Sierra Acai Company
Sierra Acai Company
Open 7 Days a Week
MonaVie Independent Distributor
Distributor Training
Shop Online
Enroll Now
Buy Wholesale and maintain an Active status for 2 months and we will refund your $39 Distributor Fee
Friends
Buy Wholesale and maintain an Active status for 2 months and we will refund your $39 Distributor Fee
08-SEPTEMBER-2008 07:42:01 - Maximum life span Redirected from Maximum lifespan Maximum life span is a measure of the maximum amount of time one or more members of a group has been observed to survive between birth and death. Contents 1 Definition 2 In humans 3 In other animals 4 In plants 5 Increasing maximum life span 6 Research data concerning maximum life span 7 See also 8 References 9 External links Definition In animal studies, maximum life span is often taken to be the mean life span of the most long-lived 10% of a given cohort. By another definition, however, maximum life span corresponds to the age at which the oldest known member of a species or experimental group has died. Calculation of the maximum life span in the former sense depends upon initial sample size.1 Maximum life span is in contrast with mean life span average life span or life expectancy. Mean life span varies with susceptibility to disease, accident, suicide and homicide, whereas maximum life span is determined by rate of aging.2 In humans The oldest recognized person on record is Jeanne Calment, a French woman who lived for 122 years and 164 days. Maximum life span for humans has remained about 115-120 calendar years throughout recorded history, despite steady improvements in life expectancy. Reduction of infant mortality has accounted for most of this increased average longevity, but since the 1960s mortality rates among those over 80 years has decreased by about 1.5% per year. Advances in medicine, calorie restriction with adequate nutrition, or other interventions are said to have slowed the aging process. Although calorie restriction has not been proven to extend the maximum human life span, as of 2006, results in ongoing primate studies are promising3. Identical twins tend to die within 3 years of each othercitation needed, whereas fraternal twins tend to die within 6 yearscitation needed. Aging theories associated with DNA include programmed aging or programmed aging-resistance and theories that link aging with DNA damage/mutation or DNA repair capability. In other animals Small animals such as birds and squirrels rarely live to their maximum life span, usually dying of accidents and disease. Grazing animals show wear and tear to their teeth to the point where they can no longer eat, and they die of starvation. The maximum life span of most species has not been accurately determined, because the data collection has been minimal and the number of species studied in captivity or by monitoring in the wild has been small. Maximum life span is usually longer for species that are larger or have effective defenses against predation, such as bird flight, tortoise shells, porcupine quills, or large primate brains. When we look at primates, of the approximately 20,000 to 25,000 genes in the human genome, it is estimated that 6% of these are different from those of a chimpanzee, which, in contrast to the human lifespan, has an average lifespan of only 52 years. The difference in longevity between humans and chimps could be due to as few as a hundred genes or less; however there may be other factors that shorten the life span of chimpanzees. The differences between life span between species demonstrate the role of genetics in determining maximum life span rate of aging. The records in years are these: for mice, 4citation needed for dogs, 29, in Australia for cats, 36.4; for goldfish, 495 for horses, 62 for chimpanzees, 76 Cheeta for elephants, 86citation needed The longest-lived vertebrates have been variously described as tortoises Galápagos tortoise 190 yearscitation needed tuataras a New Zealand lizard species, 100-200+ years6 whales Bowhead Whale about 211 years Although this idea was considered specious for a time, recent research has indicated that bowhead whales recently killed still had harpoons in their bodies from the 1790s, which, along with analysis of amino acids, has indicated a maximum life span, so far, of at least 211 years 7. Invertebrate species which continue to grow as long as they live e.g., certain clams, some coral species can on occasion live hundreds of years: A bivalve mollusc Arctica islandica between 405-410 years8 In plants Plants are referred to as annuals which only live one year, biennials which live two years, and perennials which live longer than that. The longest-lived perennials, woody-stemmed plants such as trees and bushes, often live for hundreds and even thousands of years one may question whether or not they may die of old age. A giant sequoia, General