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Buy Wholesale and maintain an Active status for 2 months and we will refund your $39 Distributor Fee
08-SEPTEMBER-2008 07:42:01 - Premarin Premarin Systematic IUPAC name sodium 13-methyl-17-oxo-3-sulfonatooxy-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta a phenanthrene Identifiers CAS number 12126-59-9 ATC code G03CA57 PubChem 9919 DrugBank APRD00396 Chemical data Formula C18H21NaO5S Mol. mass 372.412 g/mol SMILES eMolecules PubChem Synonyms conjugated estrogens equilin sulfate Pharmacokinetic data Bioavailability ? Protein binding 90% Metabolism ? Half life 7.2 hours Excretion renal Therapeutic considerations Pregnancy cat. X Legal status ℞ Prescription only Routes Oral, topical Premarin is the commercial name for compound drug consisting primarily of conjugated estrogens. Isolated from mare's urine PREgnant MARes' urINe, it is manufactured by Wyeth Pharmaceuticals and has been marketed since 1942. It is available in oral 0.3/ 0.45/ 0.625/ 1.25mg, IV, and topical form. Contents 1 Pharmacology 2 Controversy 3 References 4 See also 5 External links Pharmacology The major forms of estrogen in Premarin are estrone 50%, equilin 15-25% and equilenin. The estrogens in Premarin are often called conjugated equine estrogens CEE because the estrogen molecules are generally present with hydrophilic side-groups attached such as sulfate. Thus, estrone sulfate is actually the major molecule in Premarin. Estrone sulfate is easily absorbed into the blood after Premarin pills are taken by women. Estrone sulfate is converted to estradiol, an active estrogen normally found in women. It is not clear if estrogens such as equilin that are foreign to the human body have effects in women that are significantly different from the estrogens like estradiol that are normally made in the human body. As Premarin is not a single compound, but a mixture of many naturally derived compounds, the structural diagram above does not show Premarin but its primary ingredient, Estrone in its sulfated form. Thus, Premarin cannot be characterized by the structure of just one of its many compounds. Controversy Premarin is the subject of some contention. Animal rights activists claim that animal husbandry and urine collection methods used in Premarin's production cause undue stress and suffering to the mares involved.1 Additionally, it is proposed that there is an overabundance of poorly bred foals produced by Pregnant Mare Urine PMU farms each year; these foals are often doomed to slaughter unless equine rescue organizations can get them to safety. Efforts are also made to rescue retired mares in lieu of their being sent to slaughter. References ^ premarin.org site See also Estrogen External links Information page of the manufacturer Premarin information at the Food and Drug Administration FDA website Menopause resource - from Wyeth Facts about Premarin - from the Humane Society Equine Advocates - clarification of care and fate of PMU mares and foals Retrieved from http://en..org/wiki/Premarin Categories: Estrogens | Bioethics | Wyeth brands | Horse products Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 30 July 2008, at 12:43
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