 Purinergics Adenosine A1, A2a, A2b, A3, P2Y, 1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14 Serotonin all but 5-HT3 5-HT1 A, B, D, E, F, 5-HT2 A, B, C, 5-HT 4, 5A, 6, 7 Other Acetylcholine M1, M2, M3, M4, M5 - Adrenomedullin - Anaphylatoxin C3a, C5a - Angiotensin 1, 2 - Apelin - Bile acid - Bombesin BRS3, GRPR, NMBR - Bradykinin B1, B2 - Cannabinoid CB1, CB2 - Chemokine - Cholecystokinin A, B - Dopamine D1, D2, D3, D4, D5 - EBI2 - Endothelin A, B - Estrogen - Formyl peptide 1, L1, L2 - Free fatty acid 1, 2, 3, 4 - FSH - Galanin 1, 2, 3 - Gonadotropin-releasing hormone 1, 2 - Ghrelin - Histamine H1, H2, H3, H4 - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid 1, 2, 3, 4, 5, 6, 7, 8 - MAS 1, 1L, D, E, F, G, X1, X2, X3, X4 - Melanocortin 1, 2, 3, 4, 5 - MCHR 1, 2 - Melatonin 1A, 1B- Motilin - neuromedin B, U 1, 2 - Neurotensin 1, 2 - Opioid Delta, Kappa, Mu, Nociceptin, but not Sigma - Olfactory - Opsin 3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH - Orexin 1, 2 - Oxytocin - Oxoglutarate - PAF - Prokineticin 1, 2 - Prolactin-releasing peptide - Protease-activated 1, 2, 3, 4 - Relaxin 1, 2, 3, 4 - Somatostatin 1, 2, 3, 4, 5 - SREB - Succinate - TAAR 1, 2, 3, 5, 6, 8, 9 - Tachykinin 1, 2, 3 - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin 1A, 1B, 2 Class B: Secretin like Brain-specific angiogenesis inhibitor 1, 2, 3 - Cadherin 1, 2, 3 - Calcitonin - CD97 - Corticotropin-releasing hormone 1, 2 - EMR 1, 2, 3 - Glucagon GR, GIPR, GLP1R, GLP2R - Growth hormone releasing hormone - PACAPR1- GPR 56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157 - Latrophilin 1, 2, 3, ELTD1 - Parathyroid hormone 1, 2 - Secretin - Vasoactive intestinal peptide 1, 2 Class C: Metabotropic glutamate / pheromone Calcium-sensing receptor - GABA B 1, 2 - Glutamate receptor Metabotropic glutamate 1, 2, 3, 4, 5, 6, 7, 8 - GPRC6A - GPR 156, 158, 179 - RAIG 1, 2, 3, 4 - Taste receptors TAS1R 1, 2, 3 TAS2R 1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50 Frizzled / Smoothened Frizzled 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 - Smoothened Retrieved from http://en..org/wiki/VIPR2 Categories: Genes on chromosome 7 | Human proteins | Transmembrane receptor stubs | G protein coupled receptorsHidden category: Protein pages needing a picture Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 8 July 2008, at 12:08
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