Sherman is alive and well in its second millennium. A Great Basin Bristlecone Pine called Methuselah is 4,838 years old and the Bristlecone Pine called Prometheus was a little older still, 4,844 years, when it was cut down in 1964. Increasing maximum life span Currently, the only non-transgenic method of increasing maximum life span that is recognized by biogerontologists is calorie restriction with adequate nutrition. Maximum life span here means the mean life span of the most long-lived 10% of a given cohort, as caloric restriction has not yet been shown to break mammalian world records for longevity. Rats, mice, and hamsters experience maximum life-span extension from a diet that contains 40-60% of the calories but all of the required nutrients that the animals consume when they can eat as much as they want. Mean life span is increased 65% and maximum life span is increased 50%, when caloric restriction is begun just before puberty.9. For fruit flies the life extending benefits of calorie restriction are gained immediately at any age upon beginning calorie restriction and ended immediately at any age upon resuming full feeding10. Mammals fed anti-oxidants show up to a 30% increase in mean life span, but no increase in maximum life span. Antioxidants are most valuable for animals that are cancer-prone or subjected to radiation or chemical toxins. There are evidently homeostatic mechanisms in cells that govern the amount of allowable antioxidant activity. Many life-extensionists have dismissed the value of antioxidants simply because they have not been shown to increase maximum life span, but such a view neglects the significance of an extended mean life span. On the other hand Michael Ristow's laboratory has recently shown that antioxidants may prevent extension of life span. Increased activity of intracellular organelles named mitochondria due to impaired metabolism of the nutritive sugar glucose extends life span of a model organism, the worm Caenorhabditis elegans. This extension occurs completely unexpectedly by increasing oxidative stress due to increased mitochondrial activity. Most importantly the life-extending effect of the low-sugar diet is abolished by various antioxidants, suggesting that induction of oxidative stress may be required for health and extended life expectancy. 11 This latter process has been previously named mitohormesis or mitochondrial hormesis on a purely hypothetical basis, 12 and suggests that increased mitochondrial activity and specifically generation of oxidative stress due to this metabolic increase exert positive biological effects ultimately promoting health. These findings fundamentally question the hypothesis of Denham Harman, and provide a mechanistic basis for the questionable use of antioxidants in humans. 13 Many transgenic species of mice have been created that have maximum life spans greater than that of wild-type or laboratory mice, including Ames dwarf mice, Snell dwarf mice, mice with increased mitochondrial catalase, and others. Some biomedical gerontologists gerontologists who search for ways to extend maximum life span believe that biomedical molecular engineering can someday extend maximum lifespan and even bring about rejuvenation. One such researcher is Aubrey de Grey, who calls his project to reverse the damage called aging SENS Strategies for Engineered Negligible Senescence. Dr. de Grey has established the The Methuselah Mouse Prize to award money to researchers who can extend the maximum life span of mice. Research data concerning maximum life span A comparison of the heart mitochondria in rats 4-year maximum life span and pigeons 35-year maximum life span showed that pigeon mitochondria leak fewer free-radicals than rat mitochondria, despite the fact that both animals have similar metabolic rate and cardiac output14 For mammals there is a direct relationship between mitochondrial membrane fatty acid saturation and maximum life span15 Studies of the liver lipids of mammals and a bird pigeon show an inverse relationship between maximum life span and number of double bonds16 Selected species of birds and mammals show an inverse relationship between telomere rate of change shortening and maximum life span17 Maximum life span correlates negatively with antioxidant enzyme levels and correlates positively with lower rate of free-radicals production and higher rate of DNA repair18 Females express both more Mn-SOD and more glutathione peroxidase antioxidant enzymes than males, and this has been suggested to be the reason females live longer than males in mammalian species19 The maximum life span of transgenic mice has been extended about 20% by overexpression of human catalase targeted to mitochondria20 A comparison of 7 non-primate mammals mouse, hamster, rat, guinea-pig, rabbit, pig and cow showed that the rate of mitochondrial superoxide and