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08-SEPTEMBER-2008 07:42:01 - Ageing brain The human brain goes through several large-scale changes as the individual progresses from embryo through to old age. Contents 1 Pre-natal development 2 Adolescence 3 Aging 4 See also 5 External links Pre-natal development Developmental neurobiology concerns itself with the development of the brain. The process of neurogenesis populates the brain, then programmed cell death cuts the growing brain down to size. Adolescence During adolescence the brain goes through a process of synaptic pruning. Aging Over the years, the human brain shows a decline in function and a change in gene expression. This modulation in gene expression may be due to oxidative DNA damage at promoter regions in the genome. Genes that are down-regulated over the age of 40 include: GluR1 AMPA receptor subunit NMDA R2A receptor subunit involved in learning Subunits of the GABA-A receptor Genes involved in long-term potentiation e.g. calmodulin 1 and CAM kinase II alpha. Calcium signalling genes Synaptic plasticity genes Synaptic vesicle release recycling genes Genes that are upregulated include: Genes associated with stress response and DNA repair Antioxidant defence Normal aging is distinct from Neurodegenerative disease. DNA damage due to oxidation increase as the brain ages, possibly due to impaired mitochondrial function. See also Aging DNA damage theory of aging Life extension List of life extension related topics Memory and aging Senescence External links Brain puzzles from Infoaging.org Researchers Gain New Insights into the Aging Brain Study suggests aging brain shifts gears to emotional advantage Brain exercise softwarecommercial This neuroscience article is a stub. Retrieved from http://en..org/wiki/Ageing_brain Categories: Central nervous system | Aging | Neuroscience stubs Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 25 April 2008, at 21:46
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