hydrogen peroxide production in heart and kidney were inversely correlated with maximum life span21 A study of 8 non-primate mammals showed a direct correlation between maximum life span and oxidative damage to mtDNA Mitochondrial DNA in heart brain22 A study of several species of mammals and a bird pigeon indicated a linear relationship between oxidative damage to protein and maximum life span23 There is a direct correlation between DNA repair and maximum life span for mammalian species24 Drosophila fruit-flies bred for 15 generations by only using eggs that were laid toward the end of reproductive life achieved maximum life spans 30% greater than that of controls25 Overexpression of the enzyme which synthesizes glutathione in long-lived transgenic Drosophila fruit-flies extended maximum lifespan by nearly 50%26 A mutation in the age-1 gene of the nematode worm Caenorhabditis elegans increased mean life span 65% and maximum life span 110%27 Fat-specific Insulin Receptor KnockOut FIRKO mice have reduced fat mass, normal calorie intake and an increased maximum life span of 18%28 The capacity of mammalian species to detoxify the carcinogenic chemical benzoapyrene to a water-soluble form also correlates well with maximum life span29 Short-term induction of oxidative stress due to calorie restriction increases life span in Caenorhabditis elegans by promoting stress defense, specifically by inducing an enzyme called catalase. As shown by Michael Ristow and co-workers nutritive antioxidants completely abolish this extension of life span by inhibiting a process called mitohormesis. 11 See also Aging American Aging Association Aubrey de Grey Gerontology Biodemography Biological immortality Calorie restriction Compression of morbidity DNA damage theory of aging Strategies for Engineered Negligible Senescence SENS Indefinite lifespan Life expectancy Life extension List of long-living organisms Longevity Methuselah Mouse Prize Michael Ristow Mitohormesis Oldest people Senescence References ^ Leonid A. Gavrilov Natalia S. Gavrilova 1991, The Biology of Life Span: A Quantitative Approach. New York: Harwood Academic Publisher, ISBN 3-7186-4983-7 ^ Jane E. Brody Tuesday, August 26, 2008 Living Longer, in Good Health to the End, New York Times p. D7, is an article on compression of morbidity: adults can be vigorous well into their 80's, with their illnesses and disabilities compressed into a short period before their deaths. ^ SpringerLink - Journal Article ^ Feline Statistics. Retrieved on 2005-08-15. ^ 1, 2 ^ Tuatara#cite_note-43 ^ Bada Whales ^ http://www.newsdaily.com/Science/UPI-1-20071028-18102000-bc-britain-clam-crn.xml ^ Koubova J, Guarente L. 2003. How does calorie restriction work?. Genes Development 17 3: 313-321. doi:10.1101/gad.1052903. PMID 12569120. ^ Mair W, Goymer P, Pletcher SD, Partridge L. 2003. Demography of dietary restriction and death in Drosophila. SCIENCE 301 5640: 1731-1733. doi:10.1126/science.1086016. PMID 114500985. ^ a b Publication demonstrating that oxidative stress is promoting life span ^ Publication that first used the term mitohormesis ^ Publication demonstrating negative effects of antioxidants on human health ^ Herrero A, Barja G. 1997. Sites and mechanisms responsible for the low rate of free radical production of heart mitochondria in the long-lived pigeon. Mechanisms Of Aging And Development 98 2: 95-111. doi:10.1016/S0047-63749700076-6. PMID 9379714. ^ Pamplona R, Portero-Otin M, Riba D, Ruiz C, Prat J, Bellmunt MJ, Barja G. 1998. Mitochondrial membrane peroxidizability index is inversely related to maximum life span in mammals. Journal Of Lipid Research 39 2: 1989-1994. PMID 9788245. ^ Pamplona R, Portero-Otin M, Riba D, Requena JR, Thorpe SR, Lopez-Torres M, Barja G. 2000. Low fatty acid unsaturation: a mechanism for lowered lipoperoxidative modification of tissue proteins in mammalian species with long life spans. JOURNALS OF GERONTOLOGY SERIES A BIOLOGICAL SCIENCES AND MEDICAL SCIENCES 55A 6: B286-B291. PMID 10843345. ^ Haussmann MF, Winkler DW, O'Reilly KM, Huntington CE, Nisbet IC, Vleck CM 2003. Telomeres shorten more slowly in long-lived birds and mammals than in short-lived ones. Proceedings. Biological Sciences / The Royal Society 270 1522: 1387-1392. doi:10.1098/rspb.2003.2385. PMID 12965030. ^ Perez-Campo R, Lopez-Torres M, Cadenas S, Rojas C, Barja G. 1998. The rate of free radical production as a determinant of the rate of aging: evidence from the comparative approach.. JOURNAL OF COMPARATIVE PHYSIOLOGY. B, Biochemical, systemic, and environmental physiology 168 3: 149-158. doi:10.1007/s003600050131. PMID 9591361. ^ Vina J, Borras C, Gambini J, Sastre J, Pallardo FV. 2005. Why females live longer than males? Importance of the upregulation of longevity-associated genes by oestrogenic compounds. Febs Letters 579 12: 2541-2545. doi:10.1016/j.febslet.2005.03.090. PMID 15862287. ^ Schriner SE, Linford NJ, Martin GM, Treuting P, Ogburn CE, Emond M, Coskun PE, Ladiges W, Wolf N, Van Remmen H, Wallace DC, Rabinovitch PS. 2005. Extension of murine life span by overexpression of catalase targeted to mitochondria. SCIENCE 308 5730: 1909-1911. doi:10.1126/science.1106653. PMID 15879174. ^ Ku HH, Brunk UT, Sohal RS. 1993. Relationship between mitochondrial superoxide and hydrogen peroxide production and longevity of mammalian species. Free Radical Biology Medicine 15 6: 621-627. doi:10.1016/0891-58499390165-Q. PMID 8138188. ^ Barja G, Herrero A. 2000. Oxidative damage to mitochondrial DNA is inversely related to maximum life span in the heart and brain of mammals. The Faseb Journal 14 2: 312-318. PMID 10657987. ^ Agarwal S, Sohal RS. 1996. Relationship between susceptibility to protein oxidation, aging, and maximum life span potential of different species. Experimental Gerontology 31 3: 365-372. doi:10.1016/0531-55659502039-X. PMID 9415119. ^ Cortopassi GA, Wang E. 1996. There is substantial agreement among interspecies estimates of DNA repair activity. Mechanisms Of Aging And Development 91 3: 211-218. doi:10.1016/S0047-63749601788-5. PMID 9055244. ^ Kurapati R, Passananti HB, Rose MR, Tower J. 2000. Increased hsp22 RNA levels in Drosophila lines genetically selected for increased longevity. JOURNALS OF GERONTOLOGY SERIES A BIOLOGICAL SCIENCES AND MEDICAL SCIENCES 55A 11: B552-B559. PMID 11078089. ^ Orr WC, Radyuk SN, Prabhudesai L, Toroser D, Benes JJ, Luchak JM, Mockett RJ, Rebrin I, Hubbard JG, Sohal RS 2005. Overexpression of glutamate-cysteine ligase extends life span in Drosophila melanogaster. The Journal Of Biological Chemistry 280 45: 37331-37338. doi:10.1074/jbc.M508272200. PMID 16148000. ^ Friedman DB, Johnson TE. 1988. A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility. GENETICS 118 1: 75-86. PMID 8608934. ^ Bluher M, Kahn BB, Kahn CR. 2003. Extended longevity in mice lacking the insulin receptor in adipose tissue. SCIENCE 299 5606: 572-574. doi:10.1126/science.1078223. PMID 12543978. ^ Moore CJ, Schwartz AG. 1978. Inverse correlation between species lifespan and capacity of cultured fibroblasts to convert benzoapyrene to water-soluble metabolites. Experimental Cell Research 116 2: 359-364. doi:10.1016/0014-48277890459-7. PMID 101383. External links AnAge Database Centenarians' Road Calorie Restriction Society Informational website on the biology of aging. Living Longer, Living Stronger Mechanisms of Aging Strategies for Engineered Negligible Senescence SENS The animals with the longest and shortest life spans The Longevity Meme Longevity Activism The Secrets of Long Life National Geographic magazine v d e Longevity Terminology Centenarian · Supercentenarian · Maximum life span · Life extension · Life expectancy Lists Oldest people · 100 verified oldest people · 100 verified oldest men · Centenarians · National longevity recordholders · Living national longevity recordholders · Living supercentenarians · American supercentenarians · British supercentenarians · Canadian supercentenarians · Dutch supercentenarians · French supercentenarians · Nordic supercentenarians · Portuguese supercentenarians · Longevity claims · Longevity myths · Oldest validated person by year of birth · Oldest people by U.S. state · Oldest living people by U.S. state · List of life extension-related topics War-related Last surviving United States war veterans · Surviving veterans of World War I · Last surviving World War I veteran by country · Surviving veterans of the Spanish Civil War Non-human Long-living organisms · List of oldest trees See also Gerontology · Ageing Retrieved from http://en..org/wiki/Maximum_life_span Categories: Actuarial science | Aging | Demography | GerontologyHidden categories: All articles with statements | Articles with statements since April 2008 Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages РуÑ?Ñ?кий УкраїнÑ?ька This page was last modified on 26 August 2008, at 13:38
39 Reasons to Drink Acai Juice Every Day
What is MonaVie - Watch the 8-minute video
Discovering MonaVie Video
The Power of You Video
Effects of MonaVie Active on Antioxidant Capacity in Humans
Log into your Wholesale MonaVie Account
So many of us do not eat a balanced diet, get enough sleep, have too much stress, or are impacted with toxins and pollutants. Drinking 2 ounces of MonaVie twice a day will help your body detoxify as well as build your immune system. Its the smartest thing you can do for yourself, so start today. Buying MonaVie through our company guarantees you support 7 days a week and, if you would like to share MonaVie with your family and friends we will guide you from start to finish.
1. Click on Enroll Now (30 - 55% off retail price)
2. Pay $39 for your Wholesale ID number.
3. NO minimum order required.
4. MonaVie is delivered to your door in 3 to 5 days.